Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study

Authors: Worhunsky, Patrick D., Mignosa, Marcella M., Gallezot, Jean-Dominique, Pittman, Brian, Nabulsi, Nabeel B., Stryjewski, Adam, Jalilian-Khave, Laya, Trinko, Richard, DiLeone, Ralph J., Carson, Richard E., Malison, Robert T., Potenza, Marc N., Angarita, Gustavo A.

Source: In Biological Psychiatry September 2024

Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PET

Authors: Silva-Rudberg, Jason A., Salardini, Elaheh, O'Dell, Ryan S., Chen, Ming-Kai, Ra, Jocelyn, Georgelos, Jamie K., Morehouse, Mackenzie R., Melino, Kaitlyn P., Varma, Pradeep, Toyonaga, Takuya, Nabulsi, Nabeel B., Huang, Yiyun, Carson, Richard E., van Dyck, Christopher H., Mecca, Adam P.

Source: In The American Journal of Geriatric Psychiatry January 2024 32(1):17-28

Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease

Authors: O'Dell, Ryan S., Higgins-Chen, Albert, Gupta, Dhruva, Chen, Ming-Kai, Naganawa, Mika, Toyonaga, Takuya, Lu, Yihuan, Ni, Gessica, Chupak, Anna, Zhao, Wenzhen, Salardini, Elaheh, Nabulsi, Nabeel B., Huang, Yiyun, Arnsten, Amy F.T., Carson, Richard E., van Dyck, Christopher H., Mecca, Adam P.

Source: In NeuroImage: Clinical 2023 39

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study.

Authors: Salardini, Elaheh, O'Dell, Ryan S., Tchorz, Em, Nabulsi, Nabeel B., Huang, Yiyun, Carson, Richard E., van Dyck, Christopher H., Mecca, Adam P.

Source: Alzheimer's Research & Therapy; 5/6/2025, Vol. 17 Issue 1, p1-12, 12p

Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease

Authors: Mecca, Adam P., Chen, Ming-Kai, O'Dell, Ryan S., Naganawa, Mika, Toyonaga, Takuya, Godek, Tyler A., Harris, Joanna E., Bartlett, Hugh H., Zhao, Wenzhen, Banks, Emmie R., Ni, Gessica S., Rogers, Kelly, Gallezot, Jean Dominique, Ropchan, Jim, Emery, Paul R., Nabulsi, Nabeel B., Vander Wyk, Brent C., Arnsten, Amy F.T., Huang, Yiyun, Carson, Richard E., van Dyck, Christopher H.

Source: In Neurobiology of Aging March 2022 111:44-53

Noninvasive quantification of [¹⁸F]SynVesT-1 binding using simplified reference tissue model 2.

Authors: Naganawa, Mika, Gallezot, Jean-Dominique, Li, Songye, Nabulsi, Nabeel B., Henry, Shannan, Cai, Zhengxin, Matuskey, David, Huang, Yiyun, Carson, Richard E.

Source: European Journal of Nuclear Medicine & Molecular Imaging; Dec2024, Vol. 52 Issue 1, p113-121, 9p

Subject Terms: POSITRON emission tomography, SYNAPTIC vesicles, STATISTICAL reliability, ESTIMATION bias, BLOOD sampling

Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [¹¹C]UCB-J PET.

Authors: Young, Juan J., O'Dell, Ryan S., Naganawa, Mika, Toyonaga, Takuya, Chen, Ming-Kai, Nabulsi, Nabeel B., Huang, Yiyun, Cooper, Emma, Miller, Alyssa, Lam, Jessica, Bates, Kara, Ruan, Audrey, Nelsen, Kimberly, Salardini, Elaheh, Carson, Richard E., van Dyck, Christopher H., Mecca, Adam P.

Source: Journal of Nuclear Medicine; Nov2024, Vol. 65 Issue 11, p1782-1785, 4p

A multi species evaluation of the radiation dosimetry of [11C]erlotinib, the radiolabeled analog of a clinically utilized tyrosine kinase inhibitor

Authors: Petrulli, J. Ryan, Hansen, Søren B., Abourbeh, Galith, Yaqub, Maqsood, Bahce, Idris, Holden, Daniel, Huang, Yiyun, Nabulsi, Nabeel B., Contessa, Joseph N., Mishani, Eyal, Lammertsma, Adriaan A., Morris, Evan D.

Source: In Nuclear Medicine and Biology April 2017 47:56-61

The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [¹¹C]UCB-J.

Authors: Toyonaga, Takuya, Khattar, Nikkita, Wu, Yanjun, Lu, Yihuan, Naganawa, Mika, Gallezot, Jean-Dominique, Matuskey, David, Mecca, Adam P., Pittman, Brian, Dias, Mark, Nabulsi, Nabeel B., Finnema, Sjoerd J., Chen, Ming-Kai, Arnsten, Amy, Radhakrishnan, Rajiv, Skosnik, Patrick D., D'Souza, Deepak Cyril, Esterlis, Irina, Huang, Yiyun, van Dyck, Christopher H.

