CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study.

Authors: Silhavy, Jan¹ (AUTHOR) jan.silhavy@fgu.cas.cz, Mlejnek, Petr¹ (AUTHOR), Šimáková, Miroslava¹ (AUTHOR), Marková, Irena² (AUTHOR), Malínská, Hana² (AUTHOR), Hüttl, Martina² (AUTHOR), Kazdová, Ludmila² (AUTHOR), Kazantsev, Dmitry^3,4 (AUTHOR), Mancini, Massimiliano⁵ (AUTHOR), Novotný, Jiří³ (AUTHOR), Pravenec, Michal¹ (AUTHOR)

Source: PLoS ONE. 4/13/2023, Vol. 18 Issue 4, p1-11. 11p.

Subject Terms: *BROWN adipose tissue, *GLYCOGEN synthase kinase, *LIPIDS, *LABORATORY rats, *HYPERTENSION, *IN vitro studies

What Is the Significance of Lysosomal-Mediated Resistance to Imatinib?

Authors: Mlejnek, Petr¹ (AUTHOR) mlejnek_petr@volny.cz

Source: Cells (2073-4409). Mar2023, Vol. 12 Issue 5, p709. 15p.

Subject Terms: *NILOTINIB, *DRUG accessibility, *IMATINIB, *CHRONIC myeloid leukemia, *GASTROINTESTINAL stromal tumors, *DRUG bioavailability

Hemodynamic Mechanisms Initiating Salt-Sensitive Hypertension in Rat Model of Primary Aldosteronism.

Authors: PRAVENEC, Michal, MLEJNEK, Petr, ŠIMÁKOVÁ, Miroslava, ŠILHAVÝ, Jan

Source: Physiological Research; 2024 Supplement, Vol. 73, pS365-S376, 12p

Subject Terms: HYPERTENSION, LABORATORY rats, HEMODYNAMICS, HUMAN physiology, BLOOD pressure, HYPERALDOSTERONISM, NEPHRECTOMY, VASCULAR resistance, ANIMAL models in research, CARDIAC output

Estimation of ABCB1 concentration in plasma membrane

Authors: Mlejnek, Petr, Kosztyu, Petr, Dolezel, Petr, Kimura, Yasuhisa, Cizkova, Katerina, Ruzickova, Eliska

Source: Journal of cellular biochemistry. 120(10):18406-18414

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123672198.0x000001&indx=1&recIds=ETOCvdc_100123672198.0x000001

Transgenic rescue approach ameliorates ATP synthase deficiency caused by the dysfunction of TMEM70 assembly factor in rat

Authors: Alán, Lukáš, Marković, Aleksandra, Tauchmannová, Kateřina, Šimáková, Miroslava, Mlejnek, Petr, Kaplanová, Vilma, Pecina, Petr, Pecinová, Alena, Šilhavý, Jan, Houštěk, Josef, Pravenec, Michal, Mráček, Tomáš

Source: Biochimica et biophysica acta. 1863(S)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168839880.0x000001&indx=1&recIds=ETOCvdc_100168839880.0x000001

Reversal of ABCB1 mediated efflux by imatinib and nilotinib in cells expressing various transporter levels

Authors: Mlejnek, Petr, Kosztyu, Petr, Dolezel, Petr, Bates, Susan E., Ruzickova, Eliska

Source: In Chemico-Biological Interactions 1 August 2017 273:171-179

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Lysosomal-mediated drug resistance – Fact or illusion?

Authors: Mlejnek, Petr

Source: In Pharmacological Research January 2024 199

Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat.

Authors: Silhavy, Jan¹, Mlejnek, Petr¹, Simáková, Miroslava¹, Liška, František^1,2, Malínská, Hana³, Marková, Irena³, H€uttl, Martina³, Miklánková, Denisa³, Mušálková, Dita⁴, Stránecky, Viktor⁴, Kmoch, Stanislav⁴, Sticová, Eva^3,5, Vrbacky, Marek¹, Mrácek, Tomáš¹, Pravenec, Michal^1,2 Michal.Pravenec@fgu.cas.cz

Source: Physiological Genomics. Jan2024, Vol. 56 Issue 1, p65-73. 9p.

