Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD

Authors: Smith, Alicia K. ^{a, b, c, ⁎}, Katrinli, Seyma ^a, Maihofer, Adam X. ^{d, e, f}, Aiello, Allison E. ^g, Baker, Dewleen G. ^d, Boks, Marco P. ^{h, i, j}, Brick, Leslie A. ^k, Chen, Chia-Yen ^l, Dalvie, Shareefa ^m, Fani, Negar ^c, Fortier, Catherine B. ^{n, o, p}, Gelernter, Joel ^{q, r}, Geuze, Elbert ^{s, t}, Gillespie, Charles F. ^c, Hayes, Jasmeet P. ^u, Hong, Suzi ^{d, e, v}, Kessler, Ronald C. ^w, King, Anthony P. ^{x, y}, Koen, Nastassja ^{z, aa, ab}, Koenen, Karestan C. ^{ac, ad, ae}, Liberzon, Israel ^af, Linnstaedt, Sarah D. ^{ag, ah}, McLean, Samuel A. ^{ah, ai}, Michopoulos, Vasiliki ^c, Milberg, William P. ^{n, o, p}, Miller, Mark W. ^{aj, ak}, Mufford, Mary S. ^al, Nugent, Nicole R. ^{am, an, ao}, Orcutt, Holly K. ^ap, Powers, Abigail ^c, Rauch, Sheila A.M. ^{aq, ar}, Ressler, Kerry J. ^{c, n, as}, Risbrough, Victoria B. ^{d, e, f}, Rutten, Bart P.F. ^{ac, at}, Smoller, Jordan W. ^{ac, ae, au}, Stein, Dan J. ^{z, aa, ab}, Stein, Murray B. ^{d, av, aw}, Ursano, Robert J. ^ax, Verfaellie, Mieke H. ^{ay, az}, Vermetten, Eric ^{ba, bb}, Vinkers, Christiaan H. ^{bc, bd, be}, Wani, Agaz H. ^bf, WareVinkers, Erin B. ^bg, Wildman, Derek E. ^bh, Wolf, Erika J. ^{aj, ak}, Zhao, Ying ^{ag, ah}, Logue, Mark W. ^{aj, ak, bi, bj}, Nievergelt, Caroline M. ^{d, e, f}, Uddin, Monica ^bf, Zannas, Anthony S. ^{ah, ai, bj, bk}

Source: In Brain Behavior and Immunity August 2025 128:540-548

Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study

Authors: Hyatt, Courtland S., Reddi, Preethi J., Sharpe, Brinkley M., Michopoulos, Vasiliki, van Rooij, Sanne J.H., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Stevens, Jennifer S., Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Lewandowski, Christopher, Musey, Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Swor, Robert A., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., McLean, Samuel A., Kessler, Ronald C., Ressler, Kerry J., Koenen, Karestan C., Maples-Keller, Jessica L.

Source: In Journal of Research in Personality October 2024 112

Longitudinal study of traumatic-stress related cellular and cognitive aging

Authors: Wolf, Erika J., Miller, Mark W., Hawn, Sage E., Zhao, Xiang, Wallander, Sara E., McCormick, Beth, Govan, Christine, Rasmusson, Ann, Stone, Annjanette, Schichman, Steven A., Logue, Mark W.

Source: In Brain Behavior and Immunity January 2024 115:494-504

Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study

Authors: Rowland, Grace E., Roeckner, Alyssa, Ely, Timothy D., Lebois, Lauren A.M., van Rooij, Sanne J.H., Bruce, Steven E., Jovanovic, Tanja, House, Stacey L., Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Gentile, Nina T., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., Sergot, Paulina, Sanchez, Leon D., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., Kessler, Ronald C., Koenen, Karestan C., McLean, Samuel A., Ressler, Kerry J., Stevens, Jennifer S., Harnett, Nathaniel G.

Source: In Biological Psychiatry Global Open Science October 2023 3(4):705-715

Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision

Authors: Jones, Christopher W., An, Xinming, Ji, Yinyao, Liu, Mochuan, Zeng, Donglin, House, Stacey L., Beaudoin, Francesca L., Stevens, Jennifer S., Neylan, Thomas C., Clifford, Gari D., Jovanovic, Tanja, Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Punches, Brittany E., Lyons, Michael S., Kurz, Michael C., Swor, Robert A., McGrath, Meghan E., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Datner, Elizabeth M., Harris, Erica, Chang, Anna M., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O'Neil, Brian J., Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., Koenen, Karestan C., Ressler, Kerry J., Kessler, Ronald C., McLean, Samuel A.

