The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer.

Authors: Alaouna, Mohammed^1,2 (AUTHOR), Molefi, Thulo^2,3,4 (AUTHOR), Khanyile, Richard^3,4 (AUTHOR), Chauke-Malinga, Nkhensani^2,4,5 (AUTHOR), Chatziioannou, Aristotelis^2,4,6 (AUTHOR), Luvhengo, Thifhelimbilu Emmanuel^2,7 (AUTHOR), Raletsena, Maropeng^2,8 (AUTHOR), Penny, Clement^1,2 (AUTHOR), Hull, Rodney^2,4 (AUTHOR) Rodney.hull@up.ac.za, Dlamini, Zodwa^2,4 (AUTHOR) Zodwa.Dlamini@up.ac.za

Source: Scientific Reports. 2/17/2025, Vol. 15 Issue 1, p1-29. 29p.

From Genes to Clinical Practice: Exploring the Genomic Underpinnings of Endometrial Cancer.

Authors: Molefi, Thulo^1,2,3 (AUTHOR) thulo.molefi@up.ac.za, Mabonga, Lloyd² (AUTHOR) rodney.hull@up.ac.za, Hull, Rodney² (AUTHOR), Sebitloane, Motshedisi¹ (AUTHOR) sebitloanem@ukzn.ac.za, Dlamini, Zodwa² (AUTHOR) sebitloanem@ukzn.ac.za

Source: Cancers. Jan2025, Vol. 17 Issue 2, p320. 34p.

Subject Terms: *GENOMICS, *INTERPROFESSIONAL relations, *MULTIOMICS, *TUMOR markers, *ENDOMETRIAL tumors, *GENE expression profiling, *CANCER genes, *MAPS, *INTERDISCIPLINARY research, *GENETIC profile

The Histomorphology to Molecular Transition: Exploring the Genomic Landscape of Poorly Differentiated Epithelial Endometrial Cancers.

Authors: Molefi, Thulo, Mabonga, Lloyd, Hull, Rodney, Mwazha, Absalom, Sebitloane, Motshedisi, Dlamini, Zodwa

Source: Cells (2073-4409); Mar2025, Vol. 14 Issue 5, p382, 58p

Subject Terms: ENDOMETRIAL cancer, GENETIC mutation, CANCER-related mortality, EPITHELIAL tumors, TREATMENT effectiveness

AI and precision oncology in clinical cancer genomics: From prevention to targeted cancer therapies-an outcomes based patient care

Authors: Dlamini, Zodwa, Skepu, Amanda, Kim, Namkug, Mkhabele, Mahlori, Khanyile, Richard, Molefi, Thulo, Mbatha, Sikhumbuzo, Setlai, Botle, Mulaudzi, Thanyani, Mabongo, Mzubanzi, Bida, Meshack, Kgoebane-Maseko, Minah, Mathabe, Kgomotso, Lockhat, Zarina, Kgokolo, Mahlatse, Chauke-Malinga, Nkhensani, Ramagaga, Serwalo, Hull, Rodney

Source: In Informatics in Medicine Unlocked 2022 31

Chapter Five - Overcoming chemotherapy resistance in colorectal cancer

Authors: Demetriou, Demetra, Molefi, Thulo, Chatziioannou, Aristotelis, Dlamini, Zodwa

Source: In Colorectal Cancer Treatment Resistance 2025:85-105

Exploring Water-Soluble South African Tulbaghia violacea Harv Extract as a Therapeutic Approach for Triple-Negative Breast Cancer Metastasis.

