Generation of murine tumor models refractory to αPD-1/-L1 therapies due to defects in antigen processing/presentation or IFNγ signaling using CRISPR/Cas9.

Authors: Chariou, Paul L.¹ (AUTHOR), Minnar, Christine M.¹ (AUTHOR), Tandon, Mayank^2,3 (AUTHOR), Guest, Mary R.⁴ (AUTHOR), Chari, Raj⁴ (AUTHOR), Schlom, Jeffrey¹ (AUTHOR) schlomj@mail.nih.gov, Gameiro, Sofia R.¹ (AUTHOR)

Source: PLoS ONE. 3/1/2024, Vol. 19 Issue 2, p1-22. 22p.

Subject Terms: *ANTIGEN processing, *CRISPRS, *DELETION mutation, *TUMOR antigens, *IMMUNE checkpoint proteins

Exploiting an Interleukin-15 Heterodimeric Agonist (N803) for Effective Immunotherapy of Solid Malignancies.

Authors: Lui, Grace¹ (AUTHOR) grace.lui@nih.gov, Minnar, Christine M.¹ (AUTHOR) christine.minnar@nih.gov, Soon-Shiong, Patrick² (AUTHOR) pss@nantworks.com, Schlom, Jeffrey¹ (AUTHOR) schlomj@mail.nih.gov, Gameiro, Sofia R.¹ (AUTHOR)

Source: Cells (2073-4409). Jun2023, Vol. 12 Issue 12, p1611. 15p.

Subject Terms: *INTERLEUKIN-15, *IMMUNE checkpoint inhibitors, *PROGRAMMED cell death 1 receptors, *NON-small-cell lung carcinoma, *IMMUNOTHERAPY, *T cells

Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients.

Authors: Collins, Craig P., Khuat, Lam T., Sckisel, Gail D., Vick, Logan V., Minnar, Christine M., Dunai, Cordelia, Le, Catherine T., Curti, Brendan D., Crittenden, Marka, Merleev, Alexander, Sheng, Michael, Chao, Nelson J., Maverakis, Emanual, Rosario, Spencer R., Monjazeb, Arta M., Blazar, Bruce R., Longo, Dan L., Canter, Robert J., Murphy, William J.

Source: Frontiers in Immunology; 2024, p1-18, 18p

Subject Terms: T cells, IMMUNOLOGIC memory, CELL populations, MIDDLE age, VIRUS diseases, DYSTHYMIC disorder

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Authors: Wang, Ziming, Aguilar, Ethan, Luna, Jesus, Dunai, Cordelia, Khuat, Lam, Le, Catherine, Mirsoian, Annie, Minnar, Christine, Stoffel, Kevin, Sturgill, Ian, Grossenbacher, Steven, Withers, Sita, Rebhun, Robert, Hartigan-O'Connor, Dennis, Méndez-Lagares, Gema, Tarantal, Alice, Isseroff, R., Griffith, Thomas, Schalper, Kurt, Merleev, Alexander, Saha, Asim, Maverakis, Emanual, Kelly, Karen, Aljumaily, Raid, Ibrahimi, Sami, Mukherjee, Sarbajit, Machiorlatti, Michael, Vesely, Sara, Longo, Dan, Blazar, Bruce, Canter, Robert, Murphy, William, Monjazeb, Arta

Source: Nature medicine. 25(1):141-151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102162192.0x000001&indx=1&recIds=ETOCvdc_100102162192.0x000001

Preclinical and clinical studies of a tumor targeting IL-12 immunocytokine.

Authors: Minnar, Christine M., Lui, Grace, Gulley, James L., Schlom, Jeffrey, Gameiro, Sofia R.

Source: Frontiers in Oncology; 2024, p1-11, 11p

Subject Terms: IMMUNE checkpoint inhibitors, NATURAL immunity, CANCER treatment, T cells, CHIMERIC proteins

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Authors: Sckisel, Gail, Mirsoian, Annie, Minnar, Christine, Crittenden, Marka, Curti, Brendan, Chen, Jane, Blazar, Bruce, Borowsky, Alexander, Monjazeb, Arta, Murphy, William

Source: Journal for immunotherapy of cancer. 5(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127956576.0x000001&indx=1&recIds=ETOCvdc_100127956576.0x000001

Immunoregulatory pathways following strong inflammatory processes markedly impair CD4+ T cell responses

Authors: Minnar, Christine M., Murphy, William J.

Source: Human vaccines & immunotherapeutics. 12(9):2249-2252

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100035969659.0x000001&indx=1&recIds=ETOCvdc_100035969659.0x000001

Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape.

Authors: Hicks, Kristin C., Chariou, Paul L., Ozawa, Yohei, Minnar, Christine M., Knudson, Karin M., Meyer, Thomas J., Bian, Jing, Cam, Margaret, Schlom, Jeffrey, Gameiro, Sofia R.

Source: Nature Communications; 8/26/2021, Vol. 12 Issue 1, p1-18, 18p

Subject Terms: INTERLEUKIN-12, IMMUNE checkpoint proteins, HISTONE deacetylase inhibitors, TUMOR microenvironment, OVERALL survival, T cells

Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa.

Authors: Yohei Ozawa, Hicks, Kristin C., Minnar, Christine M., Knudson, Karin M., Schlom, Jeffrey, Gameiro, Sofia R.

Source: OncoImmunology; 2021, Vol. 10 Issue 1, p1-11, 11p

Subject Terms: TUMOR microenvironment, REGULATORY T cells, CHIMERIC proteins, SUPPRESSOR cells, TRANSFORMING growth factors, IMMUNE checkpoint inhibitors

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Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms.

Authors: Monjazeb, Arta M., Wang, Ziming, Vick, Logan V., Dunai, Cordelia, Minnar, Christine, Khuat, Lam T., Murphy, William J., Muthumani, Kar, Ugen, Kenneth E., Srinivasan, Alagarsamy

Source: Cancers; 2/15/2021, Vol. 13 Issue 4, p729-729, 1p

Subject Terms: TUMOR treatment, BIOLOGICAL models, DRUG approval, IMMUNE checkpoint inhibitors, ANIMAL experimentation, APOPTOSIS, COMPARATIVE studies, IMMUNOTHERAPY, MICE

Company/Entity: UNITED States. Food & Drug Administration

Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa

Authors: Ozawa, Yohei, Hicks, Kristin C., Minnar, Christine M., Knudson, Karin M., Schlom, Jeffrey, Gameiro, Sofia R.

Source: OncoImmunology; January 2021, Vol. 10 Issue: 1