Continuous flow synthesis of cyclobutenes via lithium ynolates.

Authors: Kohyama, Aki¹ (AUTHOR) koyama.aki.6a@kyoto-u.ac.jp, Namioka, Motoki¹ (AUTHOR), Naka, Hiroshi^1,2 (AUTHOR), Ashikari, Yosuke³ (AUTHOR), Nagaki, Aiichiro³ (AUTHOR), Takikawa, Hiroshi¹ (AUTHOR), Yamaoka, Yousuke¹ (AUTHOR) yyamaoka@hyo-med.ac.jp, Takasu, Kiyosei¹ (AUTHOR) takasu.kiyosei.6r@kyoto-u.ac.jp

Source: Green Chemistry. 3/14/2025, Vol. 27 Issue 10, p2760-2765. 6p.

Subject Terms: *RING formation (Chemistry), *CHEMICAL species, *RAMAN spectroscopy, *CYCLOBUTENES, *ENOLATES

Entry into Lithium Ynolates from α,α,α-Tribromomethyl Ketones: Synthesis of Cyclobutenes via the [2 + 2] Cycloaddition with α,β-Unsaturated Carbonyls.

Authors: Yamaoka, Yousuke, Imahori, Hidetaka, Namioka, Motoki, Nishina, Ryo, Kobori, Yukiko, Ueda, Motoki, Shindo, Mitsuru, Takasu, Kiyosei

Source: Organic Letters; 3/8/2024, Vol. 26 Issue 9, p1896-1901, 6p