GPR68 supports AML cells through the calcium/calcineurin pro-survival pathway and confers chemoresistance by mediating glucose metabolic symbiosis

Authors: He, Xiaofei, Hawkins, Caleb, Lawley, Lauren, Phan, Tra Mi, Park, Isaac, Joven, Nicole, Zhang, Jiajia, Wunderlich, Mark, Mizukawa, Benjamin, Pei, Shanshan, Patel, Amisha, VanOudenhove, Jennifer, Halene, Stephanie, Fang, Jing

Source: In BBA - Molecular Basis of Disease January 2025 1871(1)

SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

Authors: Chang, Yu-Hsuan ^{1, 2}, Yamamoto, Keita ¹, Fujino, Takeshi ¹, Wang, Teh-Wei ³, Sugimoto, Emi ¹, Zhang, Wenyu ¹, Yabushita, Tomohiro ², Suzaki, Ken ¹, Pietsch, E. Christine ⁴, Weir, Barbara A. ⁵, Crescenzo, Ramona ⁶, Cowley, Glenn S. ⁴, Attar, Ricardo ⁴, Philippar, Ulrike ⁶, Wunderlich, Mark ⁷, Mizukawa, Benjamin ⁷, Zheng, Yi ⁷, Enomoto, Yutaka ², Imai, Yoichi ⁸, Kitamura, Toshio ^{2, 9}, Goyama, Susumu ^{1, 10, ∗}

Source: In Cell Reports 27 August 2024 43(8)

Hyperdiploid Precursor B-acute Lymphoblastic Leukemia Presenting as a Cavernous Sinus Mass in a 4-Year-old Male

Authors: Sabulski, Anthony, Bartlett, Allison L., Koch, Bernadette L., Vatner, Ralph, Mizukawa, Benjamin, Phillips, Christine L.

Source: Journal of pediatric hematology/oncology. 43(4):e494-e497

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181810116.0x000001&indx=1&recIds=ETOCvdc_100181810116.0x000001

Cyclosporine enhances the sensitivity to lenalidomide in MDS/AML in vitro

Authors: He, Xiaofei, Dou, Aixia, Feng, Saran, Roman-Rivera, Ashley, Hawkins, Caleb, Lawley, Lauren, Zhang, Jiajia, Wunderlich, Mark, Mizukawa, Benjamin, Halene, Stephanie, Patel, Amisha, Fang, Jing

Source: In Experimental Hematology June 2020 86:21-27

Use of gemcitabine, oxaliplatin, and anti‐CD20 therapy in children and adolescents with non‐Hodgkin lymphoma unfit for intensive therapy

Authors: Bender, Jonathan D., Rubinstein, Jeremy D., Mizukawa, Benjamin, Perentesis, John P., Pommert, Lauren

Source: Pediatric blood & cancer. 70(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177930408.0x000001&indx=1&recIds=ETOCvdc_100177930408.0x000001

IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

Authors: Liu, Xiaoxiao, Sato, Naru, Yabushita, Tomohiro, Li, Jingmei, Jia, Yuhan, Tamura, Moe, Asada, Shuhei, Fujino, Takeshi, Fukushima, Tsuyoshi, Yonezawa, Taishi, Tanaka, Yosuke, Fukuyama, Tomofusa, Tsuchiya, Akiho, Shikata, Shiori, Iwamura, Hiroyuki, Kinouchi, Chieko, Komatsu, Kensuke, Yamasaki, Satoshi, Shibata, Tatsuhiro, Sasaki, Atsuo T, Schibler, Janet, Wunderlich, Mark, O'Brien, Eric, Mizukawa, Benjamin, Mulloy, James C, Sugiura, Yuki, Takizawa, Hitoshi, Shibata, Takuma, Miyake, Kensuke, Kitamura, Toshio, Goyama, Susumu

Source: EMBO molecular medicine. 15(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170734409.0x000001&indx=1&recIds=ETOCvdc_100170734409.0x000001

Clinical outcomes of hypomethylating agents and venetoclax in newly diagnosed unfit and relapsed/refractory paediatric, adolescent and young adult acute myeloid leukaemia patients.

Authors: LeBlanc, Francis R., Breese, Erin H., Burns, Karen C., Chang, Ellen K., Jones, LaQuita M., Lee, Lynn, Mizukawa, Benjamin, Norris, Robin E., O'Brien, Maureen M., Phillips, Christine L., Perentesis, John P., Rubinstein, Jeremy, Pommert, Lauren

Source: British Journal of Haematology; Sep2024, Vol. 205 Issue 3, p1055-1066, 12p

Subject Terms: HEMATOPOIETIC stem cell transplantation, ACUTE myeloid leukemia, YOUNG adults, DISEASE relapse, CHILDREN'S hospitals

Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

Authors: Hayashi, Yasutaka, Goyama, Susumu, Liu, XiaoXiao, Tamura, Moe, Asada, Shuhei, Tanaka, Yosuke, Fukuyama, Tomofusa, Wunderlich, Mark, O'Brien, Eric, Mizukawa, Benjamin, Yamazaki, Satoshi, Matsumoto, Akiko, Yamasaki, Satoshi, Shibata, Tatsuhiro, Matsuda, Koichi, Sashida, Goro, Takizawa, Hitoshi, Kitamura, Toshio

Source: Nature communications. 10(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190869184.0x000001&indx=1&recIds=ETOCvdc_100190869184.0x000001

