Characterizing substructure via mixture modeling in large-scale genetic summary statistics

Authors: Anderson, Heather D., Aquilante, Christina L., Arbogast, Kelsey, Arehart, Christopher H., Brooks, Ian M., Brunetti, Tonya M., Brutus-Lestin, Judith, Burke, Elizabeth E., Casteel, Emily M., Cole, Joanne B., Coughlin, Curtis R., II, Crooks, Kristy, Crawford, Jacob, Culver, Erin, Edelmann, Michelle N., Fisher, Matthew J., Franklin, Alan W., Frye, Teresa C., George, Hunter, Gignoux, Chris R., Gilliland, Elizabeth K., Greene, Casey S., Hawkes, Brooke, Hearst, Emily, Hendricks, Audrey E., Johnson, Randi K., Julian, Colleen G., Kao, Dave, Konigsberg, Iain, Ku, Lisa, Kudron, Elizabeth L., Lacy, Rashawnda, Lange, Ethan M., Lee, Yee Ming, Lesny, Joe A., Lin, Meng, Lowery, Jan T., Vargas, Luciana B., Maldonado, Betzaida L., Marceau, Darcy, Martin, James L., Gates, Brianna L., Mayer, David, McDaniel, Nicole L., Monte, Andrew, Moore, Ethan, Nadrash, Ann, Pattee, Jack, Pozdeyev, Nikita, Radwan, Alaa, Rafaels, Nick, Raghavan, Sridharan, Rasouli, Neda, Shalowitz, Elise L., Sherif, Hoda, Shortt, Johnathan A., Stewart, Adrian M., Sutton, Kristen J., Swartz, Carolyn T., Tanaka, Anna, Taylor, Matthew R.G., Teague, Candace, Todd, Emily B., Trinkley, Katy E., Wiley, Laura K., Stoneman, Hayley R. ^{1, 2, 7}, Price, Adelle M. ^{1, 3, 7}, Trout, Nikole Scribner ^{1, 3}, Lamont, Riley ³, Tifour, Souha ^{1, 3}, Rafaels, Nicholas ⁴, Gignoux, Christopher R. ^{1, 2, 4}, Marker, Katie M. ^{1, 2, 4}

Source: In The American Journal of Human Genetics 6 February 2025 112(2):235-253

People entering opioid substance use treatment have low rates of naloxone knowledge and possession

Authors: Bredenberg, Erin ^{a, ⁎}, Olsen, Heather ^b, Ladka, Michael ^b, Beekman, Kyle ^b, Black, Joshua C. ^b, Ellis, Matthew S. ^c, Monte, Andrew A. ^{b, d}

Source: In Drug and Alcohol Dependence 1 June 2025 271

Elevated initial blood kynurenine is associated with increased odds of post-stroke infection: Kynurenine and post-stroke infection

Authors: Dylla, Layne ^{a, ⁎}, Reisz, Julie A. ^b, Poisson, Sharon N. ^c, Herson, Paco S. ^d, Sansing, Lauren H. ^e, Monte, Andrew A. ^f

Source: In Journal of Stroke and Cerebrovascular Diseases May 2025 34(5)

Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke

Authors: Dylla, Layne, Higgins, Hannah M., Poisson, Sharon N., Vu, Thao, Reisz, Julie A., Herson, Paco S., Monte, Andrew

Source: In Clinical Therapeutics December 2024 46(12):960-966

Clinical Effects of Psychedelic Substances Reported to United States Poison Centers: 2012 to 2022

Authors: Simon, Mark W., Olsen, Heather A., Hoyte, Christopher O., Black, Joshua C., Reynolds, Kate M., Dart, Richard C., Monte, Andrew A.

Source: In Annals of Emergency Medicine December 2024 84(6):605-618

Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit

Authors: Kowalski, Robert G., Ledreux, Aurélie, Violette, John E., Neumann, Robert T., Ornelas, David, Yu, Xiaoli, Griffiths, Steven G., Lewis, Scott, Nash, Priscilla, Monte, Andrew A., Coughlan, Christina M., Deighan, Clayton, Grotta, James C., Jones, William J., Graner, Michael W.

