Weight cycling exacerbates glucose intolerance and hepatic triglyceride storage in mice with a history of chronic high fat diet exposure

Authors: Miriam Bernecker, Anna Lin, Annette Feuchtinger, Anna Molenaar, Sonja C. Schriever, Paul T. Pfluger

Source: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-15 (2025)

Subject Terms: Weight cycling, Yoyo dieting, Weight loss, Obesity, Insulin resistance, Obesogenic memory, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/b7df6f9af5af4ef1904695fbb619f09b

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice

Authors: Raian E. Contreras, Tim Gruber, Ismael González-García, Sonja C. Schriever, Meri De Angelis, Noemi Mallet, Miriam Bernecker, Beata Legutko, Dhiraj Kabra, Mathias Schmidt, Matthias H. Tschöp, Ruth Gutierrez-Aguilar, Jane Mellor, Cristina García-Cáceres, Paul T. Pfluger

Source: Molecular Metabolism, Vol 90, Iss , Pp 102033- (2024)

Subject Terms: Adult-onset obesity, Dopamine, Hypothalamus, Brown fat thermogenesis, Histone deacetylase 5, Futile ATP-consuming cycles, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877824001649; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/89b3b5348a5c4a20ab8e96a7a643232f

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

Authors: Christin Krause, Jan H Britsemmer, Miriam Bernecker, Anna Molenaar, Natalie Taege, Nuria Lopez-Alcantara, Cathleen Geißler, Meike Kaehler, Katharina Iben, Anna Judycka, Jonas Wagner, Stefan Wolter, Oliver Mann, Paul Pfluger, Ingolf Cascorbi, Hendrik Lehnert, Kerstin Stemmer, Sonja C Schriever, Henriette Kirchner

Source: eLife, Vol 12 (2024)

Subject Terms: microRNA, liver, human, type 2 diabetes, obesity, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/92075; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/61a65780677c4d41af349194722f905a

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Authors: Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller

Source: Molecular Metabolism, Vol 83, Iss , Pp 101915- (2024)

Subject Terms: Obesity, Type 2 diabetes, GIP, GLP-1, GIPR:GLP-1R co-agonism, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877824000462; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/4df457ac59ce49e8af09680efdd590e2

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

Authors: Aaron Novikoff, Shannon L. O'Brien, Miriam Bernecker, Gerald Grandl, Maximilian Kleinert, Patrick J. Knerr, Kerstin Stemmer, Martin Klingenspor, Anja Zeigerer, Richard DiMarchi, Matthias H. Tschöp, Brian Finan, Davide Calebiro, Timo D. Müller

Source: Molecular Metabolism, Vol 49, Iss , Pp 101181- (2021)

Subject Terms: GLP-1R, GIPR, Biased agonism, Receptor Internalization, Receptor Trafficking, Dual-agonists, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877821000211; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/3747ffadfcfc4ababd52d92c0564e71b

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