Individual use of self-medication and other remedies in COVID-19 outpatients in Western-Pomerania

Authors: Svea Stüdemann, Eik Schäfer, Klaus Hahnenkamp, Mladen V. Tzvetkov, Stefan Engeli

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)

Subject Terms: COVID-19, Outpatients, Self-medication, OTC, Herbal remedies, Phytopharmaceuticals, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/830b1efe90234eaab8df62d5e4dc9413

Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents

Authors: Céline Tolksdorf, Andrea Seidel, Christian Baume, Eileen Moritz, Karen Saljé, Kathrin Lehmann, Karsten Becker, Ulrike Garscha, Thomas Thiele, Edzard Schwedhelm, Mirjam von Lucadou, Mladen V. Tzvetkov, Stefan Engeli, Gabriele Jedlitschky, Bernhard H. Rauch

Source: Platelets, Vol 35, Iss 1 (2024)

Subject Terms: COVID-19, MRP4, platelet activation, S1P, viral infection, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/29ead04519cb4821897fc2cf247ef46a

Exopeptidase combination enhances the degradation of isotopically labelled gluten immunogenic peptides in humans

Authors: Sulayman Mourabit, Sarah Römer, Erin R. Bonner, Fabian Winter, Julian Tschollar, Mladen V. Tzvetkov, Werner Weitschies, Stefan Engeli, Werner Tschollar

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: gluten, gluten immunogenic peptide, celiac disease, exopeptidase, glutenase, 33-mer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1425982/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/bde4e3f06cc24660b833ea9a15c69414

Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro

Authors: Andreas Nitsch, Sara Qarqash, Sarah Römer, Janosch Schoon, Debora Singer, Sander Bekeschus, Axel Ekkernkamp, Georgi I. Wassilew, Mladen V. Tzvetkov, Lyubomir Haralambiev

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Ewing sarcoma, Chemotherapy, Cold physical plasma, Methotrexate, Cisplatin, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f729aa8b685c4c438613682b69dddb8e

Course of disease and risk factors for hospitalization in outpatients with a SARS-CoV-2 infection

Authors: Eik Schäfer, Christian Scheer, Karen Saljé, Anja Fritz, Thomas Kohlmann, Nils-Olaf Hübner, Matthias Napp, Lizon Fiedler-Lacombe, Dana Stahl, Bernhard Rauch, Matthias Nauck, Uwe Völker, Stephan Felix, Guglielmo Lucchese, Agnes Flöel, Stefan Engeli, Wolfgang Hoffmann, Klaus Hahnenkamp, Mladen V. Tzvetkov

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3e45487736134bfb8db8879a75557477

Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells

Authors: Angelique Kragl, Janosch Schoon, Ana Tzvetkova, Christoph Wenzel, Martina Blaschke, Wolfgang Böcker, Heide Siggelkow, Mladen V. Tzvetkov

Source: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Subject Terms: 11β-HSD1, osteoporosis, glucocorticoids, CRISPR-Cas9, targeted chromosomal integration, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2022.953034/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/852deb572432487f84929e57f03d2a56

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets

Authors: Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V. Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky

Source: Haematologica, Vol 107, Iss 9 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10571; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/a5ae591cc6e54628a9ab1ad72836b4fe

OCT1 Polyspecificity—Friend or Foe?

Authors: Marleen J. Meyer, Mladen V. Tzvetkov

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: OCT1, SLC22A1, polyspecificity, structure-to-function relationship, ligand-transporter interaction, species differences, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.698153/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/38f673a96218470bb67292ff2bfd41a8

Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

Authors: Ole Jensen, Johannes Matthaei, Henry G. Klemp, Marleen J. Meyer, Jürgen Brockmöller, Mladen V. Tzvetkov

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: OCT1, SLC22A1 (OCT1), isobutyrylcarnitine, efflux, organic cation transporter, carnitine, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.674559/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/133a118e41ef48d29319fcc36a20268a

Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

Authors: Sarah Römer, Marleen J. Meyer, Kathrin Klein, Lennart V. Schneider, Johannes Matthaei, Ana Tzvetkova, Joanna Łapczuk-Romańska, Jochen Gaedcke, Marek Droździk, Jürgen Brockmöller, Anne T. Nies, Mladen V. Tzvetkov

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: ins/del variant, organic cation transporter 1, SLC22A1, minigene, allelic expression imbalance (AEI), fenoterol, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.661480/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/830b00b369d741069648215b61af6c25

The Effect of Capsule-in-Capsule Combinations on In Vivo Disintegration in Human Volunteers: A Combined Imaging and Salivary Tracer Study

Authors: Adrian Rump, Franziska N. Weiss, Louisa Schulz, Marie-Luise Kromrey, Eberhard Scheuch, Mladen V. Tzvetkov, Tyler White, Shane Durkee, Kevin W. Judge, Vincent Jannin, Aouatef Bellamine, Werner Weitschies, Michael Grimm

Source: Pharmaceutics, Vol 13, Iss 12, p 2002 (2021)

Subject Terms: MRI, salivary tracer, DUOCAP®, capsule-in-capsule, HPMC, in vivo disintegration, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/12/2002; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/23bb7f9e40bd4f1ca17bc2316b3eb792

Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A

Authors: Muhammad Rafehi, Frank Faltraco, Johannes Matthaei, Thomas Prukop, Ole Jensen, Aileen Grytzmann, Felix G. Blome, Ralf Günter Berger, Ulrich Krings, Stefan V. Vormfelde, Mladen V. Tzvetkov, Jürgen Brockmöller

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: biogenic amine, CYP2D6, MAO, monoamine oxidase, OCT1, pressor response, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.01297/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/f55790e222414a8e9795d76df9fa1ea9

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

Authors: Johannes Matthaei, Mladen V. Tzvetkov, Valerie Gal, Cordula Sachse-Seeboth, Daniel Sehrt, Jakob B. Hjelmborg, Ute Hofmann, Matthias Schwab, Reinhold Kerb, Jürgen Brockmöller

Source: Genome Medicine, Vol 8, Iss 1, Pp 1-12 (2016)

Subject Terms: Talinolol, MDR1, P-glycoprotein, ABCB1, MDR5, MRP2, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-016-0372-2; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/5077177727214b0b85b2ff38ab65f715

Effects of Single Nucleotide Polymorphism Ala270Ser (rs316019) on the Function and Regulation of hOCT2

Authors: Dominik Frenzel, Christina Köppen, Oliver Bolle Bauer, Uwe Karst, Rita Schröter, Mladen V. Tzvetkov, Giuliano Ciarimboli

Source: Biomolecules, Vol 9, Iss 10, p 578 (2019)

Subject Terms: organic cation transporter 2, single nucleotide polymorphism, cisplatin, nephrotoxicity, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/9/10/578; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/9b0ec03de8d54c9e91e6e8224a8df51b

Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1

Authors: Marleen J Meyer (Department of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald), Pascale C F Schreier (Department of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald), Mert Basaran (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Stefaniia Vlasova (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Tina Seitz (Institute of Clinical Pharmacology, University Medical Center Göttingen), Jürgen Brockmöller (Institute of Clinical Pharmacology, University Medical Center Göttingen), Barbara Zdrazil (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Mladen V Tzvetkov (Department of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_1664303

Genome-wide single-nucleotide polymorphism arrays demonstrate high fidelity of multiple displacement-based whole-genome amplification.

Authors: Mladen V. Tzvetkov, Christian Becker, Bettina Kulle, Peter Nürnberg, Jürgen Brockmöller, Leszek Wojnowski

Source: Electrophoresis; Feb2005, Vol. 26 Issue 3, p710-715, 6p

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