Methods of treating or preventing fibrosis in non-alcoholic fatty liver disease

The liver–brain axis in metabolic dysfunction-associated steatotic liver disease

Authors: Mikkelsen, Anne Catrine Daugaard ^{a, b}, Kjærgaard, Kristoffer ^{a, b}, Schapira, Anthony H V ^c, Mookerjee, Rajeshwar P ^{a, d}, Thomsen, Karen Louise ^{a, b, d, *}

Source: In The Lancet Gastroenterology & Hepatology March 2025 10(3):248-258

The new digital era in decompensated cirrhosis

Authors: Gananandan, Kohilan ^a, Kazankov, Konstantin ^b, Tapper, Elliot B ^c, Mookerjee, Rajeshwar P ^{a, b, *}

Source: In The Lancet Digital Health January 2025 7(1):e54-e63

An Accurate Data Preparation Approach for the Prediction of Mortality in ACLF Patients using the CANONIC Dataset

Authors: Garcia, M. S., Doyle, Gordon, Ranco, Gabriele, Arroyo, Vicente, Pavesi, Marco, Garcia, Elizabet, Saliba, Faouzi, Banares, Rafael, Fernandez, Javier, Agarwal, Banwari, Mookerjee, Rajeshwar P., Jalan, Rajiv

Source: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2019 41st Annual International Conference of the IEEE. :1371-1377 Jul, 2019

Relation: 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

AlcoChange: A digital therapeutic for patients with alcohol-related liver disease

Authors: Mehta, Gautam, Lin, Su, Nadar, Aida, PV, Bharadwaj, Kumar, Ravi, Balaji, Anu, Macdonald, Stewart, Sheikh, Mohammed F., Saeidinejad, MohammadMahdi, Sharma, Shiv-Raj, King, Ji J., Mookerjee, Rajeshwar P., McDonagh, Lorraine, Afuwape, Sarah A., Moore, Kevin, Jalan, Rajiv

Source: In JHEP Reports April 2024 6(4)

Cognitive dysfunction in early experimental metabolic dysfunction-associated steatotic liver disease is associated with systemic inflammation and neuroinflammation

Authors: Kjærgaard, Kristoffer, Daugaard Mikkelsen, Anne Catrine, Landau, Anne M., Eriksen, Peter Lykke, Hamilton-Dutoit, Stephen, Magnusson, Nils Erik, Thomsen, Majken Borup, Chen, Fenghua, Vilstrup, Hendrik, Mookerjee, Rajeshwar Prosad, Bay-Richter, Cecilie, Thomsen, Karen Louise

Source: In JHEP Reports March 2024 6(3)

Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure

Authors: Agarwal, Banwari, Cañizares, Rafael Bañares, Saliba, Faouzi, Ballester, Maria Pilar, Tomescu, Dana Rodica, Martin, Daniel, Stadlbauer, Vanessa, Wright, Gavin, Sheikh, Mohammed, Morgan, Carrie, Alzola, Carlos, Lavin, Phillip, Green, Daniel, Kumar, Rahul, Sacleux, Sophie Caroline, Schilcher, Gernot, Koball, Sebastian, Tudor, Andrada, Minten, Jaak, Domenech, Gema, Aragones, Juan Jose, Oettl, Karl, Paar, Margret, Waterstradt, Katja, Bode-Boger, Stefanie M., Ibáñez-Samaniego, Luis, Gander, Amir, Ramos, Carolina, Chivu, Alexandru, Stange, Jan, Lamprecht, Georg, Sanchez, Moises, Mookerjee, Rajeshwar P., Davenport, Andrew, Davies, Nathan, Pavesi, Marco, Andreola, Fausto, Albillos, Agustin, Cordingley, Jeremy, Schmidt, Hartmut, Carbonell-Asins, Juan Antonio, Arroyo, Vicente, Fernandez, Javier, Mitzner, Steffen, Jalan, Rajiv

Source: In Journal of Hepatology July 2023 79(1):79-92

Evaluation of CirrhoCare® – a digital health solution for home management of individuals with cirrhosis

Authors: Kazankov, Konstantin, Novelli, Simone, Chatterjee, Devnandan A., Phillips, Alexandra, Balaji, Anu, Raja, Maruthi, Foster, Graham, Tripathi, Dhiraj, Boddu, Ravan, Kumar, Ravi, Jalan, Rajiv, Mookerjee, Rajeshwar P.

