Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis

Authors: Milne, Paul, Bomken, Simon, Slater, Olga, Kumar, Ashish, Nelson, Adam, Roy, Somak, Velazquez, Jessica, Mankad, Kshitij, Nicholson, James, Yeomanson, Dan, Grundy, Richard, Kamal, Ahmed, Penn, Anthony, Pears, Jane, Millen, Gerard, Morland, Bruce, Hayden, James, Lam, Jason, Madkhali, Maymoon, MacDonald, Jamie, Singh, Preeti, Pagan, Sarah, Rodriguez-Galindo, Carlos, Minkov, Milen, Donadieu, Jean, Picarsic, Jennifer, Allen, Carl, Bigley, Venetia, Collin, Matthew

Source: In Blood Advances 23 May 2023 7(10):2171-2176

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

Authors: Tirtakusuma, Ricky, Szoltysek, Katarzyna, Milne, Paul, Grinev, Vasily V., Ptasinska, Anetta, Chin, Paulynn S., Meyer, Claus, Nakjang, Sirintra, Hehir-Kwa, Jayne Y., Williamson, Daniel, Cauchy, Pierre, Keane, Peter, Assi, Salam A., Ashtiani, Minoo, Kellaway, Sophie G., Imperato, Maria R., Vogiatzi, Fotini, Schweighart, Elizabeth K., Lin, Shan, Wunderlich, Mark, Stutterheim, Janine, Komkov, Alexander, Zerkalenkova, Elena, Evans, Paul, McNeill, Hesta, Elder, Alex, Martinez-Soria, Natalia, Fordham, Sarah E., Shi, Yuzhe, Russell, Lisa J., Pal, Deepali, Smith, Alex, Kingsbury, Zoya, Becq, Jennifer, Eckert, Cornelia, Haas, Oskar A., Carey, Peter, Bailey, Simon, Skinner, Roderick, Miakova, Natalia, Collin, Matthew, Bigley, Venetia, Haniffa, Muzlifah, Marschalek, Rolf, Harrison, Christine J., Cargo, Catherine A., Schewe, Denis, Olshanskaya, Yulia, Thirman, Michael J., Cockerill, Peter N., Mulloy, James C., Blair, Helen J., Vormoor, Josef, Allan, James M., Bonifer, Constanze, Heidenreich, Olaf, Bomken, Simon

Source: In Blood 27 October 2022 140(17):1875-1890

Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function

Authors: Bellmann, Lydia, Zelle-Rieser, Claudia, Milne, Paul, Resteu, Anastasia, Tripp, Christoph H., Hermann-Kleiter, Natascha, Zaderer, Viktoria, Wilflingseder, Doris, Hörtnagl, Paul, Theochari, Maria, Schulze, Jessica, Rentzsch, Mareike, Del Frari, Barbara, Collin, Matthew, Rademacher, Christoph, Romani, Nikolaus, Stoitzner, Patrizia

Source: In Journal of Investigative Dermatology January 2021 141(1):84-94

Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Authors: Cytlak, Urszula, Resteu, Anastasia, Pagan, Sarah, Green, Kile, Milne, Paul, Maisuria, Sheetal, McDonald, David, Hulme, Gillian, Filby, Andrew, Carpenter, Benjamin, Queen, Rachel, Hambleton, Sophie, Hague, Rosie, Lango Allen, Hana, Thaventhiran, James E.D., Doody, Gina, Collin, Matthew, Bigley, Venetia

Source: In Immunity 18 August 2020 53(2):353-370

Extracorporeal membrane oxygenation: Bridging therapy in paediatric pulmonary Langerhans cell histiocytosis

Authors: Bhatt, Reena, Semple, Thomas, Slater, Olga, Nicholson, Andrew G, Casanueva, Lidia, Desai, Ajay, Hoschtitzky, Andreas, Milne, Paul, Langley, Ross

