First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection

Authors: Bergougnan, Luc, Armani, Sara, Golor, Georg, Tardat, Agnes, Vitse, Olivier, Hurbin, Fabrice, Scemama, Michel, Poitiers, Franck, Radzik, David, Gaudin, Christophe, Hovsepian, Lionel, Muslin, Anthony J., Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.

Source: British journal of clinical pharmacology. 87(2):598-611

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Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient trial

Authors: Bergougnan, Luc, Andersen, Grit, Plum‐Mörschel, Leona, Evaristi, Maria Francesca, Poirier, Bruno, Tardat, Agnes, Ermer, Marcel, Herbrand, Theresa, Arrubla, Jorge, Coester, Hans Veit, Sansone, Roberto, Heiss, Christian, Vitse, Olivier, Hurbin, Fabrice, Boiron, Rania, Benain, Xavier, Radzik, David, Janiak, Philip, Muslin, Anthony J., Hovsepian, Lionel, Kirkesseli, Stephane, Deutsch, Paul, Parkar, Ashfaq A.

Source: British journal of clinical pharmacology. 87(5):2303-2320

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120008974.0x000001&indx=1&recIds=ETOCvdc_100120008974.0x000001

Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy

Authors: Beauverger, Philippe, Ozoux, Marie-Laure, Bégis, Guillaume, Glénat, Valérie, Briand, Véronique, Philippo, Marie-Claire, Daveu, Cyril, Tavares, Georges, Roy, Sébastien, Corbier, Alain, Briand, Pascale, Dorchies, Olivier, Bauchet, Anne-Laure, Nicolai, Eric, Duclos, Olivier, Tamarelle, Dorothée, Pruniaux, Marie-Pierre, Muslin, Anthony J, Janiak, Philip

Source: Cardiovascular research. 116(2):329-338

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099931741.0x000001&indx=1&recIds=ETOCvdc_100099931741.0x000001

PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo: An Effect Blunted by Alirocumab

Authors: Villard, Elise F., Thedrez, Aurélie, Blankenstein, Jorg, Croyal, Mikaël, Tran, Thi-Thu-Trang, Poirier, Bruno, Le Bail, Jean-Christophe, Illiano, Stéphane, Nobécourt, Estelle, Krempf, Michel, Blom, Dirk J., Marais, A. David, Janiak, Philip, Muslin, Anthony J., Guillot, Etienne, Lambert, Gilles

Source: In JACC: Basic to Translational Science October 2016 1(6):419-427

RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm

Authors: Pang, Paul, Jin, Xiaohua, Proctor, Brandon M., Farley, Michelle, Roy, Nilay, Chin, Matthew S., von Andrian, Ulrich H., Vollmann, Elisabeth, Perro, Mario, Hoffman, Ryan J., Chung, Joseph, Chauhan, Nikita, Mistri, Murti, Muslin, Anthony J., Bonventre, Joseph V., Siedlecki, Andrew M. ^*

Source: In Kidney International April 2015 87(4):771-783

RGS4, a GTPase activator, improves renal function in ischemia–reperfusion injury

Authors: Siedlecki, Andrew M. ^*, Jin, Xiaohua, Thomas, Winston, Hruska, Keith A., Muslin, Anthony J.

Source: In Kidney International 1 August 2011 80(3):263-271

14-3-3 Protein Protects Against Cardiac Endoplasmic Reticulum Stress (ERS) and ERS-Initiated Apoptosis in Experimental Diabetes

Authors: Sari, Flori R. ^{1, 2}, Watanabe, Kenichi ^{1, *}, Thandavarayan, Rajarajan A. ¹, Harima, Meilei ¹, Zhang, Shaosong ³, Muslin, Anthony J. ⁴, Kodama, Makoto ⁵, Aizawa, Yoshifusa ⁵

Source: In Journal of Pharmacological Sciences 2010 113(4):325-334

Modulation of doxorubicin-induced cardiac dysfunction in dominant-negative p38α mitogen-activated protein kinase mice

