A placebo-controlled Phase 2 trial of E6011, anti-human fractalkine monoclonal antibody, in primary biliary cholangitis

Authors: Tanaka, Atsushi ^{a, ⁎}, Abe, Masanori ^b, Namisaki, Tadashi ^c, Shimoda, Shinji ^d, Zeniya, Mikio ^e, Ido, Akio ^f, Yoshiji, Hitoshi ^c, Ohira, Hiromasa ^g, Harada, Kenichi ^h, Kakuda, Yuko ⁱ, Umeda, Atsushi ^j, Kamiya, Yuki ^j, Higashine, Yukari ^k, Hojo, Seiichiro ^k, Imai, Toshio ^{l, m}, Kawano, Tetsu ^{l, n}, Nakanuma, Yasuni ^o, Tsubouchi, Hirohito ^p

Source: In Journal of Translational Autoimmunity June 2025 10

Cabozantinib prevents the progression of metabolic dysfunction-associated steatohepatitis by inhibiting the activation of hepatic stellate cell and macrophage and attenuating angiogenic activity

Authors: Matsuda, Takuya, Kaji, Kosuke ^⁎, Nishimura, Norihisa, Asada, Shohei, Koizumi, Aritoshi, Tanaka, Misako, Yorioka, Nobuyuki, Tsuji, Yuki, Kitagawa, Koh, Sato, Shinya, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

Source: In Heliyon 15 October 2024 10(19)

Blockade of angiotensin II modulates insulin-like growth factor 1-mediated skeletal muscle homeostasis in experimental steatohepatitis

Authors: Tanaka, Misako, Kaji, Kosuke ^⁎, Nishimura, Norihisa, Asada, Shohei, Koizumi, Aritoshi, Matsuda, Takuya, Yorioka, Nobuyuki, Tsuji, Yuki, Fujinaga, Yukihisa, Sato, Shinya, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

Source: In BBA - Molecular Cell Research February 2024 1871(2)

Hemoglobin levels as a surrogate marker of sarcopenia in patients with liver cirrhosis

Authors: Shibamoto, Akihiko, Namisaki, Tadashi, Suzuki, Junya, Kubo, Takahiro, Iwai, Satoshi, Tomooka, Fumimasa, Takeda, Soichi, Fujimoto, Yuki, Enomoto, Masahide, Murata, Koji, Inoue, Takashi, Tsuji, Yuki, Fujinaga, Yukihisa, Nishimura, Norihisa, Kitagawa, Koh, Takaya, Hiroaki, Kaji, Kosuke, Kawaratani, Hideto, Akahane, Takemi, Mitoro, Akira, Yoshiji, Hitoshi

Source: Hepatology research. 53(8):713-722

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189962238.0x000001&indx=1&recIds=ETOCvdc_100189962238.0x000001

Efficacy of a dedicated plastic stent in endoscopic ultrasound-guided hepaticogastrostomy during the learning curve: cumulative multi-center experience

Authors: Kitagawa, Koh, Mitoro, Akira, Minami, Ryuki, Nagamatsu, Shinsaku, Ozutsumi, Takahiro, Fujinaga, Yukihisa, Nishimura, Norihisa, Sawada, Yasuhiko, Namisaki, Tadashi, Akahane, Takemi, Kaji, Kosuke, Tomooka, Fumimasa, Asada, Shohei, Kaneko, Miki, Yoshiji, Hitoshi

Source: Scandinavian journal of gastroenterology. 58(3):296-303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174008743.0x000001&indx=1&recIds=ETOCvdc_100174008743.0x000001

Clinical features of patients with chronic liver disease in Japan related to alcohol use: Nationwide examination using alcohol use disorders identification test

Authors: Hiraoka, Atsushi, Nakai, Masato, Hara, Nagisa, Hanai, Tatsunori, Namisaki, Tadashi, Miyaaki, Hisamitsu, Nakahara, Takashi, Hiramatsu, Akira, Ohama, Hideko, Tada, Fujimasa, Takahashi, Hirokazu, Aikata, Hiroshi, Eguchi, Yuichiro, Hiasa, Yoichi, Yoshiji, Hitoshi

