Dual biological role and clinical impact of de novo chromatin activation in chronic lymphocytic leukemia

Authors: Chapaprieta, Vicente ^{1, 2, 3}, Maiques-Diaz, Alba ^{1, 3}, Nadeu, Ferran ^{1, 3}, Clot, Guillem ^{1, 3, 4}, Massoni-Badosa, Ramon ⁵, Mozas, Pablo ⁶, Mateos-Jaimez, Judith ^{1, 3}, Vidal, Anna ¹, Charalampopoulou, Stella ^{1, 2, 3}, Duran-Ferrer, Martí ^{1, 3}, Royo, Romina ⁷, Russiñol, Núria ¹, Llaó-Cid, Laura ¹, Piñeyroa, Juan A. ^{1, 6}, Villamor, Neus ⁶, Heyn, Holger ^{5, 8}, Herbst, Sophie A. ⁹, Lu, Junyan ^{10, 11}, Bryant, Dean J. ¹², Strefford, Jonathan C. ¹², Dietrich, Sascha ^{13, 14}, Zenz, Thorsten ^{15, 16}, Delgado, Julio ^{1, 3, 7}, López-Guillermo, Armando ^{1, 3, 7}, Campo, Elias ^{1, 3, 4, 6}, Martin-Subero, Jose I. ^{1, 3, 4, 8, ∗}

Source: In Blood December 2024

Epigenetic features support the diagnosis of B-cell prolymphocytic leukemia and identify 2 clinicobiological subtypes

Authors: Charalampopoulou, Stella, Chapiro, Elise, Nadeu, Ferran, Zenz, Thorsten, Beà, Sílvia, Martínez-Farran, Ares, Aymerich, Marta, Rozman, Maria, Roos-Weil, Damien, Bernard, Olivier, Susin, Santos A., Parker, Helen, Walewska, Renata, Oakes, Christopher C., Strefford, Jonathan C., Campo, Elías, Matutes, Estela, Duran-Ferrer, Martí, Nguyen-Khac, Florence, Martín-Subero, José I.

Source: In Blood Advances 24 December 2024 8(24):6297-6307

SOX11 expression is restricted to EBV-negative Burkitt lymphoma and is associated with molecular genetic features

Authors: Sureda-Gómez, Marta, Iaccarino, Ingram, De Bolòs, Anna, Meyer, Mieke, Balsas, Patricia, Richter, Julia, Rodríguez, Marta-Leonor, López, Cristina, Carreras-Caballé, Maria, Glaser, Selina, Nadeu, Ferran, Jares, Pedro, Clot, Guillem, Siciliano, Maria Chiara, Bellan, Cristiana, Tornambè, Salvatore, Boccacci, Roberto, Leoncini, Lorenzo, Campo, Elias, Siebert, Reiner, Amador, Virginia, Klapper, Wolfram

Source: In Blood 11 July 2024 144(2):187-200

From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia

Authors: Abrisqueta, Pau, Nadeu, Ferran, Bosch-Schips, Jan, Iacoboni, Gloria, Serna, Angel, Cabirta, Alba, Yáñez, Lucrecia, Quintanilla-Martínez, Leticia, Bosch, Francesc

Source: In Cancer Treatment Reviews November 2023 120

Genomic landscape of follicular lymphoma across a wide spectrum of clinical behaviors

Authors: Mozas, Pablo, López, Cristina, Grau, Marta, Nadeu, Ferran, Clot, Guillem, Valle, Sara, Kulis, Marta, Navarro, Alba, Ramis‐Zaldivar, Joan Enric, González‐Farré, Blanca, Rivas‐Delgado, Alfredo, Rivero, Andrea, Frigola, Gerard, Balagué, Olga, Giné, Eva, Delgado, Julio, Villamor, Neus, Matutes, Estella, Magnano, Laura, García‐Sanz, Ramón, Huet, Sarah, Russell, Robert B., Campo, Elías, López‐Guillermo, Armando, Beà, Sílvia

