YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

Authors: Noorizadeh, Rahil ^{1, 2}, Sax, Barbara ³, Javaheri, Tahereh ³, Radic-Sarikas, Branka ^{1, 4}, Fock, Valerie ¹, Suresh, Veveeyan ¹, Kauer, Maximilian ¹, Bykov, Aleksandr ¹, Kurija, Danijela ⁵, Schlederer, Michaela ^{3, 6}, Kenner, Lukas ^{6, 7, 8, 9, 10}, Weber, Gerhard ², Mikulits, Wolfgang ², Halbritter, Florian ¹, Moriggl, Richard ^{3, 11, 12}, Kovar, Heinrich ^{1, 13, 14, ∗}

Source: In Cell Reports 25 March 2025 44(3)

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells

Authors: Fabian, Alexander, Stegner, Simon, Miarka, Lauritz, Zimmermann, Johannes, Lenk, Lennart, Rahn, Sascha, Buttlar, Jann, Viol, Fabrice, Knaack, Hendrike, Esser, Daniela, Schäuble, Sascha, Großmann, Peter, Marinos, Georgios, Häsler, Robert, Mikulits, Wolfgang, Saur, Dieter, Kaleta, Christoph, Schäfer, Heiner, Sebens, Susanne

Source: In Cancer Letters 1 July 2019 453:95-106

Transforming growth factor-β-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma

Authors: Malfettone, Andrea, Soukupova, Jitka, Bertran, Esther, Crosas-Molist, Eva, Lastra, Raquel, Fernando, Joan, Koudelkova, Petra, Rani, Bhavna, Fabra, Ángels, Serrano, Teresa, Ramos, Emilio, Mikulits, Wolfgang, Giannelli, Gianluigi, Fabregat, Isabel

Source: In Cancer Letters 28 April 2017 392:39-50

Epithelial to mesenchymal transition-related proteins ZEB1, β-catenin, and β-tubulin-III in idiopathic pulmonary fibrosis

Authors: Chilosi, Marco, Caliò, Anna, Rossi, Andrea, Gilioli, Eliana, Pedica, Federica, Montagna, Licia, Pedron, Serena, Confalonieri, Marco, Doglioni, Claudio, Ziesche, Rolf, Grubinger, Markus, Mikulits, Wolfgang, Poletti, Venerino

Source: In Modern Pathology January 2017 30(1):26-38

Role of epithelial to mesenchymal transition in hepatocellular carcinoma

Authors: Giannelli, Gianluigi, Koudelkova, Petra, Dituri, Francesco, Mikulits, Wolfgang

Source: In Journal of Hepatology October 2016 65(4):798-808

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche

Authors: Govaere, Olivier, Wouters, Jasper, Petz, Michaela, Vandewynckel, Yves-Paul, Van den Eynde, Kathleen, Van den broeck, Anke, Verhulst, Stefaan, Dollé, Laurent, Gremeaux, Lies, Ceulemans, An, Nevens, Frederik, van Grunsven, Leo A., Topal, Baki, Vankelecom, Hugo, Giannelli, Gianluigi, Van Vlierberghe, Hans, Mikulits, Wolfgang, Komuta, Mina, Roskams, Tania

Source: In Journal of Hepatology March 2016 64(3):609-617

Tumor-Extrinsic Axl Expression Shapes an Inflammatory Microenvironment Independent of Tumor Cell Promoting Axl Signaling in Hepatocellular Carcinoma.

Authors: Breitenecker, Kristina, Heiden, Denise, Demmer, Tobias, Weber, Gerhard, Primorac, Ana-Maria, Hedrich, Viola, Ortmayr, Gregor, Gruenberger, Thomas, Starlinger, Patrick, Herndler-Brandstetter, Dietmar, Barozzi, Iros, Mikulits, Wolfgang

Source: International Journal of Molecular Sciences; Apr2024, Vol. 25 Issue 8, p4202, 22p

Subject Terms: HEPATOCELLULAR carcinoma, TUMOR microenvironment, PROTEIN-tyrosine kinases, T cells, EPITHELIAL-mesenchymal transition, LIVER cancer, CXCR4 receptors

Development of an optimized, non‐stem cell line for intranasal delivery of therapeutic cargo to the central nervous system.

Authors: El‐Ayoubi, Ali, Arakelyan, Arsen, Klawitter, Moritz, Merk, Luisa, Hakobyan, Siras, Gonzalez‐Menendez, Irene, Quintanilla Fend, Leticia, Holm, Per Sonne, Mikulits, Wolfgang, Schwab, Matthias, Danielyan, Lusine, Naumann, Ulrike

Source: Molecular Oncology; Mar2024, Vol. 18 Issue 3, p528-546, 19p

Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma.

Authors: Breitenecker, Kristina, Hedrich, Viola, Pupp, Franziska, Chen, Doris, Řezníčková, Eva, Ortmayr, Gregor, Huber, Heidemarie, Weber, Gerhard, Balcar, Lorenz, Pinter, Matthias, Mikulits, Wolfgang

Source: Frontiers in Oncology; 2023, p1-15, 15p

Subject Terms: PROTEIN-tyrosine kinases, SORAFENIB, FIBROBLAST growth factor 2, HEPATOCELLULAR carcinoma, ERLOTINIB, REGORAFENIB, PROTEIN-tyrosine kinase inhibitors

M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues

Authors: Puxbaum, Verena, Nimmerfall, Elisabeth, Bäuerl, Christine, Taub, Nicole, Blaas, Pia-Maria, Wieser, Johannes, Mikula, Mario, Mikulits, Wolfgang, Ng, Ken M., Yeoh, George C.T., Mach, Lukas

Source: In Journal of Hepatology August 2012 57(2):337-343

Initial steps of metastasis: Cell invasion and endothelial transmigration

Authors: van Zijl, Franziska, Krupitza, Georg, Mikulits, Wolfgang

Source: In Mutation Research-Reviews in Mutation Research July-October 2011 728(1-2):23-34

Gas6 in chronic liver disease—a novel blood-based biomarker for liver fibrosis.

