The Role of Mitochondria in Diabetic Kidney Disease and Potential Therapeutic Targets

Authors: Takasu, Masanobu ¹, Kishi, Seiji ^{1, ∗}, Nagasu, Hajime ¹, Kidokoro, Kengo ¹, Brooks, Craig R. ², Kashihara, Naoki ^{3, 4}

Source: In Kidney International Reports February 2025 10(2):328-342

ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice.

Authors: Kajimoto, Eriko¹ (AUTHOR), Nagasu, Hajime¹ (AUTHOR) hajimenagasu@med.kawasaki-m.ac.jp, Takasu, Masanobu¹ (AUTHOR), Kishi, Seiji¹ (AUTHOR), Wada, Masafumi¹ (AUTHOR), Tatsugawa, Rie¹ (AUTHOR), Hirano, Akira¹ (AUTHOR), Iwakura, Tsukasa¹ (AUTHOR), Umeno, Reina¹ (AUTHOR), Wada, Yoshihisa¹ (AUTHOR), Itano, Seiji¹ (AUTHOR), Kadoya, Hiroyuki^1,2 (AUTHOR), Kidokoro, Kengo¹ (AUTHOR), Sasaki, Tamaki¹ (AUTHOR), Kashihara, Naoki³ (AUTHOR)

Source: Scientific Reports. 11/2/2024, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *CELLULAR aging, *DISEASE progression, *REACTIVE oxygen species, *LABORATORY mice, *ALBUMINURIA, *DIABETIC nephropathies

Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging

Authors: Wada, Yoshihisa, Kidokoro, Kengo, Kondo, Megumi, Tokuyama, Atsuyuki, Kadoya, Hiroyuki, Nagasu, Hajime, Kanda, Eiichiro, Sasaki, Tamaki, Cherney, David Z.I., Kashihara, Naoki

Source: In Kidney International September 2024 106(3):408-418

Kidney outcomes associated with haematuria and proteinuria trajectories among patients with IgA nephropathy in real‐world clinical practice: The Japan Chronic Kidney Disease Database.

Authors: Yano, Yuichiro^1,2 (AUTHOR) yano.yuichiro@jichi.ac.jp, Nagasu, Hajime³ (AUTHOR), Kanegae, Hiroshi⁴ (AUTHOR), Nangaku, Masaomi⁵ (AUTHOR), Hirakawa, Yosuke⁵ (AUTHOR), Sugawara, Yuka⁵ (AUTHOR), Nakagawa, Naoki⁶ (AUTHOR), Wada, Jun⁷ (AUTHOR), Sugiyama, Hitoshi⁸ (AUTHOR), Nakano, Toshiaki⁹ (AUTHOR), Wada, Takashi¹⁰ (AUTHOR), Shimizu, Miho¹⁰ (AUTHOR), Suzuki, Hitoshi¹¹ (AUTHOR), Komatsu, Hiroyuki¹² (AUTHOR), Nakashima, Naoki¹³ (AUTHOR), Kitaoka, Kaori¹ (AUTHOR), Narita, Ichiei¹⁴ (AUTHOR), Okada, Hirokazu¹⁵ (AUTHOR), Suzuki, Yusuke¹¹ (AUTHOR), Kashihara, Naoki³ (AUTHOR)

Source: Nephrology. Feb2024, Vol. 29 Issue 2, p65-75. 11p.

Subject Terms: *IGA glomerulonephritis, *CHRONIC kidney failure, *HEMATURIA, *PROTEINURIA, *DATABASES

Glomerular Classification Using Convolutional Neural Networks Based on Defined Annotation Criteria and Concordance Evaluation Among Clinicians

Authors: Yamaguchi, Ryohei, Kawazoe, Yoshimasa, Shimamoto, Kiminori, Shinohara, Emiko, Tsukamoto, Tatsuo, Shintani-Domoto, Yukako, Nagasu, Hajime, Uozaki, Hiroshi, Ushiku, Tetsuo, Nangaku, Masaomi, Kashihara, Naoki, Shimizu, Akira, Nagata, Michio, Ohe, Kazuhiko

Source: In Kidney International Reports March 2021 6(3):716-726

Association between proteinuria and mineral metabolism disorders in chronic kidney disease: the Japan chronic kidney disease database extension (J-CKD-DB-Ex).

