HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells

Authors: Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

Source: Cancer Immunology, Immunotherapy, Vol 74, Iss 3, Pp 1-13 (2025)

Subject Terms: Myeloid-derived suppressor cells, Histone deacetylase, NEDD4, CCR2, Hepatocellular carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-0851

Access URL: https://doaj.org/article/8563f410ea1342b38275d5a22b11cc63

Unified total body CT image with multiple organ specific windowings: validating improved diagnostic accuracy and speed in trauma cases

Authors: Naoki Okada, Shusuke Inoue, Chang Liu, Sho Mitarai, Shinichi Nakagawa, Yohsuke Matsuzawa, Satoshi Fujimi, Goshiro Yamamoto, Tomohiro Kuroda

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025)

Subject Terms: Diagnostic imaging, Deep learning model, Automated windowing, Trauma, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/309482cc6e5a4d80bc1c4789bcf36edf

A machine learning model for early and accurate prediction of overt disseminated intravascular coagulation before its progression to an overt stage

Authors: Yutaka Umemura, Naoki Okada, Hiroshi Ogura, Jun Oda, Satoshi Fujimi

Source: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 5, Pp 102519- (2024)

Subject Terms: biomarkers, diagnosis, disseminated intravascular coagulation, machine learning, sepsis, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2475037924002140; https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/84af7424c9624742b7bd64d29e58ccad

Laparoscopic Resection of Transverse Colon Cancer with an Anomaly of the Middle Colic Artery Originating from the Splenic Artery: A Case Report

Authors: Yoshiaki Maeda, Nozomi Minagawa, Takuya Kato, Naoki Okada, Takuto Suzuki, Chihiro Ishizuka, Akihisa Fukuda, Yoichi Mori

Source: Case Reports in Gastroenterology, Vol 18, Iss 1, Pp 105-109 (2024)

Subject Terms: colon cancer, middle colic artery, splenic artery, anomaly, laparoscopic surgery, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://beta.karger.com/Article/FullText/536672; https://doaj.org/toc/1662-0631

Access URL: https://doaj.org/article/9252f9bd8cb14286b3302c64210994cb

'KAIZEN' method realizing implementation of deep-learning models for COVID-19 CT diagnosis in real world hospitals

Authors: Naoki Okada, Yutaka Umemura, Shoi Shi, Shusuke Inoue, Shun Honda, Yohsuke Matsuzawa, Yuichiro Hirano, Ayano Kikuyama, Miho Yamakawa, Tomoko Gyobu, Naohiro Hosomi, Kensuke Minami, Natsushiro Morita, Atsushi Watanabe, Hiroyuki Yamasaki, Kiyomitsu Fukaguchi, Hiroki Maeyama, Kaori Ito, Ken Okamoto, Kouhei Harano, Naohito Meguro, Ryo Unita, Shinichi Koshiba, Takuro Endo, Tomonori Yamamoto, Tomoya Yamashita, Toshikazu Shinba, Satoshi Fujimi

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3a9763ca04cb4d99b957cda61fb9b90d

Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide for T-Cell Prolymphocytic Leukemia after Alemtuzumab Induction Therapy: A Case Report

Authors: Naoki Okada, Ryusuke Yamamoto, Hayato Maruoka, Mayuko Himeno, Nobuhiro Hiramoto, Takayuki Ishikawa

Source: Case Reports in Oncology, Vol 16, Iss 1, Pp 604-612 (2023)

Subject Terms: haploidentical stem cell transplantation, post-transplant cyclophosphamide, t-cell prolymphocytic leukemia, alemtuzumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://beta.karger.com/Article/FullText/531471; https://doaj.org/toc/1662-6575

Access URL: https://doaj.org/article/46dc5f994c1a435e8bf84e4556da82fd

Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis

Authors: Katsuyoshi Tomomatsu, Hirotaka Yasuba, Takashi Ishiguro, Shiro Imokawa, Johsuke Hara, Seiko Soeda, Norihiro Harada, Naomi Tsurikisawa, Naohiro Oda, Shigeki Katoh, Takanori Numata, Yasuteru Sugino, Mitsuhiro Yamada, Mitsuhiro Kamimura, Takeshi Terashima, Naoki Okada, Jun Tanaka, Tsuyoshi Oguma, Koichiro Asano