Source: Stroke. 54(3):e52-e57

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189942843.0x000001&indx=1&recIds=ETOCvdc_100189942843.0x000001

Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization

Authors: Tolan, Nicole V., Krasowski, Matthew D., Mathias, Patrick C., Wiencek, Joesph R., Babic, Nikolina, Chai, Peter R., Chambliss, Allison B., Choucair, Ibrahim, Demetriou, Christiana A., Erickson, Timothy B., Feldhammer, Matthew, French, Deborah, Hayes, Bryan D., Kang, Phillip, El-Khoury, Joe M., Knezevic, Claire E., Monte, Andrew, Nerenz, Robert D., Okorodudu, Anthony O., Roper, Stephen M., Saitman, Alec, Thiriveedhi, Vamsi, Uljon, Sacha N., Vest, Alexis, Woodworth, Alison, Yu, Min, Melanson, Stacy E. F.

Source: Clinical toxicology. 61(4):248-259

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184893329.0x000001&indx=1&recIds=ETOCvdc_100184893329.0x000001

Specialized interferon action in COVID-19

Authors: Galbraith, Matthew D., Kinning, Kohl T., Sullivan, Kelly D., Araya, Paula, Smith, Keith P., Granrath, Ross E., Shaw, Jessica R., Baxter, Ryan, Jordan, Kimberly R., Russell, Seth, Dzieciatkowska, Monika, Reisz, Julie A., Gamboni, Fabia, Cendali, Francesca, Ghosh, Tusharkanti, Guo, Kejun, Wilson, Cara C., Santiago, Mario L., Monte, Andrew A., Bennett, Tellen D., Hansen, Kirk C., Hsieh, Elena W. Y., D’Alessandro, Angelo, Espinosa, Joaquin M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Mar . 119(11), 1-12.

Access URL: https://www.jstor.org/stable/27150988

Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen

Authors: Sonn, Brandon J., Heard, Kennon J., Heard, Susan M., D'Alessandro, Angelo, Reynolds, Kate M., Dart, Richard C., Rumack, Barry H., Monte, Andrew A.

Source: Clinical toxicology. 60(2):221-230

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139232539.0x000001&indx=1&recIds=ETOCvdc_100139232539.0x000001

Genetic variants associated with ALT elevation from therapeutic acetaminophen

Authors: Monte, Andrew A., Arriaga Mackenzie, Ian, Pattee, Jack, Kaiser, Sasha, Willems, Emileigh, Rumack, Barry, Reynolds, Kate M., Dart, Richard C., Heard, Kennon J.

Source: Clinical toxicology. 60(11):1198-1204

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165442223.0x000001&indx=1&recIds=ETOCvdc_100165442223.0x000001

Motivational interviewing to treat substance use disorders in the emergency department: A scoping review

Authors: Siegel, Rebecca, Sullivan, Natalie, Monte, Andrew A., Vargas, Nataly Montano, Cooper, Ziva D., Ma, Yan, Meltzer, Andrew C.

Source: American journal of emergency medicine. 51:414-417

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161567336.0x000001&indx=1&recIds=ETOCvdc_100161567336.0x000001

The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation.

Authors: Cavallari, Larisa H., Hicks, J. Kevin, Patel, Jai N., Elchynski, Amanda L., Smith, D. Max, Bargalh, Salma A., Flecki, Ashley, Aquilante, Christina L., Killam, Shayna R., Lemke, Lauren, Taichi Ochin, Ramsey, Laura B., Haidar, Cyrine E., Ho, Teresa, El Rouby, Nihal, Monte, Andrew A., Allen, Josiah D., Beitelshees, Amber L., Bishop, Jeffrey R., Bousman, Chad

Source: Pharmacogenetics & Genomics; Jan2025, Vol. 35 Issue 1, p1-11, 11p

Analysis of Stroke Care Among 2019-2020 National Emergency Medical Services Information System Encounters

Authors: Dylla, Layne, Rice, John D., Poisson, Sharon N., Monte, Andrew A., Higgins, Hannah M., Ginde, Adit A., Herson, Paco S.

Source: In Journal of Stroke and Cerebrovascular Diseases March 2022 31(3)

The COVIDome Explorer researcher portal

Authors: Sullivan, Kelly Daniel, Galbraith, Matthew Dominic, Kinning, Kohl Thomas, Bartsch, Kyle William, Levinsky, Nik Caldwell, Araya, Paula, Smith, Keith Patrick, Granrath, Ross Erich, Shaw, Jessica Rose, Baxter, Ryan Michael, Jordan, Kimberly Rae, Russell, Seth Aaron, Dzieciatkowska, Monika Ewa, Reisz, Julie Ann, Gamboni, Fabia, Cendali, Francesca Isabelle, Ghosh, Tusharkanti, Monte, Andrew Albert, Bennett, Tellen Demeke, Miller, Michael George, Hsieh, Elena Wen-Yuan, D’Alessandro, Angelo, Hansen, Kirk Charles, Espinosa, Joaquin Maximiliano

