FHL2 deteriorates IL-1β induced inflammation, apoptosis, and extracellular matrix degradation in chondrocyte-like ATDC5 cells by mTOR and NF-ĸB pathways

Authors: Yicheng Li, Fei Wang, Baochao Ji, Abdusami Amati, Li Cao

Source: BMC Musculoskeletal Disorders, Vol 26, Iss 1, Pp 1-11 (2025)

Subject Terms: FHL2, IL-1β, mTOR, NF-ĸB, Signaling pathway, Osteoarthritis, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2474

Access URL: https://doaj.org/article/abe09bc06d1c4293af1180cbd38eb414

Elucidating the mechanism of anti-apoptotic activity of α-crystallin and its therapeutic potential

Authors: Aparajita Chakraborty, Priyanka De, Sudipa Saha

Source: Journal of Stress Physiology & Biochemistry, Vol 21, Iss 1, Pp 182-189 (2025)

Subject Terms: α- crystallin, antiapoptotic mechanism, pro-apoptotic members, bax, bcl-2, caspase-3, caspase-9, retinal degenerations, ikkβ, nf- ĸb, therapeutic purposes, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.jspb.ru/issues/2025/N1/JSPB_2025_1_182-189.pdf; https://doaj.org/toc/1997-0838

Access URL: https://doaj.org/article/511b392189fc46c085e26fef45c6f7a2

Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1 G93A mice

Authors: Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zhou

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-22 (2024)

Subject Terms: Small extracellular vesicles, Amyotrophic lateral sclerosis, Intranasal administration, Complement & coagulation cascade, NF-ĸB signaling, Motoneuron degeneration, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

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Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/55635ea822c147fb8e471bec3d7a360e

Versatile function of NF-ĸB in inflammation and cancer

Authors: Qiang Ma, Shuai Hao, Weilong Hong, Vinay Tergaonkar, Gautam Sethi, Yu Tian, Chenyang Duan

Source: Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-28 (2024)

Subject Terms: NF-ĸB, Inflammation, Tumor microenvironment, Small molecule inhibitors, Cancer therapy, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/fbaaff45cfe44ba486d68af52f8e2194

Lycorine Pre-Treatment Alleviates Microglia Inflammation After Cerebral Ischemia by Inhibiting NF-κB Phosphorylation

Authors: Wuyan Zheng, Wanyu Wu, Yuhan Li, Bo Qin, Yuping Wang, Yunhan Zeng, Betty Yuen Kwan Law, Vincent Kam Wai Wong

Source: Brain Sciences, Vol 15, Iss 3, p 290 (2025)

Subject Terms: ischemic stroke, lycorine, MCAO, inflammation, NF-ĸB pathway, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: https://www.mdpi.com/2076-3425/15/3/290; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/93db5700ff944b3594b70f7605ba6703

DNA methylation-mediated FGFR1 silencing enhances NF-κB signaling: implications for asthma pathogenesis

Authors: Minglu Meng, Yingjiao Ma, Jianguo Xu, Gao Chen, Roshan Kumar Mahato

Source: Frontiers in Molecular Biosciences, Vol 11 (2024)

Subject Terms: FGFR1, NF-ĸB, DNA methylation, asthma, 5-aza-CdR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2024.1433557/full; https://doaj.org/toc/2296-889X

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Synthesis and protective effect of pyrazole conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and apoptosis

Authors: Zang Binbin, Wang Lihui

Source: Acta Pharmaceutica, Vol 73, Iss 3, Pp 341-362 (2023)

Subject Terms: pyrazole-conjugated imidazo[1, 2-a]pyrazine derivatives, synthesis, rats, sepsis, nf-ĸb, inflammation, oxidative stress, apoptosis, Pharmaceutical industry, HD9665-9675

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Relation: https://doaj.org/toc/1846-9558

Access URL: https://doaj.org/article/dd25ca6449344409ac09b40d54b67b1f

Plant and Marine-Derived Natural Product Research in Drug Discovery: Strengths and Perspective