Authors: Shimamoto, Sho, Nakahara, Takako, Yamada, Shunsuke, Nagasu, Hajime, Kishi, Seiji, Nakashima, Naoki, Tsuruya, Kazuhiko, Okada, Hirokazu, Tamura, Kouichi, Narita, Ichiei, Maruyama, Shoichi, Yano, Yuichiro, Yokoo, Takashi, Wada, Takashi, Wada, Jun, Kanda, Eiichiro, Kataoka, Hiromi, Nangaku, Masaomi, Kashihara, Naoki, Nakano, Toshiaki

Source: Scientific Reports; 11/11/2024, Vol. 14 Issue 1, p1-9, 9p

Subject Terms: RENAL osteodystrophy, METABOLIC disorders, CHRONIC kidney failure, LOGISTIC regression analysis, PROGNOSIS

Effects of Beraprost on Intestinal Microcirculation and Barrier Function in a Mouse Model of Renal Failure.

Authors: Hirano, Akira, Kadoya, Hiroyuki, Takasu, Masanobu, Iwakura, Tsukasa, Kajimoto, Eriko, Tatsugawa, Rie, Matsuura, Takumi, Kurumatani, Hajimu, Yamamoto, Toshiya, Kidokoro, Kengo, Kishi, Seiji, Nagasu, Hajime, Sasaki, Tamaki, Kashihara, Naoki

Source: Microcirculation; Nov2024, Vol. 31 Issue 8, p1-11, 11p

Subject Terms: TIGHT junctions, CHRONIC kidney failure, REACTIVE oxygen species, SMALL intestine, LABORATORY mice

Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis

Authors: Kadoya, Hiroyuki, Hirano, Akira, Umeno, Reina, Kajimoto, Eriko, Iwakura, Tsukasa, Kondo, Megumi, Wada, Yoshihisa, Kidokoro, Kengo, Kishi, Seiji, Nagasu, Hajime, Sasaki, Tamaki, Taniguchi, Shun'ichiro, Takahashi, Masafumi, Kashihara, Naoki

Source: FASEB journal. 37(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191761631.0x000001&indx=1&recIds=ETOCvdc_100191761631.0x000001

Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease.

Authors: Kishi, Seiji, Nakashima, Takaya, Goto, Tadahiro, Nagasu, Hajime, Brooks, Craig R., Okada, Hirokazu, Tamura, Kouichi, Nakano, Toshiaki, Narita, Ichiei, Maruyama, Shoichi, Yano, Yuichiro, Yokoo, Takashi, Wada, Takashi, Wada, Jun, Nangaku, Masaomi, Kashihara, Naoki

Source: Clinical & Experimental Nephrology; Aug2024, Vol. 28 Issue 8, p784-792, 9p

Subject Terms: CHRONIC kidney failure, MAGNESIUM, CHRONICALLY ill, MAGNESIUM group, PROGNOSIS

Factors affecting the sodium‐glucose cotransporter 2 inhibitors‐related initial decline in glomerular filtration rate and its possible effect on kidney outcome in chronic kidney disease with type 2 diabetes: The Japan Chronic Kidney Disease Database

Authors: Kanaoka, Tomohiko, Wakui, Hiromichi, Yano, Yuichiro, Nagasu, Hajime, Kanegae, Hiroshi, Nangaku, Masaomi, Hirakawa, Yosuke, Nakagawa, Naoki, Wada, Jun, Tsuruya, Kazuhiko, Nakano, Toshiaki, Maruyama, Shoichi, Wada, Takashi, Konishi, Masaaki, Nagahiro, Takanori, Yamagata, Kunihiro, Narita, Ichiei, Yanagita, Motoko, Terada, Yoshio, Araki, Shinichi

Source: Diabetes, Obesity & Metabolism; Jul2024, Vol. 26 Issue 7, p2905-2914, 10p

Subject Terms: SODIUM-glucose cotransporters, CHRONIC kidney failure, GLOMERULAR filtration rate, TYPE 2 diabetes, DATABASES, RENIN-angiotensin system, DEAD

Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells

Authors: Porter, Robert S., Murata-Nakamura, Yumie, Nagasu, Hajime, Kim, Hyung-Goo, Iwase, Shigeki

Source: In Neuroscience 1 February 2018 370:170-180

Bardoxolone methyl analog attenuates proteinuria‐induced tubular damage by modulating mitochondrial function

Authors: Nagasu, Hajime, Sogawa, Yuji, Kidokoro, Kengo, Itano, Seiji, Yamamoto, Toshiya, Satoh, Minoru, Sasaki, Tamaki, Suzuki, Takafumi, Yamamoto, Masayuki, Wigley, W. Christian, Proksch, Joel W., Meyer, Colin J., Kashihara, Naoki

Source: FASEB journal. 33(11):12253-12263

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132984385.0x000001&indx=1&recIds=ETOCvdc_100132984385.0x000001

