Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy

Authors: Wang, Yujue, Liu, Sixue, Yang, Zhentao, Algazi, Alain P., Lomeli, Shirley H., Wang, Yan, Othus, Megan, Hong, Aayoung, Wang, Xiaoyan, Randolph, Chris E., Jones, Alexis M., Bosenberg, Marcus W., Byrum, Stephanie D., Tackett, Alan J., Lopez, Henry, Yates, Clayton, Solit, David B., Ribas, Antoni, Piva, Marco, Moriceau, Gatien, Lo, Roger S.

Source: In Cancer Cell 11 October 2021 39(10):1375-1387

High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity

Authors: Huang, Dian, Leslie, Kevin A., Guest, Daniel, Yeshcheulova, Olga, Roy, Irena J., Piva, Marco, Moriceau, Gatien, Zangle, Thomas A., Lo, Roger S., Teitell, Michael A.

Source: Analytical chemistry. 90(5):3299-3306

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615140774&indx=1&recIds=ETOCRN615140774

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

Authors: Hugo, Willy, Shi, Hubing, Sun, Lu, Piva, Marco, Song, Chunying, Kong, Xiangju, Moriceau, Gatien, Hong, Aayoung, Dahlman, Kimberly B., Johnson, Douglas B., Sosman, Jeffrey A., Ribas, Antoni, Lo, Roger S.

Source: In Cell 10 September 2015 162(6):1271-1285

Tunable-Combinatorial Mechanisms of Acquired Resistance Limit the Efficacy of BRAF/MEK Cotargeting but Result in Melanoma Drug Addiction

Authors: Moriceau, Gatien, Hugo, Willy, Hong, Aayoung, Shi, Hubing, Kong, Xiangju, Yu, Clarissa C., Koya, Richard C., Samatar, Ahmed A., Khanlou, Negar, Braun, Jonathan, Ruchalski, Kathleen, Seifert, Heike, Larkin, James, Dahlman, Kimberly B., Johnson, Douglas B., Algazi, Alain, Sosman, Jeffrey A., Ribas, Antoni, Lo, Roger S.

Source: In Cancer Cell 9 February 2015 27(2):240-256

Editorial: Developing next-generation therapeutics to defeat mutation-driven cancer.

Authors: Chow, Frances, Lamoureux, François, Moriceau, Gatien

Source: Frontiers in Immunology; 2024, p1-2, 2p

Subject Terms: T-cell exhaustion, THERAPEUTICS, NON-small-cell lung carcinoma, AP-1 transcription factor, COMBINATION drug therapy

Multi-organ landscape of therapy-resistant melanoma

Authors: Liu, Sixue, Dharanipragada, Prashanthi, Lomeli, Shirley H., Wang, Yan, Zhang, Xiao, Yang, Zhentao, Lim, Raymond J., Dumitras, Camelia, Scumpia, Philip O., Dubinett, Steve M., Moriceau, Gatien, Johnson, Douglas B., Moschos, Stergios J., Lo, Roger S.

Source: Nature Medicine; May 2023, Vol. 29 Issue: 5 p1123-1134, 12p

SPRED1 deletion confers resistance to MAPK inhibition in melanoma

Authors: Ablain, Julien, Liu, Sixue, Moriceau, Gatien, Lo, Roger S., Zon, Leonard I.

Source: Journal of experimental medicine. 218(3):e20201097-e20201097

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625935037&indx=1&recIds=ETOCRN625935037

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH

Authors: Hung, King L., Luebeck, Jens, Dehkordi, Siavash R., Colón, Caterina I., Li, Rui, Wong, Ivy Tsz-Lo, Coruh, Ceyda, Dharanipragada, Prashanthi, Lomeli, Shirley H., Weiser, Natasha E., Moriceau, Gatien, Zhang, Xiao, Bailey, Chris, Houlahan, Kathleen E., Yang, Wenting, González, Rocío Chamorro, Swanton, Charles, Curtis, Christina, Jamal-Hanjani, Mariam, Henssen, Anton G., Law, Julie A., Greenleaf, William J., Lo, Roger S., Mischel, Paul S., Bafna, Vineet, Chang, Howard Y.

Source: Nature Genetics; November 2022, Vol. 54 Issue: 11 p1746-1754, 9p

Imatinib Mesylate Exerts Anti-Proliferative Effects on Osteosarcoma Cells and Inhibits the Tumour Growth in Immunocompetent Murine Models.

Authors: Gobin, Bérengère^1,2, Moriceau, Gatien^1,2, Ory, Benjamin^1,2,3, Charrier, Céline^1,2,3, Brion, Régis^1,2,3,4, Blanchard, Frederic^1,2,3, Redini, Françoise^1,2,3,4, Heymann, Dominique^1,2,3,4 dominique.heymann@univ-nantes.fr

Source: PLoS ONE. Mar2014, Vol. 9 Issue 3, p1-13. 13p.

Subject Terms: *OSTEOSARCOMA, *IMATINIB, *METHANESULFONATES, *ANTINEOPLASTIC agents, *IMMUNOCOMPETENT cells, *TUMOR growth, *CANCER chemotherapy, *THERAPEUTICS

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High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity.

Authors: Dian Huang¹, Leslie, Kevin A.², Guest, Daniel², Yeshcheulova, Olga², Roy, Irena J.³, Piva, Marco⁴, Moriceau, Gatien⁴, Zangle, Thomas A.⁵, Lo, Roger S.^4,6,7, Teitell, Michael A.^1,3,7,8, mteitell@ucla.edu, Reed, Jason^2,9, jreed@vcu.edu

Source: Analytical Chemistry; 3/6/2018, Vol. 90 Issue 5, p3299-3306, 8p

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).

Authors: Poulikakos, Poulikos I., Persaud, Yogindra, Janakiraman, Manickam, Kong, Xiangju, Ng, Charles, Moriceau, Gatien, Shi, Hubing, Atefi, Mohammad, Titz, Bjoern, Gabay, May Tal, Salton, Maayan, Dahlman, Kimberly B., Tadi, Madhavi, Wargo, Jennifer A., Flaherty, Keith T., Kelley, Mark C., Misteli, Tom, Chapman, Paul B., Sosman, Jeffrey A., Graeber, Thomas G.

Source: Nature. 12/15/2011, Vol. 480 Issue 7377, p387-390. 4p. 2 Diagrams, 1 Graph.

Subjects: DIMERIZATION, MELANOMA, APOPTOSIS, PROTEIN-tyrosine kinases, SOMATIC cells

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