Source: Hematological oncology. 41(4):631-643

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195171352.0x000001&indx=1&recIds=ETOCvdc_100195171352.0x000001

MYC and TP53 Alterations but Not MAPK Pathway Mutations Are Common Oncogenic Mechanisms in Follicular Dendritic Cell Sarcomas

Authors: Frigola, Gerard, Bühler, Marco, Marginet, Marta, Enjuanes, Anna, Nadeu, Ferran, Papaleo, Natalia, Salido, Marta, Haralambieva, Eugenia, Alamo, José, Garcia-Bragado, Federico

Source: Archives of pathology & laboratory medicine. 147(8):896-906

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633165887&indx=1&recIds=ETOCRN633165887

Intravascular Large B-Cell Lymphoma Genomic Profile Is Characterized by Alterations in Genes Regulating NF-κB and Immune Checkpoints

Authors: Gonzalez-Farre, Blanca, Ramis-Zaldivar, Joan E., Castrejón de Anta, Natalia, Rivas-Delgado, Alfredo, Nadeu, Ferran, Salmeron-Villalobos, Julia, Enjuanes, Anna, Karube, Kennosuke, Balagué, Olga, Cobo, Francesc, Kelleher, Nicholas, Victoria, Ingrid, Veloza, Luis, Teixido, Cristina, Giné, Eva, Lopez-Guerra, Mónica, Quintanilla-Martinez, Leticia, Lopez-Guillermo, Armando, Salaverria, Itziar, Campo, Elias

Source: American journal of surgical pathology. 47(2):202-211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178110479.0x000001&indx=1&recIds=ETOCvdc_100178110479.0x000001

Unraveling the genetics of transformed splenic marginal zone lymphoma

Authors: Grau, Marta, López, Cristina, Navarro, Alba, Frigola, Gerard, Nadeu, Ferran, Clot, Guillem, Bastidas-Mora, Gabriela, Alcoceba, Miguel, Baptista, Maria Joao, Blanes, Margarita, Colomer, Dolors, Costa, Dolors, Domingo-Domènech, Eva, Enjuanes, Anna, Escoda, Lourdes, Forcada, Pilar, Giné, Eva, Lopez-Guerra, Mónica, Ramón, Olga, Rivas-Delgado, Alfredo, Vicente Folch, Laura, Wotherspoon, Andrew, Climent, Fina, Campo, Elias, López-Guillermo, Armando, Matutes, Estella, Beà, Sílvia

Source: In Blood Advances 25 July 2023 7(14):3695-3709

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target.

Authors: Dobaño-López, Cèlia, Valero, Juan García, Araujo-Ayala, Ferran, Nadeu, Ferran, Gava, Fabien, Faria, Carla, Norlund, Marine, Morin, Renaud, Bernes-Lasserre, Pascale, Arenas, Fabian, Grau, Marta, López, Cristina, López-Oreja, Irene, Serrat, Neus, Martínez-Farran, Ares, Hernández, Lluís, Playa-Albinyana, Heribert, Giménez, Rubén, Beà, Silvia, Campo, Elías

Source: Blood Cancer Journal; 2/5/2025, Vol. 14 Issue 1, p1-14, 14p

Subject Terms: MEDICAL sciences, FOLLICULAR lymphoma, NON-Hodgkin's lymphoma, TREATMENT effectiveness, CANCER cells

Revised International Prognostic Index and genetic alterations are associated with early failure to R‐CHOP in patients with diffuse large B‐cell lymphoma

Authors: Dlouhy, Ivan, Karube, Kennosuke, Enjuanes, Anna, Salaverria, Itziar, Nadeu, Ferran, Ramis‐Zaldivar, Juan Enric, Valero, Juan G., Rivas‐Delgado, Alfredo, Magnano, Laura, Martin‐García, David, Pérez‐Galán, Patricia, Clot, Guillem, Rovira, Jordina, Jares, Pedro, Balagué, Olga, Giné, Eva, Mozas, Pablo, Briones, Javier, Sancho, Juan‐Manuel, Salar, Antonio, Mercadal, Santiago, Alcoceba, Miguel, Valera, Alexandra, Campo, Elías, López‐Guillermo, Armando

