The multifaceted role of the CXC chemokines and receptors signaling axes in ALS pathophysiology

Authors: La Cognata, Valentina, Morello, Giovanna, Guarnaccia, Maria, Cavallaro, Sebastiano

Source: In Progress in Neurobiology April 2024 235

Neuroprotective effect of the PACAP-ADNP axis on SOD1G93A mutant motor neuron death induced by trophic factors deprivation

Authors: Magrì, Benedetta, D'Amico, Agata Grazia, Maugeri, Grazia, Morello, Giovanna, La Cognata, Valentina, Saccone, Salvatore, Federico, Concetta, Cavallaro, Sebastiano, D'Agata, Velia

Source: In Neuropeptides December 2023 102

CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice

Authors: La Cognata, Valentina, Golini, Elisabetta, Iemmolo, Rosario, Balletta, Sara, Morello, Giovanna, De Rosa, Carla, Villari, Ambra, Marinelli, Sara, Vacca, Valentina, Bonaventura, Gabriele, Dell'Albani, Paola, Aronica, Eleonora, Mammano, Fabio, Mandillo, Silvia, Cavallaro, Sebastiano

Source: In Neurobiology of Disease December 2021 160

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment.

Authors: Morello, Giovanna¹ (AUTHOR) giovanna.morello@irib.cnr.it, Guarnaccia, Maria¹ (AUTHOR) maria.guarnaccia@cnr.it, La Cognata, Valentina¹ (AUTHOR) valentina.lacognata@cnr.it, Latina, Valentina² (AUTHOR) v.latina@ebri.it, Calissano, Pietro² (AUTHOR) p.calissano@ebri.it, Amadoro, Giuseppina^2,3 (AUTHOR) giuseppina.amadoro@cnr.it, Cavallaro, Sebastiano¹ (AUTHOR) sebastiano.cavallaro@cnr.it

Source: Cells (2073-4409). Sep2023, Vol. 12 Issue 18, p2254. 13p.

Subject Terms: *OXIDATIVE phosphorylation, *TRANSCRIPTOMES, *MITOCHONDRIA, *HIPPOCAMPUS (Brain), *ALZHEIMER'S disease, *TAU proteins, *MONOCLONAL antibodies

A Diagnostic Gene-Expression Signature in Fibroblasts of Amyotrophic Lateral Sclerosis.

Authors: Morello, Giovanna¹ (AUTHOR) giovanna.morello@irib.cnr.it, La Cognata, Valentina¹ (AUTHOR) valentina.lacognata@cnr.it, Guarnaccia, Maria¹ (AUTHOR) maria.guarnaccia@cnr.it, La Bella, Vincenzo² (AUTHOR) vincenzo.labella@unipa.it, Conforti, Francesca Luisa³ (AUTHOR) francescaluisa.conforti@unical.it, Cavallaro, Sebastiano¹ (AUTHOR) sebastiano.cavallaro@cnr.it

Source: Cells (2073-4409). Jul2023, Vol. 12 Issue 14, p1884. 19p.

Subject Terms: *AMYOTROPHIC lateral sclerosis, *FIBROBLASTS, *GENE expression, *SUPPORT vector machines, *NEURODEGENERATION, *NEURAL transmission

Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in ALS

Authors: Volonté, Cinzia ^*, Morello, Giovanna, Spampinato, Antonio Gianmaria, Amadio, Susanna, Apolloni, Savina, D’Agata, Velia, Cavallaro, Sebastiano

Source: In Ageing Research Reviews September 2020 62

Cracking the Code of Neuronal Cell Fate.

Authors: Morello, Giovanna¹ (AUTHOR), La Cognata, Valentina¹ (AUTHOR), Guarnaccia, Maria¹ (AUTHOR), D'Agata, Velia² (AUTHOR), Cavallaro, Sebastiano¹ (AUTHOR) sebastiano.cavallaro@cnr.it

Source: Cells (2073-4409). Apr2023, Vol. 12 Issue 7, p1057. 18p.

