Suppressive effects of ketamine on auditory steady-state responses in intact, awake macaques: A non-human primate model of schizophrenia

Authors: Nakamura, Tomoya, Dinh, Trong Ha, Asai, Makoto, Matsumoto, Jumpei, Nishimaru, Hiroshi, Setogawa, Tsuyoshi, Honda, Sokichi, Yamada, Hiroshi, Mihara, Takuma, Nishijo, Hisao

Source: Brain research bulletin. 193:84-94

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Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment

Authors: Featherstone, Robert E, Shimada, Takeshi, Crown, Lindsey M, Melnychenko, Olya, Yi, Janice, Matsumoto, Mitsuyuki, Tajinda, Katsunori, Mihara, Takuma, Adachi, Megumi, Siegel, Steven J

Source: Neuroscience. 499:104-117

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Non-invasive electroencephalographical (EEG) recording system in awake monkeys

Authors: Nakamura, Tomoya, Dinh, Trong Ha, Asai, Makoto, Nishimaru, Hiroshi, Matsumoto, Jumpei, Takamura, Yusaku, Hori, Etsuro, Honda, Sokichi, Yamada, Hiroshi, Mihara, Takuma, Matsumoto, Mitsuyuki, Nishijo, Hisao

Source: In Heliyon May 2020 6(5)

A novel GABAB receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia

Authors: Murai, Nobuhito, Kondo, Yuji, Akuzawa, Shinobu, Mihara, Takuma, Shiraishi, Nobuyuki, Kakimoto, Shuichiro, Matsumoto, Mitsuyuki

Source: In European Journal of Pharmacology 15 December 2019 865

Auditory Steady State Response; nature and utility as a translational science tool

Authors: Kozono, Naoki, Honda, Sokichi, Tada, Mariko, Kirihara, Kenji, Zhao, Zhilei, Jinde, Seiichiro, Uka, Takanori, Yamada, Hiroshi, Matsumoto, Mitsuyuki, Kasai, Kiyoto, Mihara, Takuma

Source: Scientific reports. 9(1):1-10

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Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436

Authors: Hamaguchi, Wataru, Masuda, Naoyuki, Miyamoto, Satoshi, Kikuchi, Shigetoshi, Narazaki, Fumie, Shiina, Yasuhiro, Seo, Ryushi, Amano, Yasushi, Mihara, Takuma, Moriguchi, Hiroyuki, Hattori, Kouji

Source: In Bioorganic & Medicinal Chemistry 1 July 2015 23(13):3351-3367

Amygdala activity associated with social choice in mice

Authors: Mihara, Takuma, Mensah-Brown, Kobina, Sobota, Rosanna, Lin, Robert, Featherstone, Robert, Siegel, Steven J.

Source: Behavioural brain research. 332:84-89

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Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition

Authors: Hamaguchi, Wataru, Masuda, Naoyuki, Miyamoto, Satoshi, Shiina, Yasuhiro, Kikuchi, Shigetoshi, Mihara, Takuma, Moriguchi, Hiroyuki, Fushiki, Hiroshi, Murakami, Yoshihiro, Amano, Yasushi, Honbou, Kazuya, Hattori, Kouji

Source: In Bioorganic & Medicinal Chemistry 15 January 2015 23(2):297-313

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability

Authors: Chino, Ayaka, Masuda, Naoyuki, Amano, Yasushi, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki

Source: In Bioorganic & Medicinal Chemistry 1 July 2014 22(13):3515-3526

Computational identification of variables in neonatal vocalizations predictive for postpubertal social behaviors in a mouse model of 16p11.2 deletion

Authors: Nakamura, Mitsuteru, Ye, Kenny, e Silva, Mariel Barbachan, Yamauchi, Takahira, Hoeppner, Daniel J., Fayyazuddin, Amir, Kang, Gina, Yuda, Emi A., Nagashima, Masako, Enomoto, Shingo, Hiramoto, Takeshi, Sharp, Richard, Kaneko, Itaru, Tajinda, Katsunori, Adachi, Megumi, Mihara, Takuma, Tokuno, Shinichi, Geyer, Mark A., Broin, Pilib Ó, Matsumoto, Mitsuyuki, Hiroi, Noboru