Source: Hepatology research. 53(1):43-50

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170016790.0x000001&indx=1&recIds=ETOCvdc_100170016790.0x000001

Vitamin D deficiency exacerbates alcohol-related liver injury via gut barrier disruption and hepatic overload of endotoxin

Authors: Shibamoto, Akihiko, Kaji, Kosuke, Nishimura, Norihisa, Kubo, Takahiro, Iwai, Satoshi, Tomooka, Fumimasa, Suzuki, Junya, Tsuji, Yuki, Fujinaga, Yukihisa, Kawaratani, Hideto, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

Source: In The Journal of Nutritional Biochemistry December 2023 122

Glucagon-like peptide-1 receptor agonist, semaglutide attenuates chronic liver disease-induced skeletal muscle atrophy in diabetic mice

Authors: Iwai, Satoshi, Kaji, Kosuke, Nishimura, Norihisa, Kubo, Takahiro, Tomooka, Fumimasa, Shibamoto, Akihiko, Suzuki, Junya, Tsuji, Yuki, Fujinaga, Yukihisa, Kitagawa, Koh, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

Source: In BBA - Molecular Basis of Disease October 2023 1869(7)

Efficacy and safety of the siRNA JNJ-73763989 and the capsid assembly modulator JNJ-56136379 (bersacapavir) with nucleos(t)ide analogues for the treatment of chronic hepatitis B virus infection (REEF-1): a multicentre, double-blind, active-controlled, randomised, phase 2b trial

Authors: Bourgeois, Stefan, Vanwolleghem, Thomas, Nevens, Frederik, Horsmans, Yves, Van Vlierberghe, Hans, Nastri, Ana Catharina, Lacerda, Marcus, Ramji, Alnoor, Conway, Brian, Coffin, Carla, Janssen, Harry, Fung, Scott, Shafran, Stephen, Hou, Jin Lin, Sperl, Jan, Urbanek, Petr, Plisek, Stanislav, Hejda, Vaclav, Samuel, Didier, Lacombe, Karine, Zoulim, Fabien, Guyader, Dominique, Raffi, Francois, Asselah, Tarik, Bourliere, Marc, Hilleret, Marie-Noelle, Wedemeyer, Heiner, Schulze zur Wiesch, Julian, Sprinzl, Kathrin, van Boemmel, Florian, Hilgard, Gudrun, Sabranski, Michael, Arasteh, Keikawus, Chan, Henry LY, Yuen, Man Fung, Wong, Vincent Ws, Brunetto, Maurizia Rossana, Taliani, Gloria, Andreone, Pietro, Lampertico, Pietro, Kurosaki, Masayuki, Yatsuhashi, Hiroshi, Fujiwara, Kei, Takehara, Tetsuo, Kawaoka, Tomokazu, Asahina, Yasuhiro, Enomoto, Hirayuki, Yabushita, Kazuhisa, Notsumata, Kazuo, Takaguchi, Koichi, Kawabe, Naoto, Kato, Naoya, Koji, Ogawa, Namisaki, Tadashi, Suzuki, Yoshiyuki, Yoon, Jung-Hwan, Ahn, SangHoon, Lim, Young-Suk, Paik, Seung Woon, Kiew, Kuang Kiat, Mohamed, Rosmawati, Tan, Soek Siam, Lee, Yeong Yeh, Hlebowicz, Maria, Berak, Hanna, Gasiorowski, Jacek, Halota, Waldemar, Janczewska, Ewa, Geyvandova, Natalia, Morozov, Viacheslav, Andreeva, Alla, Gusev, Denis, Bessonova, Elena, Osipenko, Marina, Romanova, Svetlana, Gankina, Natalia, Sagalova, Olga, Stepanova, Tatiana, Crespo Garcia, Javier, Diago, Moises, Inmaculada, Fernandez, Calleja, Jose Luis, Forns, Xavier, Buti, Maria, Tangkijvanich, Pisit, Tanwandee, Tawesak, Piratvisuth, Teerha, Leerapun, Apinya, Yilmaz, Gurdal, Tabak, Ömer Fehmi, Akarca, Ulus Salih, Akova, Murat, Idilman, Ramazan, Forton, Daniel, Bell, David, Agarwal, Kosh, Kennedy, Patrick, Felizarta, Franco, Sulkowski, Mark, Nahass, Ronald, Rojter, Sergio, Jacobson, Ira, Korenblat, Kevin, Gitlin, Norman, Yuen, Man-Fung ^*, Jacobson, Ira M, Janssen, Harry L A, Kakuda, Thomas N, Lambrecht, Tom, Beumont, Maria, Kalmeijer, Ronald, Guinard-Azadian, Carine, Mayer, Cristiana, Jezorwski, John, Verbinnen, Thierry, Lenz, Oliver, Shukla, Umesh, Biermer, Michael