Subject Terms: *GENETIC transcription regulation, *THERAPEUTICS, *SYNTHETIC biology, *DRUG repositioning, *SYSTEMS biology, *GENOMICS, *DRUG target

Increased copy-number variant load of associated risk genes in sporadic cases of amyotrophic lateral sclerosis.

Authors: Guarnaccia, Maria¹ (AUTHOR), Morello, Giovanna¹ (AUTHOR), La Cognata, Valentina¹ (AUTHOR), La Bella, Vincenzo² (AUTHOR), Conforti, Francesca Luisa³ (AUTHOR), Cavallaro, Sebastiano¹ (AUTHOR) sebastiano.cavallaro@cnr.it

Source: Cellular & Molecular Life Sciences. 7/27/2024, Vol. 81 Issue 1, p1-11. 11p.

Subject Terms: *AMYOTROPHIC lateral sclerosis, *SINGLE nucleotide polymorphisms, *DISEASE risk factors, *AGE of onset, *MOTOR neurons, *SPINAL cord

Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway

Authors: Fetoni, Anna Rita, Zorzi, Veronica, Paciello, Fabiola, Ziraldo, Gaia, Peres, Chiara, Raspa, Marcello, Scavizzi, Ferdinando, Salvatore, Anna Maria, Crispino, Giulia, Tognola, Gabriella, Gentile, Giulia, Spampinato, Antonio Gianmaria, Cuccaro, Denis, Guarnaccia, Maria, Morello, Giovanna, Van Camp, Guy, Fransen, Erik, Brumat, Marco, Girotto, Giorgia, Paludetti, Gaetano, Gasparini, Paolo, Cavallaro, Sebastiano, Mammano, Fabio

Source: In Redox Biology October 2018 19:301-317

Molecular mechanisms involved in the protective effect of pituitary adenylate cyclase‐activating polypeptide in an in vitro model of amyotrophic lateral sclerosis

Authors: Maugeri, Grazia, D'Amico, Agata G., Rasà, Daniela M., Federico, Concetta, Saccone, Salvatore, Morello, Giovanna, Cognata, Valentina, Cavallaro, Sebastiano, D'Agata, Velia

Source: Journal of cellular physiology. 234(4):5203-5214

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123651539.0x000001&indx=1&recIds=ETOCvdc_100123651539.0x000001

Integrative multi-omic analysis identifies new drivers and pathways in molecularly distinct subtypes of ALS

Authors: Morello, Giovanna, Guarnaccia, Maria, Spampinato, Antonio Gianmaria, Salomone, Salvatore, D'Agata, Velia, Conforti, Francesca Luisa, Aronica, Eleonora, Cavallaro, Sebastiano

Source: Scientific reports. 9(1):1-18

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184309327.0x000001&indx=1&recIds=ETOCvdc_100184309327.0x000001

PDXK mutations cause polyneuropathy responsive to pyridoxal 5′‐phosphate supplementation

