Conserved patterns of transcriptional dysregulation, heterogeneity, and cell states in clear cell kidney cancer

Authors: Lombardi, Olivia ^{1, 7}, Li, Ran ^{1, 7}, Jabbar, Faiz ¹, Evans, Hannah ¹, Halim, Silvia ¹, Lima, Joanna D.C.C. ^{1, 4}, Browning, Lisa ², Byrne, Helen M. ^{3, 4}, Choudhry, Hani ⁵, Ratcliffe, Peter J. ^{4, 6}, Mole, David R. ^{1, 8, ∗}

Source: In Cell Reports 28 January 2025 44(1)

The Neoarchean, a turning point for geodynamic and magmatic processes within the Superior craton?

Authors: Mathieu, Lucie, Mole, David, Tóth, Zsuzsanna, Rubingh, Kate, Haugaard, Rasmus, White, Shawna, Ma, Chong, Frieman, Ben, Lodge, Robert, Sherlock, Ross

Source: Memoir. 220:43-54

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632572360&indx=1&recIds=ETOCRN632572360

Atypical hemolytic uremic syndrome in the era of terminal complement inhibition: an observational cohort study

Authors: Holt, Richard, Jones, Caroline, Ashman, Neil, Fan, Stanley, Forbes, Suzanne, Rajakariar, Ravindra, De Freitas, Declan, Magee, Colm, Hanko, Jennifer, Milford, David, Muorah, Mordi, Howie, Alexander J., Baharani, Jyoti, Dasgupta, Indranil, Roberts, Russell, MacDiarmaid-Gordon, Adam, Fry, Andrew, Torpey, Nicholas, Waldron, Mary, Awan, Atif, Raftery, Tara, Ratcliffe, Laura, Vilar, Enric, Newman, Joel, Seviar, Dale, Marks, Stephen D., Rees, Lesley, Veligratli, Faidra, Waters, Aoife, Chowdhury, Paramit, Pattison, James, Booth, Caroline, Williams, Nicole, Corbett, Richard, Amin, Beena, Pickering, Matthew, Bramham, Kate, Al-Hamed, Mohamed, Hill, Anita, Mooney, Andrew, Finlay, Eric, Newnham, Amanda, Yadav, Pallavi, Kaur, Amrit, Plant, Nicholas, Shenoy, Mohan, Choong, Lye Wai, Helps, Aileen, McLemon, Robert, Muniraju, Thalakunte, Khan, Izhar, Kidder, Dana, Padmanabhan, Neal, Cousland, Zoe, Price, Jonathan, Taylor, Alison, Jennings, Claudine, Ahmad, Sohail, Mead, Paul, Aslam, Mona, Bebb, Charlotte, Byrne, Catherine, Ferraro, Alastair, Christian, Martin, Evans, Jonathan, Kim, Jon Jin, Lunn, Andrew, Mallik, Meeta, Mason, Phil, Mole, David, Craze, Janet, Sangala, Nicholas, Uniacke, Mark, McGregor, Ellon, Lambie, Stewart, Bhandary, Nitin, Flossmann, Oliver, Mohteshamzadeh, Mobin, Abeyaratne, Asanga, Bingham, Coralie, Clissold, Rhian, Smyth, Lucy, Connolly, John, Reynolds, Ben, Neary, John, Bell, Joanne, Roxburgh, Sarah, Popoola, Joyce, Donne, Rosie, Fardon, Nicholas, Khwaja, Arif, Siddiqi, Shareen, Kumar, Gurinder, Kardasz, Steve, Moore, Iain, Tez, Didem, Willows, Jamie, Davison, Rachel, Harty, John, Wong, William, Williams, Andrew J., Gale, Daniel, Coward, Richard, Inward, Carol, Mraz, Martin, Ayub, Waqar, Short, Andrew, Lappin, David, Baines, Richard, Bommayya, Girish, Houlberg, Kris, Saif, Imran, Gilbert, Rodney, Griffin, Sian, Smith, Graham, Van Der Voort, Judith, Chandar, Jayanthi, Freundlich, Michael, McCarroll, Frank, Wong, Germaine, Laboi, Paul, Molyneux, Rebekah, Brocklebank, Vicky, Walsh, Patrick R., Smith-Jackson, Kate, Hallam, Thomas M., Marchbank, Kevin J., Wilson, Valerie, Bigirumurame, Theophile, Dutt, Tina, Montgomery, Emma K., Malina, Michal, Wong, Edwin K. S., Johnson, Sally, Sheerin, Neil S., Kavanagh, David