Source: British journal of haematology. 196(3):589-598

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139297858.0x000001&indx=1&recIds=ETOCvdc_100139297858.0x000001

Serum soluble CD23 levels are an independent predictor of time to first treatment in chronic lymphocytic leukemia

Authors: Piñeyroa, Juan A., Magnano, Laura, Rivero, Andrea, Rivas‐Delgado, Alfredo, Nadeu, Ferran, Correa, Juan Gonzalo, Giné, Eva, Villamor, Neus, Filella, Xavier, Colomer, Dolors, López, Mònica, López‐Oreja, Irene, Costa, Dolors, Aymerich, Marta, Beà, Sílvia, López‐Guillermo, Armando, Campo, Elías, Delgado, Julio, Mozas, Pablo

Source: Hematological oncology. 40(4):588-595

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194610120.0x000001&indx=1&recIds=ETOCvdc_100194610120.0x000001

Ibrutinib in Combination With Rituximab for Indolent Clinical Forms of Mantle Cell Lymphoma (IMCL-2015): A Multicenter, Open-Label, Single-Arm, Phase II Trial

Authors: Giné, Eva, de la Cruz, Fátima, Jiménez Ubieto, Ana, López Jimenez, Javier, Martín García-Sancho, Alejandro, Terol, M. José, González Barca, Eva, Casanova, María, de la Fuente, Adolfo, Marín-Niebla, Ana, Muntañola, Ana, González-López, Tomás José, Aymerich, Marta, Setoain, Xavier, Cortés-Romera, Montserrat, Rotger, Amanda, Rodríguez, Sonia, Medina Herrera, Alejandro, García Sanz, Ramón, Nadeu, Ferran, Beà, Silvia, Campo, Elías, López-Guillermo, Armando

Source: Journal of clinical oncology. 40(11):1196-1205

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152853177.0x000001&indx=1&recIds=ETOCvdc_100152853177.0x000001

The Prognostic Nutritional Index (PNI) is an independent predictor of overall survival in older patients with follicular lymphoma

Authors: Mozas, Pablo, Rivero, Andrea, Rivas-Delgado, Alfredo, Nadeu, Ferran, Giné, Eva, Delgado, Julio, Villamor, Neus, Campo, Elías, Pérez-Galán, Patricia, Magnano, Laura, López-Guillermo, Armando

Source: Leukemia & lymphoma. 63(4):903-910

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159244951.0x000001&indx=1&recIds=ETOCvdc_100159244951.0x000001

Copy‐number intratumor heterogeneity increases the risk of relapse in chemotherapy‐naive stage II colon cancer

Authors: Lahoz, Sara, Archilla, Ivan, Asensio, Elena, Hernández‐Illán, Eva, Ferrer, Queralt, López‐Prades, Sandra, Nadeu, Ferran, Del Rey, Javier, Sanz‐Pamplona, Rebeca, Lozano, Juan José, Castells, Antoni, Cuatrecasas, Miriam, Camps, Jordi

Source: Journal of pathology. 257(1):68-81

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150332229.0x000001&indx=1&recIds=ETOCvdc_100150332229.0x000001

First external validation of the FLIPI‐L score in a single‐center series of patients with follicular lymphoma

Authors: Mozas, Pablo, Rivero, Andrea, Rivas‐Delgado, Alfredo, Correa, Juan Gonzalo, Condom, Maria, Nadeu, Ferran, Giné, Eva, Delgado, Julio, Villamor, Neus, Campo, Elías, Magnano, Laura, López‐Guillermo, Armando

