Defining a Unique Gene Expression Profile in Mature and Developing Keloids

Authors: Zhu, Yuan O., MacDonnell, Scott, Kaplan, Theodore, Liu, Chien, Ali, Yasmeen, Rangel, Stephanie M., Wipperman, Matthew F., Belback, Madeleine, Sun, Daphne S., Ren, Ziyou, Zhou, Xiaolong Alan, Halasz, Gabor, Morton, Lori, Kundu, Roopal V.

Source: In JID Innovations September 2023 3(5)

Association of complement pathways with COVID-19 severity and outcomes

Authors: Devalaraja-Narashimha, Kishor, Ehmann, Peter J., Huang, Cong, Ruan, Qin, Wipperman, Matthew F., Kaplan, Theodore, Liu, Chien, Afolayan, Simisola, Glass, David J., Mellis, Scott, Yancopoulos, George D., Hamilton, Jennifer D., MacDonnell, Scott, Hamon, Sara C., Boyapati, Anita, Morton, Lori

Source: In Microbes and Infection May 2023 25(4)

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Authors: Henry, Albert, Mo, Xiaodong, Finan, Chris, Chaffin, Mark D., Speed, Doug, Issa, Hanane, Denaxas, Spiros, Ware, James S., Zheng, Sean L., Malarstig, Anders, Gratton, Jasmine, Bond, Isabelle, Roselli, Carolina, Miller, David, Chopade, Sandesh, Schmidt, A. Floriaan, Abner, Erik, Adams, Lance, Andersson, Charlotte, Aragam, Krishna G., Ärnlöv, Johan, Asselin, Geraldine, Raja, Anna Axelsson, Backman, Joshua D., Bartz, Traci M., Biddinger, Kiran J., Biggs, Mary L., Bloom, Heather L., Boersma, Eric, Brandimarto, Jeffrey, Brown, Michael R., Brunak, Søren, Bruun, Mie Topholm, Buckbinder, Leonard, Bundgaard, Henning, Carey, David J., Chasman, Daniel I., Chen, Xing, Cook, James P., Czuba, Tomasz, de Denus, Simon, Dehghan, Abbas, Delgado, Graciela E., Doney, Alexander S., Dörr, Marcus, Dowsett, Joseph, Dudley, Samuel C., Engström, Gunnar, Erikstrup, Christian, Esko, Tõnu, Farber-Eger, Eric H., Felix, Stephan B., Finer, Sarah, Ford, Ian, Ghanbari, Mohsen, Ghasemi, Sahar, Ghouse, Jonas, Giedraitis, Vilmantas, Giulianini, Franco, Gottdiener, John S., Gross, Stefan, Guðbjartsson, Daníel F., Gui, Hongsheng, Gutmann, Rebecca, Hägg, Sara, Haggerty, Christopher M., Hedman, Åsa K., Helgadottir, Anna, Hemingway, Harry, Hillege, Hans, Hyde, Craig L., Aagaard Jensen, Bitten, Jukema, J. Wouter, Kardys, Isabella, Karra, Ravi, Kavousi, Maryam, Kizer, Jorge R., Kleber, Marcus E., Køber, Lars, Koekemoer, Andrea, Kuchenbaecker, Karoline, Lai, Yi-Pin, Lanfear, David, Langenberg, Claudia, Lin, Honghuang, Lind, Lars, Lindgren, Cecilia M., Liu, Peter P., London, Barry, Lowery, Brandon D., Luan, Jian’an, Lubitz, Steven A., Magnusson, Patrik, Margulies, Kenneth B., Marston, Nicholas A., Martin, Hilary, März, Winfried, Melander, Olle, Mordi, Ify R., Morley, Michael P., Morris, Andrew P., Morrison, Alanna C., Morton, Lori, Nagle, Michael W., Nelson, Christopher P., Niessner, Alexander, Niiranen, Teemu, Noordam, Raymond, Nowak, Christoph, O’Donoghue, Michelle L., Ostrowski, Sisse Rye, Owens, Anjali T., Palmer, Colin N. A., Paré, Guillaume, Pedersen, Ole Birger, Perola, Markus, Pigeyre, Marie, Psaty, Bruce M., Rice, Kenneth M., Ridker, Paul M., Romaine, Simon P. R., Rotter, Jerome I., Ruff, Christian T., Sabatine, Marc S., Sallah, Neneh, Salomaa, Veikko, Sattar, Naveed, Shalaby, Alaa A., Shekhar, Akshay, Smelser, Diane T., Smith, Nicholas L., Sørensen, Erik, Srinivasan, Sundararajan, Stefansson, Kari, Sveinbjörnsson, Garðar, Svensson, Per, Tammesoo, Mari-Liis, Tardif, Jean-Claude, Teder-Laving, Maris, Teumer, Alexander, Thorgeirsson, Guðmundur, Thorsteinsdottir, Unnur, Torp-Pedersen, Christian, Tragante, Vinicius, Trompet, Stella, Uitterlinden, Andre G., Ullum, Henrik, van der Harst, Pim, van Heel, David, van Setten, Jessica, van Vugt, Marion, Veluchamy, Abirami, Verschuuren, Monique, Verweij, Niek, Vissing, Christoffer Rasmus, Völker, Uwe, Voors, Adriaan A., Wallentin, Lars, Wang, Yunzhang, Weeke, Peter E., Wiggins, Kerri L., Williams, L. Keoki, Yang, Yifan, Yu, Bing, Zannad, Faiez, Zheng, Chaoqun, Asselbergs, Folkert W., Cappola, Thomas P., Dubé, Marie-Pierre, Dunn, Michael E., Lang, Chim C., Samani, Nilesh J., Shah, Svati, Vasan, Ramachandran S., Smith, J. Gustav, Holm, Hilma, Shah, Sonia, Ellinor, Patrick T., Hingorani, Aroon D., Wells, Quinn, Lumbers, R. Thomas

