Estrogen-regulated miRs in bone enhance osteoblast differentiation and matrix mineralization

Authors: Emch, Michael J., Wicik, Zofia, Aspros, Kirsten G.M., Vukajlovic, Tanja, Pitel, Kevin S., Narum, Anders K., Weivoda, Megan M., Tang, Xiaojia, Kalari, Krishna R., Turner, Russell T., Iwaniec, Urszula T., Monroe, David G., Subramaniam, Malayannan, Hawse, John R.

Source: In Molecular Therapy - Nucleic Acids 12 September 2023 33:28-41

Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice

Authors: Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Eckhardt, Brittany, Vos, Stephanie, Grain, Sarah, Kroupova, Kveta, Ruan, Ming, Weivoda, Megan, Oursler, Merry Jo, Farr, Joshua N., Monroe, David G., Khosla, Sundeep

Source: Journal of bone and mineral research. 37(9):1750-1760

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161041917.0x000001&indx=1&recIds=ETOCvdc_100161041917.0x000001

Bone Marrow Adiposity in Models of Radiation‐ and Aging‐Related Bone Loss Is Dependent on Cellular Senescence

Authors: Chandra, Abhishek, Lagnado, Anthony B., Farr, Joshua N., Schleusner, Megan, Monroe, David G., Saul, Dominik, Passos, João F., Khosla, Sundeep, Pignolo, Robert J.

Source: Journal of bone and mineral research. 37(5):997-1011

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150050132.0x000001&indx=1&recIds=ETOCvdc_100150050132.0x000001

The role of senolytics in osteoporosis and other skeletal pathologies

Authors: Doolittle, Madison L., Monroe, David G., Farr, Joshua N., Khosla, Sundeep ^*

Source: In Mechanisms of Ageing and Development October 2021 199

miRNAs in osteoclast biology

Authors: Weivoda, Megan M., Lee, Sun-Kyeong, Monroe, David G.

Source: In Bone February 2021 143

Characterization of Human Senescent Cell Biomarkers for Clinical Trials.

Authors: Farr, Joshua N.^1,2 (AUTHOR) jfarr@arizona.edu, Monroe, David G.^1,2 (AUTHOR), Atkinson, Elizabeth J.³ (AUTHOR), Froemming, Mitchell N.^1,2 (AUTHOR), Ruan, Ming^1,2 (AUTHOR), LeBrasseur, Nathan K.^2,4 (AUTHOR), Khosla, Sundeep^1,2 (AUTHOR) jfarr@arizona.edu

Source: Aging Cell. Jan2025, p1. 9p. 7 Illustrations.

Subject Terms: *POLYMERASE chain reaction, *BONE metabolism, *POSTMENOPAUSE, *CLINICAL trials, *DNA damage

Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice

Authors: Aquino‐Martinez, Ruben, Eckhardt, Brittany A., Rowsey, Jennifer L., Fraser, Daniel G., Khosla, Sundeep, Farr, Joshua N., Monroe, David G.

Source: Journal of periodontology. 92(10):1483-1495

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131300504.0x000001&indx=1&recIds=ETOCvdc_100131300504.0x000001

Isolation and characterization of bone mesenchymal cell small extracellular vesicles using a novel mouse model.

Authors: Monroe, David G, Javeed, Naureen, Rowsey, Jennifer L, Ruan, Ming, McCabe, Chantal E, Piatkowski, Bryan T, Roy, Abhishek, Bobbili, Madhusudhan R, Grillari, Johannes, Khosla, Sundeep

Source: Journal of Bone & Mineral Research; Nov2024, Vol. 39 Issue 11, p1633-1643, 11p

Modest Effects of Osteoclast‐Specific ERα Deletion after Skeletal Maturity

Authors: Doolittle, Madison L., Eckhardt, Brittany A., Vos, Stephanie J., Grain, Sarah, Rowsey, Jennifer L., Ruan, Ming, Saul, Dominik, Farr, Joshua N., Weivoda, Megan M., Khosla, Sundeep, Monroe, David G.

Source: JBMR plus. 7(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195087010.0x000001&indx=1&recIds=ETOCvdc_100195087010.0x000001

MicroRNA‐19a‐3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence

Authors: Kaur, Japneet, Saul, Dominik, Doolittle, Madison L., Farr, Joshua N., Khosla, Sundeep, Monroe, David G.

