Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation

Authors: Morris, Zachary S ^{a, *}, Demaria, Sandra ^b, Monjazeb, Arta M ^c, Formenti, Silvia C ^b, Weichselbaum, Ralph R ^d, Welsh, James ^e, Enderling, Heiko ^e, Schoenfeld, Jonathan D ^g, Brody, Joshua D ^h, McGee, Heather M ⁱ, Mondini, Michele ^j, Kent, Michael S ^k, Young, Kristina H ^l, Galluzzi, Lorenzo ^m, Karam, Sana D ⁿ, Theelen, Willemijn S M E ^o, Chang, Joe Y ^e, Huynh, Mai Anh ^g, Daib, Adi ^e, Pitroda, Sean ^d, Chung, Caroline ^e, Serre, Raphael ^p, Grassberger, Clemens ^q, Deng, Jie ^r, Sodji, Quaovi H ^a, Nguyen, Anthony T ^s, Patel, Ravi B ^t, Krebs, Simone ^{u, v}, Kalbasi, Anusha ^w, Kerr, Caroline ^a, Vanpouille-Box, Claire ^b, Vick, Logan ^x, Aguilera, Todd A ^y, Ong, Irene M ^a, Herrera, Fernanda ^z, Menon, Hari ^a, Smart, DeeDee ^aa, Ahmed, Jalal ^h, Gartrell, Robyn D ^{ab, ac}, Roland, Christina L ^e, Fekrmandi, Fatemeh ^ad, Chakraborty, Binita ^af, Bent, Eric H ^ag, Berg, Tracy J ^a, Hutson, Alan ^ae, Khleif, Samir ^ah, Sikora, Andrew G ^f, Fong, Lawrence ^q

Source: In The Lancet Oncology March 2025 26(3):e152-e170

A Phase 1/1B Trial of Pembrolizumab and Trametinib in Advanced NSCLC Enriched for KRAS Mutations

Authors: Riess, Jonathan W. ^{a, ∗}, Lara, Matthew S. ^a, Luxardi, Guillaume ^a, Lopez de Rodas, Miguel ^b, Shimoda, Michiko ^a, Kelly, Karen ^a, Lara, Primo N. ^a, Beckett, Laurel ^a, Monjazeb, Arta ^a, Schalper, Kurt A. ^b, Maverakis, Emanual ^a, Gandara, David R. ^a

Source: In JTO Clinical and Research Reports February 2025

Immune Cell Dynamics in EGFR-Mutated NSCLC Treated With Afatinib and Pembrolizumab: Results From a Phase IB Study

Authors: Riess, Jonathan W., Lara, Matthew S., Lopez de Rodas, Miguel, Luxardi, Guillaume, Herbert, Samantha, Shimoda, Michiko, Kelly, Karen, Meerlev, Alexander, Moore, Elizabeth, Beckett, Laurel, Monjazeb, Arta, Schalper, Kurt, Maverakis, Emanual, Gandara, David R.

Source: In JTO Clinical and Research Reports October 2024 5(10)

Challenges and opportunities for early phase clinical trials of novel drug–radiotherapy combinations: recommendations from NRG Oncology, the American Society for Radiation Oncology (ASTRO), the American College of Radiology (ACR), the Sarah Cannon Research Institute, and the American College of Radiation Oncology (ACRO)

Authors: Zumsteg, Zachary S ^*, Sheth, Siddharth, Jabbour, Salma K, Patel, Krishnan R, Kimple, Randall J, Williams, Terence M, Xu-Welliver, Meng, Torres-Saavedra, Pedro A, Monjazeb, Arta M, Mayadev, Jyoti, Finkelstein, Steven E, Buatti, John M, Patel, Sandip P, Lin, Steven H

Source: In The Lancet Oncology October 2024 25(10):e489-e500

Radiotherapy Combined with Intralesional Immunostimulatory Agents for Soft Tissue Sarcomas

Authors: Su, Chang ^*, Kim, Soo Kyoung, Wang, Charles X., Kirsch, David G. ^*, Monjazeb, Arta M.