Authors: Alaouna, Mohammed, Hull, Rodney, Molefi, Thulo, Khanyile, Richard, Mbodi, Langanani, Luvhengo, Thifhelimbilu Emmanuel, Chauke-Malinga, Nkhensani, Phakathi, Boitumelo, Penny, Clement, Dlamini, Zodwa

Source: Current Issues in Molecular Biology; Oct2024, Vol. 46 Issue 10, p10806-10828, 23p

Chapter 5 - Reversal of resistance mechanisms in cervical cancer

Authors: Hull, Rodney, Mabeta, Peace, Chauke-Malinga, Nkhensani, Molefi, Thulo, Chatziioannou, Aristotelis, Dlamini, Zodwa

Source: In Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer 2024:71-93

Chapter 10 - Conclusion: Overcoming chemoresistance in cervical cancer

Authors: Dlamini, Zodwa, Khanyile, Richard, Molefi, Thulo, Damane, Botle Precious, Hull, Rodney, Mehrotra, Ravi

Source: In Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer 2024:179-183

List of contributors

Authors: Basera, Afra, Bates, David O., Belancio, Victoria, Bida, Meshack, Chatziioannou, Aristotelis, Chipiti, Talent, Damane, Botle Precious, Demetriou, Demetra, Dlamini, Zodwa, Ecker, Rupert C., Fadebi, Olalekan, Fourie, Leony, Grech, Godfrey, Hull, Rodney, Kader, Shakeel, Kappo, Abidemi Paul, Kaufmann, Andreas M., Kgomo, Koena A., Khanyile, Richard, Ledet, Elisa, Leenders, William, Lin, Zhen, Lolas, Georgios, Luvhengo, Thifhelimbilu Emmanuel, Lyantagaye, Sylvester, Mabeta, Peace, Mabonga, Lloyd, Makgoo, Lilian, Manabile, Mosebo A., Marima, Rahaba, Mbatha, Sikhumbuzo Z., Mbita, Zukile, Mbodi, Langanani, Mehrotra, Ravi, Mirza, Sheefa, Miya, Thabiso Victor, Mkhize-Kwitshana, Zilungile, Moela, Pontsho, Molefi, Thulo, Montwedi, Odisang Daniel, Mosoane, Benny, Mulaudzi, Thanyani, Naidoo, Pragalathan, Penny, Clem, Pillay, Roxanne, Reis, Rui Manuel, Savkovic, Suzana, Skepu, Amanda, Syrigos, Konstantinos N., Ubanako, Philemon

Source: In Colorectal Cancer Treatment Resistance 2025:xiii-xvii

From Incidence to Intervention: A Comprehensive Look at Breast Cancer in South Africa

Authors: Dlamini, Zodwa, Molefi, Thulo, Khanyile, Richard, Mkhabele, Mahlori, Damane, Botle, Kokoua, Alexandre, Bida, Meshack, Saini, Kamal S., Chauke-Malinga, Nkhensani, Luvhengo, Thifhelimbilu Emmanuel, Hull, Rodney

Source: Oncology and Therapy; March 2024, Vol. 12 Issue: 1 p1-11, 11p

Alternative Splicing Events and Their Clinical Significance in Colorectal Cancer: Targeted Therapeutic Opportunities.

Authors: Manabile, Mosebo Armstrong, Hull, Rodney, Khanyile, Richard, Molefi, Thulo, Damane, Botle Precious, Mongan, Nigel Patrick, Bates, David Owen, Dlamini, Zodwa

Source: Cancers; Aug2023, Vol. 15 Issue 15, p3999, 21p

Subject Terms: RNA, DISEASE incidence, COLORECTAL cancer, DEVELOPING countries

Geographic Terms: UNITED Kingdom

Overcoming the Challenges of Phytochemicals in Triple Negative Breast Cancer Therapy: The Path Forward.

Authors: Alaouna, Mohammed, Penny, Clement, Hull, Rodney, Molefi, Thulo, Chauke-Malinga, Nkhensani, Khanyile, Richard, Makgoka, Malose, Bida, Meshack, Dlamini, Zodwa

Source: Plants (2223-7747); Jun2023, Vol. 12 Issue 12, p2350, 20p

Subject Terms: TRIPLE-negative breast cancer, PHYTOCHEMICALS, RESVERATROL, NOTCH genes, PROGESTERONE receptors, CANCER treatment

Genomic Interplay between Neoneurogenesis and Neoangiogenesis in Carcinogenesis: Therapeutic Interventions.