Source: In Blood 19 October 2023 142(16):1371-1386

Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature

Authors: Lombardi, Olivia, Li, Ran, Halim, Silvia, Choudhry, Hani, Ratcliffe, Peter J., Mole, David R.

Source: In Cell Reports 15 November 2022 41(7)

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers.

Authors: Goncalves, Tomas, Cunniffe, Siobhan, Ma, Tiffany S, Mattis, Natalie, Rose, Andrew W, Kent, Thomas, Mole, David R, Geiller, Helene E B, van Bijsterveldt, Linda, Humphrey, Timothy C, Hammond, Ester M, Gibbons, Richard J, Clynes, David, Rose, Anna M

Source: Nucleic Acids Research; 2/28/2025, Vol. 53 Issue 4, p1-23, 23p

Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus

Authors: Colli, Leandro M., Jessop, Lea, Myers, Timothy A., Camp, Sabrina Y., Machiela, Mitchell J., Choi, Jiyeon, Cunha, Renato, Onabajo, Olusegun, Mills, Grace C., Schmid, Virginia, Brodie, Seth A., Delattre, Olivier, Mole, David R., Purdue, Mark P., Yu, Kai, Brown, Kevin M., Chanock, Stephen J.

Source: In The American Journal of Human Genetics 2 September 2021 108(9):1590-1610

Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

Authors: Wing, Peter A.C., Liu, Peter Jianrui, Harris, James M., Magri, Andrea, Michler, Thomas, Zhuang, Xiaodong, Borrmann, Helene, Minisini, Rosalba, Frampton, Nicholas R., Wettengel, Jochen M., Mailly, Laurent, D’Arienzo, Valentina, Riedl, Tobias, Nobre, Luis, Weekes, Michael P., Pirisi, Mario, Heikenwalder, Mathias, Baumert, Thomas F., Hammond, Ester M., Mole, David R., Protzer, Ulrike, Balfe, Peter, McKeating, Jane A.

Source: In Journal of Hepatology July 2021 75(1):64-73

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI

Authors: Lauer, Victoria, Grampp, Steffen, Platt, James, Lafleur, Veronique, Lombardi, Olivia, Choudhry, Hani, Kranz, Franziska, Hartmann, Arndt ^**, Wullich, Bernd, Yamamoto, Atsushi, Coleman, Mathew L., Ratcliffe, Peter J., Mole, David R., Schödel, Johannes

Source: In Journal of Biological Chemistry 27 March 2020 295(13):4065-4078

Multidisciplinary study of a complex magmatic system: The Savannah Ni-Cu-Co Camp, Western Australia

Authors: Le Vaillant, Margaux, Barnes, Stephen J., Mole, David R., Fiorentini, Marco L., Laflamme, Crystal, Denyszyn, Steven W., Austin, James, Patterson, Ben, Godel, Belinda, Hicks, John, Mao, Ya-Jing, Neaud, Antoine

Source: In Ore Geology Reviews February 2020 117

Hf isotopic fingerprinting of geodynamic settings: Integrating isotopes and numerical models

Authors: Kohanpour, Fariba, Kirkland, Christopher L., Gorczyk, Weronika, Occhipinti, Sandra, Lindsay, Mark D., Mole, David, Le Vaillant, Margaux

Source: In Gondwana Research September 2019 73:190-199

The Archean Fortescue large igneous province: A result of komatiite contamination by a distinct Eo-Paleoarchean crust

Authors: Mole, David R., Barnes, Stephen J., Yao, Zhuosen, White, Alistair J.R., Maas, R., Kirkland, Christopher L.