Source: Molecular Psychiatry; 20240101, Issue: Preprints p1-11, 11p

Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition

Authors: Hamaguchi, Wataru, Masuda, Naoyuki, Isomura, Mai, Miyamoto, Satoshi, Kikuchi, Shigetoshi, Amano, Yasushi, Honbou, Kazuya, Mihara, Takuma, Watanabe, Toshihiro

Source: In Bioorganic & Medicinal Chemistry 15 December 2013 21(24):7612-7623

Gamma power abnormalities in a Fmr1-targeted transgenic rat model of fragile X syndrome

Authors: Kozono, Naoki, Okamura, Ai, Honda, Sokichi, Matsumoto, Mitsuyuki, Mihara, Takuma

Source: Scientific reports. 10(1)

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Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism

Authors: Sobota, Rosanna, Mihara, Takuma, Forrest, Alexandra, Featherstone, Robert E., Siegel, Steven J.

Source: Behavioral neuroscience. 129(4):389-398

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Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: Validation with olanzapine and ziprasidone

Authors: Shobo, Miwako, Yamada, Hiroshi, Mihara, Takuma, Kondo, Yuji, Irie, Megumi, Harada, Katsuya, Ni, Keni, Matsuoka, Nobuya, Kayama, Yukihiko

Source: In Behavioural Brain Research 2011 216(2):561-568

A novel adenosine A 1 and A 2A receptor antagonist ASP5854 ameliorates motor impairment in MPTP-treated marmosets: Comparison with existing anti-Parkinson's disease drugs

Authors: Mihara, Takuma, Iwashita, Akinori, Matsuoka, Nobuya

Source: In Behavioural Brain Research 2008 194(2):152-161

Pharmacological Characterization of a Novel, Potent Adenosine A1 and A2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1 H)-one (ASP5854), in Models of Parkinson’s Disease and Cognition

Authors: Mihara, Takuma, Mihara, Kayoko ^*, Yarimizu, Junko, Mitani, Yasuyuki, Matsuda, Ritsuko, Yamamoto, Hiroko, Aoki, Satoshi, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2007 323(2):708-719

Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques.

Authors: Nakamura, Tomoya, Dinh, Trong Ha, Asai, Makoto, Nishimaru, Hiroshi, Matsumoto, Jumpei, Setogawa, Tsuyoshi, Ichijo, Hiroyuki, Honda, Sokichi, Yamada, Hiroshi, Mihara, Takuma, Nishijo, Hisao

Source: BMC Neuroscience; 9/30/2022, Vol. 23 Issue 1, p1-13, 13p

Anxiolytic activity of a novel potent serotonin 5-HT 2C receptor antagonist FR260010: A comparison with diazepam and buspirone

Authors: Harada, Katsuya, Aota, Masaki, Inoue, Tatsuo, Matsuda, Ritsuko, Mihara, Takuma, Yamaji, Takayuki, Ishibashi, Koji, Matsuoka, Nobuya

Source: In European Journal of Pharmacology 2006 553(1):171-184

F162. Construction of a Mouse Model of Mismatch Negativity (MMN)

Authors: Honda, Sokichi, Sugiyama, Azusa, Mihara, Takuma, Tajinda, Katsunori, Matsumoto, Mitsuyuki, Adachi, Megumi

Source: Biological psychiatry. 85(S):S275-S276

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Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors

Authors: Maemoto, Takuya ¹, Tada, Miho ¹, Mihara, Takuma ¹, Ueyama, Noriko ¹, Matsuoka, Hideaki ¹, Harada, Katsuya ¹, Yamaji, Takayuki ¹, Shirakawa, Kiyoharu ¹, Kuroda, Satoru ², Akahane, Atsushi ², Iwashita, Akinori ¹, Matsuoka, Nobuya ^{1, *}, Mutoh, Seitaro ¹

Source: In Journal of Pharmacological Sciences 2004 96(1):42-52