Source: Journal of paediatrics and child health. 58(5):906-908

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187177241.0x000001&indx=1&recIds=ETOCvdc_100187177241.0x000001

Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells

Authors: Lim, Karen Phaik Har, Milne, Paul, Poidinger, Michael, Duan, Kaibo, Lin, Howard, McGovern, Naomi, Abhyankar, Harshal, Zinn, Daniel, Burke, Thomas M., Eckstein, Olive S., Chakraborty, Rikhia, Sengal, Amel, Scull, Brooks, Newell, Evan, Merad, Miriam, McClain, Kenneth L., Man, Tsz-Kwong, Ginhoux, Florent, Collin, Matthew, Allen, Carl E.

Source: In Blood Advances 14 January 2020 4(1):87-99

Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia

Authors: Milne, Paul, Wilhelm-Benartzi, Charlotte, Grunwald, Michael R., Bigley, Venetia, Dillon, Richard, Freeman, Sylvie D., Gallagher, Kathleen, Publicover, Amy, Pagan, Sarah, Marr, Helen, Jones, Gail L., Dickinson, Anne M., Grech, Angela, Burnett, Alan K., Russell, Nigel H., Levis, Mark, Knapper, Steven ^*, Collin, Matthew

Source: In Blood Advances 22 October 2019 3(20):3052-3061

Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation

Authors: Bigley, Venetia, Maisuria, Sheetal, Cytlak, Urszula, Jardine, Laura, Care, Matthew A., Green, Kile, Gunawan, Merry ^‡, Milne, Paul, Dickinson, Rachel, Wiscombe, Sarah, Parry, David ^§, Doffinger, Rainer, Laurence, Arian, Fonseca, Claudia, Stoevesandt, Oda, Gennery, Andrew, Cant, Andrew, Tooze, Reuben, Simpson, A. John, Hambleton, Sophie, Savic, Sinisa, Doody, Gina, Collin, Matthew

Source: In The Journal of Allergy and Clinical Immunology June 2018 141(6):2234-2248

Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase

Authors: Fordham, Sarah E., Blair, Helen J., Elstob, Claire J., Plummer, Ruth, Drew, Yvette, Curtin, Nicola J., Heidenreich, Olaf, Pal, Deepali, Jamieson, David, Park, Catherine, Pollard, John, Fields, Scott, Milne, Paul, Jackson, Graham H., Marr, Helen J., Menne, Tobias, Jones, Gail L., Allan, James M.

Source: In Blood Advances 22 May 2018 2(10):1157-1169

Mineral processing

Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults

Authors: Milne, Paul, Bigley, Venetia, Bacon, Chris M., Néel, Antoine, McGovern, Naomi, Bomken, Simon, Haniffa, Muzlifah, Diamond, Eli L., Durham, Benjamin H., Visser, Johannes, Hunt, David, Gunawardena, Harsha, Macheta, Mac, McClain, Kenneth L., Allen, Carl, Abdel-Wahab, Omar, Collin, Matthew

Source: In Blood 13 July 2017 130(2):167-175

Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL

Authors: Tirtakusuma, Ricky, Milne, Paul, Blair, Helen J., Shi, Yuzhe, Bomken, Simon, Heidenreich, Olaf

Source: Leukemia; April 2024, Vol. 38 Issue: 4 p883-886, 4p

Genome‐Wide Association Study Identifies the First Germline Genetic Variant Associated With Erdheim‐Chester Disease.

