Pharmacological Characterization of a Novel, Potent Adenosine A1 and A2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1 H)-one (ASP5854), in Models of Parkinson’s Disease and Cognition

Authors: Mihara, Takuma, Mihara, Kayoko ^*, Yarimizu, Junko, Mitani, Yasuyuki, Matsuda, Ritsuko, Yamamoto, Hiroko, Aoki, Satoshi, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2007 323(2):708-719

Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor δ-Selective Agonists in Vitro and in Vivo

Authors: Iwashita, Akinori ^*, Muramatsu, Yuko, Yamazaki, Takao, Muramoto, Masakazu, Kita, Yasuhiro, Yamazaki, Shunji, Mihara, Kayoko, Moriguchi, Akira, Matsuoka, Nobuya

Source: In The Journal of Pharmacology and Experimental Therapeutics March 2007 320(3):1087-1096

TRIAZOLE DERIVATIVE OR SALT THEREOF

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling

Authors: Ishida, Junya, Yamamoto, Hirofumi, Kido, Yoshiyuki, Kamijo, Kazunori, Murano, Kenji, Miyake, Hiroshi, Ohkubo, Mitsuru, Kinoshita, Takayoshi, Warizaya, Masaichi, Iwashita, Akinori, Mihara, Kayoko, Matsuoka, Nobuya, Hattori, Kouji

Source: In Bioorganic & Medicinal Chemistry 2006 14(5):1378-1390

Design, synthesis, and structure–activity relationships of potent GPIIb/IIIa antagonists: discovery of FK419

Authors: Yamanaka, Toshio, Ohkubo, Mitsuru, Kuroda, Satoru, Nakamura, Hideko, Takahashi, Fumie, Aoki, Toshiaki, Mihara, Kayoko, Seki, Jiro, Kato, Masayuki

Source: In Bioorganic & Medicinal Chemistry 2005 13(13):4343-4352

Restoration of middle cerebral artery thrombosis by novel glycoprotein IIb/IIIa antagonist FK419 in guinea pig

Authors: Moriguchi, Akira, Mihara, Kayoko ^*, Aoki, Toshiaki, Maeda, Masashi, Tojo, Nobuteru, Matsuoka, Nobuya, Mutoh, Seitaro

Source: In European Journal of Pharmacology 2004 498(1):179-188

Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig

Authors: Kato, Yasuko ^*, Kita, Yasuhiro, Hirasawa-Taniyama, Yoshimi, Nishio, Mie, Mihara, Kayoko, Ito, Kiyotaka, Yamanaka, Toshio, Seki, Jiro, Miyata, Susumu, Mutoh, Seitaro

Source: In European Journal of Pharmacology 25 July 2003 473(2-3):163-169

Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase

Authors: Hattori, Kouji, Kido, Yoshiyuki, Yamamoto, Hirofumi, Ishida, Junya, Iwashita, Akinori, Mihara, Kayoko

Source: In Bioorganic & Medicinal Chemistry Letters 2007 17(20):5577-5581

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4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors

Authors: Ishida, Junya, Hattori, Kouji, Yamamoto, Hirofumi, Iwashita, Akinori, Mihara, Kayoko, Matsuoka, Nobuya

Source: In Bioorganic & Medicinal Chemistry Letters 2005 15(19):4221-4225

Brain Adenosine A2A Receptor Occupancy by a Novel A1/A2A Receptor Antagonist, ASP5854, in Rhesus Monkeys: Relationship to Anticataleptic Effect.

Authors: Mihara, Takuma, Noda, Akihiro, Arai, Hiroshi, Mihara, Kayoko, Iwashita, Akinori, Murakami, Yoshihiro, Matsuya, Takahiro, Miyoshi, Sosuke, Nishimura, Shintaro, Matsuoka, Nobuya

Source: Journal of Nuclear Medicine; Jul2008, Vol. 49 Issue 7, p1183-1188, 6p, 1 Color Photograph, 3 Graphs

FK419, a novel nonpeptide GPIIb/IIIa antagonist, restores microvascular patency and improves outcome in the guinea-pig middle cerebral artery thrombotic occlusion model: comparison with tirofiban.

Authors: Moriguchi, Akira, Maeda, Masashi, Mihara, Kayoko, Aoki, Toshiaki, Matsuoka, Nobuya, Mutoh, Seitaro

Source: Journal of Cerebral Blood Flow & Metabolism; Jan2005, Vol. 25 Issue 1, p75-86, 12p, 1 Chart, 7 Graphs

Subject Terms: GLYCOPROTEINS, BLOOD platelet aggregation, GUINEA pigs as laboratory animals, NEUTROPHILS, CEREBROVASCULAR disease

FK419, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, ameliorates brain infarction associated with thrombotic focal cerebral ischemia in monkeys: comparison with tissue plasminogen activator.

