Neurological adverse events of immune checkpoint inhibitors and the development of paraneoplastic neurological syndromes

Authors: Farina, Antonio, Villagrán-García, Macarena, Vogrig, Alberto, Zekeridou, Anastasia, Muñiz-Castrillo, Sergio, Velasco, Roser, Guidon, Amanda C, Joubert, Bastien, Honnorat, Jérôme ^*

Source: In The Lancet Neurology January 2024 23(1):81-94

Glial Fibrillary Acidic Protein Autoimmunity

Authors: Gravier-Dumonceau, Alice, Ameli, Roxana, Rogemond, Veronique, Ruiz, Anne, Joubert, Bastien, Muñiz-Castrillo, Sergio, Vogrig, Alberto, Picard, Geraldine, Ambati, Aditya, Benaiteau, Marie, Rulquin, Florence, Ciron, Jonathan, Deiva, Kumaran, de Broucker, Thomas, Kremer, Laurent, Kerschen, Philippe, Sellal, François, Bouldoires, Bastien, Genet, Roxana, Biberon, Julien, Bigot, Adrien, Duval, Fanny, Issa, Nahema, Rusu, Elena-Camelia, Goudot, Mathilde, Dutray, Anais, Devoize, Jean Louis, Hopes, Lucie, Kaminsky, Anne-Laure, Philbert, Marion, Chanson, Eve, Leblanc, Amelie, Morvan, Erwan, Andriuta, Daniela, Diraison, Philippe, Mirebeau, Gabriel, Derollez, Celine, Bourg, Veronique, Bodard, Quentin, Fort, Clementine, Grigorashvili-Coin, Irina, Rieul, Guillaume, Molinier-Tiganas, Daniela, Bonnan, Mickaël, Tchoumi, Thierry, Honnorat, Jérôme, Marignier, Romain

Source: Neurology. 98(6):e653-e668

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Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts.

Authors: Binks, Sophie N M^1,2,3, Elliott, Katherine S³, Muñiz-Castrillo, Sergio⁴, Gilbert, Edmund^5,6, Araujo, Tânia Kawasaki de⁷, Harper, Andrew R⁸, Brown, Andrew C³, Chong, Amanda Y³, Band, Gavin³, Sempere, Vicente Peris⁴, Pinto, Anne-Laurie⁹, Costantino, Felicie^10,11, Rayner, N William^3,12,13,14, Mentzer, Alexander J^3,15, Delanty, Norman^5,6, Rogemond, Veronique⁹, Picard, Géraldine⁹, Handel, Adam E^1,2, Melzer, Nico¹⁶, Titulaer, Maarten J¹⁷

Source: Brain: A Journal of Neurology; Mar2025, Vol. 148 Issue 3, p737-745, 9p

Role of LGI1 protein in synaptic transmission: From physiology to pathology

Authors: Fels, Elodie, Muñiz-Castrillo, Sergio, Vogrig, Alberto, Joubert, Bastien, Honnorat, Jérôme, Pascual, Olivier

Source: In Neurobiology of Disease December 2021 160

Application of the anti-IgLON5 disease composite score to assess severity, clinical course, and mortality in a French cohort.

Authors: Farina, Antonio, Villagrán-García, Macarena, Abichou-Klich, Amna, Benaiteau, Marie, Bernard, Emilien, Campetella, Lucia, Cluse, Florent, Desestret, Virginie, Dumez, Pauline, Fabien, Nicole, Goncalves, David, Muñiz-Castrillo, Sergio, Picard, Géraldine, Pinto, Anne-Laurie, Rogemond, Véronique, Vogrig, Alberto, Joubert, Bastien, Honnorat, Jérôme

Source: Journal of Neurology; Apr2025, Vol. 272 Issue 4, p1-10, 10p

Paraneoplastic Neurologic Syndromes Associated With Merkel Cell Carcinoma.

Authors: Ciano-Petersen, Nicolás Lundahl, Muñiz-Castrillo, Sergio, Villagrán-García, Macarena, Farina, Antonio, Vogrig, Alberto, Wucher, Valentin, Le Duy Do, Birzu, Cristina, Goncalves, David, Flabeau, Olivier, Duwicquet, Coline, Benard, Adrien, Nicole, Fabien, Rogemond, Veronique, Picard, Geraldine, Joubert, Bastien, Honnorat, Jerome

Source: Neurology® Neuroimmunology & Neuroinflammation; Nov2024, Vol. 11 Issue 6, p1-9, 9p

Anti-Hu Antibodies in Patients With Neurologic Side Effects of Immune Checkpoint Inhibitors

Authors: Farina, Antonio, Villagrán-García, Macarena, Ciano-Petersen, Nicolás Lundahl, Vogrig, Alberto, Muñiz-Castrillo, Sergio, Taillandier, Luc, Michaud, Maud, Lefilliatre, Mathilde, Wang, Adrien, Lepine, Zoe, Picard, Géraldine, Wucher, Valentin, Dhairi, Maroua, Fabien, Nicole, Goncalves, David, Rogemond, Véronique, Joubert, Bastien, Honnorat, Jèrôme