Source: In Precambrian Research June 2018 310:365-390

Post-collisional alkaline magmatism as gateway for metal and sulfur enrichment of the continental lower crust

Authors: Fiorentini, Marco L., LaFlamme, Crystal, Denyszyn, Steven, Mole, David, Maas, Roland, Locmelis, Marek, Caruso, Stefano, Bui, Thi-Hao

Source: In Geochimica et Cosmochimica Acta 15 February 2018 223:175-197

A relic of the Mozambique Ocean in south-east Tanzania

Authors: Mole, David R., Barnes, Stephen J., Taylor, Richard J.M., Kinny, Peter D., Fritz, Harald

Source: In Precambrian Research February 2018 305:386-426

MITF controls the TCA cycle to modulate the melanoma hypoxia response

Authors: Louphrasitthiphol, Pakavarin, Ledaki, Ioanna, Chauhan, Jagat, Falletta, Paola, Siddaway, Robert, Buffa, Francesca M., Mole, David R., Soga, Tomoyoshi, Goding, Colin R.

Source: Pigment cell & melanoma research. 32(6):792-808

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090983523.0x000001&indx=1&recIds=ETOCvdc_100090983523.0x000001

Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma

Authors: Purshouse, Karin, Chamberlain, Sarah, Soares, Maria, Tuthill, Mark, Protheroe, Andrew, Mole, David

Source: BMC cancer. 19(1):1-6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190437102.0x000001&indx=1&recIds=ETOCvdc_100190437102.0x000001

Nickel-Copper Sulfide Mineralization in the Ntaka Hill Ultramafic Complex, Nachingwea Region, Tanzania

Authors: Barnes, Stephen J., Mole, David R., Hornsey, Richard, Schoneveld, Louise E.

Source: Economic geology and the bulletin of the Society of Economic Geologists. 114(6):1135-1158

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631874950&indx=1&recIds=ETOCRN631874950

Rapid mineralogical and geochemical characterisation of the Fisher East nickel sulphide prospects, Western Australia, using hyperspectral and pXRF data

Authors: Burley, Lauren L., Barnes, Stephen J., Laukamp, Carsten, Mole, David R., Le Vaillant, Margaux, Fiorentini, Marco L.

Source: In Ore Geology Reviews November 2017 90:371-387

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Authors: Jaakkola, Panu, Mole, David R., Tian, Ya-Min, Wilson, Michael I., Gielbert, Janine, Gaskell, Simon J., von Kriegsheim, Alexander, Hebestreit, Holger F., Mukherji, Mridul, Schofield, Christopher J., Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.

Source: Science, 2001 Apr . 292(5516), 468-472.

Access URL: https://www.jstor.org/stable/3082778

Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status

Authors: Messai, Yosra, Gad, Sophie, Noman, Muhammad Zaeem, Le Teuff, Gwenael, Couve, Sophie, Janji, Bassam, Kammerer, Solenne Florence, Rioux-Leclerc, Nathalie, Hasmim, Meriem, Ferlicot, Sophie, Baud, Véronique, Mejean, Arnaud, Mole, David Robert, Richard, Stéphane, Eggermont, Alexander M.M., Albiges, Laurence, Mami-Chouaib, Fathia, Escudier, Bernard, Chouaib, Salem

Source: In European Urology October 2016 70(4):623-632

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

Authors: Chan, Mun Chiang, Ilott, Nicholas E., Schödel, Johannes, Sims, David, Tumber, Anthony, Lippl, Kerstin, Mole, David R., Pugh, Christopher W., Ratcliffe, Peter J., Ponting, Chris P., Schofield, Christopher J.

Source: In Journal of Biological Chemistry September 2016 291(39):20661-20673