CpG hypomethylation at proximal promoter and 5'UTR along with IL6 signaling loop associates with MYD88 upregulation in epithelial ovarian cancer.

Authors: Li, Junyang¹ (AUTHOR), Mei, Bingjie¹ (AUTHOR), Zhu, Yi^1,2 (AUTHOR), Huang, Jianmei¹ (AUTHOR), Li, Meiying³ (AUTHOR), Wang, Dengfeng¹ (AUTHOR), Huang, Jianming³ (AUTHOR) huangjianming1@scszlyy.org.cn, Zhang, Guonan¹ (AUTHOR) zhangguonan@scszlyy.org.cn

Source: Scientific Reports. 12/28/2024, Vol. 14 Issue 1, p1-13. 13p.

Subject Terms: *MYELOID differentiation factor 88, *INTERFERON regulatory factors, *OVARIAN epithelial cancer, *GENE expression, *INTERLEUKIN-6

MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis.

Authors: Lainšček, Duško^1,2,3 (AUTHOR), Horvat, Simon⁴ (AUTHOR), Dolinar, Klemen⁵ (AUTHOR), Ivanovski, Filip¹ (AUTHOR), Romih, Rok⁶ (AUTHOR), Pirkmajer, Sergej⁵ (AUTHOR), Jerala, Roman^1,2,3 (AUTHOR), Manček-Keber, Mateja^1,2 (AUTHOR) mateja.mancek@ki.si

Source: Cell Communication & Signaling. 11/16/2024, Vol. 22 Issue 1, p1-14. 14p.

Subject Terms: *MYELOID differentiation factor 88, *PHENOTYPIC plasticity, *CANCER treatment, *OXIDATIVE stress, *BRUTON tyrosine kinase

Enhancing MyD88 oligomerization is one important mechanism by which IBDV VP2 induces inflammatory response.

Authors: Huang, Mengmeng^1,2, Xu, Mengmeng^1,2,3, Han, Jingzhe^1,2,3, Ke, Erjing^1,2,3, Niu, Xinxin^1,2, Zhang, Yulong^1,2, Wang, Guodong^1,2, Yu, Hangbo^1,2, Liu, Runhang^1,2, Wang, Suyan^1,2,4, Liu, Yongzhen^1,2,4, Chen, Yuntong^1,2,4, Han, Jinze^1,2,3, Wu, Ziwen^1,2, Cui, Hongyu^1,2,4, Zhang, Yanping^1,2,4, Duan, Yulu^1,2,4, Gao, Yulong^1,2,4, gaoyulong@caas.cn, Qi, Xiaole^1,2,4, qixiaole@caas.cn

Source: PLoS Pathogens; 3/11/2025, Vol. 21 Issue 3, p1-25, 25p

Protective Effect of Coated Benzoic Acid on Intestinal Epithelium in Weaned Pigs upon Enterotoxigenic Escherichia coli Challenge.

Authors: Qi, Jiawen^1,2 (AUTHOR) miaowu777@126.com, Yu, Bing^1,2 (AUTHOR) ybingtian@163.com, Hu, Youjun³ (AUTHOR) 61368851@163.com, Luo, Yuheng^1,2 (AUTHOR) luoluo212@126.com, Zheng, Ping^1,2 (AUTHOR) zpind05@163.com, Mao, Xiangbing^1,2 (AUTHOR) acatmxb2003@163.com, Yu, Jie^1,2 (AUTHOR) yujie@sicau.edu.cn, Zhao, Xiaonan³ (AUTHOR) zxn780213675@126.com, He, Taiqian³ (AUTHOR) heqiantai2009@126.com, Yan, Hui^1,2 (AUTHOR) yan.hui@sicau.edu.cn, Wu, Aimin^1,2 (AUTHOR) wuaimin0608@163.com, He, Jun^1,2 (AUTHOR) hejun8067@163.com

Source: Animals (2076-2615). Aug2024, Vol. 14 Issue 16, p2405. 16p.

Subject Terms: *INTESTINAL barrier function, *MYELOID differentiation factor 88, *INTESTINAL mucosa, *NF-kappa B, *WEIGHT gain, *ENDOTOXINS

MyD88 Signaling Accompanied by Microbiota Changes Supports Urinary Bladder Carcinogenesis.