Source: Nature Genetics; 20250101, Issue: Preprints p1-14, 14p

Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties

Authors: Macdonald, Lynn E., Meagher, Karoline A., Franklin, Matthew C., Levenkova, Natasha, Hansen, Johanna, Badithe, Ashok T., Zhong, Maggie, Krueger, Pamela, Rafique, Ashique, Tu, Naxin, Shevchuk, James, Wadhwa, Saurabh, Ehrlich, George, Bautista, Joannie, Grant, Craig, Esau, Lakeisha, Poueymirou, William T., Auerbach, Wojtek, Morton, Lori, Babb, Robert, Chen, Gang, Huang, Tammy, MacDonald, Douglas, Graham, Kenneth, Gurer, Cagan, Voronina, Vera A., McWhirter, John R., Guo, Chunguang, Yancopoulos, George D., Murphy, Andrew J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jan 01. 117(1), 292-299.

Access URL: https://www.jstor.org/stable/26897465

Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study

Authors: Townsend, Raymond R., Guarnieri, Paolo, Argyropoulos, Christos, Blady, Shira, Boustany-Kari, Carine M., Devalaraja-Narashimha, Kishor, Morton, Lori, Mottl, Amy K., Patel, Uptal, Palmer, Matthew, Ross, Michael J., Sarov-Blat, Lea, Steinbugler, Kathryn, Susztak, Katalin

Source: Kidney international. 97(1):10-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100100554946.0x000001&indx=1&recIds=ETOCvdc_100100554946.0x000001

Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit.

Authors: Patel, Siddharth M, Lopes, Mathew S, Morrow, David A, Bellavia, Andrea, Bhatt, Ankeet S, Butler, Kayleigh K, D'Antonio, Jessica, Dunn, Michael, Fagundes Jr, Antonio A, Jarolim, Petr, Marin, Ethan P, Morton, Lori, Olenchock, Benjamin O, Senman, Balimkiz, da Silva, Danuzia S, Varshney, Anubodh S, Bohula, Erin A, Berg, David D

Source: European Heart Journal: Acute Cardiovascular Care; Aug2024, Vol. 13 Issue 8, p624-628, 5p

Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone

Authors: Dunn, Michael E., Kithcart, Aaron, Kim, Jee Hae, Ho, Andre Jo-Hao, Franklin, Matthew C., Romero Hernandez, Annabel, de Hoon, Jan, Botermans, Wouter, Meyer, Jonathan, Jin, Ximei, Zhang, Dongqin, Torello, Justin, Jasewicz, Daniel, Kamat, Vishal, Garnova, Elena, Liu, Nina, Rosconi, Michael, Pan, Hao, Karnik, Satyajit, Burczynski, Michael E., Zheng, Wenjun, Rafique, Ashique, Nielsen, Jonas B., De, Tanima, Verweij, Niek, Pandit, Anita, Locke, Adam, Chalasani, Naga, Melander, Olle, Schwantes-An, Tae-Hwi, Baras, Aris, Lotta, Luca A., Musser, Bret J., Mastaitis, Jason, Devalaraja-Narashimha, Kishor B., Rankin, Andrew J., Huang, Tammy, Herman, Gary, Olson, William, Murphy, Andrew J., Yancopoulos, George D., Olenchock, Benjamin A., Morton, Lori