Source: In Seminars in Radiation Oncology April 2024 34(2):243-257

Advances in Radiotherapy Immune Modulation: From Bench-to-Bedside and Back Again

Authors: Wang, Charles X., Hunt, Jared, Feinstein, Shera, Kim, Soo Kyoung, Monjazeb, Arta M.

Source: In Surgical Oncology Clinics of North America July 2023 32(3):617-629

Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(L)-1 therapy: an open-label, multicentre, randomised, phase 2 trial

Authors: Schoenfeld, Jonathan D ^*, Giobbie-Hurder, Anita, Ranasinghe, Srinika, Kao, Katrina Z, Lako, Ana, Tsuji, Junko, Liu, Yang, Brennick, Ryan C, Gentzler, Ryan D, Lee, Carrie, Hubbard, Joleen, Arnold, Susanne M, Abbruzzese, James L, Jabbour, Salma K, Uboha, Nataliya V, Stephans, Kevin L, Johnson, Jennifer M, Park, Haeseong, Villaruz, Liza C, Sharon, Elad, Streicher, Howard, Ahmed, Mansoor M, Lyon, Hayley, Cibuskis, Carrie, Lennon, Niall, Jhaveri, Aashna, Yang, Lin, Altreuter, Jennifer, Gunasti, Lauren, Weirather, Jason L, Mak, Raymond H, Awad, Mark M, Rodig, Scott J, Chen, Helen X, Wu, Catherine J, Monjazeb, Arta M, Hodi, F Stephen

Source: In The Lancet Oncology February 2022 23(2):279-291

MRI Radiomics for Prediction of Tumor Response and Downstaging in Rectal Cancer Patients after Preoperative Chemoradiation

Authors: Chen, Haihui, Shi, Liting, Nguyen, Ky Nam Bao, Monjazeb, Arta M., Matsukuma, Karen E., Loehfelm, Thomas W., Huang, Haixin, Qiu, Jianfeng, Rong, Yi

Source: In Advances in Radiation Oncology November-December 2020 5(6):1286-1295

Radiotherapy is Associated With Improved Survival in Patients With Synovial Sarcoma Undergoing Surgery: A National Cancer Database Analysis

Authors: Gingrich, Alicia A., Marrufo, Angelica S., Liu, Yu, Li, Chin-Shang, Darrow, Morgan A., Monjazeb, Arta M., Thorpe, Steven W., Canter, Robert J.

Source: In Journal of Surgical Research November 2020 255:378-387

Effect and Safety of Radiation Therapy Boost to Extramesorectal Lymph Nodes in Rectal Cancer

Authors: Chen, Haihui, Nguyen, Ky Nam Bao, Huang, Haixin, Feng, Chengjun, Zhao, Xiao, Daly, Megan E., Rao, Shyam, Fragoso, Ruben, Valicenti, Richard, Sekhon, Simran, Navarro, Shannon M., Kim, Edward J., Cho, May, Tam, Kit, Farkas, Linda, Halabi, Wissam J., Monjazeb, Arta M., Rong, Yi

Source: In Practical Radiation Oncology September-October 2020 10(5):e372-e377

Effects of Radiation on the Tumor Microenvironment

Authors: Monjazeb, Arta M. ^*, Schalper, Kurt A., Villarroel-Espindola, Franz, Nguyen, Anthony, Shiao, Stephen L., Young, Kristina

Source: In Seminars in Radiation Oncology April 2020 30(2):145-157

Prospective, Randomized Control Trial Investigating the Impact of a Physician-Communicated Radiation Therapy Plan Review on Breast Cancer Patient-Reported Satisfaction

Authors: Dyer, Brandon A., Li, Chin-Shang, Daly, Megan E., Monjazeb, Arta M., Mayadev, Jyoti S.