Source: In The Lancet Gastroenterology & Hepatology September 2023 8(9):790-802

ADAMTS-13: A Prognostic Biomarker for Portal Vein Thrombosis in Japanese Patients with Liver Cirrhosis.

Authors: Suzuki, Junya¹ (AUTHOR) suzukij@naramed-u.ac.jp, Namisaki, Tadashi¹ (AUTHOR) htky@naramed-u.ac.jp, Takya, Hiroaki¹ (AUTHOR) kajik@naramed-u.ac.jp, Kaji, Kosuke¹ (AUTHOR) a-shibamoto@naramed-u.ac.jp, Nishimura, Norihisa¹ (AUTHOR) asahei@naramed-u.ac.jp, Shibamoto, Akihiko¹ (AUTHOR) kubotaka@naramed-u.ac.jp, Asada, Shohei¹ (AUTHOR) satoshi181@naramed-u.ac.jp, Kubo, Takahiro¹ (AUTHOR) tomooka@naramed-u.ac.jp, Iwai, Satoshi¹ (AUTHOR) souitit@naramed-u.ac.jp, Tomooka, Fumimasa¹ (AUTHOR) yuring0309@naramed-u.ac.jp, Takeda, Soichi¹ (AUTHOR) mtanaka@naramed-u.ac.jp, Koizumi, Aritoshi¹ (AUTHOR) takuya@naramed-u.ac.jp, Tanaka, Misako¹ (AUTHOR) yukifuji@naramed-u.ac.jp, Matsuda, Takuya¹ (AUTHOR) tsujih@naramed-u.ac.jp, Inoue, Takashi² (AUTHOR) tkinoue0@naramed-u.ac.jp, Fujimoto, Yuki¹ (AUTHOR) fujinaga@naramed-u.ac.jp, Tsuji, Yuki¹ (AUTHOR) shinyasato@naramed-u.ac.jp, Fujinaga, Yukihisa¹ (AUTHOR) kawara@naramed-u.ac.jp, Sato, Shinya¹ (AUTHOR) stakemi@naramed-u.ac.jp, Kitagawa, Koh¹ (AUTHOR) mitoroak@naramed-u.ac.jp

Source: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2678. 13p.

Subject Terms: *PORTAL vein, *JAPANESE people, *SPIRAL computed tomography, *CIRRHOSIS of the liver, *FIBRIN fibrinogen degradation products, *FIBRIN

Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet–induced rat steatohepatitis

Authors: Enomoto, Masahide, Kaji, Kosuke, Nishimura, Norihisa, Fujimoto, Yuki, Murata, Koji, Takeda, Soichi, Tsuji, Yuki, Fujinaga, Yukihisa, Takaya, Hiroaki, Kawaratani, Hideto, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

Source: In Digestive and Liver Disease October 2022 54(10):1392-1402

Machine learning in primary biliary cholangitis: A novel approach for risk stratification

Authors: Gerussi, Alessio, Verda, Damiano, Bernasconi, Davide Paolo, Carbone, Marco, Komori, Atsumasa, Abe, Masanori, Inao, Mie, Namisaki, Tadashi, Mochida, Satoshi, Yoshiji, Hitoshi, Hirschfield, Gideon, Lindor, Keith, Pares, Albert, Corpechot, Christophe, Cazzagon, Nora, Floreani, Annarosa, Marzioni, Marco, Alvaro, Domenico, Vespasiani‐Gentilucci, Umberto, Cristoferi, Laura, Valsecchi, Maria Grazia, Muselli, Marco, Hansen, Bettina E., Tanaka, Atsushi, Invernizzi, Pietro

Source: Liver international. 42(3):615-627

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100142264424.0x000001&indx=1&recIds=ETOCvdc_100142264424.0x000001

Prognostic significance of skeletal muscle mass in patients with alcohol‐related cirrhosis.

