Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

Authors: Suhasini Joshi, Erica DaGama Gomes, Tai Wang, Adriana Corben, Tony Taldone, Srinivasa Gandu, Chao Xu, Sahil Sharma, Salma Buddaseth, Pengrong Yan, Lon Yin L. Chan, Askan Gokce, Vinagolu K. Rajasekhar, Lisa Shrestha, Palak Panchal, Justina Almodovar, Chander S. Digwal, Anna Rodina, Swathi Merugu, NagaVaraKishore Pillarsetty, Vlad Miclea, Radu I. Peter, Wanyan Wang, Stephen D. Ginsberg, Laura Tang, Marissa Mattar, Elisa de Stanchina, Kenneth H. Yu, Maeve Lowery, Olivera Grbovic-Huezo, Eileen M. O’Reilly, Yelena Janjigian, John H. Healey, William R. Jarnagin, Peter J. Allen, Chris Sander, Hediye Erdjument-Bromage, Thomas A. Neubert, Steven D. Leach, Gabriela Chiosis

Source: Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/c73d69998238486ba39d6f85c901b64d

Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

Authors: Alexander Bolaender, Danuta Zatorska, Huazhong He, Suhasini Joshi, Sahil Sharma, Chander S. Digwal, Hardik J. Patel, Weilin Sun, Brandon S. Imber, Stefan O. Ochiana, Maulik R. Patel, Liza Shrestha, Smit. K. Shah, Shuo Wang, Rashad Karimov, Hui Tao, Pallav D. Patel, Ananda Rodilla Martin, Pengrong Yan, Palak Panchal, Justina Almodovar, Adriana Corben, Andreas Rimner, Stephen D. Ginsberg, Serge Lyashchenko, Eva Burnazi, Anson Ku, Teja Kalidindi, Sang Gyu Lee, Milan Grkovski, Bradley J. Beattie, Pat Zanzonico, Jason S. Lewis, Steve Larson, Anna Rodina, Nagavarakishore Pillarsetty, Viviane Tabar, Mark P. Dunphy, Tony Taldone, Fumiko Shimizu, Gabriela Chiosis

Source: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ed3d8f0c921541cb8291f5f96c64889e

Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action

Authors: Sahil Sharma, Suhasini Joshi, Teja Kalidindi, Chander S. Digwal, Palak Panchal, Sang-Gyu Lee, Pat Zanzonico, Nagavarakishore Pillarsetty, Gabriela Chiosis

Source: Biomedicines, Vol 11, Iss 10, p 2599 (2023)

Subject Terms: zelavespib, epichaperomes, drug–target residence time, target–ligand interactions, target engagement and occupancy, mechanisms of drug action, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/10/2599; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/969e67720f1d409abb4c4efbd6be63ea

Synthesis of 124I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice

Authors: Sahil Sharma, Teja Kalidindi, Suhasini Joshi, Chander S. Digwal, Palak Panchal, Eva Burnazi, Sang Gyu Lee, Nagavarakishore Pillarsetty, Gabriela Chiosis

Source: STAR Protocols, Vol 3, Iss 2, Pp 101318- (2022)

Subject Terms: Cell culture, Cancer, Model Organisms, Molecular/Chemical Probes, Chemistry, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166722001988; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/7a5a4e7ccd824979bc471bc7f2693c33

Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor

Authors: James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm

Source: Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)

Subject Terms: autoradiography, capecitabine, gemcitabine, LC–MS, pancreatic cancer, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2052-1707

Access URL: https://doaj.org/article/9a2617618920471fbdb6fb46405f3a90

Targeting Carbohydrate Mimetics of Tetrahydrofuran-Containing Acetogenins to Prostate Cancer

Authors: Patricia Gonzalez Periche, Jacky Lin, Naga V. S. D. K. Bhupathiraju, Teja Kalidindi, Delissa S. Johnson, Nagavarakishore Pillarsetty, David R. Mootoo

Source: Molecules, Vol 28, Iss 7, p 2884 (2023)

Subject Terms: acetogenin, mannose, mimetic, PSMA, selectivity, prostate cancer, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/7/2884; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/c6dc728265074fe9bd313b2a053c9c8f

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

Authors: Maria Carmen Inda, Suhasini Joshi, Tai Wang, Alexander Bolaender, Srinivasa Gandu, John Koren III, Alicia Yue Che, Tony Taldone, Pengrong Yan, Weilin Sun, Mohammad Uddin, Palak Panchal, Matthew Riolo, Smit Shah, Afsar Barlas, Ke Xu, Lon Yin L. Chan, Alexandra Gruzinova, Sarah Kishinevsky, Lorenz Studer, Valentina Fossati, Scott A. Noggle, Julie R. White, Elisa de Stanchina, Sonia Sequeira, Kyle H. Anthoney, John W. Steele, Katia Manova-Todorova, Sujata Patil, Mark P. Dunphy, NagaVaraKishore Pillarsetty, Ana C. Pereira, Hediye Erdjument-Bromage, Thomas A. Neubert, Anna Rodina, Stephen D. Ginsberg, Natalia De Marco Garcia, Wenjie Luo, Gabriela Chiosis

Source: Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c776838301d2406eb50617b6e0cb86a1

Comparing the intra-tumoral distribution of Gemcitabine, 5-Fluorouracil, and Capecitabine in a murine model of pancreatic ductal adenocarcinoma.

Authors: Louise M Fanchon, James Russell, Nagavarakishore Pillarsetty, Isabella O'Donoghue, Kishore Gangangari, Kenneth H Yu, John L Humm

Source: PLoS ONE, Vol 15, Iss 4, p e0231745 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7adf9221d4bb4d8e964ed7d9acc68bdd

Fluorine-labeled Dasatinib Nanoformulations as Targeted Molecular Imaging Probes in a PDGFB-driven Murine Glioblastoma Model

Authors: Miriam Benezra, Dolores Hambardzumyan, Oula Penate-Medina, Darren R. Veach, Nagavarakishore Pillarsetty, Peter Smith-Jones, Evan Phillips, Tatsuya Ozawa, Pat B. Zanzonico, Valerie Longo, Eric C. Holland, Steven M. Larson, Michelle S. Bradbury

Source: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 12, Pp 1132-1143 (2012)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558612800509; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

Access URL: https://doaj.org/article/2c08ae7489e040099780f8259071fc02

Synthesis and Biological Evaluation of a Fluorine-18 Derivative of Dasatinib.

Authors: Darren R. Veach, Mohammad Namavari, Nagavarakishore Pillarsetty, Elmer B. Santos, Tatiana Beresten-Kochetkov, Caryl Lambek, Blesida J. Punzalan, Christophe Antczak, Peter M. Smith-Jones, Hakim Djaballah, Bayard Clarkson, Steven M. Larson

Source: Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 23, p5853-5857, 5p