Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

Authors: Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

Source: Endocrine Journal, Vol 71, Iss 11, Pp 1055-1067 (2024)

Subject Terms: tofogliflozin, chronic kidney disease (ckd), inflammation, peroxisome proliferator activated receptor alpha (pparα), micro-rna-21(mir-21), Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.jstage.jst.go.jp/article/endocrj/71/11/71_EJ24-0087/_html/-char/en; https://doaj.org/toc/1348-4540

Access URL: https://doaj.org/article/c8547725ada84510b6ac63c3efbd6bcb

Environmental Factor Index (EFI): A Novel Approach to Measure the Strength of Environmental Influence on DNA Methylation in Identical Twins

Authors: Yoichi Takenaka, Osaka Twin Research Group, Mikio Watanabe

Source: Epigenomes, Vol 8, Iss 4, p 44 (2024)

Subject Terms: epigenetics, DNA methylation, environmental factors, twin study, Genetics, QH426-470, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4655/8/4/44; https://doaj.org/toc/2075-4655

Access URL: https://doaj.org/article/d606b2bbfa544113838ee4b4f425b28c

Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases

Authors: Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

Source: Endocrine Journal, Vol 70, Iss 12, Pp 1169-1174 (2023)

Subject Terms: acetylation, daily variation, circadian variation, autoimmune thyroid disease, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.jstage.jst.go.jp/article/endocrj/70/12/70_EJ23-0204/_html/-char/en; https://doaj.org/toc/1348-4540

Access URL: https://doaj.org/article/1fafb4da2f48492cbf56e82462671c7e

Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

Authors: Karri Silventoinen, Maarit Piirtola, Aline Jelenkovic, Reijo Sund, Adam D. Tarnoki, David L. Tarnoki, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Margaret Gatz, David A. Butler, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Carol E. Franz, William S. Kremen, Michael J. Lyons, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Per Tynelius, Finn Rasmussen, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Ingunn Brandt, Thomas S. Nilsen, Jennifer R. Harris, Jessica Tyler, John L. Hopper, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucia Colodro-Conde, Esther Rebato, Dongfeng Zhang, Zengchang Pang, Qihua Tan, Judy L. Silberg, Hermine H. Maes, Dorret I. Boomsma, Thorkild I. A. Sørensen, Tellervo Korhonen, Jaakko Kaprio

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a04289e4c6684fb58b460af114fe9ff4

The HIF‐1α pathway plays a critical role in salivary gland development in ex vivo organ cultures

Authors: Tomomasa Kimura, Manabu Sakai, Nao Gojo, Mikio Watanabe, Narikazu Uzawa, Takayoshi Sakai

Source: FEBS Open Bio, Vol 12, Iss 2, Pp 460-469 (2022)

Subject Terms: development, HIF‐1α, hypoxia, salivary glands, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/3267a8e1d1e048d9b270982c40120f54

PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves’ and Hashimoto’s diseases

Authors: Mayumi Kawabata, Naoya Inoue, Mikio Watanabe, Ayaka Kobayashi, Yoh Hidaka, Akira Miyauchi, Yoshinori Iwatani

Source: Autoimmunity, Vol 54, Iss 7, Pp 450-459 (2021)

Subject Terms: pd-1, pd-l1, pd-l2, regulatory t cell, single nucleotide polymorphism, severity, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/959f50e7963a4823b7e03537c7980459

Association of IL6 gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases

Authors: Nachi Hirai, Mikio Watanabe, Naoya Inoue, Riku Kinoshita, Hiroki Ohtani, Yoh Hidaka, Yoshinori Iwatani

Source: Autoimmunity, Vol 52, Iss 7-8, Pp 251-255 (2019)

Subject Terms: il-6, methylation, severity, intractability, autoimmune thyroid disease, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/810613432a59451c9b6821dc21e3fcce

Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease

Authors: Takayuki Kunisato, Mikio Watanabe, Naoya Inoue, Azusa Okada, Takashi Nanba, Wataru Kobayashi, Yuka Inoue, Yuka Katsumata, Naoki Omori, Takayuki Nobuhara, Kazuya Takemura, Yoh Hidaka, Yoshinori Iwatani

Source: Autoimmunity, Vol 51, Iss 7, Pp 360-369 (2018)

Subject Terms: th17, single nucleotide polymorphism, intractability, severity, il-17f, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/a950b972b1024d25870173fac324059d

Methylation levels of the TNFA gene are different between Graves’ and Hashimoto’s diseases and influenced by the TNFA polymorphism

Authors: Emi Morita, Mikio Watanabe, Naoya Inoue, Hidemi Hashimoto, Emi Haga, Yoh Hidaka, Yoshinori Iwatani

Source: Autoimmunity, Vol 51, Iss 3, Pp 118-125 (2018)

Subject Terms: tnf-α, methylation, graves’ disease, hashimoto’s disease, polymorphism, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/90c6060f421d4de98f19baa8da8d86f8

Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases

Authors: Ena Tokiyoshi, Mikio Watanabe, Naoya Inoue, Yoh Hidaka, Yoshinori Iwatani

Source: Autoimmunity, Vol 51, Iss 1, Pp 35-42 (2018)

Subject Terms: ago, polymorphism, autoimmune thyroid disease, severity, intractability, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/43404855c8d342589a6936f0e61cfdb5

Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease

Authors: Tomoyo Mizuma, Mikio Watanabe, Naoya Inoue, Yuya Arakawa, Saki Tomari, Yoh Hidaka, Yoshinori Iwatani

Source: Autoimmunity, Vol 50, Iss 6, Pp 386-392 (2017)

Subject Terms: thyroglobulin, graves’ disease, hashimoto’s disease, polymorphism, severity, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/06b6d257ba0b4afc91eecfa463d05b4c

Polymorphisms and expression of toll-like receptors in autoimmune thyroid diseases

Authors: Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani

Source: Autoimmunity, Vol 50, Iss 3, Pp 182-191 (2017)

Subject Terms: autoimmune thyroid diseases, tlr7, tlr9, unc93b1, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/42dab3f68763442cb68541970ce3db61

Relationship between Nutrient Intake and Human Gut Microbiota in Monozygotic Twins

Authors: Natsuko Matsumoto, Jonguk Park, Rie Tomizawa, Hitoshi Kawashima, Koji Hosomi, Kenji Mizuguchi, Chika Honda, Ritsuko Ozaki, Yoshinori Iwatani, Mikio Watanabe, Jun Kunisawa

Source: Medicina, Vol 57, Iss 3, p 275 (2021)

Subject Terms: monozygotic twins, gut microbiome, nutrients, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/1648-9144/57/3/275; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144

Access URL: https://doaj.org/article/218fbdd43ba84d79ba65d9a6356fab1b

Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts.

Authors: Maarit Piirtola, Aline Jelenkovic, Antti Latvala, Reijo Sund, Chika Honda, Fujio Inui, Mikio Watanabe, Rie Tomizawa, Yoshinori Iwatani, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Adam D Tarnoki, David L Tarnoki, Nicholas G Martin, Grant W Montgomery, Sarah E Medland, Finn Rasmussen, Per Tynelius, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Esther Rebato, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Andreas Busjahn, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Tessa L Cutler, John L Hopper, Robin P Corley, Brooke M Huibregtse, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Margaret Gatz, David A Butler, Carol E Franz, William S Kremen, Michael J Lyons, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Sevgi Y Öncel, Fazil Aliev, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Judy L Silberg, Hermine H Maes, Dorret I Boomsma, Thorkild I A Sørensen, Tellervo Korhonen, Jaakko Kaprio, Karri Silventoinen

Source: PLoS ONE, Vol 13, Iss 7, p e0200140 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0200140&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ad481e1eec1846b88be11db23d4fe8fd

