Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine

Authors: Cajander, Sara ^*, Kox, Matthijs ^*, Scicluna, Brendon P, Weigand, Markus A, Mora, Raquel Almansa, Flohé, Stefanie B, Martin-Loeches, Ignacio, Lachmann, Gunnar, Girardis, Massimo, Garcia-Salido, Alberto, Brunkhorst, Frank M, Bauer, Michael, Torres, Antoni, Cossarizza, Andrea, Monneret, Guillaume, Cavaillon, Jean-Marc, Shankar-Hari, Manu, Giamarellos-Bourboulis, Evangelos J, Winkler, Martin Sebastian, Skirecki, Tomasz, Osuchowski, Marcin, Rubio, Ignacio, Bermejo-Martin, Jesus F ^†, Schefold, Joerg C ^†, Venet, Fabienne ^{†, *}

Source: In The Lancet Respiratory Medicine April 2024 12(4):305-322

Interferon-Gamma-Release assay and absolute CD8 lymphocyte count for acquired immunosuppression monitoring in critically ill patients

Authors: Haem Rahimi, Muzhda ^{a, b}, Venet, Fabienne ^{a, c}, Lukaszewicz, Anne-Claire ^{b, d}, Peronnet, Estelle ^{b, e}, Cerrato, Elisabeth ^{b, e}, Rimmelé, Thomas ^{b, d}, Monneret, Guillaume ^{a, b, ⁎}

Source: In Cytokine February 2024 174

Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial

Authors: Vacheron, Charles-Hervé, Lepape, Alain, Venet, Fabienne, Monneret, Guillaume, Gueyffier, Francois, Boutitie, Florent, Vallin, Helene, Schwebel, Carole, Maucort-Boulch, Delphine, Friggeri, Arnaud

Source: In Journal of Critical Care December 2023 78

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Authors: Manry, Jérémy, Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina, Bizien, Lucy, Parra-Martínez, Alba, Yang, Rui, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Cognasse, Fabrice, Troya, Jesús, Trouillet-Assant, Sophie, Belot, Alexandre, Saker, Kahina, Garçon, Pierre, Rivière, Jacques G., Lagier, Jean-Christophe, Gentile, Stéphanie, Rosen, Lindsey B., Shaw, Elana, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis, Sene, Damien, Stepanian, Alain, Mégarbane, Bruno, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R., Franco, José Luis, Anaya, Juan-Manuel, Solé-Violán, Jordi, Imberti, Luisa, Biondi, Andrea, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M., Zhang, Yu, Snow, Andrew L., Holland, Steven M., Biggs, Catherine M., Moncada-Vélez, Marcela, Arias, Andrés Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Anglicheau, Dany, Planas, Anna M., Haerynck, Filomeen, Duvlis, Sotirija, Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A., Bakkouri, Jalila El, Ramirez-Santana, Carolina, Paul, Stéphane, Pan-Hammarström, Qiang, Hammarström, Lennart, Dupont, Annabelle, Kurolap, Alina, Metz, Christine N., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A., Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G., Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y., Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C., Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H., Kennelly, Sean P., Bourke, Nollaig M., Halwani, Rabih, Sharif-Askari, Fatemeh Saheb, Dorgham, Karim, Sallette, Jérôme, Sedkaoui, Souad Mehlal, AlKhater, Suzan, Rigo-Bonnin, Raúl, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C., Erikstrup, Christian, Condino-Neto, Antonio, Prando, Carolina, Bondarenko, Anastasiia, Spaan, András N., Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P., Mane, Shrikant, Anderson, Mark S., Boisson, Bertrand, Béziat, Vivien, Zhang, Shen-Ying, Andreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Pärt, Mogensen, Trine H., Rowen, Lee, Mond, James, Debette, Stéphanie, de Lamballerie, Xavier, Burdet, Charles, Bouadma, Lila, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier, Vasse, Marc, Gregersen, Peter K., Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D., Su, Helen C., Kisand, Kai, Okada, Satoshi, Puel, Anne, Jouanguy, Emmanuelle, Rice, Charles M., Tiberghien, Pierre, Zhang, Qian, Casanova, Jean-Laurent, Abel, Laurent, Cobat, Aurélie

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 May . 119(21), 1-10.