Source: European Journal of Nuclear Medicine & Molecular Imaging; Mar2024, Vol. 51 Issue 4, p1012-1022, 11p

Subject Terms: VOXEL-based morphometry, GRAY matter (Nerve tissue), POSITRON emission tomography, NEURAL circuitry, MAGNETIC resonance imaging, SYNAPTIC vesicles, NERVE endings

[11C]GR103545: novel one-pot radiosynthesis with high specific activity

Authors: Nabulsi, Nabeel B., Zheng, Ming-Qiang, Ropchan, Jim, Labaree, David, Ding, Yu-Shin, Blumberg, Laura, Huang, Yiyun

Source: In Nuclear Medicine and Biology February 2011 38(2):215-221

Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [¹¹C]UCB‐J.

Authors: Mecca, Adam P., O'Dell, Ryan S., Sharp, Emily S., Banks, Emmie R., Bartlett, Hugh H., Zhao, Wenzhen, Lipior, Sylwia, Diepenbrock, Nina G., Chen, Ming‐Kai, Naganawa, Mika, Toyonaga, Takuya, Nabulsi, Nabeel B., Vander Wyk, Brent C., Arnsten, Amy F. T., Huang, Yiyun, Carson, Richard E., van Dyck, Christopher H.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022, Vol. 18 Issue 12, p2527-2536, 10p

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Drug characteristics derived from kinetic modeling: combined ¹¹C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A.

Authors: Naganawa, Mika, Gallezot, Jean-Dominique, Finnema, Sjoerd J., Maguire, Ralph Paul, Mercier, Joël, Nabulsi, Nabeel B., Kervyn, Sophie, Henry, Shannan, Nicolas, Jean-Marie, Huang, Yiyun, Chen, Ming-Kai, Hannestad, Jonas, Klitgaard, Henrik, Stockis, Armel, Carson, Richard E.

Source: EJNMMI Research; 11/8/2022, Vol. 12 Issue 1, p1-11, 11p

Subject Terms: POSITRON emission tomography, LEVETIRACETAM, NONLINEAR differential equations, SYNAPTIC vesicles, DRUG analysis

[ 11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice

Authors: Nabulsi, Nabeel B., Smith, David E., Kilbourn, Michael R.

Source: In Bioorganic & Medicinal Chemistry 2005 13(8):2993-3001

Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory ¹¹C‐UCB‐J positron emission tomography study in humans.

Authors: Angarita, Gustavo A., Worhunsky, Patrick D., Naganawa, Mika, Toyonaga, Takuya, Nabulsi, Nabeel B., Li, Chiang‐Shan R., Esterlis, Irina, Skosnik, Patrick D., Radhakrishnan, Rajiv, Pittman, Brian, Gueorguieva, Ralitza, Potenza, Marc N., Finnema, Sjoerd J., Huang, Yiyun, Carson, Richard E., Malison, Robert T.

Source: Addiction Biology; Mar2022, Vol. 27 Issue 2, p1-10, 10p

Subject Terms: COCAINE-induced disorders, POSITRON emission tomography, SYNAPTIC vesicles, CINGULATE cortex, PREFRONTAL cortex

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Synaptic density is associated with cognitive performance in Alzheimer’s disease: A PET imaging study with [11C]UCB‐J.

Authors: van Dyck, Christopher H., Sharp, Emily, O'Dell, Ryan S., Banks, Emmie R., Bartlett, Hugh H., Chen, Ming‐Kai, Naganawa, Mika, Toyonaga, Takuya, Harris, Joanna E., Ni, Gessica S., Zhao, Wenzhen, Nabulsi, Nabeel B., Wyk, Brent C. Vander, Huang, Yiyun, Arnsten, Amy F. T., Carson, Richard E., Mecca, Adam P.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2021 Supplement S5, Vol. 17, p1-4, 4p

Imaging pituitary vasopressin 1B receptor in humans with the novel PET radiotracer ¹¹C-TASP699.

Authors: Naganawa, Mika, Nabulsi, Nabeel B., Matuskey, David, Henry, Shannan, Ropchan, Jim, Shu-Fei Lin, Gao, Hong, Pracitto, Richard, Labaree, David, Ming-Rong Zhang, Suhara, Tetsuya, Nishino, Izumi, Sabia, Helene, Ozaki, Satoshi, Huang, Yiyun, Carson, Richard E.

Source: Journal of Nuclear Medicine; Dec2021, Vol. 62 Issue 12, p1-25, 25p

P95. Cortical Amyloid Burden is Associated With Basal Forebrain but Not Medial Temporal Lobe Atrophy in Adults at Varying APOE ɛ4 Risk for Alzheimer’s Disease

Authors: Kelly, Kaitlin, O'Dell, Ryan, Toyonaga, Takuya, Barcelos, Nicole, Gelernter, Joel, Varma, Pradeep, Nabulsi, Nabeel B., Huang, Yiyun, Carson, Richard E., van Dyck, Christopher H., Mecca, Adam P.

Source: In Biological Psychiatry 1 May 2022 91(9) Supplement:S125-S126

The relationship between cortical amyloid burden and basal forebrain volume in adults at varying APOE ?4 risk for Alzheimer's disease

Authors: Kelly, Kaitlin, Toyonaga, Takuya, Zhao, Wenzhen, Barcelos, Nicole, Gelernter, Joel, Varma, Pradeep, Nabulsi, Nabeel B., Vander Wyk, Brent, Huang, Yiyun, Carson, Richard, van Dyck, Christopher H., Mecca, Adam P.

Source: In The American Journal of Geriatric Psychiatry April 2022 30(4) Supplement:S25-S25