Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics

Authors: Desai, Trishna A., Hedman, Åsa K., Dimitriou, Marios, Koprulu, Mine, Figiel, Sandy, Yin, Wencheng, Johansson, Mattias, Watts, Eleanor L., Atkins, Joshua R., Sokolov, Aleksandr V., Schiöth, Helgi B., Gunter, Marc J., Tsilidis, Konstantinos K., Martin, Richard M., Pietzner, Maik, Langenberg, Claudia, Mills, Ian G., Lamb, Alastair D., Mälarstig, Anders, Key, Tim J., Travis, Ruth C., Smith-Byrne, Karl

Source: In eBioMedicine July 2024 105

Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells

Authors: Steiner, Ivana, Flores-Tellez, Teresita del N.J., Mevel, Renaud, Ali, Amin, Wang, Pengbo, Schofield, Pieta, Behan, Caron, Forsythe, Nicholas, Ashton, Garry, Taylor, Catherine, Mills, Ian G., Oliveira, Pedro, McDade, Simon S., Zaiss, Dietmar M., Choudhury, Ananya, Lacaud, Georges, Baena, Esther

Source: In Cell Reports 25 April 2023 42(4)

Low Blood Levels of LRG1 Before Radical Prostatectomy Identify Patients with High Risk of Progression to Castration-resistant Prostate Cancer

Authors: Guldvik, Ingrid Jenny, Braadland, Peder Rustøen, Sivanesan, Shivanthe, Ramberg, Håkon, Kristensen, Gitte, Tennstedt, Pierre, Røder, Andreas, Schlomm, Thorsten, Berge, Viktor, Eri, Lars Magne, Lilleby, Wolfgang, Mills, Ian G., Taskén, Kristin Austlid

Source: In European Urology Open Science November 2022 45:68-75

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers.

Authors: Erickson, Andrew, Figiel, Sandy, Rajakumar, Timothy, Rao, Srinivasa, Yin, Wencheng, Doultsinos, Dimitrios, Magnussen, Anette, Singh, Reema, Poulose, Ninu, Bryant, Richard J., Cussenot, Olivier, Hamdy, Freddie C., Woodcock, Dan, Mills, Ian G., Lamb, Alastair D.

Source: PLoS ONE; 1/3/2025, Vol. 20 Issue 1, p1-14, 14p

Subject Terms: DNA copy number variations, CANCER genetics, PROSTATE cancer, SPATIAL resolution, MACHINE learning

Identification and Validation of Leucine-rich α-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification

Authors: Guldvik, Ingrid J., Zuber, Verena, Braadland, Peder R., Grytli, Helene H., Ramberg, Håkon, Lilleby, Wolfgang, Thiede, Bernd, Zucknick, Manuela, Saatcioglu, Fahri, Gislefoss, Randi, Kvåle, Rune, George, Anne, Grönberg, Henrik, Wiklund, Fredrik, Neal, David E., Gnanapragasam, Vincent J., Taskén, Kristin A., Mills, Ian G.

Source: In European Urology Open Science October 2020 21:51-60

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA

Authors: Ray, Jessica, Haughey, Charles, Hoey, Christianne, Jeon, Jouhyun, Murphy, Ross, Dura-Perez, Lara, McCabe, Nuala, Downes, Michelle, Jain, Suneil, Boutros, Paul C., Mills, Ian G., Liu, Stanley K.

Source: In Cancer Letters 31 March 2020 473:107-117

Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer

Authors: Carabet, Lavinia A., Lallous, Nada, Leblanc, Eric, Ban, Fuqiang, Morin, Helene, Lawn, Sam, Ghaidi, Fariba, Lee, Joseph, Mills, Ian G., Gleave, Martin E., Rennie, Paul S., Cherkasov, Artem

Source: In European Journal of Medicinal Chemistry 5 December 2018 160:108-119

Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts

Authors: Nash, Claire, Boufaied, Nadia, Mills, Ian G., Franco, Omar E., Hayward, Simon W., Thomson, Axel A.

Source: In Molecular and Cellular Endocrinology 15 August 2018 471:1-14

Bromodomain-containing proteins in prostate cancer

Authors: Urbanucci, Alfonso, Mills, Ian G.

Source: In Molecular and Cellular Endocrinology 15 February 2018 462 Part A:31-40

Huntingtin Interacting Protein 1 Modulates the Transcriptional Activity of Nuclear Hormone Receptors

Authors: Mills, Ian G., Gaughan, Luke, Robson, Craig, Ross, Theodora, McCracken, Stuart, Kelly, John, Neal, David E.

Source: The Journal of Cell Biology, 2005 Jul . 170(2), 191-200.

Access URL: https://www.jstor.org/stable/3658380

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

Authors: Peter, Brian J., Kent, Helen M., Mills, Ian G., Vallis, Yvonne, Evans, Philip R., McMahon, Harvey T.

Source: Science, 2004 Jan . 303(5657), 495-499.