Authors: Knezović, Dora¹ (AUTHOR) dora.knezovic@mefst.hr, Milić Roje, Blanka¹ (AUTHOR) blanka.roje@mefst.hr, Vilović, Katarina² (AUTHOR) katarina.vilovic@mefst.hr, Franković, Lucija¹ (AUTHOR) lucija.frankovic@mefst.hr, Korac-Prlic, Jelena¹ (AUTHOR) jelena.korac.prlic@mefst.hr, Terzić, Janoš¹ (AUTHOR) janos.terzic@mefst.hr

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 13, p7176. 16p.

Subject Terms: *MYELOID differentiation factor 88, *BACILLUS (Bacteria), *BCG immunotherapy, *INTRAVESICAL administration, *SCHISTOSOMA haematobium, *BLADDER

Recent Advances in IRAK1: Pharmacological and Therapeutic Aspects.

Authors: Kim, Kyeong Min¹ (AUTHOR), Hwang, Na-Hee¹ (AUTHOR), Hyun, Ja-Shil¹ (AUTHOR) jashilhyun@gachon.ac.kr, Shin, Dongyun¹ (AUTHOR) jashilhyun@gachon.ac.kr

Source: Molecules. May2024, Vol. 29 Issue 10, p2226. 17p.

Subject Terms: *MYELOID differentiation factor 88, *DRY eye syndromes, *NATURAL immunity, *COVALENT bonds, *DISEASE complications, *CELLULAR signal transduction, *INTERLEUKIN-1 receptors

Artesunate Ameliorates Osteoarthritis Pain and Inflammatory Response of Chondrocytes in rats Through Modulation of Toll-Like Receptor 4/Myeloid Differentiation Response Gene 88/Nuclear Factor Kappa B Pathway.

Authors: YISONG SUN¹ shenhong999@163.com, DONG FANG², LEI QI³

Source: Indian Journal of Pharmaceutical Sciences. May/Jun2024, Vol. 86 Issue 3, p1083-1090. 8p.

Subject Terms: *MYELOID differentiation factor 88, *TOLL-like receptors, *REVERSE transcriptase polymerase chain reaction, *INFLAMMATION, *TUMOR necrosis factors, *OSTEOARTHRITIS

MyD88 and Its Inhibitors in Cancer: Prospects and Challenges.

Authors: Song, Jiali¹ (AUTHOR) songjl@zjcc.org.cn, Li, Yuying² (AUTHOR) layn998@wmu.edu.cn, Wu, Ke¹ (AUTHOR) wuke@zjcc.org.cn, Hu, Yan¹ (AUTHOR) huyan@zjcc.org.cn, Fang, Luo¹ (AUTHOR) huyan@zjcc.org.cn

Source: Biomolecules (2218-273X). May2024, Vol. 14 Issue 5, p562. 22p.

Subject Terms: *MYELOID differentiation factor 88, *NATURAL immunity

CSF1R antagonism results in increased supraspinal infiltration in EAE.

Authors: Wang, Marilyn¹ (AUTHOR), Caryotakis, Sofia E.^2,3 (AUTHOR), Smith, Glendalyn G.² (AUTHOR), Nguyen, Alan V.^1,4 (AUTHOR), Pleasure, David E.^2,5 (AUTHOR), Soulika, Athena M.^1,2 (AUTHOR) asoulika@ucdavis.edu

Source: Journal of Neuroinflammation. 4/20/2024, Vol. 21 Issue 1, p1-23. 23p.

Subject Terms: *MACROPHAGE colony-stimulating factor, *MYELOID differentiation factor 88, *HEPATOCELLULAR carcinoma, *SPINAL cord

Human Intelectin-1 (hITL-1) as Modulator of Metabolic Syndrome (MetS): An In Silico Study.

Authors: Vishnupriya, N.¹, Narayanaswamy, Radhakrishnan¹ radhakrishnann.smc@saveetha.com

Source: Journal of Pharmacy & Bioallied Sciences. 2024 Supplement, Vol. 16, pS1173-S1180. 8p.

Subject Terms: *MYELOID differentiation factor 88, *VASCULAR cell adhesion molecule-1, *LEPTIN receptors, *METABOLIC syndrome, *NF-kappa B, *TUMOR necrosis factors, *CELL adhesion molecules, *CYCLOOXYGENASE 2, *BASIC proteins

Nano-selenium supplementation upregulate TLR-7, MyD88, NF-kB, and TRAF6 genes in thymus of Wistar rats following treatment with cyclosporine A.