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Authors: Aline Jelenkovic, Yoon-Mi Hur, Reijo Sund, Yoshie Yokoyama, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Sari Aaltonen, Kauko Heikkilä, Sevgi Y Öncel, Fazil Aliev, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Tessa L Cutler, John L Hopper, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Wendy Cozen, Amie E Hwang, Thomas M Mack, Joohon Sung, Yun-Mi Song, Sarah Yang, Kayoung Lee, Carol E Franz, William S Kremen, Michael J Lyons, Andreas Busjahn, Tracy L Nelson, Keith E Whitfield, Christian Kandler, Kerry L Jang, Margaret Gatz, David A Butler, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Glen E Duncan, Dedra Buchwald, Catherine A Derom, Robert F Vlietinck, Ruth JF Loos, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Hoe-Uk Jeong, Gary E Swan, Ruth Krasnow, Patrik KE Magnusson, Nancy L Pedersen, Anna K Dahl-Aslan, Tom A McAdams, Thalia C Eley, Alice M Gregory, Per Tynelius, Laura A Baker, Catherine Tuvblad, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Paul Lichtenstein, Timothy D Spector, Massimo Mangino, Genevieve Lachance, Meike Bartels, Toos CEM van Beijsterveldt, Gonneke Willemsen, S Alexandra Burt, Kelly L Klump, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Robert F Krueger, Matt McGue, Shandell Pahlen, Robin P Corley, Jacob v B Hjelmborg, Jack H Goldberg, Yoshinori Iwatani, Mikio Watanabe, Chika Honda, Fujio Inui, Finn Rasmussen, Brooke M Huibregtse, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen

Source: eLife, Vol 5 (2016)

Subject Terms: height, twins, heritability, birth cohorts, CODATwins project, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/20320; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/50d2ac0e398245b48ab8dfc75f845471

Transcriptional activity of the 5'-flanking region of the thyroid transcription factor-1 gene in human thyroid cell lines

Authors: Hiroya Yamada, Toru Takano, Fumio Matsuzuka, Mikio Watanabe, Akira Miyauchi, Yoshinori Iwatani

Source: Genetics and Molecular Biology, Vol 34, Iss 1, Pp 06-10 (2011)

Subject Terms: thyroid, TTF-1, transcription, human cell line, stem cell, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100002; https://doaj.org/toc/1415-4757; https://doaj.org/toc/1678-4685

Access URL: https://doaj.org/article/675c353ea2bf4b298668582803763668

Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases.

Authors: Haga, Emi, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

Source: Endocrine Journal; 2023, Vol. 70 Issue 12, p1169-1174, 6p

Twin Study: Genetic and Epigenetic Factors Affecting Circulating Adiponectin Levels.

Authors: Mika Hasegawa, Jumpei Taniguchi, Hiromichi Ueda, Mikio Watanabe

Source: Journal of Clinical Endocrinology & Metabolism; Jan2023, Vol. 108 Issue 1, p144-154, 11p

Subject Terms: ADIPONECTIN, PHENOTYPES, INSULIN resistance

Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs.

Authors: Mikio Watanabe^1,2 iwatani@sahs.med.osaka-u.ac.jp, Chika Honda²

Source: BMC Medical Genomics. 8/26/2016, Vol. 9, p1-9. 9p.

Subject Terms: *TWINS, *DNA methylation, *EPIGENESIS, *X chromosome, *GENETICS

Company/Entity: OSAKA University

Gene polymorphisms of VEGF and VEGFR2 are associated with the severity of Hashimoto's disease and the intractability of Graves' disease, respectively.

Authors: Mami Okamoto, Mikio Watanabe, Naoya Inoue, Kazane Ogawa, Yoh Hidaka, Yoshinori Iwatani

Source: Endocrine Journal; 2020, Vol. 67 Issue 5, p545-559, 15p