Ubiquitin-specific proteases as therapeutic targets in paediatric primary bone tumours?

Authors: Mullard, Mathilde, Lavaud, Mélanie, Regnier, Laura, Tesfaye, Robel, Ory, Benjamin, Rédini, Françoise, Verrecchia, Franck

Source: In Biochemical Pharmacology December 2021 194

Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma viaaberrant expression of KCNN1/SK1 and dysregulation of calcium signaling

Authors: Dupuy, Maryne, Gueguinou, Maxime, Postec, Anaïs, Brion, Régis, Tesfaye, Robel, Mullard, Mathilde, Regnier, Laura, Amiaud, Jérôme, Hubsch, Clémence, Potier-Cartereau, Marie, Chantôme, Aurélie, Brounais-Le Royer, Bénédicte, Baud’huin, Marc, Georges, Steven, Lamoureux, François, Ory, Benjamin, Entz-Werlé, Natacha, Delattre, Olivier, Rédini, Françoise, Vandier, Christophe, Verrecchia, Franck

Source: Oncogene; January 2025, Vol. 44 Issue: 2 p79-91, 13p

Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation.

Authors: Dupuy, Maryne, Postec, Anaïs, Mullard, Mathilde, Chantôme, Aurélie, Hulin, Philippe, Brion, Régis, Gueguinou, Maxime, Regnier, Laura, Potier-Cartereau, Marie, Brounais-Le Royer, Bénédicte, Baud'huin, Marc, Georges, Steven, Lamoureux, François, Ory, Benjamin, Rédini, Françoise, Vandier, Christophe, Verrecchia, Franck

Source: Cell Communication & Signaling; 12/18/2024, Vol. 22 Issue 1, p1-17, 17p

Subject Terms: MOLECULAR biology, LIFE sciences, CYTOLOGY, CHIMERIC proteins, GENE expression

Analysis of gap junctional intercellular communications using a dielectrophoresis-based microchip

Authors: Tellez-Gabriel, Marta, Charrier, Céline, Brounais-Le Royer, Bénédicte, Mullard, Mathilde, Brown, Hannah K., Verrecchia, Franck, Heymann, Dominique

Source: In European Journal of Cell Biology March 2017 96(2):110-118

Connexin43 intercellular communication drives the early differentiation of human bone marrow stromal cells into osteoblasts

Authors: Talbot, Julie, Brion, Régis, Lamora, Audrey, Mullard, Mathilde, Morice, Sarah, Heymann, Dominique, Verrecchia, Franck

Source: Journal of cellular physiology. 233(2):946-957

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123861357.0x000001&indx=1&recIds=ETOCvdc_100123861357.0x000001

Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis.

Authors: Morice, Sarah, Danieau, Geoffroy, Tesfaye, Robel, Mullard, Mathilde, Brion, Régis, Dupuy, Maryne, Ory, Benjamin, Brounais-Le Royer, Bénédicte, Corre, Isabelle, Redini, Françoise, Verrecchia, Franck

Source: Frontiers in Oncology; 10/26/2021, Vol. 11, p1-13, 13p

Subject Terms: CELLULAR signal transduction, EPITHELIAL-mesenchymal transition, OSTEOSARCOMA, SURVIVAL rate, LUNG development

Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619.

Authors: Lavaud, Mélanie¹ (AUTHOR) melanie.lavaud@etu.univ-nantes.fr, Mullard, Mathilde¹ (AUTHOR) mathilde.mullard@univ-nantes.fr, Tesfaye, Robel¹ (AUTHOR) robel.tesfaye@etu.univ-nantes.fr, Amiaud, Jérôme¹ (AUTHOR) jerome.amiaud@univ-nantes.fr, Legrand, Mélanie¹ (AUTHOR) melanie.legrand2@gmail.com, Danieau, Geoffroy¹ (AUTHOR) geoffroydn@gmail.com, Brion, Régis^1,2 (AUTHOR) regis.brion@univ-nantes.fr, Morice, Sarah¹ (AUTHOR) sarah.morice@univ-nantes.fr, Regnier, Laura¹ (AUTHOR) laura.regnier@univ-nantes.fr, Dupuy, Maryne¹ (AUTHOR) maryne.dupuy@etu.univ-nantes.fr, Brounais-Le Royer, Bénédicte¹ (AUTHOR) Benedicte.brounais@univ-nantes.fr, Lamoureux, François¹ (AUTHOR) francois.lamoureux@univ-nantes.fr, Ory, Benjamin¹ (AUTHOR) Benjamin.Ory@univ-nantes.fr, Rédini, Françoise¹ (AUTHOR) francoise.redini@univ-nantes.fr, Verrecchia, Franck¹ (AUTHOR) franck.verrecchia@univ-nantes.fr

Source: Cells (2073-4409). Sep2021, Vol. 10 Issue 9, p2268. 1p.