Access URL: https://www.jstor.org/stable/27151949

Demultiplexing Ig repertoires by parallel mRNA/DNA sequencing shows major differential alterations in severe COVID-19

Authors: Pascal, Virginie ^{1, 10}, Dupont, Marine ^{2, 10}, de Rouault, Paco ³, Rizzo, David ², Rossille, Delphine ^{4, 5}, Jeannet, Robin ^{2, 6}, Daix, Thomas ⁶, François, Bruno ⁶, Genebrier, Steve ^{4, 5}, Cornic, Marie ⁵, Monneret, Guillaume ⁷, Venet, Fabienne ⁷, Ferrant, Juliette ⁴, Roussel, Mikael ^{4, 5}, Reizine, Florian ^{4, 8}, Le Souhaitier, Mathieu ^{4, 8}, Tadié, Jean-Marc ^{4, 8}, Tarte, Karin ^{4, 5}, Feuillard, Jean ^{2, 9}, Cogné, Michel ^{4, 5, 9, 11, ∗}

Source: In iScience 17 March 2023 26(3)

HLA-DR expression on monocytes and outcome of anti-CD19 CAR T-cell therapy for large B-cell lymphoma

Authors: Bourbon, Estelle ^∗, Sesques, Pierre ^∗, Gossez, Morgane, Tordo, Jérémie, Ferrant, Emmanuelle, Safar, Violaine, Wallet, Florent, Aussedat, Guillaume, Maarek, Alizée, Bouafia, Fadhela, Karlin, Lionel, Ghergus, Dana, Golfier, Camille, Lequeu, Hélène, Lazareth, Anne, Schwiertz, Vérane, Viel, Sébastien, Idlhaj, Maryam, Ghesquières, Hervé, Monneret, Guillaume, Bachy, Emmanuel, Venet, Fabienne

Source: In Blood Advances 14 March 2023 7(5):744-755

Sepsis et immunodépression acquise en réanimation

Alternate Title: Sepsis and acquired immunodeficiency in intensive care unit (English)

Authors: Lepage, Margot, Haem Rahimi, Muzhda, Gossez, Morgane, Bidar, Frank, Lukaszewicz, Anne-Claire, Venet, Fabienne, Monneret, Guillaume ^*

Source: In Revue Francophone des Laboratoires February 2023 2023(549):47-53

T cell response against SARS-CoV-2 persists after one year in patients surviving severe COVID-19

Authors: Venet, Fabienne, Gossez, Morgane, Bidar, Frank, Bodinier, Maxime, Coudereau, Rémy, Lukaszewicz, Anne-Claire, Tardiveau, Claire, Brengel-Pesce, Karen, Cheynet, Valérie, Cazalis, Marie-Angélique, Pescarmona, Rémi, Garnier, Lorna, Ortillon, Marine, Buisson, Marielle, Bouscambert-Duchamp, Maude, Morfin-Sherpa, Florence, Casalegno, Jean-Sébastien, Conti, Filippo, Rimmelé, Thomas, Argaud, Laurent, Cour, Martin, Saadatian-Elahi, Mitra, Henaff, Laetitia, Vanhems, Philippe, Monneret, Guillaume

Source: In eBioMedicine April 2022 78

Altered Ex Vivo NLRP3 Inflammasome Activation Is Associated with 28-Day Mortality in Septic Patients.

Authors: Coudereau, Rémy^1,2 (AUTHOR) anne-claire.lukaszewicz@chu-lyon.fr, Monneret, Guillaume^1,2 (AUTHOR) frank.bidar@chu-lyon.fr, Lukaszewicz, Anne-Claire^2,3 (AUTHOR), Py, Bénédicte F.⁴ (AUTHOR) benedicte.py@inserm.fr, Argaud, Laurent⁵ (AUTHOR) laurent.argaud@chu-lyon.fr, Cour, Martin⁵ (AUTHOR) martin.cour@chu-lyon.fr, Bidar, Frank^2,3 (AUTHOR), Gossez, Morgane^1,4 (AUTHOR) morgane.gossez@chu-lyon.fr, Venet, Fabienne^1,4 (AUTHOR) fabienne.venet@chu-lyon.fr

Source: Viruses (1999-4915). Dec2023, Vol. 15 Issue 12, p2419. 14p.

Subject Terms: *SEPSIS, *NLRP3 protein, *INFLAMMASOMES, *SEPTIC shock, *MYELOID cells, *COVID-19

Seroconversion in septic ICU patients presenting with COVID-19: necessary but not sufficient

Authors: Conti, Filippo, Oriol, Guy, Cheynet, Valerie, Tardiveau, Claire, Cerrato, Elizabeth, Rimmelé, Thomas, Lukaszewicz, Anne-Claire, Argaud, Laurent, Cour, Martin, Brengel-Pesce, Karen, Venet, Fabienne, Monneret, Guillaume

Source: In Archives of Medical Research November 2021 52(8):850-857

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Authors: Osuchowski, Marcin F, Winkler, Martin S, Skirecki, Tomasz, Cajander, Sara, Shankar-Hari, Manu, Lachmann, Gunnar, Monneret, Guillaume, Venet, Fabienne, Bauer, Michael, Brunkhorst, Frank M, Weis, Sebastian, Garcia-Salido, Alberto, Kox, Matthijs, Cavaillon, Jean-Marc, Uhle, Florian, Weigand, Markus A, Flohé, Stefanie B, Wiersinga, W Joost, Almansa, Raquel, de la Fuente, Amanda, Martin-Loeches, Ignacio, Meisel, Christian, Spinetti, Thibaud, Schefold, Joerg C, Cilloniz, Catia, Torres, Antoni, Giamarellos-Bourboulis, Evangelos J, Ferrer, Ricard, Girardis, Massimo, Cossarizza, Andrea, Netea, Mihai G, van der Poll, Tom, Bermejo-Martín, Jesús F, Rubio, Ignacio ^*

