Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V

Authors: Collins, Peter W. ^{1, ∗}, Whyte, Claire S. ², de Lloyd, Lucy ³, Narwal, Anuj ², Bell, Sarah F. ³, Gill, Nicholas ³, Collis, Rachel E. ³, Jenkins, Peter V. ^{1, 4}, Mutch, Nicola J. ²

Source: In Blood Advances January 2025

Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation

Authors: Sang, Yaqiu, Lee, Robert H., Luong, Annie, Katona, Éva, Whyte, Claire S., Smith, Nicholas L., Mast, Alan E., Flick, Matthew J., Mutch, Nicola J., Bergmeier, Wolfgang, Wolberg, Alisa S.

Source: In Blood Advances 8 October 2024 8(19):5072-5085

A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma

Authors: Morrow, Gael B., Flannery, Sarah, Charles, Philip D., Heilig, Raphael, Feller, Timea, McQuilten, Zoe, Wake, Elizabeth, Ariens, Robert A.S., Winearls, James, Mutch, Nicola J., Fischer, Roman, Laffan, Mike A., Curry, Nicola

Source: In Journal of Thrombosis and Haemostasis June 2024 22(6):1758-1771

The fibrinolysis renaissance

Authors: Mutch, Nicola J., Medcalf, Robert L.

Source: In Journal of Thrombosis and Haemostasis December 2023 21(12):3304-3316

Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability

Authors: Mitchell, Joanne L., Little, Gemma, Bye, Alexander P., Gaspar, Renato S., Unsworth, Amanda J., Kriek, Neline, Sage, Tanya, Stainer, Alexander, Sangowawa, Ibidayo, Morrow, Gael B., Bastos, Ricardo N., Shapiro, Susan, Desborough, Michael J.R., Curry, Nicola, Gibbins, Jonathan M., Whyte, Claire S., Mutch, Nicola J., Jones, Christopher I.

Source: In Research and Practice in Thrombosis and Haemostasis July 2023 7(5)

Acute obstetric coagulopathy during postpartum hemorrhage is caused by hyperfibrinolysis and dysfibrinogenemia: an observational cohort study

Authors: de Lloyd, Lucy, Jenkins, Peter V., Bell, Sarah F., Mutch, Nicola J., Martins Pereira, Julia Freyer, Badenes, Pilar M., James, Donna, Ridgeway, Anouk, Cohen, Leon, Roberts, Thomas, Field, Victoria, Collis, Rachel E., Collins, Peter W.

Source: In Journal of Thrombosis and Haemostasis April 2023 21(4):862-879

S100A8/A9 drives the formation of procoagulant platelets through GPIbα

Authors: Colicchia, Martina, Schrottmaier, Waltraud C., Perrella, Gina, Reyat, Jasmeet S., Begum, Jenefa, Slater, Alexandre, Price, Joshua, Clark, Joanne C., Zhi, Zhaogong, Simpson, Megan J., Bourne, Joshua H., Poulter, Natalie S., Khan, Abdullah O., Nicolson, Phillip L. R., Pugh, Matthew, Harrison, Paul, Iqbal, Asif J., Rainger, George E., Watson, Steve P., Thomas, Mark R., Mutch, Nicola J., Assinger, Alice, Rayes, Julie

Source: In Blood 15 December 2022 140(24):2626-2643

Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

Authors: Kanji, Rahim, Gue, Ying X., Farag, Mohamed F., Spencer, Neil H., Mutch, Nicola J., Gorog, Diana A.

Source: In JACC: Basic to Translational Science November 2022 7(11):1069-1082

The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1

Authors: Whyte, Claire S., Simpson, Megan, Morrow, Gael B., Wallace, Carol A., Mentzer, Alexander J., Knight, Julian C., Shapiro, Susan, Curry, Nicola, Bagot, Catherine N., Watson, Henry, Cooper, Jamie G., Mutch, Nicola J. ^*

Source: In Journal of Thrombosis and Haemostasis October 2022 20(10):2394-2406

Basic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH

Authors: Mutch, Nicola J. ^*, Walters, Sam, Gardiner, Elizabeth E., McCarty, Owen J.T., De Meyer, Simon F., Schroeder, Verena, Meijers, Joost C.M.