Source: Nature; September 2024, Vol. 633 Issue: 8030 p654-661, 8p

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression

Authors: Abedini, Amin, Levinsohn, Jonathan, Klötzer, Konstantin A., Dumoulin, Bernhard, Ma, Ziyuan, Frederick, Julia, Dhillon, Poonam, Balzer, Michael S., Shrestha, Rojesh, Liu, Hongbo, Vitale, Steven, Bergeson, Andi M., Devalaraja-Narashimha, Kishor, Grandi, Paola, Bhattacharyya, Tanmoy, Hu, Erding, Pullen, Steven S., Boustany-Kari, Carine M., Guarnieri, Paolo, Karihaloo, Anil, Traum, Daniel, Yan, Hanying, Coleman, Kyle, Palmer, Matthew, Sarov-Blat, Lea, Morton, Lori, Hunter, Christopher A., Kaestner, Klaus H., Li, Mingyao, Susztak, Katalin

Source: Nature Genetics; August 2024, Vol. 56 Issue: 8 p1712-1724, 13p

Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates.

Authors: Devalaraja-Narashimha, Kishor, Huang, Cong, Cao, Marc, Chen, Ya Ping, Borodovsky, Anna, Olson, William C., Morton, Lori G., Retter, Marc W.

Source: PLoS ONE; 6/16/2022, Vol. 17 Issue 6, p1-10, 10p

Subject Terms: COMPLEMENT inhibition, PAROXYSMAL hemoglobinuria, MONOCLONAL antibodies, PHARMACOKINETICS, PRIMATES, PHARMACODYNAMICS

The Association between Factor XI Deficiency and the Risk of Bleeding, Cardiovascular, and Venous Thromboembolic Events.

Authors: Sharman Moser, Sarah, Chodick, Gabriel, Ni, Yan G., Chalothorn, Dan, Wang, Ming-Dauh, Shuldiner, Alan R., Morton, Lori, Salomon, Ophira, Jalbert, Jessica J.

Source: Thrombosis & Haemostasis; May2022, Vol. 122 Issue 5, p808-817, 10p

The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients.

Authors: McAleavy, Megan, Zhang, Qian, Ehmann, Peter J., Xu, Jianing, Wipperman, Matthew F., Ajithdoss, Dharani, Pan, Li, Wakai, Matthew, Simonson, Raphael, Gadi, Abhilash, Oyejide, Adelekan, Hamon, Sara C., Boyapati, Anita, Morton, Lori G., Shavlakadze, Tea, Kyratsous, Christos A., Glass, David J.

Source: Molecular & Cellular Biology; Jan2022, Vol. 42 Issue 1, p1-19, 19p

Interim Analysis of an Open-Label, Ascending-Dose, Phase 1 Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Doses of the Subcutaneously Administered Human Monoclonal Antibody Pozelimab in Combination with Single Doses of the Subcutaneously Administered siRNA Cemdisiran in Healthy Volunteers

Authors: van Zyl, Tavé, Weyne, Jonathan, Chaudhari, Umesh, Harari, Olivier, Levy, Oren, Miller, Jutta, Chen, Yiziying, Meagher, Karoline A, Rodgers, Merideth L, Perlee, Lorah, Morton, Lori, Weinreich, David M, Yancopoulos, George D.

Source: In Blood 23 November 2021 138 Supplement 1:1998-1998

Pozelimab, a Human Monoclonal Antibody Against Complement Factor C5, Provided Inhibition of Intravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria

Authors: Jang, Jun-Ho, Weyne, Jonathan, Chaudhari, Umesh, Harari, Olivier, Miller, Jutta, Dain, Bradley, Meagher, Karoline A, Rodgers, Merideth L, Perlee, Lorah, Morton, Lori, Weinreich, David M, Yancopoulos, George D., Griffin, Morag

Source: In Blood 23 November 2021 138 Supplement 1:1128-1128

Development of a semi-automated segmentation tool for high frequency ultrasound image analysis of mouse echocardiograms.