Authors: Thandavarayan, Rajarajan A., Watanabe, Kenichi, Sari, Flori R., Ma, Meilei, Lakshmanan, Arun Prasath, Giridharan, Vijayasree V., Gurusamy, Narasimman, Nishida, Hiroshi, Konishi, Tetsuya, Zhang, Shaosong, Muslin, Anthony J., Kodama, Makoto, Aizawa, Yoshifusa

Source: In Free Radical Biology and Medicine 2010 49(9):1422-1431

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity

Authors: Etzion, Sharon, Etzion, Yoram, DeBosch, Brian, Crawford, Peter A., Muslin, Anthony J.

Source: In Journal of Molecular and Cellular Cardiology 2010 49(6):931-940

Molecular Basis for Zinc Transporter 1 Action as an Endogenous Inhibitor of L-type Calcium Channels

Authors: Levy, Shiri, Beharier, Ofer, Etzion, Yoram, Mor, Merav, Buzaglo, Liat, Shaltiel, Lior, Gheber, Levi A., Kahn, Joy, Muslin, Anthony J., Katz, Amos ^**, Gitler, Daniel, Moran, Arie

Source: In Journal of Biological Chemistry 20 November 2009 284(47):32434-32443

Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure

Authors: Siedlecki, Andrew M., Jin, Xiaohua, Muslin, Anthony J. ^*

Source: In Kidney International 2 April 2009 75(8):800-808

The Application of Phenotypic High-Throughput Screening Techniques to Cardiovascular Research

Authors: Etzion, Yoram, Muslin, Anthony J.

Source: In Trends in Cardiovascular Medicine 2009 19(6):207-212

Insulin signaling pathways and cardiac growth

Authors: DeBosch, Brian J., Muslin, Anthony J.

Source: In Journal of Molecular and Cellular Cardiology 2008 44(5):855-864

14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy

Authors: Thandavarayan, Rajarajan A., Watanabe, Kenichi, Ma, Meilei, Veeraveedu, Punniyakoti T., Gurusamy, Narasimman, Palaniyandi, Suresh S., Zhang, Shaosong, Muslin, Anthony J., Kodama, Makoto, Aizawa, Yoshifusa

Source: In Biochemical Pharmacology 2008 75(9):1797-1806

β 3 Integrin deficiency promotes cardiac hypertrophy and inflammation

Authors: Ren, Jie, Avery, Joan, Zhao, Haibo, Schneider, Jochen G., Ross, F. Patrick, Muslin, Anthony J.

Source: In Journal of Molecular and Cellular Cardiology 2007 42(2):367-377

Akt2 Regulates Cardiac Metabolism and Cardiomyocyte Survival

Authors: DeBosch, Brian, Sambandam, Nandakumar, Weinheimer, Carla, Courtois, Michael, Muslin, Anthony J.

Source: In Journal of Biological Chemistry 27 October 2006 281(43):32841-32851

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

Authors: Schneider, Jochen G., Finck, Brian N., Ren, Jie, Standley, Kara N., Takagi, Masatoshi, Maclean, Kirsteen H., Bernal-Mizrachi, Carlos, Muslin, Anthony J., Kastan, Michael B., Semenkovich, Clay F.

Source: In Cell Metabolism 2006 4(5):377-389

Role of Raf Proteins in Cardiac Hypertrophy and Cardiomyocyte Survival

Authors: Muslin, Anthony J.

Source: In Trends in Cardiovascular Medicine 2005 15(6):225-229

Role of p38α MAPK in cardiac apoptosis and remodeling after myocardial infarction

Authors: Ren, Jie, Zhang, Shaosong, Kovacs, Attila, Wang, Yibin, Muslin, Anthony J. ^*

Source: In Journal of Molecular and Cellular Cardiology 2005 38(4):617-623

Inhibition of intracellular signal transduction by 14-3-3-binding peptides