Source: Neurology.Neuroimmunology & neuroinflammation. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177613315.0x000001&indx=1&recIds=ETOCvdc_100177613315.0x000001

Early-Stage Contactin-Associated Protein-like 2 Limbic Encephalitis

Authors: Benoit, Jeanne, Muñiz-Castrillo, Sergio, Vogrig, Alberto, Farina, Antonio, Pinto, Anne-Laurie, Picard, Geraldine, Rogemond, Veronique, Guery, Deborah, Alentorn, Agusti, Psimaras, Dimitri, Rheims, Sylvain, Honnorat, Jérôme, Joubert, Bastien

Source: Neurology.Neuroimmunology & neuroinflammation. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177612953.0x000001&indx=1&recIds=ETOCvdc_100177612953.0x000001

Transient Neurological Symptoms Preceding Cerebellar Ataxia with Glutamic Acid Decarboxylase Antibodies

Authors: Muñiz-Castrillo, Sergio, Vogrig, Alberto, Joubert, Bastien, Pinto, Anne-Laurie, Gonçalves, David, Chaumont, Hugo, Rogemond, Véronique, Picard, Géraldine, Fabien, Nicole, Honnorat, Jérôme

Source: Cerebellum. 19(5):715-721

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174317052.0x000001&indx=1&recIds=ETOCvdc_100174317052.0x000001

Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies

Authors: Muñiz-Castrillo, Sergio, Ambati, Aditya, Dubois, Valérie, Vogrig, Alberto, Joubert, Bastien, Rogemond, Véronique, Picard, Geraldine, Lin, Ling, Fabien, Nicole, Mignot, Emmanuel, Honnorat, Jérôme

Source: Journal of neurology. 267(7):1906-1911

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168044078.0x000001&indx=1&recIds=ETOCvdc_100168044078.0x000001

HLA-DR3 ~ DQ2 associates with sensory neuropathy in paraneoplastic neurological syndromes with Hu antibodies.

Authors: Muñiz-Castrillo, Sergio¹ (AUTHOR), Villagrán-García, Macarena^2,3 (AUTHOR), Peris Sempere, Vicente¹ (AUTHOR), Farina, Antonio^2,3 (AUTHOR), Pinto, Anne-Laurie^2,3 (AUTHOR), Picard, Géraldine^2,3 (AUTHOR), Rogemond, Véronique^2,3 (AUTHOR), Honnorat, Jérôme^2,3 (AUTHOR), Mignot, Emmanuel¹ (AUTHOR) mignot@stanford.edu

Source: Journal of Neurology. Sep2024, Vol. 271 Issue 9, p6336-6342. 7p.

Subject Terms: *HLA histocompatibility antigens, *PERIPHERAL nervous system, *SYMPTOMS, *GENOME-wide association studies, *CENTRAL nervous system, *PARANEOPLASTIC syndromes

HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis.

Authors: Peris Sempere, Vicente, Guo Luo, Muñiz-Castrillo, Sergio, Pinto, Anne-Laurie, Picard, Géraldine, Rogemond, Véronique, Titulaer, Maarten J., Finke, Carsten, Leypoldt, Frank, Kuhlenbäumer, Gregor, Jones, Hannah F., Dale, Russell C., Binks, Sophie, Irani, Sarosh R., Bastiaansen, Anna E., de Vries, Juna M., de Bruijn, Marienke A. A. M., Roelen, Dave L., Tae-Joon Kim, Kon Chu

Source: Frontiers in Immunology; 2024, p1-14, 14p

Subject Terms: ANTI-NMDA receptor encephalitis, KILLER cells, MONONUCLEAR leukocytes, GENOME-wide association studies, HLA histocompatibility antigens, METHYL aspartate receptors

HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease.

Authors: Yogeshwar, Selina M^1,2,3 (AUTHOR), Muñiz-Castrillo, Sergio¹ (AUTHOR), Sabater, Lidia⁴ (AUTHOR), Peris-Sempere, Vicente¹ (AUTHOR), Mallajosyula, Vamsee⁵ (AUTHOR), Luo, Guo¹ (AUTHOR), Yan, Han¹ (AUTHOR), Yu, Eric¹ (AUTHOR), Zhang, Jing¹ (AUTHOR), Lin, Ling¹ (AUTHOR), Bueno, Flavia Fagundes¹ (AUTHOR), Ji, Xuhuai⁶ (AUTHOR), Picard, Géraldine^7,8 (AUTHOR), Rogemond, Véronique^7,8 (AUTHOR), Pinto, Anne Laurie^7,8 (AUTHOR), Heidbreder, Anna⁹ (AUTHOR), Höftberger, Romana¹⁰ (AUTHOR), Graus, Francesc¹¹ (AUTHOR), Dalmau, Josep^11,12,13,14 (AUTHOR), Santamaria, Joan¹¹ (AUTHOR)

Source: Brain: A Journal of Neurology. Jul2024, Vol. 147 Issue 7, p2579-2592. 14p.