Authors: Martínez‐López, Javier, Márquez, Ana, Pegoraro, Francesco, Ortiz‐Fernández, Lourdes, Acosta‐Herrera, Marialbert, Kerick, Martin, Gelain, Elena, Diamond, Eli L., Durham, Benjamin H., Abdel‐Wahab, Omar, Go, Ronald S., Koster, Matthew J., Dagna, Lorenzo, Campochiaro, Corrado, Collin, Matthew, Milne, Paul, Estrada‐Veras, Juvianee I., O'Brien, Kevin, Papo, Matthias, Cohen‐Aubar, Fleur

Source: Arthritis & Rheumatology; Jan2024, Vol. 76 Issue 1, p141-145, 5p

Subject Terms: GENETIC mutation, CONFIDENCE intervals, GENOME-wide association studies, CELLULAR signal transduction, GENE expression, DESCRIPTIVE statistics, DATA analysis software, ODDS ratio, HEMATOPOIESIS, LOGISTIC regression analysis, ERDHEIM-Chester disease

Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages

Authors: McGovern, Naomi, Schlitzer, Andreas, Gunawan, Merry, Jardine, Laura, Shin, Amanda, Poyner, Elizabeth, Green, Kile, Dickinson, Rachel, Wang, Xiao-nong, Low, Donovan, Best, Katie, Covins, Samuel, Milne, Paul, Pagan, Sarah, Aljefri, Khadija, Windebank, Martin, Miranda-Saavedra, Diego, Larbi, Anis, Wasan, Pavandip Singh, Duan, Kaibo, Poidinger, Michael, Bigley, Venetia, Ginhoux, Florent, Collin, Matthew, Haniffa, Muzlifah

Source: In Immunity 18 September 2014 41(3):465-477

Composite articles and methods of producing same

The evolution of cellular deficiency in GATA2 mutation

Authors: Dickinson, Rachel E., Milne, Paul, Jardine, Laura, Zandi, Sasan, Swierczek, Sabina I., McGovern, Naomi, Cookson, Sharon, Ferozepurwalla, Zaveyna, Langridge, Alexander, Pagan, Sarah, Gennery, Andrew, Heiskanen-Kosma, Tarja, Hämäläinen, Sari, Seppänen, Mikko, Helbert, Matthew, Tholouli, Eleni, Gambineri, Eleonora, Reykdal, Sigrún, Gottfreðsson, Magnús, Thaventhiran, James E., Morris, Emma, Hirschfield, Gideon, Richter, Alex G., Jolles, Stephen, Bacon, Chris M., Hambleton, Sophie, Haniffa, Muzlifah, Bryceson, Yenan, Allen, Carl, Prchal, Josef T., Dick, John E., Bigley, Venetia, Collin, Matthew

Source: In Blood 6 February 2014 123(6):863-874

Langerhans cell origin and regulation

Authors: Collin, Matthew, Milne, Paul

Source: Current opinion in hematology. 23(1):28-35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100032616056.0x000001&indx=1&recIds=ETOCvdc_100032616056.0x000001

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation

Authors: Llibre, Alba, López-Macías, Constantino, Marafioti, Teresa, Mehta, Hema, Partridge, Amy, Kanzig, Carina, Rivellese, Felice, Galson, Jacob D., Walker, Lucy J., Milne, Paul

Source: Journal of immunology. 196(5):2085-2094

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605126387&indx=1&recIds=ETOCRN605126387

T cell differentiation drives the negative selection of pathogenic mitochondrial DNA variants.

Authors: Franklin, Imogen G., Milne, Paul, Childs, Jordan, Boggan, Róisín M., Barrow, Isabel, Lawless, Conor, Gorman, Gráinne S., Yi Shiau Ng, Collin, Matthew, Russell, Oliver M., Pickett, Sarah J.

Source: Life Science Alliance; Nov2023, Vol. 6 Issue 11, p1-15, 15p

Quality assurance of the Applied Knowledge Test (AKT) of the MRCGP examination – an immediate post-test questionnaire evaluation of the candidates' views

Authors: Dixon, Hilton, Blow, Carol, Milne, Paul, Siriwardena, Niroshan, Milne, Heather, Elfes, Christopher

Source: Education for primary care. 26(4):223-232

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050625686.0x000001&indx=1&recIds=ETOCvdc_100050625686.0x000001