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation

Authors: Mizukawa, Benjamin, O'Brien, Eric, Moreira, Daniel C., Wunderlich, Mark, Hochstetler, Cindy L., Duan, Xin, Liu, Wei, Orr, Emily, Grimes, H.Leighton, Mulloy, James C., Zheng, Yi

Source: In Blood 14 September 2017 130(11):1336-1346

Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells

Authors: Mizukawa, Benjamin, O Brien, Eric, Mulloy, James C., Zheng, Yi

Source: Methods in molecular biology. 1821:257-266

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN616896233&indx=1&recIds=ETOCRN616896233

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells

Authors: Du, Wei, Liu, Wei, Mizukawa, Benjamin, Shang, Xun, Sipple, Jared, Wunderlich, Mark, Geiger, Hartmut, Davies, Stella, Mulloy, James, Pang, Qishen, Zheng, Yi

Source: Leukemia. 32(9):2041-2046

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179710577.0x000001&indx=1&recIds=ETOCvdc_100179710577.0x000001

Treatment of posttransplant lymphoproliferative disorder with poor prognostic features in children and young adults: Short‐course EPOCH regimens are safe and effective

Authors: Rubinstein, Jeremy D., Shah, Rachana, Breese, Erin H., Burns, Karen C., Mangino, Jennifer L., Norris, Robin E., Lee, Lynn, Mizukawa, Benjamin, O'Brien, Maureen M., Phillips, Christine L., Perentesis, John P., Pommert, Lauren, Absalon, Michael J.

Source: Pediatric blood & cancer. 68(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138994886.0x000001&indx=1&recIds=ETOCvdc_100138994886.0x000001

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

Authors: Sheng, Yue, Yu, Chunjie, Liu, Yin, Hu, Chao, Ma, Rui, Lu, Xinyan, Ji, Peng, Chen, Jianjun, Mizukawa, Benjamin, Huang, Yong, Licht, Jonathan D., Qian, Zhijian

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164048710.0x000001&indx=1&recIds=ETOCvdc_100164048710.0x000001

AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model

Authors: Wunderlich, Mark, Mizukawa, Benjamin, Chou, Fu-Sheng, Sexton, Christina, Shrestha, Mahesh, Saunthararajah, Yogen, Mulloy, James C.

Source: In Blood 21 March 2013 121(12):e90-e97

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO

Authors: Chou, Fu-Sheng, Griesinger, Andrea ^*, Wunderlich, Mark ^*, Lin, Shan, Link, Kevin A., Shrestha, Mahesh, Goyama, Susumu, Mizukawa, Benjamin, Shen, Shuhong, Marcucci, Guido, Mulloy, James C.

Source: In Blood 26 July 2012 120(4):709-719

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

Authors: Mizukawa, Benjamin, Wei, Junping, Shrestha, Mahesh, Wunderlich, Mark, Chou, Fu-Sheng, Griesinger, Andrea, Harris, Chad E., Kumar, Ashish R., Zheng, Yi, Williams, David A., Mulloy, James C. ^*

Source: In Blood 10 November 2011 118(19):5235-5245

V2 Trial: A phase I study of venetoclax and CPX-351 for young patients with relapsed/refractory acute leukemia.

Authors: Agresta, Laura, O'Brien, Maureen Megan, O'Brien, Eric Justin, Norris, Robin Elizabeth, Breese, Erin Haag, Burns, Karen Cristly, Mizukawa, Benjamin, Ryan, Thomas D, Desai, Pankaj B, Vinks, A.a., Grimes, H. Leighton, Absalon, Michael, Perentesis, John Peter

Source: Journal of clinical oncology. 39(15 suppl):TPS7052-TPS7052

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173215212.0x000001&indx=1&recIds=ETOCvdc_100173215212.0x000001

Multicenter Analysis of Genomically Targeted Single Patient Use Requests for Pediatric Neoplasms.

Authors: Sabnis, Himalee S, Shulman, David S, Mizukawa, Benjamin, Bouvier, Nancy, Zehir, Ahmet, Fangusaro, Jason, Fabrizio, Vanessa A, Whitlow, Chanta, Winchester, Marilyn, Agresta, Laura, Turpin, Brian, Wechsler, Daniel S, DuBois, Steven G, Glade-Bender, Julia, Castellino, Sharon M, Shukla, Neerav

Source: Journal of Clinical Oncology; 12/1/2021, Vol. 39 Issue 34, p3822-3828, 7p

Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia

Authors: Hegde, Shailaja, Gasilina, Anjelika, Wunderlich, Mark, Lin, Yuan, Buchholzer, Marcel, Krumbach, Oliver H. F., Akbarzadeh, Mohammad, Ahmadian, Mohammad Reza, Seibel, William, Zheng, Yi, Perentesis, John P., Mizukawa, Benjamin E., Vinnedge, Lisa Privette, Cancelas, José A., Nassar, Nicolas N.

Source: Leukemia; March 2022, Vol. 36 Issue: 3 p637-647, 11p

PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia.

Authors: Wunderlich, Mark, Manning, Nicole, Sexton, Christina, O'Brien, Eric, Byerly, Luke, Stillwell, Cody, Perentesis, John P., Mulloy, James C., Mizukawa, Benjamin

Source: Frontiers in Oncology; 4/13/2021, Vol. 11, pN.PAG-N.PAG, 7p

Subject Terms: PEMBROLIZUMAB, LYMPHOBLASTIC leukemia, ACUTE leukemia, CORD blood, PROGRAMMED cell death 1 receptors, YOUNG adults, SNAKEBITES