Source: JBMR plus. 7(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184661963.0x000001&indx=1&recIds=ETOCvdc_100184661963.0x000001

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

Authors: Chandra, Abhishek, Lagnado, Anthony B, Farr, Joshua N, Monroe, David G, Park, Sean, Hachfeld, Christine, Tchkonia, Tamar, Kirkland, James L, Khosla, Sundeep, Passos, João F, Pignolo, Robert J

Source: Journal of bone and mineral research. 35(6):1119-1131

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107550422.0x000001&indx=1&recIds=ETOCvdc_100107550422.0x000001

ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

Authors: Reese, Jordan M., Bruinsma, Elizabeth S., Nelson, Adam W., Chernukhin, Igor, Carroll, Jason S., Li, Ying, Subramaniam, Malayannan, Suman, Vera J., Negron, Vivian, Monroe, David G., Ingle, James N., Goetz, Matthew P., Hawse, John R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct 01. 115(41), E9580-E9589.

Access URL: https://www.jstor.org/stable/26532221

MiR‐219a‐5p Regulates Rorβ During Osteoblast Differentiation and in Age‐related Bone Loss

Authors: Aquino‐Martinez, Ruben, Farr, Joshua N, Weivoda, Megan M, Negley, Brittany A, Onken, Jennifer L, Thicke, Brianne S, Fulcer, McKenzie M, Fraser, Daniel G, van Wijnen, Andre J, Khosla, Sundeep, Monroe, David G

Source: Journal of bone and mineral research. 34(1):135-144

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130980804.0x000001&indx=1&recIds=ETOCvdc_100130980804.0x000001

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

Authors: Farr, Joshua N, Rowsey, Jennifer L, Eckhardt, Brittany A, Thicke, Brianne S, Fraser, Daniel G, Tchkonia, Tamar, Kirkland, James L, Monroe, David G, Khosla, Sundeep

Source: Journal of bone and mineral research. 34(8):1407-1418

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088918016.0x000001&indx=1&recIds=ETOCvdc_100088918016.0x000001

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

Authors: Farr, Joshua N., Atkinson, Elizabeth J., Achenbach, Sara J., Volkman, Tammie L., Tweed, Amanda J., Vos, Stephanie J., Ruan, Ming, Sfeir, Jad, Drake, Matthew T., Saul, Dominik, Doolittle, Madison L., Bancos, Irina, Yu, Kai, Tchkonia, Tamara, LeBrasseur, Nathan K., Kirkland, James L., Monroe, David G., Khosla, Sundeep

Source: Nature Medicine; September 2024, Vol. 30 Issue: 9 p2605-2612, 8p

Identification of a suitable endogenous control miRNA in bone aging and senescence

Authors: Kaur, Japneet, Saul, Dominik, Doolittle, Madison L., Rowsey, Jennifer L., Vos, Stephanie J., Farr, Joshua N., Khosla, Sundeep, Monroe, David G.

Source: Gene. 835

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166857850.0x000001&indx=1&recIds=ETOCvdc_100166857850.0x000001

Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

Authors: Chandra, Abhishek, Lagnado, Anthony B., Farr, Joshua N., Doolittle, Madison, Tchkonia, Tamara, Kirkland, James L., LeBrasseur, Nathan K., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Passos, João F., Monroe, David G., Pignolo, Robert J., Khosla, Sundeep

Source: Aging cell. 21(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150391330.0x000001&indx=1&recIds=ETOCvdc_100150391330.0x000001

Global transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women

Authors: Roforth, Matthew M., Farr, Joshua N., Fujita, Koji, McCready, Louise K., Atkinson, Elizabeth J., Therneau, Terry M., Cunningham, Julie M., Drake, Matthew T., Monroe, David G., Khosla, Sundeep

Source: In Bone July 2015 76:49-57

Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

Authors: Roforth, Matthew M., Fujita, Koji, McGregor, Ulrike I., Kirmani, Salman, McCready, Louise K., Peterson, James M., Drake, Matthew T., Monroe, David G., Khosla, Sundeep

Source: In Bone February 2014 59:1-6

LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis

Authors: Aquino-Martinez, Ruben, Rowsey, Jennifer L., Fraser, Daniel G., Eckhardt, Brittany A., Khosla, Sundeep, Farr, Joshua N., Monroe, David G.

Source: Bone. 132

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121744127.0x000001&indx=1&recIds=ETOCvdc_100121744127.0x000001