Contributors: Duarte, Noelia

Subject Terms: propyl-propane-thiosulfinate, propyl-propane-thiosulfonate, antibacterial activity, antifungal activity, vapor, mycosporines, mycosporine-like amino acids (MAAs), mass spectrometry, database, photoprotective compounds, UV-absorbing compounds, melatonin, endoplasmic reticulum stress, diabesity, kidney, cellulite, essential oil, monoterpenes, Thai herbal compress, adipogenesis, lipolysis, vasorelaxation, Asphodelus ramosus, root-tubers, inulin, fructans, fructooligosaccharide, alkaline extraction, high-performance thin layer chromatography, NMR spectroscopy, 2D NMR analyses, infrared spectroscopy, isofuranodiene, Smyrnium olusatrum L., ischemic stroke, NF-ĸB, IL-1β, TNF-α, Plectranthus, royleanone, 7α-acetoxy-6β-hydroxyroyleanone, ent-abietane, antitumoral activity, antimicrobial activity, antioxidant, Euphorbia, flavonoids, pharmacological activities, structure–activity relationship, Sambucus nigra L., ethosomes, collagenase inhibition, skin compatibility, anthocyanins, antioxidants, dietary source, bioavailability, biological activity, biosynthesis, Posidonia oceanica, autophagy, lipid accumulation, NAFLD, herbal medicine, amphotericin B, candidiasis, gel, Bursera graveolens, topical treatment, linarin, chemotaxonomy, phytochemistry, bioactivities, (−)-usnic acid, evernic acid, salazinic acid, secondary metabolites, lichen extracts, Garcinia indica, kokum, wild mangosteen, pharmacological activity, terpenoids, Trypanosoma, human African trypanosomiasis, sleeping disease, human American trypanosomiasis, Chagas disease, anticancer activity, cytotoxicity, Hymenocardia acida, nanoencapsulation, nanoparticle, plant extract, PLGA, Medicine and Nursing, Cardiovascular medicine

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Access URL: https://directory.doabooks.org/handle/20.500.12854/98078
https://mdpi.com/books/pdfview/book/6834

The NF-ĸB p50 subunit generated by KPC1-mediated ubiquitination and limited proteasomal processing, suppresses tumor growth

Authors: Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky, Aaron Ciechanover

Source: Cancer Cell International, Vol 23, Iss 1, Pp 1-7 (2023)

Subject Terms: NF-ĸB p50, Tumor-suppression, PDL1, KPC1, PROTAC, Chemokines, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/918e4432e5634576bba28c5195a42d9f

PTEN, MMP2, and NF-κB and Regulating MicroRNA-181 Aggravate Insulin Resistance and Progression of Diabetic Nephropathy: A Case-Control Study

Authors: Manoj Khokhar, Purvi Purohit, Sojit Tomo, Riddhi G. Agarwal, Ashita Gadwal, Nitin Kumar Bajpai, Gopal Krishna Bohra, Ravindra Kumar Shukla

Source: Kidney and Dialysis, Vol 3, Iss 1, Pp 121-138 (2023)

Subject Terms: T2DM, diabetic nephropathy, insulin resistance, PTEN, MMP2, NF-ĸB, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://www.mdpi.com/2673-8236/3/1/11; https://doaj.org/toc/2673-8236