Authors: Chelban, Viorica, Wilson, Matthew P., Warman Chardon, Jodi, Vandrovcova, Jana, Zanetti, M. Natalia, Zamba‐Papanicolaou, Eleni, Efthymiou, Stephanie, Pope, Simon, Conte, Maria R., Abis, Giancarlo, Liu, Yo‐Tsen, Tribollet, Eloise, Haridy, Nourelhoda A., Botía, Juan A., Ryten, Mina, Nicolaou, Paschalis, Minaidou, Anna, Christodoulou, Kyproula, Kernohan, Kristin D., Eaton, Alison, Osmond, Matthew, Ito, Yoko, Bourque, Pierre, Jepson, James E. C., Bello, Oscar, Bremner, Fion, Cordivari, Carla, Reilly, Mary M., Foiani, Martha, Heslegrave, Amanda, Zetterberg, Henrik, Heales, Simon J. R., Wood, Nicholas W., Rothman, James E., Boycott, Kym M., Mills, Philippa B., Clayton, Peter T., Houlden, Henry, Kriouile, Yamna, Khorassani, Mohamed El, Aguennouz, Mhammed, Groppa, Stanislav, Marinova Karashova, Blagovesta, Van Maldergem, Lionel, Nachbauer, Wolfgang, Boesch, Sylvia, Arning, Larissa, Timmann, Dagmar, Cormand, Bru, Pérez‐Dueñas, Belen, Di Rosa, Gabriella, Goraya, Jatinder S., Sultan, Tipu, Mine, Jun, Avdjieva, Daniela, Kathom, Hadil, Tincheva, Radka, Banu, Selina, Pineda‐Marfa, Mercedes, Veggiotti, Pierangelo, Ferrari, Michel D., van den Maagdenberg, Arn M J M, Verrotti, Alberto, Marseglia, Giangluigi, Savasta, Salvatore, García‐Silva, Mayte, Ruiz, Alfons Macaya, Garavaglia, Barbara, Borgione, Eugenia, Portaro, Simona, Sanchez, Benigno Monteagudo, Boles, Richard, Papacostas, Savvas, Vikelis, Michail, Rothman, James, Giunti, Paola, Salpietro, Vincenzo, Oconnor, Emer, Kullmann, Dimitri, Kaiyrzhanov, Rauan, Sullivan, Roisin, Khan, Alaa Matooq, Yau, Wai Yan, Hostettler, Isabel, Papanicolaou, Eleni Zamba, Dardiotis, Efthymios, Maqbool, Shazia, Ibrahim, Shahnaz, Kirmani, Salman, Rana, Nuzhat Noureen, Atawneh, Osama, Lim, Shen‐Yang, Shaikh, Farooq, Koutsis, George, Breza, Marianthi, Mangano, Salvatore, Scuderi, Carmela, Morello, Giovanna, Stojkovic, Tanya, Torti, Erin, Zollo, Massimi, Heimer, Gali, Dauvilliers, Yves A., Striano, Pasquale, Al‐Khawaja, Issam, Al‐Mutairi, Fuad, Alkuraya, Fowzan S, Sherifa, Hamed, Rizig, Mie, Okubadejo, Njideka U., Ojo, Oluwadamilola O., Oshinaike, Olajumoke O., Wahab, Kolawole, Bello, Abiodun H., Abubakar, Sanni, Obiabo, Yahaya, Nwazor, Ernest, Ekenze, Oluchi, Williams, Uduak, Iyagba, Alagoma, Taiwo, Lolade, Komolafe, Morenikeji, Oguntunde, Olapeju, Pchelina, Sofya, Senkevich, Konstantin, Haridy, Nourelhoda, Shashkin, Chingiz, Zharkynbekova, Nazira, Koneyev, Kairgali, Manizha, Ganieva, Isrofilov, Maksud, Guliyeva, Ulviyya, Salayev, Kamran, Khachatryan, Samson, Rossi, Salvatore, Silvestri, Gabriella, Bourinaris, Thomas, Xiromerisiou, Georgia, Fidani, Liana, Spanaki, Cleanthe, Tucci, Arianna

Source: Annals of neurology. 86(2):225-240

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100086949060.0x000001&indx=1&recIds=ETOCvdc_100086949060.0x000001

Histaminergic transmission slows progression of amyotrophic lateral sclerosis

Authors: Apolloni, Savina, Amadio, Susanna, Fabbrizio, Paola, Morello, Giovanna, Spampinato, Antonio Gianmaria, Latagliata, Emanuele Claudio, Salvatori, Illari, Proietti, Daisy, Ferri, Alberto, Madaro, Luca, Puglisi‐Allegra, Stefano, Cavallaro, Sebastiano, Volonté, Cinzia

Source: Journal of cachexia, sarcopenia and muscle. 10(4):872-893

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087689561.0x000001&indx=1&recIds=ETOCvdc_100087689561.0x000001

Immunoregulation of Ghrelin in neurocognitive sequelae associated with COVID-19: an in silico investigation

Authors: Russo, Cristina, Morello, Giovanna, Mannino, Giuliana, Russo, Antonella, Malaguarnera, Lucia

Source: Gene. 834

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167660242.0x000001&indx=1&recIds=ETOCvdc_100167660242.0x000001

Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome

Authors: Hannah, Michael G., Bugiardini, Enrico, Bertini, Enrico, Kriouile, Yamna, El-Khorassani, Mohamed, Aguennouz, Mhammed, Groppa, Stanislav, Karashova, Blagovesta M., Goraya, Jatinder S., Sultan, Tipu, Avdjieva, Daniela, Kathom, Hadil, Tincheva, Radka, Banu, Selina, Veggiotti, Pierangelo, Verrotti, Alberto, Lanari, Marcello, Savasta, Salvatore, Macaya, Alfons, Garavaglia, Barbara, Borgione, Eugenia, Papacostas, Savvas, Vikelis, Michail, Chelban, Viorica, Kaiyrzhanov, Rauan, Cortese, Andrea, Sullivan, Roisin, Papanicolaou, Eleni Z., Dardiotis, Efthymios, Maqbool, Shazia, Ibrahim, Shahnaz, Kirmani, Salman, Rana, Nuzhat N., Atawneh, Osama, Lim, Shen-Yang, Zuccotti, Gian V., Marseglia, Gian L., Esposito, Susanna, Shaikh, Farooq, Cogo, Paola, Corsello, Giovanni, Mangano, Salvatore, Nardello, Rosaria, Mangano, Donato, Scardamaglia, Annarita, Koutsis, George, Scuderi, Carmela, Ferrara, Pietro, Morello, Giovanna, Zollo, Massimo, Berni-Canani, Roberto, Terracciano, Luigi M., Sisto, Antonio, Di Fabio, Sandra, Strano, Federica, Scorrano, Giovanna, Di Bella, Saverio, Di Francesco, Ludovica, Manizha, Ganieva, Isrofilov, Maksud, Guliyeva, Ulviyya, Salayev, Kamran, Khachatryan, Samson, Xiromerisiou, Georgia, Spanaki, Cleanthe, Fiorillo, Chiara, Iacomino, Michele, Gaudio, Eugenio, Munell, Francina, Gagliano, Antonella, Jan, Farida, Chimenz, Roberto, Gitto, Eloisa, Iughetti, Lorenzo, Di Rosa, Gabriella, Maghnie, Mohamad, Pettoello-Mantovani, Massimo, Gupta, Neerja, Kabra, Madhulika, Benrhouma, Hanene, Tazir, Meriem, Bottone, Gabriella, Farello, Giovanni, Delvecchio, Maurizio, Di-Donato, Giulio, Obeid, Makram, Bakhtadze, Sophia, Saadi, Nebal W., Miraglia-Del-Giudice, Michele, Maccarone, Rita, Zaki, Maha S., Triki, Chahnez C., Kara, Majdi, Karimiani, Ehsan G., Salih, Ahmed M., Ramenghi, Luca A., Seri, Marco, Di-Falco, Giovanna, Mandarà, Luana, Barrano, Giuseppe, Elisa, Maurizio, Cherubini, Enrico, Operto, Francesca F., Valenzise, Mariella, Cattaneo, Antonino, Zazzeroni, Francesca, Alesse, Edoardo, Matricardi, Sara, Zafar, Faisal, Ullah, Ehsan, Afzal, Erum, Rahman, Fatima, Ahmed, Muhammad M., Parisi, Pasquale, Spalice, Alberto, De Filippo, Maria, Licari, Amelia, Trebbi, Edoardo, Romano, Ferdinando, Heimer, Gali, Al-Khawaja, Issam, Al-Mutairi, Fuad, Alkuraya, Fowzan S., Rizig, Mie, Shashkin, Chingiz, Zharkynbekova, Nazira, Koneyev, Kairgali, Salpietro, Vincenzo, Maroofian, Reza, Wangen, Jamie, Ciolfi, Andrea, Barresi, Sabina, Efthymiou, Stephanie, Lamaze, Angelique, Aughey, Gabriel N., Al Mutairi, Fuad, Rad, Aboulfazl, Rocca, Clarissa, Calì, Elisa, Accogli, Andrea, Zara, Federico, Striano, Pasquale, Mojarrad, Majid, Tariq, Huma, Giacopuzzi, Edoardo, Taylor, Jenny C., Oprea, Gabriela, Skrahina, Volha, Rehman, Khalil Ur, Abd Elmaksoud, Marwa, Bassiony, Mahmoud, El Said, Huda G., Abdel-Hamid, Mohamed S., Al Shalan, Maha, Seo, Gohun, Kim, Sohyun, Lee, Hane, Khang, Rin, Issa, Mahmoud Y., Elbendary, Hasnaa M., Rafat, Karima, Marinakis, Nikolaos M., Traeger-Synodinos, Joanne, Ververi, Athina, Sourmpi, Mara, Eslahi, Atieh, Khadivi Zand, Farhad, Beiraghi Toosi, Mehran, Babaei, Meisam, Jackson, Adam, Bertoli-Avella, Aida, Pagnamenta, Alistair T., Niceta, Marcello, Battini, Roberta, Corsello, Antonio, Leoni, Chiara, Chiarelli, Francesco, Dallapiccola, Bruno, Faqeih, Eissa Ali, Tallur, Krishnaraya K., Alfadhel, Majid, Alobeid, Eman, Maddirevula, Sateesh, Mankad, Kshitij, Banka, Siddharth, Ghayoor-Karimiani, Ehsan, Tartaglia, Marco, Chung, Wendy K., Green, Rachel, Jepson, James E.C., Houlden, Henry

