Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling

Authors: Simpson, Joanne E., Muir, Morwenna T., Lee, Martin, Naughton, Catherine, Gilbert, Nick, Pollard, Steven M., Gammoh, Noor

Source: In Developmental Cell 22 January 2024 59(2):228-243

Analysis of Pancreatic Acinar Protein Solubility in Autophagy-Deficient Mice

Authors: Smith, Matthew, Salomo-Coll, Carla, Muir, Morwenna, Wilkinson, Simon

Source: Methods in molecular biology. 2445:243-254

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628468587&indx=1&recIds=ETOCRN628468587

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment

Authors: Dawson, John C., Munro, Alison, Macleod, Kenneth, Muir, Morwenna, Timpson, Paul, Williams, Robert J., Frame, Margaret, Brunton, Valerie G., Carragher, Neil O.

Source: Molecular oncology. 16(5):1072-1090

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144673672.0x000001&indx=1&recIds=ETOCvdc_100144673672.0x000001

HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies

Authors: Tracey, Natasha, Creedon, Helen, Kemp, Alain J., Culley, Jayne, Muir, Morwenna, Klinowska, Teresa, Brunton, Valerie G.

Source: Breast cancer research and treatment. 179(3):543-555

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161807560.0x000001&indx=1&recIds=ETOCvdc_100161807560.0x000001

Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

Authors: Millar, Fraser R., Pennycuick, Adam, Muir, Morwenna, Quintanilla, Andrea, Hari, Priya, Freyer, Elisabeth, Gautier, Philippe, Meynert, Alison, Grimes, Graeme, Coll, Carla Salomo, Zdral, Sofia, Victorelli, Stella, Teixeira, Vitor H., Connelly, John, Passos, João F., Ros, Marian A., Wallace, William A.H., Frame, Margaret C., Sims, Andrew H., Boulter, Luke, Janes, Sam M., Wilkinson, Simon, Acosta, Juan Carlos

Source: Cell reports. 41(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185478982.0x000001&indx=1&recIds=ETOCvdc_100185478982.0x000001

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Authors: Zimmermann, Michal, Murina, Olga, Reijns, Martin, Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou, Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie, Hart, Traver, Bono, Johann, Stankovic, Tatjana, Jackson, Andrew, Durocher, Daniel

Source: Nature. 559(7713):285-289

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171353587.0x000001&indx=1&recIds=ETOCvdc_100171353587.0x000001

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

Authors: Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.

Source: In Cell 24 September 2015 163(1):160-173

Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

Authors: Langdon, Simon P., Kay, Charlene, Um, In Hwa, Dodds, Michael, Muir, Morwenna, Sellar, Grant, Kan, Julie, Gourley, Charlie, Harrison, David J.

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131401088.0x000001&indx=1&recIds=ETOCvdc_100131401088.0x000001

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis.

Authors: Davidson, Callam T., Miller, Eileen, Muir, Morwenna, Dawson, John C., Lee, Martin, Aitken, Stuart, Serrels, Alan, Webster, Scott P., Homer, Natalie Z. M., Andrew, Ruth, Brunton, Valerie G., Hadoke, Patrick W. F., Walker, Brian R.

Source: PLoS ONE; 3/20/2023, Vol. 18 Issue 3, p1-19, 19p

Subject Terms: SECOND harmonic generation, NEOVASCULARIZATION, GLUCOCORTICOID receptors, PANCREATIC duct, CELL imaging

Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models.

Authors: Webb, Emily R., Dodd, Georgia L., Noskova, Michaela, Bullock, Esme, Muir, Morwenna, Frame, Margaret C., Serrels, Alan, Brunton, Valerie G.

Source: eLife; 3/17/2023, p1-21, 21p

Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity

Authors: Guichard, Sylvie M., Macpherson, Janet S., Mayer, Iain, Reid, Eilidh, Muir, Morwenna, Dodds, Michael, Alexander, Susan, Jodrell, Duncan I.

Source: In European Journal of Cancer 2008 44(2):310-317

MYC sensitises cells to apoptosis by driving energetic demand.

Authors: Edwards-Hicks, Joy, Su, Huizhong, Mangolini, Maurizio, Yoneten, Kubra K., Wills, Jimi, Rodriguez-Blanco, Giovanny, Young, Christine, Cho, Kevin, Barker, Heather, Muir, Morwenna, Guerrieri, Ania Naila, Li, Xue-Feng, White, Rachel, Manasterski, Piotr, Mandrou, Elena, Wills, Karen, Chen, Jingyu, Abraham, Emily, Sateri, Kianoosh, Qian, Bin-Zhi

Source: Nature Communications; 8/9/2022, Vol. 13 Issue 1, p1-16, 16p

Subject Terms: APOPTOSIS, TRICARBOXYLIC acids, GLUTAMINE, SUPPLY & demand, ONCOGENES, CELL survival

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

Authors: Fernández-Duran, Irene, Quintanilla, Andrea, Tarrats, Núria, Birch, Jodie, Hari, Priya, Millar, Fraser R., Lagnado, Anthony B., Smer-Barreto, Vanessa, Muir, Morwenna, Brunton, Valerie G., Passos, João F., Acosta, Juan Carlos

Source: Cell Death and Differentiation; June 2022, Vol. 29 Issue: 6 p1267-1282, 16p

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

Authors: Bolado-Carrancio, Alfonso, Lee, Martin, Ewing, Ailith, Muir, Morwenna, Macleod, Kenneth G., Gallagher, William M., Nguyen, Lan K., Carragher, Neil O., Semple, Colin A., Brunton, Valerie G., Caswell, Patrick T., von Kriegsheim, Alex

Source: Oncogene; November 2021, Vol. 40 Issue: 44 p6235-6247, 13p

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