Authors: Shibamoto, Akihiko¹ (AUTHOR), Namisaki, Tadashi¹ (AUTHOR) tadashin@naramed-u.ac.jp, Iwai, Satoshi¹ (AUTHOR), Tomooka, Fumimasa¹ (AUTHOR), Kubo, Takahiro¹ (AUTHOR), Koizumi, Aritoshi¹ (AUTHOR), Tanaka, Misako¹ (AUTHOR), Matsuda, Takuya¹ (AUTHOR), Inoue, Takashi² (AUTHOR), Tsuji, Yuki¹ (AUTHOR), Fujinaga, Yukihisa¹ (AUTHOR), Nishimura, Norihisa¹ (AUTHOR), Sato, Shinya¹ (AUTHOR), Kitagawa, Koh¹ (AUTHOR), Kaji, Kosuke¹ (AUTHOR), Mitoro, Akira¹ (AUTHOR), Asada, Kiyoshi³ (AUTHOR), Takaya, Hiroaki¹ (AUTHOR), Akahane, Takemi¹ (AUTHOR), Yoshiji, Hitoshi¹ (AUTHOR)

Source: Hepatology Research. Mar2025, p1. 15p. 3 Illustrations, 5 Charts.

Real-World Setting of Efficacy and Safety of 3 Years of Rifaximin Administration in Japanese Patients with Hepatic Encephalopathy: A Multicenter Retrospective Study.

Authors: Kawaratani, Hideto¹ (AUTHOR) kawara@naramed-u.ac.jp, Namisaki, Tadashi¹ (AUTHOR) tadashin@naramed-u.ac.jp, Kondo, Yasuteru² (AUTHOR) yasuteru@ebony.plala.or.jp, Tatsumi, Ryoji³ (AUTHOR) nyantyu_seijin@yahoo.co.jp, Kawabe, Naoto⁴ (AUTHOR) kawabe@fujita-hu.ac.jp, Tanabe, Norikazu⁵ (AUTHOR) norikazu@yamaguchi-u.ac.jp, Sakamaki, Akira⁶ (AUTHOR) saka-a@med.niigata-u.ac.jp, Hoshikawa, Kyoko⁷ (AUTHOR) to.kyoko@med.id.yamagata-u.ac.jp, Uchida, Yoshihito⁸ (AUTHOR) uchida.yoshihito@1972.saitama-med.ac.jp, Endo, Kei⁹ (AUTHOR) keiendo@iwate-med.ac.jp, Kawaguchi, Takumi¹⁰ (AUTHOR) takumi@med.kurume-u.ac.jp, Oikawa, Tsunekazu¹¹ (AUTHOR), Ishizu, Yoji¹² (AUTHOR) y-ishizu@med.nagoya-u.ac.jp, Hige, Shuhei³ (AUTHOR) shuhei.hige@ja-hokkaidoukouseiren.or.jp, Takami, Taro⁵ (AUTHOR) t-takami@yamaguchi-u.ac.jp, Terai, Shuji⁶ (AUTHOR) terais@med.niigata-u.ac.jp, Ueno, Yoshiyuki⁷ (AUTHOR) y-ueno@med.id.yamagata-u.ac.jp, Mochida, Satoshi⁸ (AUTHOR) smochida@saitama-med.ac.jp, Koike, Kazuhiko¹³ (AUTHOR) kkoike.tky@gmail.com, Yoshiji, Hitoshi¹ (AUTHOR)

Source: Journal of Clinical Medicine. Feb2025, Vol. 14 Issue 4, p1358. 14p.