Source: In Journal of Hepatology January 2023 78(1):123-132

Mechanisms and treatment approaches for ACLF.

Authors: Piano, Salvatore, Mahmud, Nadim, Caraceni, Paolo, Tonon, Marta, Mookerjee, Rajeshwar Prosad

Source: Liver International; Mar2025, Vol. 45 Issue 3, p1-11, 11p

Subject Terms: THERAPEUTICS, LIVER failure, IMMUNOLOGICAL tolerance, BACTERIAL diseases, LIVER transplantation

Biomarkers of extracellular matrix formation are associated with acute-on-chronic liver failure

Authors: Kerbert, Annarein J.C., Gupta, Saurabh, Alabsawy, Eman, Dobler, Iwona, Lønsmann, Ida, Hall, Andrew, Nielsen, Signe Holm, Nielsen, Mette J., Gronbaek, Henning, Amoros, Àlex, Yeung, Dave, Macnaughtan, Jane, Mookerjee, Rajeshwar P., Macdonald, Stewart, Andreola, Fausto, Moreau, Richard, Arroyo, Vicente, Angeli, Paolo, Leeming, Diana J., Treem, William, Karsdal, Morten A., Jalan, Rajiv

Source: In JHEP Reports December 2021 3(6)

Management of the major complications of cirrhosis: Beyond guidelines

Authors: Garcia-Pagan, Juan Carlos, Francoz, Claire, Montagnese, Sara, Senzolo, Marco, Mookerjee, Rajeshwar P.

Source: In Journal of Hepatology July 2021 75 Supplement 1:S135-S146

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Authors: Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Brol, Maximilian J., Chang, Johannes, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Janicko, Martin, Markwardt, Daniel, Mandorfer, Mattias, Welsch, Christoph, Welzel, Tanja M., Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Bendtsen, Flemming, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Aamann, Luise, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Rupprechter, Harald, Engelmann, Cornelius, Özdogan, Osman Cavit, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jansen, Christian, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Jarcuska, Peter, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Shawcross, Debbie L., Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Danielsen, Karen Vagner, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solé, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia-Lopez, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Praktiknjo, Michael, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Bernal, William, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Gerbes, Alexander, Vargas, Victor, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Moreau, Richard, Angeli, Paolo, Jalan, Rajiv, Arroyo, Vicente

Source: In Journal of Hepatology May 2021 74(5):1097-1108

Determinants of mortality in patients with cirrhosis and uncontrolled variceal bleeding

Authors: Kumar, Rahul, Kerbert, Annarein J.C., Sheikh, M. Faisal, Roth, Noam, Calvao, Joana A.F., Mesquita, Monica D., Barreira, Ana I., Gurm, Haqeeqat S., Ramsahye, Komal, Mookerjee, Rajeshwar P., Yu, Dominic, Davies, Neil H., Mehta, Gautam, Agarwal, Banwari, Patch, David, Jalan, Rajiv

Source: In Journal of Hepatology January 2021 74(1):66-79

The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

Authors: Maschmeier, Miriam, Semela, David, Elkrief, Laure, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Praktiknjo, Michael, Schierwagen, Robert, Solà, Elsa, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik, Clemente, Ana, Jarcuska, Peter, Gerbes, Alexander, Mandorfer, Mattias, Welsch, Christoph, Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul, Danielsen, Karen Vagner, Gluud, Lise Lotte, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica, Alvarado-Tapias, Edilmar, Akpata, Osagie, Lykke Eriksen, Peter, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón-Talero, Macarena, Smits, Francois, van den Ende, Natalie, Martinez, Javier, Garcia, Rita, Markwardt, Daniel, Rupprechter, Harald, Engelmann, Cornelius, Trebicka, Jonel, Fernandez, Javier, Papp, Maria, Caraceni, Paolo, Laleman, Wim, Gambino, Carmine, Giovo, Ilaria, Uschner, Frank Erhard, Jimenez, Cesar, Mookerjee, Rajeshwar, Gustot, Thierry, Albillos, Agustin, Bañares, Rafael, Janicko, Martin, Steib, Christian, Reiberger, Thomas, Acevedo, Juan, Gatti, Pietro, Bernal, William, Zeuzem, Stefan, Zipprich, Alexander, Piano, Salvatore, Berg, Thomas, Bruns, Tony, Bendtsen, Flemming, Coenraad, Minneke, Merli, Manuela, Stauber, Rudolf, Zoller, Heinz, Ramos, José Presa, Solè, Cristina, Soriano, Germán, de Gottardi, Andrea, Gronbaek, Henning, Saliba, Faouzi, Trautwein, Christian, Özdogan, Osman Cavit, Francque, Sven, Ryder, Stephen, Nahon, Pierre, Romero-Gomez, Manuel, Van Vlierberghe, Hans, Francoz, Claire, Manns, Michael, Garcia, Elisabet, Tufoni, Manuel, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Curto, Anna, Pitarch, Carla, Putignano, Antonella, Moreno, Esau, Shawcross, Debbie, Aguilar, Ferran, Clària, Joan, Ponzo, Paola, Jansen, Christian, Vitalis, Zsuzsanna, Zaccherini, Giacomo, Balogh, Boglarka, Vargas, Victor, Montagnese, Sara, Alessandria, Carlo, Bernardi, Mauro, Ginès, Pere, Jalan, Rajiv, Moreau, Richard, Angeli, Paolo, Arroyo, Vicente

