Airway extracellular LTA4H concentrations are governed by release from liver hepatocytes and changes in lung vascular permeability

Authors: Mincham, Kyle T. ¹, Akthar, Samia ¹, Patel, Dhiren F. ^{1, 2}, Meyer, Garance F. ¹, Lloyd, Clare M. ¹, Gaggar, Amit ^{3, 4, 5, 6}, Blalock, James E. ^{3, 4, 5}, Snelgrove, Robert J. ^{1, 7, ∗}

Source: In Cell Reports 27 August 2024 43(8)

Protease-armed, Pathogenic Extracellular Vesicles Link Smoking and Chronic Obstructive Pulmonary Disease

Authors: Madison, Matthew C., Margaroli, Camilla, Genschmer, Kristopher R., Russell, Derek W., Wells, James M., Sari, Ezgi, Soto-Vazquez, Yixel M., Guo, Yuan-Yuan, Mincham, Kyle T., Snelgrove, Robert J.

Source: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 208(10):1115-1125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632800825&indx=1&recIds=ETOCRN632800825

OMIP‐086: Full spectrum flow cytometry for high‐dimensional immunophenotyping of mouse innate lymphoid cells

Authors: Mincham, Kyle T., Snelgrove, Robert J.

Source: Cytometry.Part A. 103(2):110-116

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173635540.0x000001&indx=1&recIds=ETOCvdc_100173635540.0x000001

Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies

Authors: Troy, Niamh M., Strickland, Deborah, Serralha, Michael, de Jong, Emma, Jones, Anya C., Read, James, Galbraith, Sally, Islam, Zahir, Kaur, Parwinder, Mincham, Kyle T., Holt, Barbara J., Sly, Peter D., Bosco, Anthony, Holt, Patrick G.

Source: In The Journal of Allergy and Clinical Immunology July 2022 150(1):93-103

Our evolving view of neutrophils in defining the pathology of chronic lung disease

Authors: Mincham, Kyle T., Bruno, Nicoletta, Singanayagam, Aran, Snelgrove, Robert J.

Source: Immunology. 164(4):701-721

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134568994.0x000001&indx=1&recIds=ETOCvdc_100134568994.0x000001

OMIP 076: High‐dimensional immunophenotyping of murine T‐cell, B‐cell, and antibody secreting cell subsets

Authors: Mincham, Kyle T., Young, Jacob D., Strickland, Deborah H.

Source: Cytometry.Part A. 99(9):888-892

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128275551.0x000001&indx=1&recIds=ETOCvdc_100128275551.0x000001

Metabolic dysfunction induced by a high‐fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

Authors: Mincham, Kyle T, Panchal, Kunjal, Hart, Prue H, Lucas, Robyn M, Feelisch, Martin, Weller, Richard B, Matthews, Vance B, Strickland, Deborah H, Gorman, Shelley

Source: Immunology and cell biology. 99(7):749-766

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124962860.0x000001&indx=1&recIds=ETOCvdc_100124962860.0x000001

Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model.

Authors: Hancock, David G., Berry, Luke, Scott, Naomi M., Mincham, Kyle T., Ditcham, William, Larcombe, Alexander N., Clements, Barry

Source: Experimental Lung Research; 2024, Vol. 50 Issue 1, p118-126, 9p

Subject Terms: LUNG infections, RESPIRATORY infections, VIRAL load, VIRUS diseases, BRONCHOALVEOLAR lavage

Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus Infection : Mechanistic Insight Using Mouse Models

Authors: Lauzon-Joset, Jean-Francois, Scott, Naomi M., Mincham, Kyle T., Stumbles, Philip A., Holt, Patrick G., Strickland, Deborah H.

Source: The Journal of Infectious Diseases, 2019 Jun 01. 219(11), 1823-1831.