Source: Hematological oncology. 40(2):297-301

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146719794.0x000001&indx=1&recIds=ETOCvdc_100146719794.0x000001

The protein landscape of chronic lymphocytic leukemia

Authors: Meier-Abt, Fabienne ^*, Lu, Junyan ^*, Cannizzaro, Ester, Pohly, Marcel F., Kummer, Sandra, Pfammatter, Sibylle, Kunz, Laura, Collins, Ben C., Nadeu, Ferran, Lee, Kwang Seok, Xue, Peng, Gwerder, Myriam, Roiss, Michael, Hüllein, Jennifer, Scheinost, Sebastian, Dietrich, Sascha, Campo, Elias, Huber, Wolfgang ^*, Aebersold, Ruedi ^*, Zenz, Thorsten ^*

Source: In Blood 16 December 2021 138(24):2514-2525

SOX11, CD70, and Treg cells configure the tumor immune microenvironment of aggressive mantle cell lymphoma

Authors: Balsas, Patricia ^*, Veloza, Luis ^*, Clot, Guillem, Sureda-Gómez, Marta, Rodríguez, Marta-Leonor, Masaoutis, Christos, Frigola, Gerard, Navarro, Alba, Beà, Silvia, Nadeu, Ferran, Giné, Eva, López-Guillermo, Armando, Martínez, Antonio, Ribera-Cortada, Inmaculada, Engel, Pablo, Quintanilla-Martínez, Leticia, Klapper, Wolfram, Campo, Elias ^*, Amador, Virginia ^*

Source: In Blood 2 December 2021 138(22):2202-2215

IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics

Authors: Nadeu, Ferran ^*, Royo, Romina, Clot, Guillem, Duran-Ferrer, Martí, Navarro, Alba, Martín, Silvia, Lu, Junyan, Zenz, Thorsten, Baumann, Tycho, Jares, Pedro, Puente, Xose S., Martín-Subero, José I., Delgado, Julio, Campo, Elías ^**

Source: In Blood 27 May 2021 137(21):2935-2946

MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms.

Authors: Fernández-Garnacho, Elena María¹ (AUTHOR), Nadeu, Ferran^1,2 (AUTHOR), Martín, Silvia¹ (AUTHOR), Mozas, Pablo^1,3 (AUTHOR), Rivero, Andrea^1,3 (AUTHOR), Delgado, Julio^1,2,3 (AUTHOR), Giné, Eva^1,2,3 (AUTHOR), López-Guillermo, Armando^1,2,3 (AUTHOR), Duran-Ferrer, Martí¹ (AUTHOR), Salaverria, Itziar^1,2 (AUTHOR), López, Cristina^1,2 (AUTHOR), Beà, Sílvia^1,2,3 (AUTHOR), Demajo, Santiago¹ (AUTHOR), Jares, Pedro^1,2,3 (AUTHOR), Puente, Xose S.^2,4 (AUTHOR), Martín-Subero, José Ignacio^1,2,5 (AUTHOR), Campo, Elías^1,2,3 (AUTHOR), Hernández, Lluís^1,2 (AUTHOR) hernan@recerca.clinic.cat

Source: Scientific Reports. 10/6/2023, Vol. 13 Issue 1, p1-12. 12p.

Subject Terms: *B cells, *RICHTER syndrome, *CHRONIC lymphocytic leukemia, *LINCRNA, *BIOMARKERS, *FOLLICULAR lymphoma

Prognostic ability of five clinical risk scores in follicular lymphoma: A single‐center evaluation

Authors: Mozas, Pablo, Rivero, Andrea, Rivas‐Delgado, Alfredo, Correa, Juan Gonzalo, Condom, Maria, Nadeu, Ferran, Giné, Eva, Delgado, Julio, Villamor, Neus, Campo, Elías, Magnano, Laura, López‐Guillermo, Armando

Source: Hematological oncology. 39(5):639-649

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136020676.0x000001&indx=1&recIds=ETOCvdc_100136020676.0x000001