Subject Terms: *RIFAXIMIN, *HEPATIC encephalopathy, *JAPANESE people, *SERUM albumin, *OVERALL survival

Noninvasive assessment of portal hypertension based on the Baveno VII criteria.

Authors: Namisaki, Tadashi¹ (AUTHOR) tadashin@naramed-u.ac.jp

Source: Hepatology Research. Apr2024, Vol. 54 Issue 4, p323-325. 3p.

Subject Terms: *PORTAL hypertension, *ESOPHAGEAL varices, *FATTY liver

Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway

Authors: Ishida, Koji, Kaji, Kosuke, Sato, Shinya, Ogawa, Hiroyuki, Takagi, Hirotetsu, Takaya, Hiroaki, Kawaratani, Hideto, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

Source: In The Journal of Nutritional Biochemistry March 2021 89

Hemoglobin and Endotoxin Levels Predict Sarcopenia Occurrence in Patients with Alcoholic Cirrhosis.

Authors: Shibamoto, Akihiko¹ (AUTHOR), Namisaki, Tadashi¹ (AUTHOR) tadashin@naramed-u.ac.jp, Suzuki, Junya¹ (AUTHOR), Kubo, Takahiro¹ (AUTHOR), Iwai, Satoshi¹ (AUTHOR), Tomooka, Fumimasa¹ (AUTHOR), Takeda, Soichi¹ (AUTHOR), Fujimoto, Yuki¹ (AUTHOR), Inoue, Takashi² (AUTHOR), Tanaka, Misako¹ (AUTHOR), Koizumi, Aritoshi¹ (AUTHOR), Yorioka, Nobuyuki¹ (AUTHOR), Matsuda, Takuya¹ (AUTHOR), Asada, Shohei¹ (AUTHOR), Tsuji, Yuki¹ (AUTHOR), Fujinaga, Yukihisa¹ (AUTHOR), Nishimura, Norihisa¹ (AUTHOR), Sato, Shinya¹ (AUTHOR), Takaya, Hiroaki¹ (AUTHOR), Kitagawa, Koh¹ (AUTHOR)

Source: Diagnostics (2075-4418). Jul2023, Vol. 13 Issue 13, p2218. 19p.

Subject Terms: *SARCOPENIA, *ENDOTOXINS, *BLOOD urea nitrogen, *HEMOGLOBINS, *MUSCLE mass

Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis

Authors: Ogawa, Hiroyuki, Kaji, Kosuke, Nishimura, Norihisa, Takagi, Hirotetsu, Ishida, Koji, Takaya, Hiroaki, Kawaratani, Hideto, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

Source: Journal of cellular and molecular medicine. 25(8):4001-4013

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121335470.0x000001&indx=1&recIds=ETOCvdc_100121335470.0x000001

The association of histological progression with biochemical response to ursodeoxycholic acid in primary biliary cholangitis

Authors: Namisaki, Tadashi, Fujinaga, Yukihisa, Moriya, Kei, Yoshiji, Hitoshi

Source: Hepatology research. 51(1):31-38

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114740690.0x000001&indx=1&recIds=ETOCvdc_100114740690.0x000001

Ratio of von Willebrand factor to ADAMTS13 is a useful predictor of esophagogastric varices progression after sustained virologic response in patients with hepatitis C virus‐related liver cirrhosis.

Authors: Iwai, Satoshi, Akahane, Takemi, Takaya, Hiroaki, Kubo, Takahiro, Tomooka, Fumimasa, Shibamoto, Akihiko, Suzuki, Junya, Tsuji, Yuki, Fujinaga, Yukihisa, Nishimura, Norihisa, Kitagawa, Koh, Kaji, Kosuke, Kawaratani, Hideto, Namisaki, Tadashi, Matsumoto, Masanori, Yoshiji, Hitoshi

Source: Hepatology Research; Dec2024, Vol. 54 Issue 12, p1116-1127, 12p

Subject Terms: VON Willebrand factor, HEPATITIS C virus, CIRRHOSIS of the liver, HEPATITIS C, PORTAL hypertension