Mitochondrial Disease and Anesthesia

Authors: Hsieh, Vincent C., Krane, Elliot J., Morgan, Philip G.

Source: Journal of Inborn Errors of Metabolism and Screening. January 2017 5

Subject Terms: anesthetics, genetics, biochemistry, mitochondria, perioperative

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TREK-1 and TREK-2 Knockout Mice Are Not Resistant to Halothane or Isoflurane

Authors: Spencer, Kira A., Woods, Christian B., Worstman, Hailey M., Johnson, Simon C., Ramirez, Jan-Marino, Morgan, Philip G., Sedensky, Margaret M.

Source: Anesthesiology. 139(1):63-76

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194000319.0x000001&indx=1&recIds=ETOCvdc_100194000319.0x000001

Volatile anaesthetic toxicity in the genetic mitochondrial disease Leigh syndrome

Authors: Spencer, Kira A., Mulholland, Michael, Snell, John, Howe, Miranda, James, Katerina, Hanaford, Allison R., Morgan, Philip G., Sedensky, Margaret, Johnson, Simon C.

Source: In British Journal of Anaesthesia November 2023 131(5):832-846

Isoflurane inhibition of endocytosis is an anesthetic mechanism of action

Authors: Jung, Sangwook, Zimin, Pavel I., Woods, Christian B., Kayser, Ernst-Bernhard, Haddad, Dominik, Reczek, Colleen R., Nakamura, Ken, Ramirez, Jan-Marino, Sedensky, Margaret M., Morgan, Philip G.

Source: In Current Biology 25 July 2022 32(14):3016-3032

Tetraethylammonium chloride reduces anaesthetic-induced neurotoxicity in Caenorhabditis elegans and mice

Authors: Jung, Sangwook, Kayser, Ernst-Bernhard, Johnson, Simon C., Li, Li, Worstman, Hailey M., Sun, Grace X., Sedensky, Margaret M., Morgan, Philip G.

Source: In British Journal of Anaesthesia January 2022 128(1):77-88

An interview with Dr. Anne Marie Lynn, a pioneering woman in medicine

Authors: Yaster, Myron, Flack, Sean H., Martin, Lynn D., Morgan, Philip G., Davidson, Andrew

Source: Paediatric anaesthesia. 31(10):1040-1045

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131525790.0x000001&indx=1&recIds=ETOCvdc_100131525790.0x000001

Anesthetic Hypersensitivity in a Case-Controlled Series of Patients With Mitochondrial Disease

Authors: Hsieh, Vincent C., Niezgoda, Julie, Sedensky, Margaret M., Hoppel, Charles L., Morgan, Philip G.

Source: Anesthesia & analgesia. 133(4):924-932

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194374106.0x000001&indx=1&recIds=ETOCvdc_100194374106.0x000001

Mitochondrial Function and Anesthetic Sensitivity in the Mouse Spinal Cord

Authors: Woods, Christian B., Spencer, Kira A., Jung, Sangwook, Worstman, Hailey M., Ramirez, Jan-Marino, Morgan, Philip G., Sedensky, Margaret M.

Source: Anesthesiology. 134(6):901-914

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194181835.0x000001&indx=1&recIds=ETOCvdc_100194181835.0x000001

You Don't Always Get What You Want!

Authors: Morgan, Philip G.¹ (AUTHOR) philip.morgan@seattlechildrens.org, Sedensky, Margaret M.¹ (AUTHOR) margaret.sedensky@seattlechildrens.org

Source: Anesthesiology. Oct2024, Vol. 141 Issue 4, p745-749. 5p.

Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease

Authors: Johnson, Simon C., Kayser, Ernst-Bernhard, Bornstein, Rebecca, Stokes, Julia, Bitto, Alessandro, Park, Kyung Yeon, Pan, Amanda, Sun, Grace, Raftery, Daniel, Kaeberlein, Matt, Sedensky, Margaret M., Morgan, Philip G.

Source: In Molecular Genetics and Metabolism June 2020 130(2):118-132

mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases

Authors: Johnson, Simon C., Martinez, Frank, Bitto, Alessandro, Gonzalez, Brenda, Tazaerslan, Cagdas, Cohen, Camille, Delaval, Laure, Timsit, José, Knebelmann, Bertrand, Terzi, Fabiola, Mahal, Tarika, Zhu, Yizhou, Morgan, Philip G., Sedensky, Margaret M., Kaeberlein, Matt, Legendre, Christophe, Suh, Yousin, Canaud, Guillaume

Source: In Kidney International February 2019 95(2):455-466

Mitochondrial Function in Astrocytes Is Essential for Normal Emergence from Anesthesia in Mice

Authors: Ramadasan-Nair, Renjini, Hui, Jessica, Itsara, Leslie S., Morgan, Philip G., Sedensky, Margaret M.