Source: In Cell Reports 17 August 2021 36(7)

Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network

Authors: Giacomini, Kathleen M., Karnes, Jason H., Crews, Kristine R., Monte, Andrew A., Murphy, William A., Oni‐Orisan, Akinyemi, Ramsey, Laura B., Yang, Jun J., Whirl‐Carrillo, Michelle

Source: Clinical pharmacology & therapeutics. 110(3):559-562

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140923287.0x000001&indx=1&recIds=ETOCvdc_100140923287.0x000001

Genomic markers associated 506 with successful treatment of hypertension with lisinopril: A pilot study

Authors: Flaten, Hania K., Sonn, Brandon J., Saben, Jessica L., Shelton, Shelby K., Schwartz, John, Ryall, Karen, Monte, Andrew A.

Source: International journal of clinical pharmacology and therapeutics. 59(7):506-510

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626744301&indx=1&recIds=ETOCRN626744301

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy

Authors: Crews, Kristine R., Monte, Andrew A., Huddart, Rachel, Caudle, Kelly E., Kharasch, Evan D., Gaedigk, Andrea, Dunnenberger, Henry M., Leeder, J. Steven, Callaghan, John T., Samer, Caroline Flora, Klein, Teri E., Haidar, Cyrine E., Van Driest, Sara L., Ruano, Gualberto, Sangkuhl, Katrin, Cavallari, Larisa H., Müller, Daniel J., Prows, Cynthia A., Nagy, Mohamed, Somogyi, Andrew A., Skaar, Todd C.

Source: Clinical pharmacology & therapeutics. 110(4):888-896

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130127340.0x000001&indx=1&recIds=ETOCvdc_100130127340.0x000001

Selective serotonin/serotonin‐norepinephrine reuptake inhibitor serum concentrations' association with delirium duration.

Authors: Jordano, James O., Vasilevskis, Eduard E., Simmons, Sandra F., Taylor, Warren D., Monte, Andrew A., Duggan, Maria C., Han, Jin H.

Source: Journal of the American Geriatrics Society; Nov2024, Vol. 72 Issue 11, p3594-3597, 4p

Subject Terms: DISEASE duration, SEROTONIN uptake inhibitors, HOSPITAL care, LOGISTIC regression analysis, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, NORADRENALINE, DELIRIUM, RESEARCH, SEROTONIN, CONFIDENCE intervals, DATA analysis software, OLD age

Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke.

Authors: Dylla, Layne, Higgins, Hannah M., Stephenson, Daniel, Reisz, Julie A., Vu, Thao, Poisson, Sharon N., Herson, Paco S., Monte, Andrew A.

Source: Journal of Women's Health (15409996); Oct2024, Vol. 33 Issue 10, p1378-1384, 7p

Subject Terms: STROKE units, NIH Stroke Scale, PROLINE, RESEARCH funding, SEX distribution, BLOOD collection, DESCRIPTIVE statistics, AGE distribution, POSTMENOPAUSE, CARDIOVASCULAR diseases risk factors, RETROSPECTIVE studies, HOSPITALS, METABOLITES, RACE, NUCLEOTIDES, CHOLINE, ESTERASES, LONGITUDINAL method, ISCHEMIC stroke, MASS spectrometry, AMINO acids, SEX (Biology), METABOLOMICS, TRYPTOPHAN, CITRATES, REGRESSION analysis, MENTAL depression, TIME

Geographic Terms: COLORADO

Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta‐Blocker Therapy.

Authors: Duarte, Julio D., Thomas, Cameron D., Lee, Craig R., Huddart, Rachel, Agundez, Jose A. G., Baye, Jordan F., Gaedigk, Andrea, Klein, Teri E., Lanfear, David E., Monte, Andrew A., Nagy, Mohamed, Schwab, Matthias, Stein, C. Michael, Uppugunduri, Chakradhara Rao S., van Schaik, Ron H. N., Donnelly, Roseann S., Caudle, Kelly E., Luzum, Jasmine A.

Source: Clinical Pharmacology & Therapeutics; Oct2024, Vol. 116 Issue 4, p939-947, 9p

Subject Terms: ARRHYTHMIA, CYTOCHROME P-450 CYP2D6, GENETIC variation, MYOCARDIAL infarction, HEART beat