Source: In Annals of Emergency Medicine March 2023 81(3):249-261

The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

Authors: Maihofer, Adam X., Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Polimanti, Renato, Ratanatharathorn, Andrew, Torres, Katy, Wingo, Aliza P., Zai, Clement C., Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Borglum, Anders D., Babic, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Bradley, Bekh, Brashear, Meghan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, Jose Miguel, Chen, Chia-Yen, Dale, Anders M., Dalvie, Shareefa, Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Duncan, Laramie E., Kulenovic, Alma Dzubur, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gautam, Aarti, Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Uka, Aferdita Goci, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lugonja, Bozo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica L., Marmar, Charles, Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., Mehta, Divya, Mellor, Rebecca, Michopoulos, Vasiliki, Milberg, William, Miller, Mark W., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben Bo, Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O’Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, John P., Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Rutten, Bart P.F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S., Teicher, Martin H., Thompson, Wesley K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., Luella van den Heuvel, Leigh, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan, Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Yehuda, Rachel, Young, Keith A., Young, Ross McD., Zhao, Hongyu, Zoellner, Lori A., Haas, Magali, Lasseter, Heather, Provost, Allison C., Salem, Rany M., Sebat, Jonathan, Shaffer, Richard, Wu, Tianying, Ripke, Stephan, Daly, Mark J., Ressler, Kerry J., Koenen, Karestan C., Stein, Murray B., Nievergelt, Caroline M., Wendt, Frank R., Garcia-Argibay, Miguel, Cabrera-Mendoza, Brenda, Valdimarsdóttir, Unnur A., Nivard, Michel G., Larsson, Henrik, Mattheisen, Manuel, Meier, Sandra M.

Source: In Biological Psychiatry 15 February 2023 93(4):362-369

Long-term comparison of pilot UASB and AnMBR systems treating domestic sewage at ambient temperatures

Authors: Rattier, Maxime, Jimenez, Jose A., Miller, Mark W., Dhanasekar, Ashwin, Willis, John, Keller, Jürg, Batstone, Damien

Source: In Journal of Environmental Chemical Engineering December 2022 10(6)

Conceptualizing traumatic stress and the structure of posttraumatic psychopathology through the lenses of RDoC and HiTOP

Authors: Hawn, Sage E., Wolf, Erika J., Neale, Zoë, Miller, Mark W.

Source: In Clinical Psychology Review July 2022 95

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Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Authors: Maihofer, Adam X., Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Polimanti, Renato, Ratanatharathorn, Andrew, Torres, Katy, Wingo, Aliza P., Zai, Clement C., Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegović, Esmina, Borglum, Anders D., Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Bradley, Bekh, Brashear, Meghan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, José M., Chen, Chia-Yen, Dale, Anders M., Dalvie, Shareefa, Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Duncan, Laramie E., Džubur Kulenović, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gautam, Aarti, Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goçi, Aferdita, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljević, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lugonja, Božo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica L., Marmar, Charles, Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., Mehta, Divya, Mellor, Rebecca, Michopoulos, Vasiliki, Milberg, William, Miller, Mark W., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben B., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O’Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, John P., Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Rutten, Bart P.F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, Soraya, Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S., Teicher, Martin H., Thompson, Wesley K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., van den Heuvel, Leigh Luella, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Yehuda, Rachel, Young, Keith A., Young, Ross McD., Zhao, Hongyu, Zoellner, Lori A., Haas, Magali, Lasseter, Heather, Provost, Allison C., Salem, Rany M., Sebat, Jonathan, Shaffer, Richard A., Wu, Tianying, Ripke, Stephan, Daly, Mark J., Ressler, Kerry J., Koenen, Karestan C., Stein, Murray B., Nievergelt, Caroline M.

Source: In Biological Psychiatry 1 April 2022 91(7):626-636

Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD

Authors: Logue, Mark W., Zhou, Zhenwei, Morrison, Filomene G., Wolf, Erika J., Daskalakis, Nikolaos P., Chatzinakos, Christos, Georgiadis, Foivos, Labadorf, Adam T., Girgenti, Matthew J., Young, Keith A., Williamson, Douglas E., Zhao, Xiang, Grenier, Jaclyn Garza, Huber, Bertrand Russell, Miller, Mark W.

