COVID-19-neutralizing antibodies predict disease severity and survival

Authors: Garcia-Beltran, Wilfredo F., Lam, Evan C., Astudillo, Michael G., Yang, Diane, Miller, Tyler E., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Clayton, Kiera L., Nitido, Adam D., Murali, Mandakolathur R., Alter, Galit, Charles, Richelle C., Dighe, Anand, Branda, John A., Lennerz, Jochen K., Lingwood, Daniel, Schmidt, Aaron G., Iafrate, A. John, Balazs, Alejandro B.

Source: In Cell 21 January 2021 184(2):476-488

SARS-CoV-2-specific ELISA development

Authors: Roy, Vicky, Fischinger, Stephanie, Atyeo, Caroline, Slein, Matthew, Loos, Carolin, Balazs, Alejandro, Luedemann, Corinne, Astudillo, Michael Gerino, Yang, Diane, Wesemann, Duane R., Charles, Richelle, Lafrate, A. John, Feldman, Jared, Hauser, Blake, Caradonna, Tim, Miller, Tyler E., Murali, Mandakolathur R., Baden, Lindsey, Nilles, Eric, Ryan, Edward, Lauffenburger, Douglas, Beltran, Wilfredo Garcia, Alter, Galit

Source: In Journal of Immunological Methods September-October 2020 484-485

Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

Authors: Factor, Daniel C., Barbeau, Anna M., Allan, Kevin C., Hu, Lucille R., Madhavan, Mayur, Hoang, An T., Hazel, Kathryn E.A., Hall, Parker A., Nisraiyya, Sagar, Najm, Fadi J., Miller, Tyler E., Nevin, Zachary S., Karl, Robert T., Lima, Bruna R., Song, Yanwei, Sibert, Alexandra G., Dhillon, Gursimran K., Volsko, Christina, Bartels, Cynthia F., Adams, Drew J., Dutta, Ranjan, Gallagher, Michael D., Phu, William, Kozlenkov, Alexey, Dracheva, Stella, Scacheri, Peter C., Tesar, Paul J., Corradin, Olivia

Source: In Cell 16 April 2020 181(2):382-395

N6-methyladenine DNA Modification in Glioblastoma

Authors: Xie, Qi, Wu, Tao P., Gimple, Ryan C., Li, Zheng, Prager, Briana C., Wu, Qiulian, Yu, Yang, Wang, Pengcheng, Wang, Yinsheng, Gorkin, David U., Zhang, Cheng, Dowiak, Alexis V., Lin, Kaixuan, Zeng, Chun, Sui, Yinghui, Kim, Leo J.Y., Miller, Tyler E., Jiang, Li, Lee-Poturalski, Christine, Huang, Zhi, Fang, Xiaoguang, Zhai, Kui, Mack, Stephen C., Sander, Maike, Bao, Shideng, Kerstetter-Fogle, Amber E., Sloan, Andrew E., Xiao, Andrew Z., Rich, Jeremy N.

Source: In Cell 15 November 2018 175(5):1228-1243

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease

Authors: Elitt, Matthew S., Shick, H. Elizabeth, Madhavan, Mayur, Allan, Kevin C., Clayton, Benjamin L.L., Weng, Chen, Miller, Tyler E., Factor, Daniel C., Barbar, Lilianne, Nawash, Baraa S., Nevin, Zachary S., Lager, Angela M., Li, Yan, Jin, Fulai, Adams, Drew J., Tesar, Paul J.

Source: In Stem Cell Reports 11 September 2018 11(3):711-726

Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

Authors: Wang, Xiuxing, Prager, Briana C., Wu, Qiulian, Kim, Leo J.Y., Gimple, Ryan C., Shi, Yu, Yang, Kailin, Morton, Andrew R., Zhou, Wenchao, Zhu, Zhe, Obara, Elisabeth Anne Adanma, Miller, Tyler E., Song, Anne, Lai, Sisi, Hubert, Christopher G., Jin, Xun, Huang, Zhi, Fang, Xiaoguang, Dixit, Deobrat, Tao, Weiwei, Zhai, Kui, Chen, Cong, Dong, Zhen, Zhang, Guoxin, Dombrowski, Stephen M., Hamerlik, Petra, Mack, Stephen C., Bao, Shideng, Rich, Jeremy N.