Source: In The Lancet Respiratory Medicine June 2021 9(6):622-642

Methods for determining a patient's susceptibility of contracting a nosocomial infection and for establishing a prognosis of the progression of septic syndrome

Apport du dosage des chaînes légères libres kappa et lambda dans le diagnostic de la sclérose en plaques

Alternate Title: Contribution of kappa and lambda free light chains quantification in the diagnosis of multiple sclerosis (English)

Authors: Micoud, Eléonore ^*, Gossez, Morgane, Poitevin, Françoise, Malcus, Christophe, Monneret, Guillaume, Godignon, Marine

Source: In Revue Francophone des Laboratoires April 2021 2021(531):58-64

Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study.

Authors: Cazalis, Marie-Angélique, Kreitmann, Louis, Monneret, Guillaume, Pachot, Alexandre, Brengel-Pesce, Karen, Llitjos, Jean-François

Source: Frontiers in Medicine; 2025, p1-10, 10p

A new simplified and accurate sa-SOFA score

Authors: Vacheron, Charles-Hervé, Friggeri, Arnaud, Iwaz, Jean, Allaouchiche, Bernard, Bohe, Julien, Monneret, Guillaume, Venet, Fabienne, Cour, Martin, Argaud, Laurent, Aubrun, Frédéric, Rimmele, Thomas, Pachot, Alexandre, Piriou, Vincent, Lepape, Alain, Maucort-Boulch, Delphine

Source: In Journal of Critical Care June 2020 57:240-245

Method for diagnosis and/or prognosis of a septic syndrome

Current gaps in sepsis immunology: new opportunities for translational research

Authors: Rubio, Ignacio, Osuchowski, Marcin F, Shankar-Hari, Manu, Skirecki, Tomasz, Winkler, Martin Sebastian, Lachmann, Gunnar, La Rosée, Paul, Monneret, Guillaume, Venet, Fabienne, Bauer, Michael, Brunkhorst, Frank M, Kox, Matthijs, Cavaillon, Jean-Marc, Uhle, Florian, Weigand, Markus A, Flohé, Stefanie B, Wiersinga, W Joost, Martin-Fernandez, Marta, Almansa, Raquel, Martin-Loeches, Ignacio, Torres, Antoni, Giamarellos-Bourboulis, Evangelos J, Girardis, Massimo, Cossarizza, Andrea, Netea, Mihai G, van der Poll, Tom, Scherag, André, Meisel, Christian, Schefold, Joerg C, Bermejo-Martín, Jesús F ^*

Source: In The Lancet Infectious Diseases December 2019 19(12):e422-e436

Cold-Inducible RNA-Binding Protein in Cardiac Arrest and Renal Ischemia-Reperfusion Injury: A Translational Approach

Authors: Schleef, Maxime ^{a, b, ∗}, Lemoine, Sandrine ^{a, b}, Stevic, Neven ^{a, b}, Pillot, Bruno ^a, Monneret, Guillaume ^b, Bidaux, Gabriel ^a, Juillard, Laurent ^{a, b}, Guebre-Egziabher, Fitsum ^{a, b}, Cour, Martin ^{a, b, †}, Baetz, Delphine ^{a, †}

Source: In JACC: Basic to Translational Science February 2025 10(2):224-226

Shadows and lights in sepsis immunotherapy.

Authors: Monneret, Guillaume, Haem Rahimi, Muzhda, Lukaszewicz, Anne-Claire, Venet, Fabienne, Gossez, Morgane

Source: Expert Opinion on Pharmacotherapy; Nov2024, Vol. 25 Issue 16, p2125-2133, 9p

Subject Terms: SEPSIS, IMMUNOTHERAPY, RANDOMIZED controlled trials, MULTIOMICS, TRANSCRIPTOMES

B‐cell immune deficiency in twin sisters expands the phenotype of MOPDI.

Authors: Gauthier, Lucas W., Gossez, Morgane, Malcus, Christophe, Viel, Sébastien, Monneret, Guillaume, Bordonné, Remy, Pons, Linda, Cabet, Sara, Delous, Marion, Mazoyer, Sylvie, Putoux, Audrey, Edery, Patrick

Source: Clinical Genetics; Oct2024, Vol. 106 Issue 4, p476-482, 7p

Subject Terms: FETAL growth retardation, SKELETAL dysplasia, IMMUNODEFICIENCY, SMALL nuclear RNA, PROTEIN binding, DYSPLASIA