Source: In Neurobiology of Stress November 2021 15

A prospective examination of sex differences in posttraumatic autonomic functioning

Authors: Seligowski, Antonia V., Steuber, Elizabeth R., Hinrichs, Rebecca, Reda, Mariam H., Wiltshire, Charis N., Wanna, Cassandra P., Winters, Sterling J., Phillips, Karlye A., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Stevens, Jennifer S., Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Guffanti, Guia, Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Murty, Vishnu P., McGrath, Meghan E., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Datner, Elizabeth M., Chang, Anna M., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O'Neil, Brian J., Sanchez, Leon D., Bruce, Steven E., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Luna, Beatriz, Harte, Steven E., Elliott, James M., Koenen, Karestan C., Kessler, Ronald C., McLean, Samuel A., Ressler, Kerry J., Jovanovic, Tanja

Source: In Neurobiology of Stress November 2021 15

Gene expression correlates of advanced epigenetic age and psychopathology in postmortem cortical tissue

Authors: Wolf, Erika J., Zhao, Xiang, Hawn, Sage E., Morrison, Filomene G., Zhou, Zhenwei, Fein-Schaffer, Dana, Huber, Bertrand, Miller, Mark W., Logue, Mark W.

Source: In Neurobiology of Stress November 2021 15

PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L

Authors: Katrinli, Seyma, Zheng, Yuanchao, Gautam, Aarti, Hammamieh, Rasha, Yang, Ruoting, Venkateswaran, Suresh, Kilaru, Varun, Lori, Adriana, Hinrichs, Rebecca, Powers, Abigail, Gillespie, Charles F., Wingo, Aliza P., Michopoulos, Vasiliki, Jovanovic, Tanja, Wolf, Erika J., McGlinchey, Regina E., Milberg, William P., Miller, Mark W., Kugathasan, Subra, Jett, Marti, Logue, Mark W., Ressler, Kerry J., Smith, Alicia K.

Source: In Brain Behavior and Immunity January 2021 91:429-436

Localization of Cholecystokinin/Sulfakinin Neuropeptides in Biomphalaria glabrata, an Intermediate Host for Schistosomiasis.

Authors: Rivera, Alana, Bracho‐Rincón, Dina, Miller, Mark W.

Source: Journal of Comparative Neurology; Jan2025, Vol. 533 Issue 1, p1-16, 16p

Moving forward with A-stage and high-rate contact-stabilization for energy efficient water resource recovery facility: Mechanisms, factors, practical approach, and guidelines

Authors: Rahman, Arifur ^*, Hasan, Mahmudul, Meerburg, Francis, Jimenez, Jose A., Miller, Mark W., Bott, Charles B., Al-Omari, Ahmed, Murthy, Sudhir, Shaw, Andrew, De Clippeleir, Haydée, Riffat, Rumana

Source: In Journal of Water Process Engineering August 2020 36

PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation

Authors: Wolf, Erika J. ^*, Logue, Mark W., Zhao, Xiang, Daskalakis, Nikolaos P., Morrison, Filomene G., Escarfulleri, Shaline, Stone, Annjanette, Schichman, Steven A., McGlinchey, Regina E., Milberg, William P., Chen, Cidi, Abraham, Carmela R., Miller, Mark W.

Source: In Psychoneuroendocrinology July 2020 117

Biochemical and apoptotic changes in the nervous and ovotestis tissues of Biomphalaria alexandrina following infection with Schistosoma mansoni

Authors: Habib, Mohamed R., Ghoname, Samah I., Ali, Rasha E., El-Karim, Rasha M.Gad, Youssef, Alaa A., Croll, Roger P., Miller, Mark W.

Source: In Experimental Parasitology June 2020 213

Leveraging genetics to enhance the efficacy of PTSD pharmacotherapies

Authors: Miller, Mark W.

Source: In Neuroscience Letters 1 May 2020 726

Interpersonal early life trauma is associated with increased cerebral perfusion and poorer memory performance in post-9/11 veterans

Authors: Sullivan, Danielle R., Salat, David H., Wolf, Erika J., Logue, Mark W., Fortier, Catherine B., Fonda, Jennifer R., DeGutis, Joseph, Esterman, Michael, Milberg, William P., McGlinchey, Regina E., Miller, Mark W.

Source: In NeuroImage: Clinical 2020 28