Authors: Maeda, Masashi, Moriguchi, Akira, Mihara, Kayoko, Aoki, Toshiaki, Takamatsu, Hiroyuki, Matsuoka, Nobuya, Mutoh, Seitaro, Goto, Toshio

Source: Journal of Cerebral Blood Flow & Metabolism; Jan2005, Vol. 25 Issue 1, p108-118, 11p, 1 Color Photograph, 1 Chart, 6 Graphs

Subject Terms: BLOOD platelets, GLYCOPROTEINS, FIBRINOGEN, ISCHEMIA, BRAIN damage, PRIMATES as laboratory animals

An application of a new planar positron imaging system (PPIS) in a small animal: MPTP-induced parkinsonism in mouse.

Authors: Takamatsu, Hiroyuki, Kakiuchi, Takeharu, Noda, Akihiro, Uchida, Hiroshi, Nismyama, Shingo, Ichise, Rikiya, Iwashita, Akinori, Mihara, Kayoko, Yamazaki, Shunji, Matsuoka, Nobuya, Tsukada, Hideo, Nishimura, Shintaro, Nishiyama, Shingo

Source: Annals of Nuclear Medicine; Jul2004, Vol. 18 Issue 5, p427-431, 5p

Pharmacological Characterization of a Novel, Potent Adenosine A1and A2AReceptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1 H)-one (ASP5854), in Models of Parkinson’s Disease and Cognition

Authors: Mihara, Takuma, Mihara, Kayoko, Yarimizu, Junko, Mitani, Yasuyuki, Matsuda, Ritsuko, Yamamoto, Hiroko, Aoki, Satoshi, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya

Source: The Journal of Pharmacology and Experimental Therapeutics; November 2007, Vol. 323 Issue: 2 p708-719, 12p

Pharmacological Characterization of a Novel, Potent Adenosine A1 and A2A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in Models of Parkinson's Disease and Cognition.

Authors: Mihara, Takuma, Mihara, Kayoko, Yarimizu, Junko, Mitani, Yasuyuki, Matsuda, Ritsuko, Yamamoto, Hiroko, Aoki, Satoshi, Akahane, Atsushi, Iwashita, Akinori, Matsuoka, Nobuya

Source: The Journal of Pharmacology and Experimental Therapeutics; November 2007, Vol. 323 Issue: 2 p708-719, 12p

Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor {delta}-Selective Agonists in Vitro and in Vivo.

Authors: Iwashita, Akinori, Muramatsu, Yuko, Yamazaki, Takao, Muramoto, Masakazu, Kita, Yasuhiro, Yamazaki, Shunji, Mihara, Kayoko, Moriguchi, Akira, Matsuoka, Nobuya

Source: The Journal of Pharmacology and Experimental Therapeutics; March 2007, Vol. 320 Issue: 3 p1087-1096, 10p

Prohemorrhagic and Bleeding Time Activities of Recombinant Tissue Plasminogen Activator, Heparin, Aspirin, and a Glycoprotein IIb/IIIa Antagonist

Authors: Mihara, Kayoko, Aoki, Toshiaki, Moriguchi, Akira, Maeda, Masashi, Furuichi, Yasuhisa, Matsuoka, Nobuya, Mutoh, Seitaro

Source: Journal of Neurotrauma; November 2005, Vol. 22 Issue: 11 p1362-1373, 12p

A New Poly(ADP-Ribose) Polymerase Inhibitor, FR261529 [2-(4-Chlorophenyl)-5-quinoxalinecarboxamide], Ameliorates Methamphetamine-Induced Dopaminergic Neurotoxicity in Mice

Authors: Iwashita, Akinori, Mihara, Kayoko, Yamazaki, Syunji, Matsuura, Shigeru, Ishida, Junya, Yamamoto, Hirofumi, Hattori, Kouji, Matsuoka, Nobuya, Mutoh, Seitaro

Source: The Journal of Pharmacology and Experimental Therapeutics; September 2004, Vol. 310 Issue: 3 p1114-1124, 11p

Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3 H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in Mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson’s Disease

Authors: Iwashita, Akinori, Yamazaki, Syunji, Mihara, Kayoko, Hattori, Kouji, Yamamoto, Hirofumi, Ishida, Junya, Matsuoka, Nobuya, Mutoh, Seitaro

Source: The Journal of Pharmacology and Experimental Therapeutics; June 2004, Vol. 309 Issue: 3 p1067-1078, 12p