Hypothesizing glucagon-like peptide 1 (GLP-1), agonists promote hypodopaminergia, resulting in heightened addictive reward-seeking and altered mood: Breaking the bubble and adding salt to a wound

Authors: Blum, Kenneth ^{a, b, c, d, e, f, g, h, i, j, m, ⁎}, Dennen, Catherine A. ^{k, ⁎}, Lewandrowski, Kai-Uwe ^{l, m}, Sharafshah, Alireza ⁿ, Pinhasov, Albert ^h, Bowirrat, Abdalla ^h, Elman, Igor ^{h, o}, Cadet, Jean Lud ^p, Braverman, Eric R. ^g, Thanos, Panayotis K. ^q, Makale, Milan ^r, Baron, David ^{a, s}, Ashford, J.Wesson ^{t, u}, Fuehrlein, Brian ^v, Avena, Nicole ^w, Gardner, Eliot ^x, Badgaiyan, Rajendra D. ^y, Gondré—Lewis, Marjorie ^z, Modestino, Edward J. ^aa, Khalsa, Jag ^{ab, ac}, Murphy, Kevin T. ^{f, r}, Sunder, Keerthy ^{j, ad}, Foojan, Zeine ^ae, Jafari, Nicole ^af, Carney, Paul R. ^ag, Cortes, Rene ^ah, Edwards, Drew ^ai, Roy III, A.Kenison ^aj, Smith, David E. ^ak, Gold, Mark S. ^al

Source: In Medical Hypotheses May 2025 198

Dopaminergic dysfunction: Role for genetic & epigenetic testing in the new psychiatry

Authors: Blum, Kenneth, Ashford, J. Wesson, Kateb, Babak, Sipple, Daniel, Braverman, Eric, Dennen, Catherine A., Baron, David, Badgaiyan, Rajendra, Elman, Igor, Cadet, Jean Lud, Thanos, Panayotis K., Hanna, Colin, Bowirrat, Abdalla, Modestino, Edward J., Yamamoto, Vicky, Gupta, Ashim, McLaughlin, Thomas, Makale, Mlan, Gold, Mark S.

Source: In Journal of the Neurological Sciences 15 October 2023 453

Why haven't we solved the addiction crisis?

Authors: Blum, Kenneth, Bowirrat, Abdalla, Gomez, Luis Llanos, Downs, B. William, Bagchi, Debasis, Barh, Debmalya, Modestino, Edward J., Baron, David, McLaughlin, Thomas, Thanos, Panayotis, Ceccanti, Mauro, Elman, Igor, Badgaiyan, Rajendra D., Dennen, Catherine, Gupta, Ashim, Braverman, Eric R., Gold, Mark S.

Source: In Journal of the Neurological Sciences 15 November 2022 442

Genetic and Regulatory Mechanisms of Comorbidity of Anxiety, Depression and ADHD: A GWAS Meta-Meta-Analysis Through the Lens of a System Biological and Pharmacogenomic Perspective in 18.5 M Subjects.

Authors: Lewandrowski, Kai-Uwe, Blum, Kenneth, Sharafshah, Alireza, Thanos, Kyriaki Z., Thanos, Panayotis K., Zirath, Richa, Pinhasov, Albert, Bowirrat, Abdalla, Jafari, Nicole, Zeine, Foojan, Makale, Milan, Hanna, Colin, Baron, David, Elman, Igor, Modestino, Edward J., Badgaiyan, Rajendra D., Sunder, Keerthy, Murphy, Kevin T., Gupta, Ashim, Lewandrowski, Alex P. L.

Source: Journal of Personalized Medicine; Mar2025, Vol. 15 Issue 3, p103, 43p

Response to the SAMHSA Clinical Advisory: Considerations for Genetic Testing in the Assessment of Substance Use Disorder Risk.