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4b75bd46833548afa9b98b54c7dc9b69

Humoral and cellular responses after COVID-19 booster vaccination in patients recently treated with anti-CD20 antibodies

Authors: Masashi Nishikubo, Yoshimitsu Shimomura, Ryusuke Yamamoto, Satoshi Yoshioka, Hayato Maruoka, Seiko Nasu, Tomomi Nishioka, Kenji Sakizono, Satoshi Mitsuyuki, Tomoyo Kubo, Naoki Okada, Daishi Nakagawa, Kimimori Kamijo, Hiroharu Imoto, Yuya Nagai, Nobuhiro Hiramoto, Noboru Yonetani, Tadakazu Kondo, Chisato Miyakoshi, Asako Doi, Takayuki Ishikawa

Source: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-4 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/24881e0ff2e641a688c8aaa3da0a4fdb

Dissociation of retinal ganglion cell complex and superficial retinal vessel density on optical coherence tomography in a case of pediatric optic neuritis

Authors: Sonassa Diane, Naoki Okada, Takafumi Nikaido, Yoshiaki Kiuchi

Source: American Journal of Ophthalmology Case Reports, Vol 32, Iss , Pp 101937- (2023)

Subject Terms: Pediatric optic neuritis, Dissociation, Retinal ganglion cell complex, Retinal vascular density, Ophthalmology, RE1-994

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2451993623001457; https://doaj.org/toc/2451-9936

Access URL: https://doaj.org/article/306d3f7959ff452081614315348784ee

Effect of the rho-kinase inhibitor ripasudil in needling with mitomycin C for the failure of filtering bleb after trabeculectomy: a cross-sectional study

Authors: Yu Mizuno, Naoki Okada, Hiromitsu Onoe, Kana Tokumo, Hideaki Okumichi, Kazuyuki Hirooka, Yoshiaki Kiuchi

Source: BMC Ophthalmology, Vol 22, Iss 1, Pp 1-8 (2022)

Subject Terms: Needling, Ripasudil, Rho-associated protein kinase inhibitor, Trabeculectomy, Glaucoma, Mitomycin C, Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2415

Access URL: https://doaj.org/article/2402732827be4ec88a03ea527e0a6cf9

Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice

Authors: Zhiqi Xie, Haoyang Zhou, Masanori Obana, Yasushi Fujio, Naoki Okada, Masashi Tachibana

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: MDSC, poly(I:C), lung inflammation, aging, renal ischemia/reperfusion injury, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243851/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/1150503fdf7748678a7316623385c4d2

Comparison of surgical outcomes between iStent inject W implantation and microhook ab interno trabeculotomy in combination with phacoemulsification in primary open-angle glaucoma patients

Authors: Hiromitsu Onoe, Kazuyuki Hirooka, Koji Namiguchi, Shiro Mizoue, Hiroko Hosokawa, Hideki Mochizuki, Naoki Okada, Kana Tokumo, Hideaki Okumichi, Yoshiaki Kiuchi

Source: Frontiers in Medicine, Vol 10 (2023)

Subject Terms: iStent inject W, primary open-angle glaucoma, microhook, phacoemulsification, intraocular pressure, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2023.1266532/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/dab40d78a8ad47b88d5dc7166bc3c7c9

A multicenter phase II study on the safety of rho-kinase inhibitor (ripasudil) with needling for the patients after trabeculectomy

Authors: Yu Mizuno, Kaori Komatsu, Kana Tokumo, Naoki Okada, Hiromitsu Onoe, Hideaki Okumichi, Kazuyuki Hirooka, Yukiko Miura, Yoshiaki Kiuchi

Source: Contemporary Clinical Trials Communications, Vol 33, Iss , Pp 101160- (2023)

Subject Terms: Glaucoma, Trabeculectomy, Needling, A rho-associated protein kinase inhibitor, Ripasudil, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2451865423001060; https://doaj.org/toc/2451-8654

Access URL: https://doaj.org/article/d3ddb02e6836432d94568db18fba45d5

Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism

Authors: Haoyang Zhou, Zhiqi Xie, Naosuke Morikawa, Fuminori Sakurai, Hiroyuki Mizuguchi, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

