Addressing the credibility crisis in Mendelian randomization

Authors: Stephen Burgess, Benjamin Woolf, Amy M. Mason, Mika Ala-Korpela, Dipender Gill

Source: BMC Medicine, Vol 22, Iss 1, Pp 1-9 (2024)

Subject Terms: Causal inference, Genetic epidemiology, Instrumental variables, Evidence synthesis, Risk of bias, Bias evaluation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/983a6c7b1a5a41d1b8fb838855775288

Biomarkers reflecting insulin resistance increase the risk of aortic stenosis in a population-based study of 10,144 Finnish men

Authors: Maija Sohlman, Raimo Jauhiainen, Jagadish Vangipurapu, Annamaria Laakso, Mika Ala-Korpela, Teemu Kuulasmaa, Johanna Kuusisto

Source: Annals of Medicine, Vol 56, Iss 1 (2024)

Subject Terms: Aortic stenosis, insulin resistance, insulin, biomarkers, principal component analysis, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060

Access URL: https://doaj.org/article/568ed97365494a2d820c6a4eb5a1ba7f

Cross-sectional metabolic subgroups and 10-year follow-up of cardiometabolic multimorbidity in the UK Biobank

Authors: Anwar Mulugeta, Elina Hyppönen, Mika Ala-Korpela, Ville-Petteri Mäkinen

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/893d0e489ae54bad898b481b31b3c48d

Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health

Authors: Saara Marttila, Suvi Rovio, Pashupati P. Mishra, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Markus Juonala, Melanie Waldenberger, Niku Oksala, Mika Ala-Korpela, Emily Harville, Nina Hutri-Kähönen, Mika Kähönen, Olli Raitakari, Terho Lehtimäki, Emma Raitoharju

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d6935f0b93b346128975b23ece2111de

Novel biomarkers associated with incident heart failure in 10 106 Finnish men

Authors: Raimo Jauhiainen, Matti Jauhiainen, Jagadish Vangipurapu, Teemu Kuulasmaa, Mika Ala‐Korpela, Markku Laakso, Johanna Kuusisto

Source: ESC Heart Failure, Vol 8, Iss 1, Pp 605-614 (2021)

Subject Terms: Heart failure, Hypertension, Biomarkers, Metabolomics, Inflammation, Principal component analysis, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5822

Access URL: https://doaj.org/article/e8d269afbcad43b4948b1e7cf3d9a979

A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

Authors: Ivana Prokić, Lies Lahousse, Maaike de Vries, Jun Liu, Marita Kalaoja, Judith M. Vonk, Diana A. van der Plaat, Cleo C. van Diemen, Ashley van der Spek, Alexandra Zhernakova, Jingyuan Fu, Mohsen Ghanbari, Mika Ala-Korpela, Johannes Kettunen, Aki S. Havulinna, Markus Perola, Veikko Salomaa, Lars Lind, Johan Ärnlöv, Bruno H. C. Stricker, Guy G. Brusselle, H. Marike Boezen, Cornelia M. van Duijn, Najaf Amin

Source: BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-10 (2020)

Subject Terms: COPD, Metabolomics, Mendelian randomization, Glycoprotein acetyls, Biomarkers, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12890-020-01222-7; https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/7713de2df3e641e195c822e4a3b8bf44

Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young

Authors: Scott T. Chiesa, Marietta Charakida, Georgios Georgiopoulos, Justin D. Roberts, Simon J. Stafford, Chloe Park, Juha Mykkänen, Mika Kähönen, Terho Lehtimäki, Mika Ala‐Korpela, Olli Raitakari, Milla Pietiäinen, Pirkko Pussinen, Vivek Muthurangu, Alun D. Hughes, Naveed Sattar, Nicholas J. Timpson, John E. Deanfield

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 4 (2022)

Subject Terms: ALSPAC, cardiovascular disease, CRP, GlycA, Young Finns Study, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/0aac8b599987442fa69aba6e405d172e

Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease: Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts

Authors: Emmi Tikkanen, Vilma Jägerroos, Michael V. Holmes, Naveed Sattar, Mika Ala‐Korpela, Pekka Jousilahti, Annamari Lundqvist, Markus Perola, Veikko Salomaa, Peter Würtz

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)

Subject Terms: biomarker, coronary artery disease, magnetic resonance spectroscopy, metabolomics, peripheral artery disease, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/dac13f26ed3f4657be68171482bb8f6f

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study

Authors: Qin Wang, Jari Jokelainen, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Marjo-Riitta Järvelin, Johannes Kettunen, Ville-Petteri Mäkinen, Mika Ala-Korpela

Source: BMC Medicine, Vol 17, Iss 1, Pp 1-12 (2019)

Subject Terms: Insulin resistance, Metabolic profiling, Oral glucose tolerance test, Impaired glucose tolerance, Impaired fasting glucose, Type 2 diabetes, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/688a9a1a0c4d4ef6ae58ea246ba3f7e0

A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context

Authors: Apolline Gallois, Joel Mefford, Arthur Ko, Amaury Vaysse, Hanna Julienne, Mika Ala-Korpela, Markku Laakso, Noah Zaitlen, Päivi Pajukanta, Hugues Aschard

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/18f5d61c166a4f04bdb8979fa46f9cb9