Source: In Cell Stem Cell 5 April 2018 22(4):514-528

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance

Authors: Liau, Brian B., Sievers, Cem, Donohue, Laura K., Gillespie, Shawn M., Flavahan, William A., Miller, Tyler E., Venteicher, Andrew S., Hebert, Christine H., Carey, Christopher D., Rodig, Scott J., Shareef, Sarah J., Najm, Fadi J., van Galen, Peter, Wakimoto, Hiroaki, Cahill, Daniel P., Rich, Jeremy N., Aster, Jon C., Suvà, Mario L., Patel, Anoop P., Bernstein, Bradley E.

Source: In Cell Stem Cell 2 February 2017 20(2):233-246

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

Authors: Lizardo, Michael M., Morrow, James J., Miller, Tyler E., Hong, Ellen S., Ren, Ling, Mendoza, Arnulfo, Halsey, Charles H., Scacheri, Peter C., Helman, Lee J., Khanna, Chand

Source: In Neoplasia November 2016 18(11):699-710

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

Authors: Schonberg, David L., Miller, Tyler E., Wu, Qiulian, Flavahan, William A., Das, Nupur K., Hale, James S., Hubert, Christopher G., Mack, Stephen C., Jarrar, Awad M., Karl, Robert T., Rosager, Ann Mari, Nixon, Anne M., Tesar, Paul J., Hamerlik, Petra, Kristensen, Bjarne W., Horbinski, Craig, Connor, James R., Fox, Paul L., Lathia, Justin D., Rich, Jeremy N.

Source: In Cancer Cell 12 October 2015 28(4):441-455

Protocol for mitochondrial variant enrichment from single-cell RNA sequencing using MAESTER

Authors: Good, Jonathan D. ^{1, 2, 3, 4}, Safina, Ksenia R. ^{1, 2, 3, 4}, Miller, Tyler E. ⁵, van Galen, Peter ^{1, 2, 3, 4, 6, 7, ∗}

Source: In STAR Protocols 21 March 2025 6(1)

Brain tumor stem cells: Molecular characteristics and their impact on therapy

Authors: Schonberg, David L., Lubelski, Daniel, Miller, Tyler E., Rich, Jeremy N.

Source: In Molecular Aspects of Medicine October 2014 39:82-101

Remote Fingerstick Blood Collection for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Testing.

Authors: Garcia-Beltran, Wilfredo F.¹, Miller, Tyler E.¹, Kirkpatrick, Grace¹, Nixon, Andrea¹, Astudillo, Michael G.¹, Yang, Diane¹, Mahanta, Lisa M.², Murali, Mandakolathur^1,3, Dighe, Anand S.¹, Lennerz, Jochen¹, Thierauf, Julia¹, Naranbhai, Vivek³, Iafrate, A. John¹ aiafrate@partners.org

Source: Archives of Pathology & Laboratory Medicine. Apr2021, Vol. 145 Issue 4, p415-418. 4p. 2 Graphs.

Subject Terms: *MEDICAL consultation, *COVID-19, *IMMUNOGLOBULINS, *BLOOD collection, *SEROLOGY, *CORONAVIRUS diseases, *BIOLOGICAL assay, *COLLECTION & preservation of biological specimens, *TELEMEDICINE

Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition

Authors: Beach, Jordan R., Hussey, George S., Miller, Tyler E., Chaudhury, Arindam, Patel, Purvi, Monslow, James, Zheng, Qiao, Keri, Ruth A., Reizes, Ofer, Bresnick, Anne R., Howe, Philip H., Egelhoff, Thomas T.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Nov 01. 108(44), 17991-17996.

Access URL: https://www.jstor.org/stable/41352640

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

Authors: Miller, Tyler E., Ghoshal, Kalpana, Ramaswamy, Bhuvaneswari, Roy, Satavisha, Datta, Jharna, Shapiro, Charles L., Jacob, Samson, Majumder, Sarmila

Source: In Journal of Biological Chemistry 31 October 2008 283(44):29897-29903

Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas

Authors: Miller, Tyler E., Farran, Chadi A. El, Couturier, Charles P., Chen, Zeyu, D’Antonio, Joshua P., Verga, Julia, Villanueva, Martin A., Castro, L. Nicolas Gonzalez, Tong, Yuzhou Evelyn, Saadi, Tariq Al, Chiocca, Andrew N., Fischer, David S., Heiland, Dieter Henrik, Guerriero, Jennifer L., Petrecca, Kevin, Suva, Mario L., Shalek, Alex K., Bernstein, Bradley

Source: Miller TE, El Farran CA, Couturier CP, Chen Z, D'Antonio JP, Verga J, Villanueva MA, Castro LNG, Tong YE, Saadi TA, Chiocca AN, Fischer DS, Heiland DH, Guerriero JL, Petrecca K, Suva ML, Shalek AK, Bernstein BE. Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas. bioRxiv [Preprint]. 2023 Oct 27:2023.10.24.563466. doi: 10.1101/2023.10.24.563466. PMID: 37961527; PMCID: PMC10634776.