Access URL: https://doaj.org/article/710cf46d92d24730b9b7432ea0689e51

Phytochemical Omics in Medicinal Plants

Contributors: Chen, Jen-Tsung

Subject Terms: network pharmacology, traditional herbal medicine, methodological trend, polysaccharide fraction, Trichoderma atroviride, Salvia miltiorrhiza, proteomics, tanshinones, Flos Chrysanthemi indici, essential oil, extraction method, chemical composition, biological activity, Garcinia linii, hypoglycemia, benzopyran, triterpene, bioflavonoid, phenolic, in silico, neurodegenerative diseases, naringenin, pharmacological targets, signaling pathways, molecular mechanisms, drug delivery systems, luteolin, hyphenated techniques, chromatography, colorectal cancer, diterpenes, inflammatory bowel diseases, Polyalthia longifolia, herbal medicine, DESs, preparative-scale purification, flavonoids, 20-hydroxyecdysone, Chenopodium quinoa, Zinc oxide nanoparticles, anticancer, antileishmanial, antimicrobial, biocompatibility, cancer, apoptosis, herbs, cell lines, in vivo, quercetin, polyphenols, Alzheimer’s disease, mechanistic insights, clinical directions, isodon genus, ent-kaurane diterpenoids, natural compounds, pathways, medicinal plants, bioactive compounds, 4-hydroxynonenal, deleterious effects, Asiatic acid, nasopharyngeal cancer, cisplatin resistance, MAPK pathway, Anthocyanin, Solanum nigrum L., flavonoid biosynthesis, AtPAP1, licochalcone D, non-small cell lung cancer, reactive oxygen species, Acorus gramineusand, Euodia ruticarpa, pro-/anti-inflammatory cytokines, steam distillation essential oil, Th1/Th2 cytokines, lignans, Trachelospermum asiaticum, GNPS, targeted isolation, Rheum undulatum, Glycyrriza uralensis, hepatic encephalopathy, MMP-9, neuroinflammation, luteolin-7-O-glucoside, oral cancer, migration, invasion, MMP-2, Astragalus mongholicus, ultraviolet-B radiation, phenolics, untargeted gas chromatography-mass spectrometry, targeted liquid chromatography-mass spectrometry, Bacopa monnieri, cheminformatics, neurological diseases, spinocerebellar ataxia, system pharmacology, (-)-epigallocatechin-3-gallate (EGCG), bone morphogenetic protein-2 (BMP-2), catethin, fracture healing, local use, cardiovascular diseases, inflammation, lipid metabolism, non-coding RNA, oxidative stress, phenolic compounds, Peucedanum ostruthium, Apiaceae, ELINA, HetCA, STOCSY, coumarines, NF-ĸB, VCAM-1, E-selectin, Withaferin A, matrix metalloproteinases, antioxidant signaling, Curcuma aromatica, sesquiterpene, anti-inflammatory, luciferase assay, cytotoxicity, Medicine and Nursing

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Access URL: https://directory.doabooks.org/handle/20.500.12854/76327
https://mdpi.com/books/pdfview/book/3747

The interplay of arsenic, silymarin, and NF-ĸB pathway in male reproductive toxicity: A review

Authors: Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan

Source: Ecotoxicology and Environmental Safety, Vol 252, Iss , Pp 114614- (2023)

Subject Terms: Silymarin, Silibinin, Arsenic, NF-ĸB, Male, Reproductive toxicity, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651323001185; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/93b42e1f2426429c81951369fcf8e1e4

NF-κB activation impedes the transdifferentiation of hypertrophic chondrocytes at the growth plate of mouse embryos in diabetic pregnancy

Authors: Xi Liu, Fan Qian, Qiwei Fan, Li Lin, Meiyao He, Peizhi Li, Hongmei Cai, Lisha Ma, Xin Cheng, Xuesong Yang

Source: Journal of Orthopaedic Translation, Vol 31, Iss , Pp 52-61 (2021)

Subject Terms: Diabetes mellitus, Endochondral bone formation, Growth plate, Hypertrophic zone, NF-ĸB signaling, bone morphogenetic protein 2, Bmp2, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214031X21000929; https://doaj.org/toc/2214-031X

Access URL: https://doaj.org/article/c6d424e094e0452ebf705f048e3b92c7

Plausible Protective Role of Encephalartos villosus Extract in Acetic-Acid-Induced Ulcerative Colitis in Rats

Authors: Ashwag S. Alanazi, Mohammed M. Alanazi, Engy Elekhnawy, Nashwah G. M. Attallah, Walaa A. Negm, Aya H. El-Kadem

Source: Pharmaceuticals, Vol 16, Iss 10, p 1431 (2023)

Subject Terms: TLR-4, NF-ĸB, TNF-α, CAT, mucosal integrity, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/10/1431; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/cd70fb878ba84cf2aa95f7313e0a2595

Triblock Copolymer Nanomicelles Loaded with Curcumin Attenuates Inflammation via Inhibiting the NF-κB Pathway in the Rat Model of Cerebral Ischemia

Authors: Li F, Xu Y, Li X, Wang X, Yang Z, Li W, Cheng W, Yan G

Source: International Journal of Nanomedicine, Vol Volume 16, Pp 3173-3183 (2021)