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Authors: Joris Deelen, Johannes Kettunen, Krista Fischer, Ashley van der Spek, Stella Trompet, Gabi Kastenmüller, Andy Boyd, Jonas Zierer, Erik B. van den Akker, Mika Ala-Korpela, Najaf Amin, Ayse Demirkan, Mohsen Ghanbari, Diana van Heemst, M. Arfan Ikram, Jan Bert van Klinken, Simon P. Mooijaart, Annette Peters, Veikko Salomaa, Naveed Sattar, Tim D. Spector, Henning Tiemeier, Aswin Verhoeven, Melanie Waldenberger, Peter Würtz, George Davey Smith, Andres Metspalu, Markus Perola, Cristina Menni, Johanna M. Geleijnse, Fotios Drenos, Marian Beekman, J. Wouter Jukema, Cornelia M. van Duijn, P. Eline Slagboom

Source: Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6923daf567204a5eb33b751c0974e159

Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives

Authors: Tom G Richardson, PhD, Qin Wang, PhD, Eleanor Sanderson, PhD, Anubha Mahajan, PhD, Mark I McCarthy, ProfMD, Timothy M Frayling, ProfPhD, Mika Ala-Korpela, ProfPhD, Allan Sniderman, ProfMD, George Davey Smith, ProfFRS, Michael V Holmes, MD

Source: The Lancet. Healthy Longevity, Vol 2, Iss 6, Pp e317-e326 (2021)

Subject Terms: Geriatrics, RC952-954.6, Medicine

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666756821000866; https://doaj.org/toc/2666-7568

Access URL: https://doaj.org/article/bc63b18e9b274f27bdc502a9b153d18b

Characteristics of Normalization Methods in Quantitative Urinary Metabolomics—Implications for Epidemiological Applications and Interpretations

Authors: Tianqi Li, Tuulia Tynkkynen, Andrei Ihanus, Siyu Zhao, Ville-Petteri Mäkinen, Mika Ala-Korpela

Source: Biomolecules, Vol 12, Iss 7, p 903 (2022)

Subject Terms: biomarkers, disease risk, epidemiology, kidney function, metabolomics, NMR, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/7/903; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/254262474e8148deb3b946c431d26932

Metabolic characterization of menopause: cross-sectional and longitudinal evidence

Authors: Qin Wang, Diana L. Santos Ferreira, Scott M. Nelson, Naveed Sattar, Mika Ala-Korpela, Debbie A. Lawlor

Source: BMC Medicine, Vol 16, Iss 1, Pp 1-12 (2018)

Subject Terms: Metabolic profile, Reproductive status, Menopause, Post-menopausal, Cross-sectional, Longitudinal, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12916-018-1008-8; https://doaj.org/toc/1741-7015

Access URL: https://doaj.org/article/52bb1ae57acf4d22b1e59ea481f0e211

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

Authors: Maren E. Cannon, Qing Duan, Ying Wu, Monica Zeynalzadeh, Zheng Xu, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Mete Civelek, Aldons J. Lusis, Johanna Kuusisto, Francis S. Collins, Michael Boehnke, Hua Tang, Markku Laakso, Yun Li, Karen L. Mohlke

Source: G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 3217-3227 (2017)

Subject Terms: Genetics, Gene Expression, Cholesterol, Transcription, Complex genetic traits, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2160-1836

Access URL: https://doaj.org/article/ecc7f25e27af4436b24b3848b1791633

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Authors: Artika P. Nath, Scott C. Ritchie, Sean G. Byars, Liam G. Fearnley, Aki S. Havulinna, Anni Joensuu, Antti J. Kangas, Pasi Soininen, Annika Wennerström, Lili Milani, Andres Metspalu, Satu Männistö, Peter Würtz, Johannes Kettunen, Emma Raitoharju, Mika Kähönen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, Terho Lehtimäki, Gad Abraham, Olli Raitakari, Veikko Salomaa, Markus Perola, Michael Inouye

Source: Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-017-1279-y; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/e180785c8f2d4968ab0cf6652e950915

Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns

Authors: Daniel Seung Kim, Anne U. Jackson, Yatong K. Li, Heather M. Stringham, Johanna Kuusisto, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Charles F. Burant, Veikko Salomaa, Michael Boehnke, Markku Laakso, Elizabeth K. Speliotes

Source: Journal of Lipid Research, Vol 58, Iss 7, Pp 1471-1481 (2017)

Subject Terms: transmembrane 6 superfamily member 2, nonalcoholic fatty liver disease, epidemiology, cardiovascular disease, type 2 diabetes, apolipoprotein B-100, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520335963; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/c308243251f34f96be79794a109cc4c0

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.

Authors: Tom G Richardson, Eleanor Sanderson, Tom M Palmer, Mika Ala-Korpela, Brian A Ference, George Davey Smith, Michael V Holmes

Source: PLoS Medicine, Vol 17, Iss 3, p e1003062 (2020)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

Access URL: https://doaj.org/article/05d52afa4ac34bb5ab25a2523cfcdd7a

Correction: Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.

Authors: Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela

Source: PLoS Biology, Vol 18, Iss 3, p e3000694 (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/589d1a5e94154ae0af7bd16987bc96a7

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.

Authors: Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela

Source: PLoS Biology, Vol 17, Iss 12, p e3000572 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/02cf23016d6a452f98447d67e6ff0803