The impact of methylome analysis on the diagnosis and treatment of CNS tumours in children and adolescents: A population-based study in Greece

Authors: Filippidou, Maria, Glentis, Stavros, Binenbaum, Ilona, Sill, Martin, Roka, Kleoniki, Vlachou, Antonia, Avgerinou, Georgia, Ecker, Jonas, Selt, Florian, Hasselblatt, Martin, Blattner-Johnson, Mirjam, Schramm, Kathrin, Trougkou, Clio, Doganis, Dimitrios, Katzilakis, Nikolaos, Ridola, Vita, Papakonstantinou, Evgenia, Papadakis, Vassilios, Hatzipantelis, Emmanouel, Kokkinou, Eleftheria, Pons, Roser, Kanaka-Gantenbein, Christina, Sturm, Dominik, Hirsch, Steffen, Dikow, Nicola, Pajtler, Kristian W., van Tilburg, Cornelis M., Frühwald, Michael C., Milde, Till, Witt, Olaf, Jones, David T.W., Von Deimling, Andreas, Sahm, Felix, Stefanaki, Kalliopi, Pfister, Stefan M., Kattamis, Antonis

Source: In EJC Paediatric Oncology December 2024 4

Key Pharmacokinetic Parameters of 74 Pediatric Anticancer Drugs Providing Assistance in Preclinical Studies

Authors: Jamaladdin, Nora, Sigaud, Romain, Kocher, Daniela, Kolodziejczak, Anna S., Nonnenbroich, Leo F., Ecker, Jonas, Usta, Diren, Benzel, Julia, Peterziel, Heike, Pajtler, Kristian W., Tilburg, Cornelis M., Oehme, Ina, Witt, Olaf, Milde, Till

Source: Clinical pharmacology & therapeutics. 114(4):904-913

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192967974.0x000001&indx=1&recIds=ETOCvdc_100192967974.0x000001

Cerebellar Mutism Syndrome After Posterior Fossa Tumor Surgery in Children—A Retrospective Single-Center Study

Authors: Schmidt, Stephanie, Kovacs, Edina, Usta, Diren, Behnisch, Rouven, Sahm, Felix, Haux, Daniel, Witt, Olaf, Milde, Till, Unterberg, Andreas, El Damaty, Ahmed

Source: World neurosurgery. 173:e622-e628

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191324300.0x000001&indx=1&recIds=ETOCvdc_100191324300.0x000001

Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry

Authors: Ecker, Jonas, Selt, Florian, Sturm, Dominik, Sill, Martin, Korshunov, Andrey, Hirsch, Steffen, Capper, David, Dikow, Nicola, Sutter, Christian, Müller, Carina, Sigaud, Romain, Eggert, Angelika, Simon, Thorsten, Niehues, Tim, von Deimling, Andreas, Pajtler, Kristian W., van Tilburg, Cornelis M., Jones, David T.W., Sahm, Felix, Pfister, Stefan M., Witt, Olaf, Milde, Till

Source: European journal of cancer. 180:71-84

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180271560.0x000001&indx=1&recIds=ETOCvdc_100180271560.0x000001

A synergistic interaction between HDAC‐ and PARP inhibitors in childhood tumors with chromothripsis

Authors: Khalid, Umar, Simovic, Milena, Hammann, Linda A., Iskar, Murat, Wong, John K. L., Kumar, Rithu, Jugold, Manfred, Sill, Martin, Bolkestein, Michiel, Kolb, Thorsten, Hergt, Michaela, Devens, Frauke, Ecker, Jonas, Kool, Marcel, Milde, Till, Westermann, Frank, Benner, Axel, Lewis, Joe, Dietrich, Sascha, Pfister, Stefan M., Lichter, Peter, Zapatka, Marc, Ernst, Aurélie

Source: International journal of cancer. 151(4):590-606

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153796948.0x000001&indx=1&recIds=ETOCvdc_100153796948.0x000001

Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells.

Authors: Ziener, Judy, Henao-Restrepo, Julián Andrés, Leonhardi, Johanna, Sturm, Max-Johann, Becker, Sabine, Morales-Prieto, Diana M., Milde, Till, Beck, James F., Sonnemann, Jürgen

Source: BMC Cancer; 2/17/2025, Vol. 25 Issue 1, p1-15, 15p

Subject Terms: EWING'S sarcoma, RIBONUCLEOSIDE diphosphate reductase, MEMBRANE potential, MITOCHONDRIAL membranes, LIFE sciences

Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling.