File Description: application/pdf

Relation: Nature

Access URL: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37380354

Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19.

Authors: Gregory, David J., Vannier, Augustin, Duey, Akiro H., Roady, Tyler J., Dzeng, Richard K., Pavlovic, Maia N., Chapin, Michael H., Mukherjee, Sonia, Wilmot, Hannah, Chronos, Nic, Charles, Richelle C., Ryan, Edward T., LaRocque, Regina C., Miller, Tyler E., Garcia-Beltran, Wilfredo F., Thierauf, Julia C., Iafrate, A. John, Mullenbrock, Steven, Stump, Mark D., Wetzel, Randall K.

Source: Virulence; Dec2022, Vol. 13 Issue 1, p890-902, 13p

Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations.

Authors: Miller, Tyler E.^1,2,3 (AUTHOR), Lareau, Caleb A.^2,4,5,6 (AUTHOR), Verga, Julia A.^2,3 (AUTHOR), DePasquale, Erica A. K.^2,7 (AUTHOR), Liu, Vincent^4,5 (AUTHOR), Ssozi, Daniel^2,7 (AUTHOR), Sandor, Katalin⁴ (AUTHOR), Yin, Yajie⁴ (AUTHOR), Ludwig, Leif S.^2,6,8 (AUTHOR), El Farran, Chadi A.^2,3 (AUTHOR), Morgan, Duncan M.^9,10 (AUTHOR), Satpathy, Ansuman T.⁴ (AUTHOR), Griffin, Gabriel K.^2,11 (AUTHOR), Lane, Andrew A.^2,12,13 (AUTHOR), Love, J. Christopher^2,9,10 (AUTHOR), Bernstein, Bradley E.^2,3,13,14 (AUTHOR), Sankaran, Vijay G.^2,6 (AUTHOR), van Galen, Peter^2,7,13 (AUTHOR) pvangalen@bwh.harvard.edu

Source: Nature Biotechnology. Jul2022, Vol. 40 Issue 7, p1030-1034. 5p.

Comparative Immunogenicity and Effectiveness of mRNA-1273, BNT162b2, and Ad26.COV2.S COVID-19 Vaccines.

Authors: Naranbhai, Vivek, Garcia-Beltran, Wilfredo F, Chang, Christina C, Mairena, Cristhian Berrios, Thierauf, Julia C, Kirkpatrick, Grace, Onozato, Maristela L, Cheng, Ju, Denis, Kerri J St, Lam, Evan C, Kaseke, Clarety, Tano-Menka, Rhoda, Yang, Diane, Pavlovic, Maia, Yang, Wendy, Kui, Alexander, Miller, Tyler E, Astudillo, Michael G, Cahill, Jennifer E, Dighe, Anand S

Source: Journal of Infectious Diseases; Apr2022, Vol. 225 Issue 7, p1141-1150, 10p

Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.

Authors: Dixit, Deobrat, Prager, Briana C., Gimple, Ryan C., Miller, Tyler E., Wu, Qiulian, Yomtoubian, Shira, Kidwell, Reilly L., Lv, Deguan, Zhao, Linjie, Qiu, Zhixin, Zhang, Guoxin, Lee, Derrick, Park, Donglim Esther, Wechsler-Reya, Robert J., Wang, Xiuxing, Bao, Shideng, Rich, Jeremy N.

Source: Science Translational Medicine; 1/5/2022, Vol. 14 Issue 626, p1-16, 16p

Mosaicism for Receptor Tyrosine Kinase Activation in a Glioblastoma Involving Both PDGFRA Amplification and NTRK2 Fusion.

Authors: Shepherd, Daniel J., Miller, Tyler E., Forst, Deborah A., Jones, Pamela, Nardi, Valentina, Martinez‐Lage, Maria, Stemmer‐Rachamimov, Anat, Gonzalez, Ramon G., Iafrate, A. John, Ritterhouse, Lauren L.

Source: Oncologist; Nov2021, Vol. 26 Issue 11, p919-924, 6p, 4 Color Photographs

Subject Terms: MOSAICISM, GLIOMAS, PROTEIN-tyrosine kinases