Subject Terms: *DEUBIQUITINATING enzymes, *TUMOR growth, *LUNG development, *CELL lines, *LUNG tumors, *LUNGS

The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth.

Authors: Morice, Sarah¹ (AUTHOR) sarah.morice@univ-nantes.fr, Mullard, Mathilde¹ (AUTHOR) mathilde.mullard@univ-nantes.fr, Brion, Regis² (AUTHOR) regis.brion@univ-nantes.fr, Dupuy, Maryne¹ (AUTHOR) maryne.dupuy@etu.univ-nantes.fr, Renault, Sarah¹ (AUTHOR) sarah.renault@univ-nantes.fr, Tesfaye, Robel¹ (AUTHOR) robel.tesfaye@etu.univ-nantes.fr, Brounais-Le Royer, Bénédicte¹ (AUTHOR) Benedicte.brounais@univ-nantes.fr, Ory, Benjamin¹ (AUTHOR) Benjamin.Ory@univ-nantes.fr, Redini, Françoise¹ (AUTHOR) francoise.redini@univ-nantes.fr, Verrecchia, Franck¹ (AUTHOR) franck.verrecchia@univ-nantes.fr

Source: Cancers. Dec2020, Vol. 12 Issue 12, p3847. 1p.

Subject Terms: *ANIMAL experimentation, *CELL lines, *CELLULAR signal transduction, *MICE, *OSTEOSARCOMA, *RNA, *VERTEPORFIN, *PHARMACODYNAMICS

Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing's Sarcoma Tumor Growth.

Authors: Mullard, Mathilde¹ (AUTHOR) mathilde.mullard@univ-nantes.fr, Cadé, Marie^2,3 (AUTHOR) marie.cade@etu.univ-nantes.fr, Morice, Sarah¹ (AUTHOR) sarah.morice@univ-nantes.fr, Dupuy, Maryne¹ (AUTHOR) maryne.dupuy@etu.univ-nantes.fr, Danieau, Geoffroy¹ (AUTHOR) geoffroydn@gmail.com, Amiaud, Jérome¹ (AUTHOR) jerome.amiaud@univ-nantes.fr, Renault, Sarah¹ (AUTHOR) sarah.renault@univ-nantes.fr, Lézot, Frédéric¹ (AUTHOR) frederic.lezot@univ-nantes.fr, Brion, Régis^1,4 (AUTHOR) regis.brion@univ-nantes.fr, Thepault, Rose Anne¹ (AUTHOR) Rose-Anne.Thepault@univ-nantes.fr, Ory, Benjamin¹ (AUTHOR) Benjamin.Ory@univ-nantes.fr, Lamoureux, François¹ (AUTHOR) francois.lamoureux@univ-nantes.fr, Corre, Isabelle¹ (AUTHOR) isabelle.corre@univ-nantes.fr, Brounais-LeRoyer, Bénédicte¹ (AUTHOR) benedicte.brounais@univ-nantes.fr, Rédini, Françoise¹ (AUTHOR) francoise.redini@univ-nantes.fr, Verrecchia, Franck¹ (AUTHOR) franck.verrecchia@univ-nantes.fr

Source: Cancers. Nov2020, Vol. 12 Issue 11, p3438. 1p.

Subject Terms: *BONE tumors, *CELL lines, *CELLULAR signal transduction, *EWING'S sarcoma, *OSTEOSARCOMA, *RNA, *TRANSCRIPTION factors, *TRANSFORMING growth factors-beta, *DNA-binding proteins, *HEDGEHOG signaling proteins, *SEQUENCE analysis

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TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression.

Authors: Lamora, Audrey, Talbot, Julie, Mullard, Mathilde, Brounais-Le Royer, Benedicte, Redini, Françoise, Verrecchia, Franck

Source: Journal of Clinical Medicine; Nov2016, Vol. 5 Issue 11, p96, 11p

Subject Terms: OSTEOSARCOMA, BONE remodeling, BONE tumors, METASTASIS, TRANSFORMING growth factors-beta, CANCER invasiveness

LIM Kinases in Osteosarcoma Development.

Authors: Brion, Régis, Regnier, Laura, Mullard, Mathilde, Amiaud, Jérome, Rédini, Françoise, Verrecchia, Franck

Source: Cells (2073-4409); Dec2021, Vol. 10 Issue 12, p3542-3542, 1p

Subject Terms: OSTEOSARCOMA, KINASES, CHILDHOOD cancer, PROSTATE cancer, BONE cancer, MICROTUBULES, CYTOSKELETON