Authors: Powers, Kristi, Chang, Raymond, Torello, Justin, Silva, Rhonda, Cadoret, Yannick, Cupelo, William, Morton, Lori, Dunn, Michael

Source: Scientific Reports; 3/22/2021, Vol. 11 Issue 1, p1-15, 15p

Subject Terms: ECHOCARDIOGRAPHY, DRUG development, IMAGE processing, ULTRASONIC imaging, LABORATORY mice

Somatoform Disorder: Treatment Utilization and Cost by Mental Health Professions.

Authors: Crane, D.¹ RussCrane@byu.edu, Morton, Lori¹, Fawcett, David¹, Moore, Adam¹, Larson, Jeffry¹, Sandberg, Jonathan¹

Source: Contemporary Family Therapy: An International Journal. Sep2012, Vol. 34 Issue 3, p322-333. 12p. 2 Charts.

Subject Terms: *SOMATOFORM disorders, *ANALYSIS of covariance, *BEHAVIOR therapy, *CHI-squared test, *COST effectiveness, *FAMILY psychotherapy, *INSURANCE companies, *MEDICAL care costs, *MENTAL health, *CLASSIFICATION of mental disorders, *RECIDIVISM, *EFFECT sizes (Statistics), *DESCRIPTIVE statistics, *THERAPEUTICS

Geographic Terms: UNITED States

Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study

Authors: Luciano, Randy, Ross, Michael, Canetta, Pietro, Campbell, Krik, Hogan, Jonathan, Mottl, Amy, Lenz, Oliver, Szerlip, Harold, Bansal, Shweta, Brosius, Chip, Schelling, Jeffery, Almaani, Salem, Kretzler, Matthias, Isakova, Tamara, Avasare, Rupali, Lafayette, Richard, Argyropoulos, Christos, Townsend, Raymond R., Guarnieri, Paolo, Blady, Shira, Boustany-Kari, Carine M., Devalaraja-Narashimha, Kishor, Morton, Lori, Mottl, Amy K., Patel, Uptal, Palmer, Matthew, Ross, Michael J., Sarov-Blat, Lea, Steinbugler, Kathryn, Susztak, Katalin

Source: In Kidney International January 2020 97(1):10-13

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Pozelimab, a Human Antibody Against Complement Factor C5, Demonstrates Robust Inhibition of Alternative Complement Activity Both in Normal Human Serum and in Phase I Normal Healthy Volunteers

Authors: Devalaraja-Narashimha, Kishor ^*, Ni, Yan G ^*, Huang, Cong ^*, Wang, Ming-Dauh ^*, Chaudhari, Umesh ^*, Prasad, Srinivasa, Harari, Olivier ^*, Rankin, Andrew J, Morton, Lori ^*, Weyne, Jonathan ^*

Source: In Blood 13 November 2019 134 Supplement 1:2278-2278

A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of the Pharmacokinetics and Pharmacodynamics of REGN3918, a Human Antibody Against Complement Factor C5, in Healthy Volunteers

Authors: Weyne, Jonathan ^*, Ni, Yan ^*, DelGizzi, Richard ^*, Godin, Stephen ^*, Morton, Lori ^*, Prasad, Srinivasa, Rankin, Andrew J ^*, Simek-Lemos, Melissa ^*, Wang, ming-Dauh ^*, Rippley, Ronda ^*, Harari, Olivier ^*

Source: In Blood 29 November 2018 132 Supplement 1:1039-1039

Novel approaches for modeling C3 glomerulopathy in mouse and rat

Authors: Devalaraja-Narashimha, Kishor, Luo, Yifan, Huang, Cong, Kaplan, Theodore, O’Brien, John, Lorn, Dara, Lee, Jeffery, MacDonnell, Scott, Peyser, Rebecca, Halasz, Gabor, Meagher, Karoline, Casanova, Sarah, McWhirter, John, Wang, Jingjing, Hickey, Joseph, Roos, Michael, Poueymirou, William, Chiao, Eric, Auerbach, Wojtek, Olson, William, Macdonald, Lynn, Zambrowicz, Brian, Murphy, Andrew, Yancopoulos, George, Morton, Lori

Source: In Molecular Immunology October 2018 102:143-143