Source: In Practical Radiation Oncology November-December 2019 9(6):e487-e496

Tumor Control and Toxicity after SBRT for Ultracentral, Central, and Paramediastinal Lung Tumors

Authors: Nguyen, Ky Nam B., Hause, Destiny J., Novak, Jennifer, Monjazeb, Arta M., Daly, Megan E.

Source: In Practical Radiation Oncology March-April 2019 9(2):e196-e202

Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.

Authors: Collins, Craig P., Khuat, Lam T., Sckisel, Gail D., Vick, Logan V., Minnar, Christine M., Dunai, Cordelia, Le, Catherine T., Curti, Brendan D., Crittenden, Marka, Merleev, Alexander, Sheng, Michael, Chao, Nelson J., Maverakis, Emanual, Rosario, Spencer R., Monjazeb, Arta M., Blazar, Bruce R., Longo, Dan L., Canter, Robert J., Murphy, William J.

Source: Frontiers in Immunology; 2024, p1-18, 18p

Subject Terms: T cells, IMMUNOLOGIC memory, CELL populations, MIDDLE age, VIRUS diseases, DYSTHYMIC disorder

Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma.

Authors: Garibay, Eric Robles, Cruz, Sylvia M., Judge, Sean J., Monjazeb, Arta M., Thorpe, Steven W., Murphy, William J., Lyu, Jing, Chen, Shuai, Bateni, Cyrus P., Canter, Robert J.

Source: Journal of Surgical Oncology; Sep2024, Vol. 130 Issue 3, p543-551, 9p

Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs

Authors: Withers, Sita S., Moore, Peter F., Chang, Hong, Choi, Jin W., McSorley, Stephen J., Kent, Michael S., Monjazeb, Arta M., Canter, Robert J., Murphy, William J., Sparger, Ellen E., Rebhun, Robert B.

Source: In Developmental and Comparative Immunology October 2018 87:64-74

Alterations in cancer stem-cell marker CD44 expression predict oncologic outcome in soft-tissue sarcomas

Authors: Henderson, Timothy, Chen, Mingyi, Darrow, Morgan A., Li, Chin-Shang, Chiu, Chi-Lu, Monjazeb, Arta M., Murphy, William J., Canter, Robert J.

Source: In Journal of Surgical Research March 2018 223:207-214

Conservative management of desmoid tumors is safe and effective

Authors: Park, Jiwon Sarah, Nakache, Yves-Paul, Katz, Jeremy, Boutin, Robert D., Steffner, Robert J., Monjazeb, Arta M., Canter, Robert J.

Source: In Journal of Surgical Research September 2016 205(1):115-120

Low-Dose Sorafenib Promotes Cancer Stem Cell Expansion and Accelerated Tumor Progression in Soft Tissue Sarcomas.

Authors: Cruz, Sylvia M., Iranpur, Khurshid R., Judge, Sean J., Ames, Erik, Sturgill, Ian R., Farley, Lauren E., Darrow, Morgan A., Crowley, Jiwon Sarah, Monjazeb, Arta M., Murphy, William J., Canter, Robert J.

Source: International Journal of Molecular Sciences; Mar2024, Vol. 25 Issue 6, p3351, 14p

Subject Terms: CANCER stem cells, SOFT tissue tumors, SARCOMA, SORAFENIB, ALDEHYDE dehydrogenase, PROTEIN-tyrosine kinase inhibitors, CELL lines

Scrutinizing the use of contrasted chest CTs in extremity sarcoma staging and surveillance.

Authors: Priester, Jacob I., Simister, Samuel K., Sario, Matthew, Choi, Justin, Pina, Dagoberto, Theriault, Raminta, Bateni, Cyrus, Ghasemiesfe, Ahmadreza, Carr‐Ascher, Janai, Monjazeb, Arta M., Canter, Robert J., Randall, R. L., Thorpe, Steven W.

Source: Journal of Surgical Oncology; Mar2024, Vol. 129 Issue 3, p523-530, 8p