Source: Biochemistry and Biophysics Reports, Vol 33, Iss , Pp 101416- (2023)

Subject Terms: Myeloid-derived suppressor cell, Immunosuppression, Ly-6G, Tumor progression, BM-MDSC, Glutathione metabolism, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580822002163; https://doaj.org/toc/2405-5808

Access URL: https://doaj.org/article/f32405f251ad4b27b76e4673e5594d84

Spinal rosette-forming glioneuronal tumor: First case in a young child

Authors: Chiaki Shibayama, M.D., Mariko Doai, M.D.,Ph.D., Munetaka Matoba, M.D.,Ph.D., Mari Morikawa, M.D., Hitoshi Sato, M.D.,Ph.D., Naoki Okada, M.D., Yutaka Saikawa, M.D.,Ph.D., Akira Tamase, M.D.,Ph.D., Hideaki Iizuka, M.D.,Ph.D., Akihiro Shioya, M.D.,Ph.D., Sohsuke Yamada, M.D.,Ph.D.

Source: Radiology Case Reports, Vol 16, Iss 12, Pp 3982-3986 (2021)

Subject Terms: Spinal rosette-forming glioneuronal tumor, Intramedullary tumor, Young child, Pediatric, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1930043321006968; https://doaj.org/toc/1930-0433

Access URL: https://doaj.org/article/2f95a149d0af4078bae283ecab286c33

Transient ciliochoroidal detachment after microhook ab interno trabeculotomy: Its frequency and potential risk factors

Authors: Fumiya Miyako, Kazuyuki Hirooka, Hiromitsu Onoe, Naoki Okada, Hideaki Okumichi, Yoshiaki Kiuchi

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: microhook, trabeculotomy, ciliochoroidal detachment, central corneal thickness, intraocular pressure, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.1028645/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/3b77b9029d8a43759c4c777b415368ee

Efficacy and safety of nintedanib for pulmonary fibrosis in severe pneumonia induced by COVID-19: An interventional study

Authors: Yutaka Umemura, Yumi Mitsuyama, Kensuke Minami, Takeshi Nishida, Atsushi Watanabe, Naoki Okada, Kazuma Yamakawa, Kotaro Nochioka, Satoshi Fujimi

Source: International Journal of Infectious Diseases, Vol 108, Iss , Pp 454-460 (2021)

Subject Terms: COVID-19, Respiratory distress syndrome, Pulmonary fibrosis, Nintedanib, Respiration, Artificial, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971221004562; https://doaj.org/toc/1201-9712

Access URL: https://doaj.org/article/99b97fc5f908486d9afd0ed5e5f3650e

Transcutaneous immunization with a highly active form of XCL1 as a vaccine adjuvant using a hydrophilic gel patch elicits long-term CD8+ T cell responses

Authors: Momo Kamei, Kazuhiko Matsuo, Haruka Imanishi, Yuta Hara, Ying-Shu Quen, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Naoki Okada, Takashi Nakayama

Source: Journal of Pharmacological Sciences, Vol 143, Iss 3, Pp 182-187 (2020)

Subject Terms: Memory CTL, Chemokine, XCL1, Transcutaneous immunization, Adjuvant, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861320300402; https://doaj.org/toc/1347-8613

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Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF

Authors: Zhiqi Xie, Takahiro Kawasaki, Haoyang Zhou, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: myeloid-derived suppressor cells, granulocyte colony-stimulating factor, GGT1, febrile neutropenia, GGsTop, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.873792/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/148980c27c114dffbd9574d9a87ca09f

Rapid clearance of mepolizumab-resistant bronchial mucus plugs in allergic bronchopulmonary aspergillosis with benralizumab treatment

Authors: Katsuyoshi Tomomatsu, Yasuteru Sugino, Naoki Okada, Jun Tanaka, Tsuyoshi Oguma, Koichiro Asano

Source: Allergology International, Vol 69, Iss 4, Pp 636-638 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1323893020300356; https://doaj.org/toc/1323-8930

Access URL: https://doaj.org/article/5658810bdc3d40fd89379d953bf787b2