Authors: Okonechnikov, Konstantin, Ghasemi, David R., Schrimpf, Daniel, Tonn, Svenja, Mynarek, Martin, Koster, Jan, Milde, Till, Zheng, Tuyu, Sievers, Philipp, Sahm, Felix, Jones, David T.W., von Deimling, Andreas, Pfister, Stefan M., Kool, Marcel, Pajtler, Kristian W., Korshunov, Andrey

Source: Acta Neuropathologica Communications; 1/7/2025, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: GENE expression, LIFE sciences, DNA fingerprinting, PROTEIN analysis, GENETICS

Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes: A multicenter cohort study.

Authors: Schwalbe, Edward C, Lindsey, Janet C, Danilenko, Marina, Hill, Rebecca M, Crosier, Stephen, Ryan, Sarra L, Williamson, Daniel, Castle, Jemma, Hicks, Debbie, Kool, Marcel, Milde, Till, Korshunov, Andrey, Pfister, Stefan M, Bailey, Simon, Clifford, Steven C

Source: Neuro-Oncology; Jan2025, Vol. 27 Issue 1, p222-236, 15p

Soft Tissue Undifferentiated Sarcoma Carrying a Novel Onecut1::Nutm1 Fusion.

Authors: Filippidou, Maria, Glentis, Stavros, Rigatou, Efthymia, Sievers, Philipp, Selt, Florian, Dimitriadis, Efthymios, Perari, Panagiota, Binenbaum, Ilona, Avgerinou, Georgia, van Tilburg, Cornelis M., Jones, David T. W., Sahm, Felix, Milde, Till, Witt, Olaf, Pfister, Stefan M., Grünewald, Thomas G. P., Stefanaki, Kalliopi, Kattamis, Antonis

Source: Pediatric Blood & Cancer; Jan2025, Vol. 72 Issue 1, p1-4, 4p

Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data

Authors: Stichel, Damian, Schrimpf, Daniel, Sievers, Philipp, Reinhardt, Annekathrin, Suwala, Abigail K., Sill, Martin, Reuss, David E., Korshunov, Andrey, Casalini, Belén M., Sommerkamp, Alexander C., Ecker, Jonas, Selt, Florian, Sturm, Dominik, Gnekow, Astrid, Koch, Arend, Simon, Michèle, Hernáiz Driever, Pablo, Schüller, Ulrich, Capper, David, Tilburg, Cornelis M., Witt, Olaf, Milde, Till, Pfister, Stefan M., Jones, David T. W., Deimling, Andreas, Sahm, Felix, Wefers, Annika K.

Source: Neuropathology & applied neurobiology. 47(3):406-414

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116963548.0x000001&indx=1&recIds=ETOCvdc_100116963548.0x000001

Predisposition to cancer in children and adolescents

Authors: Kratz, Christian P, Jongmans, Marjolijn C, Cavé, Hélène, Wimmer, Katharina, Behjati, Sam, Guerrini-Rousseau, Lea, Milde, Till, Pajtler, Kristian W, Golmard, Lisa, Gauthier-Villars, Marion, Jewell, Rosalyn, Duncan, Catriona, Maher, Eamonn R, Brugieres, Laurence, Pritchard-Jones, Kathy, Bourdeaut, Franck

Source: Lancet.Child & adolescent health. 5(2):142-154

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183234431.0x000001&indx=1&recIds=ETOCvdc_100183234431.0x000001

A Study of Regulatory Challenges of Pediatric Oncology Phase I/II Trial Submissions and Guidance on Protocol Development

Authors: Beck, Lydia, Witt, Ruth, Nesper‐Brock, Martina, Milde, Till, Hettmer, Simone, Frühwald, Michael C., Rössig, Claudia, Fischer, Matthias, Reinhardt, Dirk, Taylor, Lenka A., Riedel, Claudia, Witt, Olaf, Tilburg, Cornelis M.

Source: Clinical pharmacology & therapeutics. 110(4):1025-1037

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130127398.0x000001&indx=1&recIds=ETOCvdc_100130127398.0x000001

Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas

Authors: Milde, Till, Rodriguez, Fausto J, Barnholtz-Sloan, Jill S, Patil, Nirav, Eberhart, Charles G, Gutmann, David H

Source: Neuro-oncology. 23(10):1634-1646

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131542577.0x000001&indx=1&recIds=ETOCvdc_100131542577.0x000001

MOST wanted: navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models.