Access URL: https://www.jstor.org/stable/26674948

Oestrogen amplifies pre‐existing atopy‐associated Th2 bias in an experimental asthma model

Authors: Lauzon‐Joset, Jean Francois, Mincham, Kyle T., Abad, Ana P., Short, Braden P., Holt, Patrick G., Strickland, Deborah H., Leffler, Jonatan

Source: Clinical & experimental allergy. 50(3):391-400

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103073435.0x000001&indx=1&recIds=ETOCvdc_100103073435.0x000001

Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection.

Authors: Mincham, Kyle T., Lauzon-Joset, Jean-Francois, Read, James F., Holt, Patrick G., Stumbles, Philip A., Strickland, Deborah H.

Source: American Journal of Respiratory Cell & Molecular Biology; Aug2024, Vol. 71 Issue 2, p219-228, 10p

Subject Terms: LUNGS, HEMATOPOIETIC stem cells, RESPIRATORY mucosa, INFLUENZA, VIRUS diseases

Functional differences in airway dendritic cells determine susceptibility to IgE‐sensitization

Authors: Leffler, Jonatan, Mincham, Kyle T, Mok, Danny, Blank, Fabian, Holt, Patrick G, Stumbles, Philip A, Strickland, Deborah H

Source: Immunology and cell biology. 96(3):316-329

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082756214.0x000001&indx=1&recIds=ETOCvdc_100082756214.0x000001

NO Casting of NETs in Allergic Asthma.

Authors: Mincham, Kyle T., Sanghavi, Krish, Snelgrove, Robert J.

Source: American Journal of Respiratory & Critical Care Medicine; 9/1/2024, Vol. 210 Issue 5, p533-535, 3p

Subject Terms: ASTHMA, IMMUNOGLOBULIN E, LEUKOCYTE elastase, MEDICAL sciences, MITOGEN-activated protein kinases, PATHOLOGY, NITRIC oxide

Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM‐85

Authors: Lauzon‐Joset, Jean‐Francois, Mincham, Kyle T, Scott, Naomi M, Khandan, Yasmine, Stumbles, Philip A, Holt, Patrick G, Strickland, Deborah H

Source: Clinical & translational immunology. 10(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123859139.0x000001&indx=1&recIds=ETOCvdc_100123859139.0x000001

CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signaling.

Authors: Giblin, Sean P., Ranawana, Sashini, Hassibi, Shyreen, Birchenough, Holly L., Mincham, Kyle T., Snelgrove, Robert J., Tomoko Tsuchiya, Shiro Kanegasaki, Dyer, Douglas, Pease, James E.

Source: Frontiers in Immunology; 2023, p1-21, 21p

Subject Terms: GLYCOSAMINOGLYCANS, CHEMOKINE receptors, CARRIER proteins, CONCENTRATION functions, PROTEIN folding, CHEMOTAXIS

Prebiotic Supplementation During Pregnancy Modifies the Gut Microbiota and Increases Metabolites in Amniotic Fluid, Driving a Tolerogenic Environment In Utero.

Authors: Brosseau, Carole, Selle, Amandine, Duval, Angeline, Misme-Aucouturier, Barbara, Chesneau, Melanie, Brouard, Sophie, Cherbuy, Claire, Cariou, Véronique, Bouchaud, Gregory, Mincham, Kyle T., Strickland, Deborah H., Barbarot, Sebastien, Bodinier, Marie

Source: Frontiers in Immunology; 7/14/2021, Vol. 12, p1-16, 16p

Subject Terms: AMNIOTIC liquid, GUT microbiome, REGULATORY T cells, REGULATORY B cells, SHORT-chain fatty acids

Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming.

Authors: Mincham, Kyle T., Jones, Anya C., Bodinier, Marie, Scott, Naomi M., Lauzon-Joset, Jean-Francois, Stumbles, Philip A., Bosco, Anthony, Holt, Patrick G., Strickland, Deborah H.

Source: Frontiers in Immunology; 12/2/2020, Vol. 11, pN.PAG-N.PAG, 11p

Subject Terms: DENDRITIC cells, MATERNAL exposure, MUCOUS membranes, BONE marrow, POPULATION dynamics

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