Source: Anesthesiology. 130(3):423-434

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181438833.0x000001&indx=1&recIds=ETOCvdc_100181438833.0x000001

Interferon‐gamma contributes to disease progression in the Ndufs4(−/−) model of Leigh syndrome.

Authors: Hanaford, Allison R., Khanna, Asheema, James, Katerina, Truong, Vivian, Liao, Ryan, Chen, Yihan, Mulholland, Michael, Kayser, Ernst‐Bernhard, Watanabe, Kino, Hsieh, Erin Shien, Sedensky, Margaret, Morgan, Philip G., Kalia, Vandana, Sarkar, Surojit, Johnson, Simon C.

Source: Neuropathology & Applied Neurobiology; Jun2024, Vol. 50 Issue 3, p1-11, 11p

Subject Terms: DISEASE progression, INTERFERON gamma, TYPE I interferons, LABORATORY mice, GENETIC disorders, INTERFERONS

Impact of dietary ketosis on volatile anesthesia toxicity in a model of Leigh syndrome.

Authors: Spencer, Kira A., Howe, Miranda N., Mulholland, Michael T., Truong, Vivian, Liao, Ryan W., Chen, Yihan, Setha, Monyreak, Snell, John C., Hanaford, Allison, James, Katerina, Morgan, Philip G., Sedensky, Margaret M., Johnson, Simon C.

Source: Pediatric Anesthesia; May2024, Vol. 34 Issue 5, p467-476, 10p

Subject Terms: ACETONEMIA, KETOGENIC diet, ANESTHESIA, FISHER exact test, GENETIC disorders, SYMPTOMS

Potassium Leak Channels and Mitochondrial Complex I Interact in Glutamatergic Interneurons of the Mouse Spinal Cord.

Authors: Woods, Christian B., Predoi, Beatrice, Howe, Miranda, Reczek, Colleen R., Kayser, Ernst-Bernhard, Ramirez, Jan-Marino, Morgan, Philip G., Sedensky, Margaret M.

Source: Anesthesiology; Apr2024, Vol. 140 Issue 4, p715-728, 14p

The genetics of isoflurane-induced developmental neurotoxicity

Authors: Na, Hyo-Seok, Brockway, Nicole L, Gentry, Katherine R, Opheim, Elyce, Sedensky, Margaret M, Morgan, Philip G

Source: In Neurotoxicology and Teratology March-April 2017 60:40-49

Anesthetics Have Different Effects on the Electrocorticographic Spectra of Wild-type and Mitochondrial Mutant Mice

Authors: Carspecken, Charles William, Chanprasert, Sirisak, Kalume, Franck, Sedensky, Margaret M., Morgan, Philip G.

Source: Anesthesiology. 129(4):744-755

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181436581.0x000001&indx=1&recIds=ETOCvdc_100181436581.0x000001

Are Genome-wide Association Studies Worth the Trouble?

Authors: Sleigh, Jamie W.¹ (AUTHOR) Jamie.Sleigh@waikatodhb.health.nz, Morgan, Philip G.² (AUTHOR) pgm4@uw.edu;philip.morgan@seattlechildrens.org

Source: Anesthesiology. Aug2024, Vol. 141 Issue 2, p214-216. 3p.

Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction

Authors: Dancy, Beverley M., Brockway, Nicole, Ramadasan-Nair, Renjini, Yang, Yoing, Sedensky, Margaret M., Morgan, Philip G.

Source: In Mechanisms of Ageing and Development January 2016 153:14-21

A Summary of Preclinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium

Authors: Griffiths, Keren K., Morgan, Philip G., Johnson, Simon C., Nambyiah, Pratheeban, Soriano, Sulpicio G., Johnson, Kenneth, Xu, Jing, Garber, Carol, Maxwell, Lynne, Saraiya, Neeta

Source: Journal of neurosurgical anesthesiology. 31(1):163-165

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100074410337.0x000001&indx=1&recIds=ETOCvdc_100074410337.0x000001