5‐Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis‐induced acute kidney injury

Authors: Uchida, Atsushi, Kidokoro, Kengo, Sogawa, Yuji, Itano, Seiji, Nagasu, Hajime, Satoh, Minoru, Sasaki, Tamaki, Kashihara, Naoki

Source: Nephrology. 24(1):28-38

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095114541.0x000001&indx=1&recIds=ETOCvdc_100095114541.0x000001

Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice Using In Vivo Imaging

Authors: Kidokoro, Kengo, Cherney, David Z.I., Bozovic, Andrea, Nagasu, Hajime, Satoh, Minoru, Kanda, Eiichiro, Sasaki, Tamaki, Kashihara, Naoki

Source: Circulation. 140(4):303-315

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085405344.0x000001&indx=1&recIds=ETOCvdc_100085405344.0x000001

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes.

Authors: Nyma, Zannatun, Kitaoka, Kaori, Yano, Yuichiro, Kanegae, Hiroshi, Bayaraa, Nomin, Kishi, Seiji, Nagasu, Hajime, Nakano, Toshiaki, Wada, Jun, Maruyama, Shoichi, Nakagawa, Naoki, Tamura, Kouichi, Yokoo, Takashi, Yanagita, Motoko, Narita, Ichiei, Yamagata, Kunihiro, Wada, Takashi, Tsuruya, Kazuhiko, Nakashima, Naoki, Isaka, Yoshitaka

Source: Scientific Reports; 5/20/2024, Vol. 14 Issue 1, p1-12, 12p

A case series of Fabry diseases with CKD in Japan.

Authors: Yusei, Oi¹ (AUTHOR), Nagasu, Hajime² (AUTHOR) hajimenagasu@kms-ndh.com, Nakagawa, Naoki³ (AUTHOR), Terawaki, Seigo⁴ (AUTHOR), Moriwaki, Takahito⁴ (AUTHOR), Itano, Seiji² (AUTHOR), Kishi, Seiji² (AUTHOR), Sasaki, Tamaki² (AUTHOR), Kashihara, Naoki² (AUTHOR), Otomo, Takanobu⁴ (AUTHOR) otomo@med.kawasaki-m.ac.jp

Source: Clinical & Experimental Nephrology. May2024, Vol. 28 Issue 5, p404-408. 5p.

Subject Terms: *ANGIOKERATOMA corporis diffusum, *CHRONIC kidney failure, *GLOMERULAR filtration rate, *RENIN-angiotensin system, *KIDNEY diseases

Geographic Terms: JAPAN

Summary of the 2018 ISN Frontiers Meeting: Kidney Disease and Cardiovascular Disease

Authors: Kume, Shinji, Nagasu, Hajime, Nangaku, Masaomi, Nishiyama, Akira, Nakamoto, Hidetomo, Kashihara, Naoki

Source: Kidney international reports. 3(4):804-816

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131044417.0x000001&indx=1&recIds=ETOCvdc_100131044417.0x000001

Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice

Authors: Nagasu, Hajime, Satoh, Minoru, Kiyokage, Emi, Kidokoro, Kengo, Toida, Kazunori, Channon, Keith M, Kanwar, Yashpal S, Sasaki, Tamaki, Kashihara, Naoki

Source: In Laboratory Investigation January 2016 96(1):25-36

Oxidative stress and the role of redox signalling in chronic kidney disease.

Authors: Kishi, Seiji¹ (AUTHOR), Nagasu, Hajime¹ (AUTHOR), Kidokoro, Kengo¹ (AUTHOR), Kashihara, Naoki¹ (AUTHOR) kashinao@med.kawasaki-m.ac.jp

Source: Nature Reviews Nephrology. Feb2024, Vol. 20 Issue 2, p101-119. 19p.

Subject Terms: *CHRONIC kidney failure, *OXIDATIVE stress, *REACTIVE oxygen species, *CELL physiology, *OXIDATION-reduction reaction

Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice

Authors: Sogawa, Yuji, Nagasu, Hajime, Iwase, Shigeki, Ihoriya, Chieko, Itano, Seiji, Uchida, Atsushi, Kidokoro, Kengo, Taniguchi, Shun'ichiro, Takahashi, Masafumi, Satoh, Minoru, Sasaki, Tamaki, Suzuki, Takafumi, Yamamoto, Masayuki, Horng, Tiffany, Kashihara, Naoki

Source: Scientific reports. 7(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175120237.0x000001&indx=1&recIds=ETOCvdc_100175120237.0x000001