Source: In The American Journal of Human Genetics 4 January 2024 111(1):200-210

NeuroArray: A Customized aCGH for the Analysis of Copy Number Variations in Neurological Disorders

Authors: La Cognata, Valentina, Morello, Giovanna, Gentile, Giulia, Cavalcanti, Francesca, Cittadella, Rita, Conforti, Francesca Luisa, De Marco, Elvira Valeria, Magariello, Angela, Muglia, Maria, Patitucci, Alessandra, Spadafora, Patrizia, D`Agata, Velia, Ruggieri, Martino, Cavallaro, Sebastiano

Source: Current genomics. 19(6):431-443

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083503371.0x000001&indx=1&recIds=ETOCvdc_100083503371.0x000001

Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation

Authors: Imperatore, Roberta, Palomba, Letizia, Morello, Giovanna, Spiezio, Alessandro Di, Piscitelli, Fabiana, Marzo, Vincenzo Di, Cristino, Luigia

Source: In Pharmacological Research September 2016 111:600-609

Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling

Authors: Morello, Giovanna, Imperatore, Roberta, Palomba, Letizia, Finelli, Carmine, Labruna, Giuseppe, Pasanisi, Fabrizio, Sacchetti, Lucia, Buono, Lorena, Piscitelli, Fabiana, Orlando, Pierangelo, Di Marzo, Vincenzo, Cristino, Luigia

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Apr . 113(17), 4759-4764.

Access URL: https://www.jstor.org/stable/26469422

Genetic investigation of amyotrophic lateral sclerosis patients in south Italy: a two-decade analysis

Authors: Ungaro, Carmine, Sprovieri, Teresa, Morello, Giovanna, Perrone, Benedetta, Spampinato, Antonio Gianmaria, Simone, Isabella Laura, Trojsi, Francesca, Monsurrò, Maria Rosaria, Spataro, Rossella, La Bella, Vincenzo, Andò, Sebastiano, Cavallaro, Sebastiano, Conforti, Francesca Luisa

Source: In Neurobiology of Aging March 2021 99:99-99

Candidate genes of SARS-CoV-2 gender susceptibility.

Authors: Russo, Cristina¹ (AUTHOR), Morello, Giovanna² (AUTHOR) giovanna.morello@irib.cnr.it, Malaguarnera, Roberta³ (AUTHOR), Piro, Salvatore⁴ (AUTHOR), Furno, Debora Lo¹ (AUTHOR), Malaguarnera, Lucia¹ (AUTHOR)

Source: Scientific Reports. 11/9/2021, Vol. 11 Issue 1, p1-16. 16p.

Subject Terms: *COVID-19, *SARS-CoV-2, *SARS disease, *GENDER, *COMPLEMENT activation