Subject Terms: *AUTOIMMUNE diseases, *HLA histocompatibility antigens, *T cells, *BINDING site assay, *AGE of onset, *PEPTIDES

Post-acute anti-NMDAR encephalitis mirrors schizophrenia

Authors: Muñiz-Castrillo, Sergio, Vogrig, Alberto, Honnorat, Jérôme

Source: In Trends in Molecular Medicine November 2022 28(11):895-896

Cerebellar Ataxia With Anti-DNER Antibodies

Authors: Peter, Elise, Do, Le Duy, Hannoun, Salem, Muñiz-Castrillo, Sergio, Vogrig, Alberto, Wucher, Valentin, Pinto, Anne-Laurie, Chounlamountri, Naura, Zakaria, Walaa, Rogemond, Veronique, Picard, Geraldine, Hedou, Julien-Jacques, Ambati, Aditya, Alentorn, Agusti, Traverse-Glehen, Alexandra, Manto, Mario, Psimaras, Dimitri, Mignot, Emmanuel, Cotton, Francois, Desestret, Virginie, Honnorat, Jérôme, Joubert, Bastien

Source: Neurology.Neuroimmunology & neuroinflammation. 9(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170416354.0x000001&indx=1&recIds=ETOCvdc_100170416354.0x000001

Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis

Authors: Peris Sempere, Vicente, Muñiz-Castrillo, Sergio, Ambati, Aditya, Binks, Sophie, Pinto, Anne-Laurie, Rogemond, Veronique, Pittock, Sean J., Dubey, Divyanshu, Geschwind, Michael D., Gelfand, Jeffrey Marc, Dilwali, Sonam, Lee, Soon-Tae, Knight, Julian, Elliott, Katherine S., Irani, Sarosh, Honnorat, Jérôme, Mignot, Emmanuel

Source: Neurology.Neuroimmunology & neuroinflammation. 9(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167471564.0x000001&indx=1&recIds=ETOCvdc_100167471564.0x000001

Genetic predisposition to autoimmune encephalitis and paraneoplastic neurological syndromes.

Authors: Muñiz-Castrillo, Sergio, Honnorat, Jérôme

Source: Current Opinion in Neurology; Jun2024, Vol. 37 Issue 3, p329-337, 9p

Dysautonomia in anti-Hu paraneoplastic neurological syndromes.

Authors: Villagrán-García, Macarena, Farina, Antonio, Arzalluz-Luque, Joaquín, Campetella, Lucia, Muñiz-Castrillo, Sergio, Benaiteau, Marie, Peter, Elise, Dumez, Pauline, Wucher, Valentin, Dhairi, Maroua, Picard, Géraldine, Rafiq, Marie, Psimaras, Dimitri, Rogemond, Véronique, Joubert, Bastien, Honnorat, Jérôme

Source: Journal of Neurology; Jun2024, Vol. 271 Issue 6, p3359-3369, 11p

Subject Terms: PARANEOPLASTIC syndromes, DYSAUTONOMIA, HYPOVENTILATION, SYMPTOMS, FREQUENCY spectra, OVERALL survival, DEATH rate

Predictors and Clinical Characteristics of Relapses in LGI1-Antibody Encephalitis.

Authors: Campetella, Lucia, Farina, Antonio, Villagrán-García, Macarena, Villard, Marine, Benaiteau, Marie, Timestit, Noémie, Vogrig, Alberto, Picard, Géraldine, Rogemond, Véronique, Psimaras, Dimitri, Rafiq, Marie, Chanson, Eve, Marchal, Cecile, Goncalves, David, Joubert, Bastien, Honnorat, Jérôme, Muñiz-Castrillo, Sergio

Source: Neurology® Neuroimmunology & Neuroinflammation; May2024, Vol. 11 Issue 3, p1-13, 13p

Comparative Study of Paraneoplastic and Nonparaneoplastic Autoimmune Encephalitis With GABABR Antibodies.

Authors: Lamblin, Florian, Kerstens, Jeroen, Muñiz-Castrillo, Sergio, Vogrig, Alberto, Goncalves, David, Rogemond, Veronique, Picard, Geraldine, Villard, Marine, Pinto, Anne-Laurie, Van Coevorden-Hameete, Marleen H., De Bruijn, Marienke A., De Vries, Juna M., Schreurs, Marco, Tyvaert, Louise, Hopes, Lucie, Aupy, Jerome, Marchal, Cecile, Psimaras, Dimitri, Kremer, Laurent, Bourg, Veronique

Source: Neurology® Neuroimmunology & Neuroinflammation; May2024, Vol. 11 Issue 3, p1-15, 15p