Subject Terms: *NONSENSE mutation, *LIPID metabolism, *GLUCOSE metabolism, *RATTUS norvegicus, *PROTEOMICS, *COAT proteins (Viruses), *PROTEOLYSIS, *INSULIN

Loss of mitochondrial transmembrane potential and glutathione depletion are not sufficient to account for induction of apoptosis by carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone in human leukemia K562 cells

Authors: Mlejnek, Petr, Dolezel, Petr

Source: In Chemico-Biological Interactions 5 September 2015 239:100-110

Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat

Authors: Liška, František, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Strnad, Hynek, Trnovská, Jaroslava, Škop, Vojtěch, Kazdová, Ludmila, Starker, Colby G., Voytas, Daniel F., Izsvák, Zsuzsanna, Mancini, Massimiliano, Šeda, Ondřej, Křen, Vladimír, Pravenec, Michal

Source: Hypertension. 69(6):1084-1091

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100044175140.0x000001&indx=1&recIds=ETOCvdc_100044175140.0x000001

N-acetylcysteine prevents the geldanamycin cytotoxicity by forming geldanamycin–N-acetylcysteine adduct

Authors: Mlejnek, Petr, Dolezel, Petr

Source: In Chemico-Biological Interactions 5 September 2014 220:248-254

Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 in human leukemia cells

Authors: Kosztyu, Petr, Bukvova, Romana, Dolezel, Petr, Mlejnek, Petr

Source: In Chemico-Biological Interactions 5 August 2014 219:203-210

Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome

Authors: Pravenec, Michal, Kožich, Viktor, Krijt, Jakub, Sokolová, Jitka, Zídek, Václav, Landa, Vladimír, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Škop, Vojtěch, Trnovská, Jaroslava, Kazdová, Ludmila, Kajiya, Takashi, Wang, Jiaming, Kurtz, Theodore W.

Source: Hypertension. 67(2):335-341

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100036769982.0x000001&indx=1&recIds=ETOCvdc_100036769982.0x000001

Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat.

Authors: Šilhavý, Jan, Mlejnek, Petr, Šimáková, Miroslava, Liška, František, Malínská, Hana, Marková, Irena, Hüttl, Martina, Miklánková, Denisa, Mušálková, Dita, Stránecký, Viktor, Kmoch, Stanislav, Sticová, Eva, Vrbacký, Marek, Mráček, Tomáš, Pravenec, Michal

Source: Physiological Genomics; Dec2023, Vol. 55 Issue 12, p65-73, 9p

Subject Terms: NONSENSE mutation, LIPID metabolism, GLUCOSE metabolism, RATTUS norvegicus, PROTEOMICS, COAT proteins (Viruses), PROTEOLYSIS, INSULIN

Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.

Authors: Senko, Anna N.^1,2, Overall, Rupert W.^1,2, Silhavy, Jan³, Mlejnek, Petr³, Malínská, Hana⁴, Hüttl, Martina⁴, Marková, Irena⁴, Fabel, Klaus S.^1,2, Lu, Lu⁵, Stuchlik, Ales³, Williams, Robert W.⁵, Pravenec, Michal³, Kempermann, Gerd^1,2, gerd.kempermann@dzne.de

Source: PLoS Genetics; 4/4/2022, Vol. 18 Issue 4, p1-35, 35p

Can P-glycoprotein mediate resistance to nilotinib in human leukaemia cells?

Authors: Kosztyu, Petr, Dolezel, Petr, Mlejnek, Petr

Source: In Pharmacological Research January 2013 67(1):79-83

A non-radioactive assay for precise determination of intracellular levels of imatinib and its main metabolite in Bcr-Abl positive cells

Authors: Mlejnek, Petr, Novak, Ondrej, Dolezel, Petr

Source: In Talanta 15 February 2011 83(5):1466-1471

Assay for determination of daunorubicin in cancer cells with multidrug resistance phenotype

Authors: Krumpochova, Petra, Kocurova, Andrea, Dolezel, Petr, Mlejnek, Petr

Source: In Journal of Chromatography B 2011 879(21):1875-1880

High cysteine diet reduces insulin resistance in SHR-CRP rats

Authors: Krijt, Jakub, Sokolová, Jitka, Šilhavý, Jan, Mlejnek, Petr, Kubovčiak, Jan, Liška, František, Malínská, Hana, Hüttl, Martina, Marková, Irena, Křížková, Michaela, Stipanuk, Martha H., Křížek, Tomáš, Ditroi, Tamas, Nagy, Peter, Kožich, Viktor, Pravenec, Michal

Source: Physiological research | 2021 Volume:70 | Number:5

Availability: http://data.europeana.eu/aggregation/europeana/336/uuid_8adae948_9616_483d_b60b_e582af88897d