Authors: Green, Richard Paul, Blum, Kenneth, Lewandrowski, Kai Uwe, Gold, Mark S, Lewandrowski, Alexander PL, Thanos, Panayotis K, Dennen, Catherine A, Baron, David, Elman, Igor, Sharafshah, Alireza, Modestino, Edward J, Badgaiyan, Rajendra D

Source: Substance Abuse & Rehabilitation; Jan2025, Vol. 16, p23-26, 4p

Exploration of Epigenetic State Hyperdopaminergia (Surfeit) and Genetic Trait Hypodopaminergia (Deficit) during Adolescent Brain Development

Authors: Blum, Kenneth, Bowirrat, Abdalla, Lewis, Marjorie C.G., Simpatico, Thomas A., Ceccanti, Mauro, Steinberg, Bruce, Modestino, Edward J., Thanos, Panayotis K., Baron, David, McLaughlin, Thomas, Brewer, Raymond, Badgaiyan, Rajendra D., Ponce, Jessica V., Lott, Lisa, Gold, Mark S.

Source: Current psychopharmacology. 10(3):181-196

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140378668.0x000001&indx=1&recIds=ETOCvdc_100140378668.0x000001

Epigenetic Repair of Terrifying Lucid Dreams by Enhanced Brain Reward Functional Connectivity and Induction of Dopaminergic Homeo - static Signaling

Authors: Blum, Kenneth, McLaughlin, Thomas, Modestino, Edward J., Baron, David, Bowirrat, Abdalla, Brewer, Raymond, Steinberg, Bruce, Roy, Alphonso K., Febo, Marcelo, Badgaiyan, Rajendra D., Gold, Marks S.

Source: Current psychopharmacology. 10(3):170-180

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140378665.0x000001&indx=1&recIds=ETOCvdc_100140378665.0x000001

Endorphinergic Enhancement Attenuation of Post-traumatic Stress Disorder (PTSD) via Activation of Neuro-immunological Function in the Face of a Viral Pandemic

Authors: Blum, Kenneth, Modestino, Edward J., Baron, David, Brewer, Raymond, Thanos, Panayotis, Elman, Igor, Badgaiyan, Rajendra D., Downs, B. William, Bagchi, Debasis, McLaughlin, Thomas, Bowirrat, Abdalla, Roy, A. Kenison, Gold, Mark S.

Source: Current psychopharmacology. 10(2):86-97

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129097779.0x000001&indx=1&recIds=ETOCvdc_100129097779.0x000001

Transmodulation of Dopaminergic Signaling to Mitigate Hypodopminergia and Pharmaceutical Opioid-induced Hyperalgesia

Authors: Brewer, Raymond, Blum, Kenneth, Bowirrat, Abdalla, Modestino, Edward J., Baron, David, Badgaiyan, Rajendra D., Moran, Mark, Boyett, Brent, Gold, Mark S.

Source: Current psychopharmacology. 9(3):164-184

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129157793.0x000001&indx=1&recIds=ETOCvdc_100129157793.0x000001

In Search of Reward Deficiency Syndrome (RDS)-Free Controls: The 'Holy Grail' in Genetic Addiction Risk Testing

Authors: Blum, Kenneth, Baron, David, Lott, Lisa, Ponce, Jessica V., Siwicki, David, Boyett, Brent, Steinberg, Bruce, Modestino, Edward J., Fried, Lyle, Hauser, Mary, Simpatico, Thomas, Downs, Bill W., McLaughlin, Thomas, Hajela, Raju, Badgaiyan, Rajendra D.

Source: Current psychopharmacology. 9(1):7-21

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129157924.0x000001&indx=1&recIds=ETOCvdc_100129157924.0x000001

Hypodopaminergia and 'Precision Behavioral Management' (PBM): It is a Generational Family Affair

Authors: Fried, Lyle, Modestino, Edward J., Siwicki, David, Lott, Lisa, Thanos, Panayotis K., Baron, David, Badgaiyan, Rajendra D., Ponce, Jessica V., Giordano, James, Downs, William B., Gondré-Lewis, Marjorie C., Bruce, Steinberg, Braverman, Eric R., Boyett, Brent, Blum, Kenneth

Source: Current pharmaceutical biotechnology. 21(6):528-541

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108190357.0x000001&indx=1&recIds=ETOCvdc_100108190357.0x000001

Putative COVID- 19 Induction of Reward Deficiency Syndrome (RDS) and Associated Behavioral Addictions with Potential Concomitant Dopamine Depletion: Is COVID-19 Social Distancing a Double Edged Sword?