Access URL: https://www.jstor.org/stable/3836080

EpsinR: An AP1/Clathrin Interacting Protein Involved in Vesicle Trafficking

Authors: Mills, Ian G., Vallis, Yvonne, Peter, Brian J., Olesen, Lene E., Gallop, Jennifer L., Evans, Philip R., McMahon, Harvey T.

Source: The Journal of Cell Biology, 2003 Jan . 160(2), 213-222.

Access URL: https://www.jstor.org/stable/1621434

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology

Authors: Walker, Steven M., Knight, Laura A., McCavigan, Andrena M., Logan, Gemma E., Berge, Viktor, Sherif, Amir, Pandha, Hardev, Warren, Anne Y., Davidson, Catherine, Uprichard, Adam, Blayney, Jaine K., Price, Bethanie, Jellema, Gera L., Steele, Christopher J., Svindland, Aud, McDade, Simon S., Eden, Christopher G., Foster, Chris, Mills, Ian G., Neal, David E., Mason, Malcolm D., Kay, Elaine W., Waugh, David J., Harkin, D. Paul, Watson, R. William, Clarke, Noel W., Kennedy, Richard D.

Source: In European Urology October 2017 72(4):509-518

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer

Authors: Urbanucci, Alfonso, Barfeld, Stefan J., Kytölä, Ville, Itkonen, Harri M., Coleman, Ilsa M., Vodák, Daniel, Sjöblom, Liisa, Sheng, Xia, Tolonen, Teemu, Minner, Sarah, Burdelski, Christoph, Kivinummi, Kati K., Kohvakka, Annika, Kregel, Steven, Takhar, Mandeep, Alshalalfa, Mohammed, Davicioni, Elai, Erho, Nicholas, Lloyd, Paul, Karnes, R. Jeffrey, Ross, Ashley E., Schaeffer, Edward M., Vander Griend, Donald J., Knapp, Stefan, Corey, Eva, Feng, Felix Y., Nelson, Peter S., Saatcioglu, Fahri, Knudsen, Karen E., Tammela, Teuvo L.J., Sauter, Guido, Schlomm, Thorsten, Nykter, Matti, Visakorpi, Tapio, Mills, Ian G.

Source: In Cell Reports 6 June 2017 19(10):2045-2059

The importance of DNA methylation in prostate cancer development

Authors: Massie, Charles E., Mills, Ian G., Lynch, Andy G.

Source: In Journal of Steroid Biochemistry and Molecular Biology February 2017 166:1-15

Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability

Authors: Munkley, Jennifer, Vodak, Daniel, Livermore, Karen E., James, Katherine, Wilson, Brian T., Knight, Bridget, Mccullagh, Paul, Mcgrath, John, Crundwell, Malcolm, Harries, Lorna W., Leung, Hing Y., Robson, Craig N., Mills, Ian G., Rajan, Prabhakar, Elliott, David J.

Source: In EBioMedicine June 2016 8:103-116

Adaptations of membrane trafficking in cancer and tumorigenesis.

Authors: Evergren, Emma¹ e.evergren@qub.ac.uk, Mills, Ian G.^1,2, Kennedy, Grace¹

Source: Journal of Cell Science. May2024, Vol. 137 Issue 10, p1-16. 16p.

Subject Terms: *DRUG resistance in cancer cells, *ENDOCYTOSIS, *PHYSIOLOGICAL adaptation, *ENDOPLASMIC reticulum, *NEOPLASTIC cell transformation, *CELL membranes, *MEMBRANE proteins, *COATED vesicles

CDK9 inhibition activates innate immune response through viral mimicry.

Authors: Yalala, Shivani, Gondane, Aishwarya, Poulose, Ninu, Jing Liang, Mills, Ian G., Itkonen, Harri M.

Source: FASEB Journal; 4/30/2024, Vol. 38 Issue 8, p1-15, 15p

Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer.

Authors: Mah, Chui Yan, Nguyen, An Dieu Trang, Niijima, Takuto, Helm, Madison, Dehairs, Jonas, Ryan, Feargal J., Ryan, Natalie, Quek, Lake-Ee, Hoy, Andrew J., Don, Anthony S., Mills, Ian G., Swinnen, Johannes V., Lynn, David J., Nassar, Zeyad D., Butler, Lisa M.

Source: British Journal of Cancer; Mar2024, Vol. 130 Issue 5, p741-754, 14p

Histomic and transcriptomic features of MRI‐visible and invisible clinically significant prostate cancers are associated with prognosis.

Authors: Lehto, Timo‐Pekka K., Pylväläinen, Juho, Sandeman, Kevin, Kenttämies, Anu, Nordling, Stig, Mills, Ian G., Tang, Jing, Mirtti, Tuomas, Rannikko, Antti

Source: International Journal of Cancer; Mar2024, Vol. 154 Issue 5, p926-939, 14p

Subject Terms: PROSTATE cancer, TRANSCRIPTOMES, MAGNETIC resonance imaging, PROSTATE biopsy, GENETIC transcription regulation, MEDICAL triage