Age-associated H3K9me2 loss alters the regenerative equilibrium between murine lung alveolar and bronchiolar progenitors

Authors: Rowbotham, Samuel P., Pessina, Patrizia, Garcia-de-Alba, Carolina, Jensen, Jake, Nguyen, Yvonne, Yoon, Joon, Li, Jingyun, Wong, Irene G., Fahey, Caroline, Moye, Aaron L., Chongsaritsinsuk, Joann, Bronson, Roderick, Ho Sui, Shannan J., Kim, Carla F.

Source: In Developmental Cell 18 December 2023 58(24):2974-2991

Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state.

Authors: Li, Jingyun, Dang, Susanna M, Sengupta, Shreoshi, Schurmann, Paul, Dost, Antonella F M, Moye, Aaron L, Trovero, Maria F, Ahmed, Sidrah, Paschini, Margherita, Bhetariya, Preetida J, Bronson, Roderick, Ho Sui, Shannan J, Kim, Carla F

Source: EMBO Journal; Mar2025, Vol. 44 Issue 6, p1804-1828, 25p

Progenitor potential of lung epithelial organoid cells in a transplantation model

Authors: Louie, Sharon M., Moye, Aaron L., Wong, Irene G., Lu, Emery, Shehaj, Andrea, Garcia-de-Alba, Carolina, Ararat, Erhan, Raby, Benjamin A., Lu, Bao, Paschini, Margherita, Bronson, Roderick T., Kim, Carla F.

Source: In Cell Reports 12 April 2022 39(2)

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells

Authors: Dost, Antonella F.M., Moye, Aaron L., Vedaie, Marall, Tran, Linh M., Fung, Eileen, Heinze, Dar, Villacorta-Martin, Carlos, Huang, Jessie, Hekman, Ryan, Kwan, Julian H., Blum, Benjamin C., Louie, Sharon M., Rowbotham, Samuel P., Sainz de Aja, Julio, Piper, Mary E., Bhetariya, Preetida J., Bronson, Roderick T., Emili, Andrew, Mostoslavsky, Gustavo, Fishbein, Gregory A., Wallace, William D., Krysan, Kostyantyn, Dubinett, Steven M., Yanagawa, Jane, Kotton, Darrell N., Kim, Carla F.

Source: In Cell Stem Cell 1 October 2020 27(4):663-678

Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.

Authors: Moye, Aaron L^1,2,3 (AUTHOR), Dost, Antonella FM^1,2,3,4 (AUTHOR), Ietswaart, Robert³ (AUTHOR), Sengupta, Shreoshi^1,2,3 (AUTHOR), Ya, VanNashlee^1,2,3 (AUTHOR), Aluya, Chrystal^1,2,3 (AUTHOR), Fahey, Caroline G^1,2,3,5 (AUTHOR), Louie, Sharon M^1,2,3 (AUTHOR), Paschini, Margherita^1,2,3 (AUTHOR), Kim, Carla F^1,2,3 (AUTHOR) carla.kim@childrens.harvard.edu

Source: EMBO Journal. Jul2024, Vol. 43 Issue 14, p2843-2861. 19p.

Subject Terms: *LUNG cancer, *GENE expression, *PROGENITOR cells, *RAS oncogenes, *GUANOSINE triphosphatase

Human Airway and Alveolar Organoids from BAL Fluid.

Authors: Liu, Monica Yun, Chen, Belinda, Borji, Mehdi, Garcia de Alba Rivas, Carolina, Dost, Antonella F. M., Moye, Aaron L., Movval Abdulla, Nusrath, Paschini, Margherita, Rollins, Stuart D., Wang, Ruobing, Schnapp, Lynn M., Khalil, Hassan A., Wu, Catherine J., Sharma, Nirmal S., Kim, Carla F.

Source: American Journal of Respiratory & Critical Care Medicine; 6/15/2024, Vol. 209 Issue 12, p1501-1504, 4p

Subject Terms: ORGANOIDS, BRONCHOALVEOLAR lavage

Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase.

Authors: El-Khoury, Roberto, Roman, Morgane, Assi, Hala Abou, Moye, Aaron L, Bryan, Tracy M, Damha, Masad J

Source: Nucleic Acids Research; 10/27/2023, Vol. 51 Issue 19, p10395-10410, 16p

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Genomic and evolutionary classification of lung cancer in never smokers

Authors: Zhang, Tongwu, Joubert, Philippe, Ansari-Pour, Naser, Zhao, Wei, Hoang, Phuc H., Lokanga, Rachel, Moye, Aaron L., Rosenbaum, Jennifer, Gonzalez-Perez, Abel, Martínez-Jiménez, Francisco, Castro, Andrea, Muscarella, Lucia Anna, Hofman, Paul, Consonni, Dario, Pesatori, Angela C., Kebede, Michael, Li, Mengying, Gould Rothberg, Bonnie E., Peneva, Iliana, Schabath, Matthew B., Poeta, Maria Luana, Costantini, Manuela, Hirsch, Daniela, Heselmeyer-Haddad, Kerstin, Hutchinson, Amy, Olanich, Mary, Lawrence, Scott M., Lenz, Petra, Duggan, Maire, Bhawsar, Praphulla M. S., Sang, Jian, Kim, Jung, Mendoza, Laura, Saini, Natalie, Klimczak, Leszek J., Islam, S. M. Ashiqul, Otlu, Burcak, Khandekar, Azhar, Cole, Nathan, Stewart, Douglas R., Choi, Jiyeon, Brown, Kevin M., Caporaso, Neil E., Wilson, Samuel H., Pommier, Yves, Lan, Qing, Rothman, Nathaniel, Almeida, Jonas S., Carter, Hannah, Ried, Thomas, Kim, Carla F., Lopez-Bigas, Nuria, Garcia-Closas, Montserrat, Shi, Jianxin, Bossé, Yohan, Zhu, Bin, Gordenin, Dmitry A., Alexandrov, Ludmil B., Chanock, Stephen J., Wedge, David C., Landi, Maria Teresa

Source: Nature Genetics; September 2021, Vol. 53 Issue: 9 p1348-1359, 12p

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