Authors: Sigaud, Romain, Brummer, Tilman, Kocher, Daniela, Milde, Till, Selt, Florian

Source: Child's Nervous System; Oct2024, Vol. 40 Issue 10, p3209-3221, 13p

Subject Terms: MITOGEN-activated protein kinases, ANIMAL models in research, TUMOR microenvironment, GLIOMAS, CAPACITY (Law)

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Authors: Gojo, Johannes, Englinger, Bernhard, Jiang, Li, Hübner, Jens M., Shaw, McKenzie L., Hack, Olivia A., Madlener, Sibylle, Kirchhofer, Dominik, Liu, Ilon, Pyrdol, Jason, Hovestadt, Volker, Mazzola, Emanuele, Mathewson, Nathan D., Trissal, Maria, Lötsch, Daniela, Dorfer, Christian, Haberler, Christine, Halfmann, Angela, Mayr, Lisa, Peyrl, Andreas, Geyeregger, Rene, Schwalm, Benjamin, Mauermann, Monica, Pajtler, Kristian W., Milde, Till, Shore, Marni E., Geduldig, Jack E., Pelton, Kristine, Czech, Thomas, Ashenberg, Orr, Wucherpfennig, Kai W., Rozenblatt-Rosen, Orit, Alexandrescu, Sanda, Ligon, Keith L., Pfister, Stefan M., Regev, Aviv, Slavc, Irene, Berger, Walter, Suvà, Mario L., Kool, Marcel, Filbin, Mariella G.

Source: In Cancer Cell 13 July 2020 38(1):44-59

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience

Authors: Pfaff, Elke, El Damaty, Ahmed, Balasubramanian, Gnana Prakash, Blattner-Johnson, Mirjam, Worst, Barbara C., Stark, Sebastian, Witt, Hendrik, Pajtler, Kristian W., van Tilburg, Cornelis M., Witt, Ruth, Milde, Till, Jakobs, Martin, Fiesel, Petra, Frühwald, Michael C., Hernáiz Driever, Pablo, Thomale, Ulrich W., Schuhmann, Martin U., Metzler, Markus, Bochennek, Konrad, Simon, Thorsten, Dürken, Matthias, Karremann, Michael, Knirsch, Stephanie, Ebinger, Martin, von Bueren, André O., Pietsch, Torsten, Herold-Mende, Christel, Reuss, David E., Kiening, Karl, Lichter, Peter, Eggert, Angelika, Kramm, Christof M., Pfister, Stefan M., Jones, David T.W., Bächli, Heidi, Witt, Olaf

Source: In European Journal of Cancer June 2019 114:27-35

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

Authors: Ecker, Jonas, Thatikonda, Venu, Sigismondo, Gianluca, Selt, Florian, Valinciute, Gintvile, Oehme, Ina, Müller, Carina, Buhl, Juliane L, Ridinger, Johannes, Usta, Diren, Qin, Nan, van Tilburg, Cornelis M, Herold-Mende, Christel, Remke, Marc, Sahm, Felix, Westermann, Frank, Kool, Marcel, Wechsler-Reya, Robert J, Chavez, Lukas, Krijgsveld, Jeroen, Jäger, Natalie, Pfister, Stefan M, Witt, Olaf, Milde, Till

Source: Neuro-oncology. 23(2):226-239

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122777442.0x000001&indx=1&recIds=ETOCvdc_100122777442.0x000001

Response to trametinib treatment in progressive pediatric low-grade glioma patients

Authors: Selt, Florian, van Tilburg, Cornelis M., Bison, Brigitte, Sievers, Philipp, Harting, Inga, Ecker, Jonas, Pajtler, Kristian W., Sahm, Felix, Bahr, Annabelle, Simon, Michèle, Jones, David T. W., Well, Lennart, Mautner, Victor-Felix, Capper, David, Hernáiz Driever, Pablo, Gnekow, Astrid, Pfister, Stefan M., Witt, Olaf, Milde, Till

Source: Journal of neuro-oncology. 149(3):499-510

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183550197.0x000001&indx=1&recIds=ETOCvdc_100183550197.0x000001

Decoding pediatric spinal tumors: a single-center retrospective case series on etiology, presentation, therapeutic strategies, and outcomes.

Authors: Lenga, Pavlina, Kühlwein, Daniel, Grutza, Martin, Issa, Mohammed, Hinz, Felix, Sahm, Felix, Selt, Florian, Milde, Till, Günther, Patrick, Unterberg, Andreas W., Krieg, Sandro M., Damaty, Ahmed El

Source: Neurosurgical Review; 9/7/2024, Vol. 47 Issue 1, p1-12, 12p

Subject Terms: CHILD patients, TERATOMA, SPINE, EWING'S sarcoma, SURGICAL decompression

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours.

Authors: Seiboldt, Till, Zeiser, Constantia, Nguyen, Duy, Celikyürekli, Simay, Herter, Sonja, Najafi, Sara, Stroh-Dege, Alexandra, Meulenbroeks, Chris, Mack, Norman, Salem-Altintas, Rabia, Westermann, Frank, Schlesner, Matthias, Milde, Till, Kool, Marcel, Holland-Letz, Tim, Vogler, Meike, Peterziel, Heike, Witt, Olaf, Oehme, Ina

Source: British Journal of Cancer; Sep2024, Vol. 131 Issue 4, p763-777, 15p