Authors: Dlamini, Zodwa, Khanyile, Richard, Molefi, Thulo, Damane, Botle Precious, Bates, David Owen, Hull, Rodney

Source: Cancers; Mar2023, Vol. 15 Issue 6, p1805, 21p

Subject Terms: TUMOR genetics, TUMOR treatment, CELL differentiation, DISEASE progression, CYTOKINES, CARCINOGENESIS, NEOVASCULARIZATION, NUTRITIONAL requirements, NEUROTRANSMITTERS, CELLULAR signal transduction, CELL motility, GENOMICS, MITOGEN-activated protein kinases

Contributors

Authors: Baloyi, Shisana, Basera, Afra, Bassa, Sheynaz, Bida, Meshack, Chatziioannou, Aristotelis, Chauke-Malinga, Nkhensani, Damane, Botle Precious, Demetriou, Demetra, Dlamini, Zodwa, Gaudji, Guy Roger, Grech, Godfrey, Hull, Rodney, Kaufmann, Andreas M., Kgatle, Mankgopo, Kgokolo, Mahlatse Cordelia, Khanyile, Richard, Leenders, William, Luvhengo, Thifhelimbilu, Mabeta, Peace, Magangane, Pumza, Manabile, Mosebo, Marima, Rahaba, Maringa, Vusumuzi D., Mbatha, Sikhumbuzo Z., Mbodi, Langanani, McCabe, Michelle, Mehrotra, Ravi, Miya, Thabiso Victor, Mkhabele, Mahlori, Mkhize-Kwitshana, Zilungile Lynette, Molefi, Thulo, Moroeng, Moleleki W., Morolo, Mantsoelengwe Viola, Mosoane, Benny, Mtshali, Nompumelelo, Muallem, Mustafa Zelal, Mulaudzi, Thanyani Victor, Perepelitsa, Victoria P., Phakathi, Boitumelo, Ramogola-Masire, Doreen, Rotimi, Solomon O., Sebitloane, Motshedisi, Skepu, Amanda, Yu, Herbert

Source: In Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer 2024:xix-xxi

Viral Encoded miRNAs in Tumorigenesis: Theranostic Opportunities in Precision Oncology.

Authors: Hull, Rodney, Marima, Rahaba, Alaouna, Mohammed, Demetriou, Demetra, Reis, Rui Manuel, Molefi, Thulo, Dlamini, Zodwa

Source: Microorganisms; Jul2022, Vol. 10 Issue 7, pN.PAG-N.PAG, 25p

Subject Terms: MICRORNA, HEPATITIS C virus, NEOPLASTIC cell transformation, VIRAL replication, KAPOSI'S sarcoma-associated herpesvirus

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Role of Precision Oncology in Type II Endometrial and Prostate Cancers in the African Population: Global Cancer Genomics Disparities.

Authors: Marima, Rahaba, Hull, Rodney, Mbeje, Mandisa, Molefi, Thulo, Mathabe, Kgomotso, Elbagory, Abdulrahman M., Demetriou, Demetra, Dlamini, Zodwa

Source: International Journal of Molecular Sciences; Jan2022, Vol. 23 Issue 2, p628-N.PAG, 1p

Subject Terms: AFRICANS, ENDOMETRIAL cancer, PROSTATE cancer, CANCER genetics, ONCOLOGY

MicroRNA and Alternative mRNA Splicing Events in Cancer Drug Response/Resistance: Potent Therapeutic Targets.

Authors: Marima, Rahaba, Francies, Flavia Zita, Hull, Rodney, Molefi, Thulo, Oyomno, Meryl, Khanyile, Richard, Mbatha, Sikhumbuzo, Mabongo, Mzubanzi, Owen Bates, David, Dlamini, Zodwa

Source: Biomedicines; Dec2021, Vol. 9 Issue 12, p1818-1818, 1p

Subject Terms: DRUG resistance in cancer cells, MESSENGER RNA, NON-coding RNA, DRUG target, DRUG resistance

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