Subject Terms: ischemia-reperfusion injury, stroke, nf-ĸb, inflammation, curcumin, nanomicelle, rat, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/triblock-copolymer-nanomicelles-loaded-with-curcumin-attenuates-inflam-peer-reviewed-fulltext-article-IJN; https://doaj.org/toc/1178-2013

Access URL: https://doaj.org/article/26e008be445341e4829901223f75b554

RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling

Authors: Laura B. Kuhn, Stefanie Valentin, Kristina Stojanovic, Daniel C. Strobl, Tea Babushku, Yan Wang, Ursula Rambold, Laura Scheffler, Sonja Grath, Dorothy John-Robbert, Helmut Blum, Annette Feuchtinger, Andreas Blutke, Falk Weih, Daisuke Kitamura, Roland Rad, Lothar J. Strobl, Ursula Zimber-Strobl

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: CD40, non-canonical NF-ĸB-signaling, RelB, IL9R, transgenic mice, B cell lymphoma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.913275/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/54c53ebf14244ecf932108fe1c3c9659

Khảo sát cơ chế kháng viêm của cao chiết ethanol cúc chỉ thiên mềm (Elephantotus mollis) trên mô hình đại thực bào RAW264.7

Authors: Nguyễn Quốc Châu Thanh, Phạm Duy Toàn, Nguyễn Trọng Tuân, Đặng Huỳnh Giao

Source: Tạp chí Khoa học Đại học Cần Thơ, Vol 58, Iss CĐ Khoa học tự nhiên (2022)

Subject Terms: Cúc chỉ thiên mềm, NF-ĸB, Nrf2, stress oxy hóa, viêm, Science

File Description: electronic resource

Relation: https://ctujsvn.ctu.edu.vn/index.php/ctujsvn/article/view/4486; https://doaj.org/toc/1859-2333; https://doaj.org/toc/2815-5599

Access URL: https://doaj.org/article/f31d9519401b48fd8c53601d30c831fd

Casticin Improves Respiratory Dysfunction and Attenuates Oxidative Stress and Inflammation via Inhibition of NF-ĸB in a Chronic Obstructive Pulmonary Disease Model of Chronic Cigarette Smoke-Exposed Rats

Authors: Li J, Qiu C, Xu P, Lu Y, Chen RC

Source: Drug Design, Development and Therapy, Vol Volume 14, Pp 5019-5027 (2020)

Subject Terms: copd, casticine, smoke, inflammation, oxidative stress, nf-ĸb., Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/casticin-improves-respiratory-dysfunction-and-attenuates-oxidative-str-peer-reviewed-article-DDDT; https://doaj.org/toc/1177-8881

Access URL: https://doaj.org/article/bdf35273b6404fc08ae0839b9a07a9c4

LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-ĸB pathway in diabetic nephropathy

Authors: Ran Jie, Pengpeng Zhu, Jiao Zhong, Yan Zhang, Hongyan Wu

Source: Diabetology & Metabolic Syndrome, Vol 12, Iss 1, Pp 1-11 (2020)

Subject Terms: KCNQ1OT1, Diabetic nephropathy, miR-18b-5p, SORBS2, NF-ĸB pathway, Nutritional diseases. Deficiency diseases, RC620-627

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Relation: http://link.springer.com/article/10.1186/s13098-020-00585-5; https://doaj.org/toc/1758-5996

Access URL: https://doaj.org/article/7c8b89bff7de48c28c41c14c71bf6739

The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expression

Authors: Sara Hemmati, Mohammad Amin Sadeghi, Razieh Mohammad Jafari, Hasan Yousefi-Manesh, Ahmad Reza Dehpour

Source: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-10 (2019)

Subject Terms: Depression, Lipopolysaccharide, Granulocyte-macrophage stimulating factor, Indoleamine 2, 3-dioxygenase, NF-ĸB, Inflammation-induced depression, Neurology. Diseases of the nervous system, RC346-429

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Relation: http://link.springer.com/article/10.1186/s12974-019-1509-1; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/60f1fe8639894cc5be0beeac1c5b9c36