Source: In Journal of Thrombosis and Haemostasis June 2022 20(6):1496-1506

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles

Authors: Somodi, Laura, Beke Debreceni, Ildikó, Kis, Gréta, Cozzolino, Marco, Kappelmayer, János, Antal, Miklós, Panyi, György, Bárdos, Helga, Mutch, Nicola J., Muszbek, László ^*

Source: In Journal of Thrombosis and Haemostasis May 2022 20(5):1223-1235

Removing plasmin from the equation – Something to chew on…

Authors: Morrow, Gael B., Mutch, Nicola J.

Source: Journal of thrombosis and haemostasis. 20(2):280-284

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148406660.0x000001&indx=1&recIds=ETOCvdc_100148406660.0x000001

Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets

Authors: Whyte, Claire S., Morrow, Gael B., Baik, Nagyung, Booth, Nuala A., Jalal, Mohammed M., Parmer, Robert J., Miles, Lindsey A., Mutch, Nicola J. ^*

Source: In Blood 14 January 2021 137(2):248-257

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery

Authors: Kaira, Bubacarr G. ^{1, *}, Slater, Alexandre ^{2, *}, McCrae, Keith R. ³, Dreveny, Ingrid ¹, Sumya, Ummay ^{4, 5}, Mutch, Nicola J. ^{4, 5}, Searle, Mark ^{1, 2}, Emsley, Jonas ^{2, 1}

Source: In Blood 1 October 2020 136(14):1685-1697

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

Authors: Whyte, Claire S., Morrow, Gael B., Mitchell, Joanne L., Chowdary, Pratima, Mutch, Nicola J. ^*

Source: In Journal of Thrombosis and Haemostasis July 2020 18(7):1548-1555

A new pedigree with thrombomodulin‐associated coagulopathy in which delayed fibrinolysis is partially attenuated by co‐inherited TAFI deficiency

Authors: Westbury, Sarah K., Whyte, Claire S., Stephens, Jonathan, Downes, Kate, Turro, Ernest, Claesen, Karen, Mertens, Joachim C., Hendriks, Dirk, Latif, Anne‐Louise, Leishman, Emma J., Mutch, Nicola J., Tait, R. Campbell, Mumford, Andrew D.

Source: Journal of thrombosis and haemostasis. 18(9):2209-2214

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169029555.0x000001&indx=1&recIds=ETOCvdc_100169029555.0x000001

Defining trauma‐induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH

Authors: Moore, Hunter B., Gando, Satoshi, Iba, Toshiaki, Kim, Paul Y., Yeh, Calvin H., Brohi, Karim, Hunt, Beverley J., Levy, Jerrold H., Draxler, Dominik F., Stanworth, Simon, Görlinger, Klaus, Neal, Matthew D., Schreiber, Martin A., Barrett, Christopher D., Medcalf, Robert L., Moore, Ernest E., Mutch, Nicola J., Thachil, Jecko, Urano, Tetsumei, Thomas, Scott, Scărlătescu, Ecaterina, Walsh, Mark

Source: Journal of thrombosis and haemostasis. 18(3):740-747

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150111433.0x000001&indx=1&recIds=ETOCvdc_100150111433.0x000001

THE CLINICAL CONTRIBUTION OF CELLULAR FXIII-A TO THROMBUS SATBILITY

Authors: Alshehri, Fahad, Mutch, Nicola, Whyte, Claire, Alshehri, Fahad S, SWhyte, Claire, Mutch, Nicola J

Source: In Atherosclerosis December 2024 399 Supplement 1

Oral Presentation No. 019 Bi-directional cross talk between coagulation, fibrinolysis and inflammatory pathways in patients with ST-segment elevation myocardial infarction

Authors: Kanji, Rahim, Gue, Ying X, Farag, Mohammed F, Mutch, Nicola J, Gorog, Diana A

Source: Cardiovascular research. 118(Supplement 2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163182985.0x000001&indx=1&recIds=ETOCvdc_100163182985.0x000001

Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity

Authors: Mitchell, Joanne L., Lionikiene, Ausra S., Georgiev, Georgi, Klemmer, Anja, Brain, Chelsea, Kim, Paul Y., Mutch, Nicola J.

Source: In Blood 15 December 2016 128(24):2834-2845