Authors: Rezvani, Nafiseh¹ shirinrostamkhani@yahoo.com, Shirvani, Hossein², Rostamkhani, Fatemeh¹

Source: Nanomedicine Journal. Spring2024, Vol. 11 Issue 2, p137-144. 8p.

Subject Terms: *LABORATORY rats, *MYELOID differentiation factor 88, *NF-kappa B, *CYCLOSPORINE, *THYMUS, *TOLL-like receptors, *BIOFORTIFICATION

Effectiveness of Narciclasine in Suppressing the Inflammatory Response in Sepsis: Molecular Docking and In Silico Studies.

Authors: Kingsley, Manoj Kumar^1,2 (AUTHOR), Rao, Gurugubelli Krishna^1,3 (AUTHOR), Bhat, Ballambattu Vishnu^1,4 (AUTHOR) drvishnubhat@yahoo.com

Source: Bioinformatics & Biology Insights. 3/16/2024, p1-18. 18p.

Subject Terms: *MYELOID differentiation factor 88, *MOLECULAR docking, *NF-kappa B, *INTERFERON regulatory factors, *INFLAMMATION, *SEPSIS

MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization.

Authors: Liu, Yu¹ (AUTHOR), Chen, Haiqiang¹ (AUTHOR), Yan, Xuanxuan¹ (AUTHOR), Zhang, Jie¹ (AUTHOR), Deng, Zhenzhong² (AUTHOR), Huang, Maosheng³ (AUTHOR), Gu, Jianchun² (AUTHOR) gujianchun@126.com, Zhang, Jinhua¹ (AUTHOR) zhangjh@bjtu.edu.cn

Source: Cell Communication & Signaling. 1/30/2024, Vol. 22 Issue 1, p1-18. 18p.

Subject Terms: *FATTY liver, *MYELOID differentiation factor 88, *NON-alcoholic fatty liver disease, *MYOFIBROBLASTS, *MACROPHAGES

Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer.

Authors: Yang, Yingxiang¹ (AUTHOR), Jin, Chengyue² (AUTHOR), Yeo, Anthony³ (AUTHOR), Jin, Bo⁴ (AUTHOR)

Source: Journal of Immunology Research. 1/13/2024, p1-28. 28p.

Subject Terms: *MYELOID differentiation factor 88, *PATTERN perception receptors, *TOLL-like receptors, *CANCER cells

Ameliorating immune-dependent inflammation and apoptosis by targeting TLR4/MYD88/NF-κB pathway by celastrol mitigates the diabetic reproductive dysfunction.

Authors: Faheem, Heba¹ (AUTHOR), Alawadhi, Rana² (AUTHOR), Basha, Eman H.^1,3 (AUTHOR), Ismail, Radwa⁴ (AUTHOR), Ibrahim, Hoda A.⁵ (AUTHOR), Elshamy, Amira M.⁵ (AUTHOR), Motawea, Shaimaa M.⁴ (AUTHOR), Seleem, Monira A.⁶ (AUTHOR), Elkordy, Alaa⁷ (AUTHOR), Homouda, Abdallah A.⁸ (AUTHOR), Khaled, Howayda E.⁹ (AUTHOR), Aboeida, Reham A.¹⁰ (AUTHOR), Ghafar, Muhammad T. Abdel¹¹ (AUTHOR), Rizk, Fatma H.¹ (AUTHOR) Eman.basha@med.tanta.edu.eg, El-Harty, Yasmeen M.¹ (AUTHOR) Yassmin.elharty@med.Tanta.edu.eg

Source: Physiological Genomics. Mar2025, Vol. 57 Issue 3, p103-114. 12p.

Subject Terms: *MYELOID differentiation factor 88, *NF-kappa B, *INFLAMMATORY mediators, *HDL cholesterol, *POLYMERASE chain reaction

Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.