Authors: Staufer, Katharina, Huber, Heidemarie, Zessner-Spitzenberg, Jasmin, Stauber, Rudolf, Finkenstedt, Armin, Bantel, Heike, Weiss, Thomas S., Huber, Markus, Starlinger, Patrick, Gruenberger, Thomas, Reiberger, Thomas, Sebens, Susanne, McIntyre, Gail, Tabibiazar, Ray, Giaccia, Amato, Zoller, Heinz, Trauner, Michael, Mikulits, Wolfgang

Source: Cell Death Discovery; 8/2/2023, Vol. 9 Issue 1, p1-8, 8p

BAMBI is overexpressed in ovarian cancer and co-translocates with Smads into the nucleus upon TGF-ß treatment

Authors: Pils, Dietmar, Wittinger, Michael, Petz, Michaela, Gugerell, Alfred, Gregor, Wolfgang, Alfanz, Angela, Horvat, Reinhard, Braicu, Elena-Ioana, Sehouli, Jalid, Zeillinger, Robert, Mikulits, Wolfgang, Krainer, Michael

Source: In Gynecologic Oncology 2010 117(2):189-197

The role of c-FLIP L in ovarian cancer: Chaperoning tumor cells from immunosurveillance and increasing their invasive potential

Authors: El-Gazzar, Ahmed, Wittinger, Michael, Perco, Paul, Anees, Mariam, Horvat, Reinhard, Mikulits, Wolfgang, Grunt, Thomas W., Mayer, Bernd, Krainer, Michael

Source: In Gynecologic Oncology 2010 117(3):451-459

Berberine and a Berberis lycium extract inactivate Cdc25A and induce α-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis

Authors: Khan, Musa, Giessrigl, Benedikt, Vonach, Caroline, Madlener, Sibylle, Prinz, Sonja, Herbaceck, Irene, Hölzl, Christine, Bauer, Sabine, Viola, Katharina, Mikulits, Wolfgang, Quereshi, Rizwana Aleem, Knasmüller, Siegfried, Grusch, Michael, Kopp, Brigitte, Krupitza, Georg

Source: In Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2010 683(1):123-130

Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis

Authors: Mair, Markus, Zollner, Gernot, Schneller, Doris, Musteanu, Monica, Fickert, Peter, Gumhold, Judith, Schuster, Christian, Fuchsbichler, Andrea, Bilban, Martin, Tauber, Stefanie, Esterbauer, Harald, Kenner, Lukas, Poli, Valeria, Blaas, Leander, Kornfeld, Jan Wilhelm, Casanova, Emilio, Mikulits, Wolfgang, Trauner, Michael, Eferl, Robert

Source: In Gastroenterology 2010 138(7):2499-2508

Nuclear β-Catenin Induces an Early Liver Progenitor Phenotype in Hepatocellular Carcinoma and Promotes Tumor Recurrence

Authors: Zulehner, Gudrun, Mikula, Mario, Schneller, Doris, van Zijl, Franziska, Huber, Heidemarie, Sieghart, Wolfgang, Grasl-Kraupp, Bettina, Waldhör, Thomas, Peck-Radosavljevic, Markus, Beug, Hartmut, Mikulits, Wolfgang

Source: In The American Journal of Pathology 2010 176(1):472-481

PRAME Is a Novel Target of Tumor-Intrinsic Gas6/Axl Activation and Promotes Cancer Cell Invasion in Hepatocellular Carcinoma.

Authors: Hedrich, Viola, Breitenecker, Kristina, Ortmayr, Gregor, Pupp, Franziska, Huber, Heidemarie, Chen, Doris, Sahoo, Sarthak, Jolly, Mohit Kumar, Mikulits, Wolfgang

Source: Cancers; May2023, Vol. 15 Issue 9, p2415, 20p

Subject Terms: RNA analysis, DISEASE progression, CELL differentiation, SEQUENCE analysis, CANCER invasiveness, CELLULAR therapy, ONCOGENES, PROTEIN kinase inhibitors, SIGNAL peptides, EPITHELIAL-mesenchymal transition, CELLULAR signal transduction, PROTEOMICS, CANCER patients, CELL motility, RESEARCH funding, CELL lines, TUMOR antigens, T cells, MITOGEN-activated protein kinases, HEPATOCELLULAR carcinoma, PHENOTYPES, IMMUNOTHERAPY, CHEMICAL inhibitors

Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay

Authors: Winter, Heike K., Ehrlich, Veronika A., Grusch, Michael, Lackner, Andreas, Schulte-Hermann, Rolf, Grasl-Kraupp, Bettina, Mikulits, Wolfgang, Knasmüller, Siegfried

Source: In Mut.Res.-Genetic Toxicology and Environmental Mutagenesis 2008 657(2):133-139

SAT-282 - Immunological impact of Axl/TGF-beta signaling in hepatocellular carcinoma

Authors: Ortmayr, Gregor, Hedrich, Viola, Starlinger, Patrick, Grünberger, Thomas, Chen, Doris, Mikulits, Wolfgang

Source: In Journal of Hepatology June 2023 78 Supplement 1:S564-S564