Source: In Journal of Hepatology October 2020 73(4):842-854

Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure

Authors: Engelmann, Cornelius, Sheikh, Mohammed, Sharma, Shreya, Kondo, Takayuki, Loeffler-Wirth, Henry, Zheng, Yu Bao, Novelli, Simone, Hall, Andrew, Kerbert, Annarein J.C., Macnaughtan, Jane, Mookerjee, Rajeshwar, Habtesion, Abeba, Davies, Nathan, Ali, Tauhid, Gupta, Saurabh, Andreola, Fausto, Jalan, Rajiv

Source: In Journal of Hepatology July 2020 73(1):102-112

Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial

Authors: Pose, Elisa, Napoleone, Laura, Amin, Ahmed, Campion, Daniela, Jimenez, César, Piano, Salvatore, Roux, Olivier, Uschner, Frank Erhard, de Wit, Koos, Zaccherini, Giacomo, Alessandria, Carlo, Angeli, Paolo, Bernardi, Mauro, Beuers, Ulrich, Caraceni, Paolo, Durand, François, Mookerjee, Rajeshwar P, Trebicka, Jonel, Vargas, Victor, Andrade, Raúl J, Carol, Marta, Pich, Judit, Ferrero, Juan, Domenech, Gema, Llopis, Marta, Torres, Ferran, Kamath, Patrick S, Abraldes, Juan G, Solà, Elsa, Ginès, Pere ^*

Source: In The Lancet Gastroenterology & Hepatology January 2020 5(1):31-41

The Macrophage Activation Marker Soluble CD163 is Associated With Early Allograft Dysfunction After Liver Transplantation

Authors: Thomsen, Karen L., Robertson, Francis P., Holland-Fischer, Peter, Davidson, Brian R., Mookerjee, Rajeshwar P., Møller, Holger J., Jalan, Rajiv, Grønbæk, Henning

Source: In Journal of Clinical and Experimental Hepatology May-June 2019 9(3):302-311

Engineered Lipids for Intracellular Reactive Oxygen Species Scavenging in Steatotic Hepatocytes.

Authors: Westensee, Isabella N., de Dios Andres, Paula, Brodszkij, Edit, Descours, Pierre‐Louis, Perez‐Rodriguez, Diego, Spinazzola, Antonella, Mookerjee, Rajeshwar Prosad, Städler, Brigitte

Source: Small; Nov2024, Vol. 20 Issue 44, p1-15, 15p

Statins: Old drugs as new therapy for liver diseases?

Authors: Pose, Elisa, Trebicka, Jonel, Mookerjee, Rajeshwar P, Angeli, Paolo, Ginès, Pere

Source: In Journal of Hepatology January 2019 70(1):194-202

Urea cycle dysregulation in non-alcoholic fatty liver disease

Authors: De Chiara, Francesco, Heebøll, Sara, Marrone, Giusi, Montoliu, Carmina, Hamilton-Dutoit, Stephen, Ferrandez, Antonio, Andreola, Fausto, Rombouts, Krista, Grønbæk, Henning, Felipo, Vicente, Gracia-Sancho, Jordi, Mookerjee, Rajeshwar P., Vilstrup, Hendrik, Jalan, Rajiv, Thomsen, Karen Louise

Source: In Journal of Hepatology October 2018 69(4):905-915