Authors: Manik, Mohammad K.^1,2, Mengqi Pan^3,4,5, Le Xiao^1,2, Weixi Gu^3,4,5, Hyoyoung Kim^3,4, Pospich, Sabrina⁵, Hedger, Andrew^3,4,5, Vajjhala, Parimala R.^3,4, Lee, Morris Y. L.^3,4, Xiaoqi Qian^3,4,5, Landsberg, Michael J.^3,4,5, Ve, Thomas⁶, Nanson, Jeffrey D.^3,4,5,7,8, Raunser, Stefan⁵, Stacey, Katryn J.^3,4,5, Hao Wu^1,2, wu@crystal.harvard.edu, Kobe, Bostjan^3,4,5, b.kobe@uq.edu.au

Source: Proceedings of the National Academy of Sciences of the United States of America; 1/14/2025, Vol. 122 Issue 2, p1-8, 26p

Tryptophan alleviates intestinal damage through regulating necroptosis and TLR4/NOD signaling pathways in pigs after lipopolysaccharide challenge.

Authors: Tao, Jingyuan¹ (AUTHOR), Liu, Guangmang¹ (AUTHOR) liugm@sicau.edu.cn, Gu, Ke¹ (AUTHOR), Jia, Gang¹ (AUTHOR), Zhao, Hua¹ (AUTHOR), Chen, Xiaoling¹ (AUTHOR), Tian, Gang¹ (AUTHOR), Cai, Jingyi¹ (AUTHOR), Wang, Jing² (AUTHOR)

Source: Animal Biotechnology. Dec2023, Vol. 34 Issue 9, p4938-4946. 9p.

Subject Terms: *SERINE/THREONINE kinases, *MYELOID differentiation factor 88, *TRYPTOPHAN, *CELLULAR signal transduction, *HEAT shock proteins, *INTERLEUKIN receptors, *PIGLETS, *LIPOPOLYSACCHARIDES, *TIGHT junctions

PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4.

Authors: Bi, Wei^1,2 (AUTHOR), Bao, Keyao³ (AUTHOR), Zhou, Xinqi³ (AUTHOR), Deng, Yihui⁴ (AUTHOR), Li, Xiaoting¹ (AUTHOR), Zhang, Jiawei³ (AUTHOR), Lan, Xin³ (AUTHOR), Zhao, Jiayi³ (AUTHOR), Lu, Daxiang³ (AUTHOR), Xu, Yezi¹ (AUTHOR), Cen, Yanmei¹ (AUTHOR), Cao, Rui¹ (AUTHOR), Xu, Mengyang⁵ (AUTHOR), Zhong, Wenbin⁵ (AUTHOR) tzhongwb@jnu.edu.cn, Zhu, Lihong^3,6 (AUTHOR) lhzhu@jnu.edu.cn

Source: Journal of Neuroinflammation. 11/24/2023, Vol. 20 Issue 1, p1-20. 20p.

Subject Terms: *MYELOID differentiation factor 88, *TOLL-like receptors, *MICROGLIA, *MOLECULAR dynamics, *HYPERCOAGULATION disorders, *THERAPEUTICS

Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma.

Authors: Wang, Jialiang¹ (AUTHOR), Zhang, Xiaoyu² (AUTHOR), Ma, Xinyi² (AUTHOR), Chen, Dongmei¹ (AUTHOR), Cai, Meina² (AUTHOR), Xiao, Lexin¹ (AUTHOR), Li, Jing¹ (AUTHOR), Huang, Zexuan¹ (AUTHOR), Huang, Yuehua^1,2 (AUTHOR) huangyh53@mail.sysu.edu.cn, Lian, Yifan¹ (AUTHOR) lianyf6@mail.sysu.edu.cn

Source: Journal of Experimental & Clinical Cancer Research (17569966). 11/16/2023, Vol. 42 Issue 1, p1-17. 17p.

Subject Terms: *MACROPHAGES, *MYELOID differentiation factor 88, *NATURAL immunity, *TUMOR microenvironment, *WESTERN immunoblotting, *INTERLEUKIN-1 receptor antagonist protein, *HEPATOCELLULAR carcinoma, *SORAFENIB

Toll-Like Receptor 9/Myeloid Differentiation Factor 88 Signal Pathway Mediates Immune Regulation of Neonatal Acute Lung Injury.

Authors: YING TANG¹, LING CHEN¹, XIAO FENG¹, FANGLIN YANG¹ kongjiaozhan050544@163.com

Source: Indian Journal of Pharmaceutical Sciences. Nov/Dec2023, Vol. 85 Issue 6, p1713-1718. 6p.

Subject Terms: *MYELOID differentiation factor 88, *TOLL-like receptors, *LUNG injuries, *MESSENGER RNA, *CELLULAR signal transduction