Authors: Blum, Kenneth, Cadet, Jean Lud, Baron, David, Badgaiyan, Rajendra D., Brewer, Raymond, Modestino, Edward J., Gold, Mark S.

Source: Substance use & misuse. 55(14):2438-2442

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110756525.0x000001&indx=1&recIds=ETOCvdc_100110756525.0x000001

Hypothesizing Major Depression as a Subset of Reward Deficiency Syndrome (RDS) Linked to Polymorphic Reward Genes: Considerations for Translational Medicine Approaches for Future Drug Development

Authors: Blum, Kenneth, Gold, Mark S., Modestino, Edward J., Elman, Igor, Baron, David, Badgaiyan, Rajendra D., Bowirrat, Abdalla

Source: Handbook of behavioral neuroscience. 29:419-426

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620739375&indx=1&recIds=ETOCRN620739375

A Systematic, Intensive Statistical Investigation of Data from the Comprehensive Analysis of Reported Drugs (CARD) for Compliance and Illicit Opioid Abstinence in Substance Addiction Treatment with Buprenorphine/naloxone

Authors: Blum, Kenneth, Han, David, Modestino, Edward J., Saunders, Scott, Roy, A. Kennison, Jacobs, W., Inaba, Darryl S., Baron, David, Oscar-Berman, Marlene, Hauser, Mary, Badgaiyan, Rajendra D., Smith, David E., Femino, John, Gold, Mark S.

Source: Substance use & misuse. 53(2):220-229

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105370214.0x000001&indx=1&recIds=ETOCvdc_100105370214.0x000001

Neurophenomenology of an Altered State of Consciousness: An fMRI Case Study

Authors: Modestino, Edward J.

Source: In Explore: The Journal of Science and Healing March-April 2016 12(2):128-135

The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer's in Aging African-Americans

Authors: Blum, Kenneth, Badgaiyan, Rajendra D., Dunston, Georgia M., Baron, David, Modestino, Edward J., McLaughlin, Thomas, Steinberg, Bruce, Gold, Mark S., Gondré-Lewis, Marjorie C.

Source: Molecular neurobiology. 55(7):5526-5536

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128584290.0x000001&indx=1&recIds=ETOCvdc_100128584290.0x000001

Decreased cortical activation in response to a motion stimulus in anisometropic amblyopic eyes using functional magnetic resonance imaging

Authors: Bonhomme, Gabrielle R., Liu, Grant T., Miki, Atsushi, Francis, Ellie, Dobre, M.-C., Modestino, Edward J., Aleman, David O., Haselgrove, John C.

Source: In Journal of AAPOS 2006 10(6):540-546

Side-of-onset of Parkinson's disease in relation to neuropsychological measures.

Authors: Modestino, Edward J.¹ edward.modestino@gmail.com, Amenechi, Chioma¹, Reinhofer, AnnaMarie¹, O'Toole, Patrick¹

Source: Brain & Behavior. Jan2017, Vol. 7 Issue 1, pn/a-N.PAG. 6p.

Subject Terms: *BRAIN diseases, *EXTRAPYRAMIDAL disorders, *PARKINSONIAN disorders, *DOPAMINERGIC neurons

Chapter 30 - Hypothesizing Major Depression as a Subset of Reward Deficiency Syndrome (RDS) Linked to Polymorphic Reward Genes: Considerations for Translational Medicine Approaches for Future Drug Development

Authors: Blum, Kenneth ^{*, **}, Gold, Mark S., Modestino, Edward J., Elman, Igor, Baron, David ^*, Badgaiyan, Rajendra D., Bowirrat, Abdalla ^***

Source: In Handbook of Behavioral Neuroscience 2019 29:419-426

A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing "Precision Behavioral Management".

Authors: Blum, Kenneth, Steinberg, Bruce, Gondre-Lewis, Marjorie C, Baron, David, Modestino, Edward J, Badgaiyan, Rajendra D, Downs, B William, Bagchi, Debasis, Brewer, Raymond, McLaughlin, Thomas, Bowirrat, Abdalla, Gold, Mark

Source: Psychology Research & Behavior Management; Dec2021, Vol. 14, p2115-2134, 20p