Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication

Authors: Yanling Liu, Jonathon Klein, Richa Bajpai, Li Dong, Quang Tran, Pandurang Kolekar, Jenny L. Smith, Rhonda E. Ries, Benjamin J. Huang, Yi-Cheng Wang, Todd A. Alonzo, Liqing Tian, Heather L. Mulder, Timothy I. Shaw, Jing Ma, Michael P. Walsh, Guangchun Song, Tamara Westover, Robert J. Autry, Alexander M. Gout, David A. Wheeler, Shibiao Wan, Gang Wu, Jun J. Yang, William E. Evans, Mignon Loh, John Easton, Jinghui Zhang, Jeffery M. Klco, Soheil Meshinchi, Patrick A. Brown, Shondra M. Pruett-Miller, Xiaotu Ma

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4295bf024052418d8f3bd3d5099ce979

Clinical parameter-based prediction of DNA methylation classification generates a prediction model of prognosis in patients with juvenile myelomonocytic leukemia

Authors: Takahiro Imaizumi, Julia Meyer, Manabu Wakamatsu, Hironobu Kitazawa, Norihiro Murakami, Yusuke Okuno, Taro Yoshida, Daichi Sajiki, Asahito Hama, Seiji Kojima, Yoshiyuki Takahashi, Mignon Loh, Elliot Stieglitz, Hideki Muramatsu

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/84c8fbf52cc34fe08afed256cf5acc20

P329: HIGH IMMUNOPROTEASOME ACTIVITY AS NOVEL INDICATOR FOR SENSITIVITY TO BORTEZOMIB-CONTAINING CHEMOTHERAPY IN ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS FROM CHILDREN’S ONCOLOGY GROUP TRIAL AALL1231

Authors: Margot Roeten, Suzanne van Dijk, Johan van Meerloo, Zinia Kwidama, Gaya Jenkins, David Teachey, Meenakshi Devidas, Mignon Loh, Gertjan Kaspers, Sonja Zweegman, Gerrit Jansen, Terzah Horton, Jacqueline Cloos

Source: HemaSphere, Vol 7, p e81299a0 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968228.81299.a0; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/40d3b42d44514f25bb8ba0bffe07ecbd

Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia

Authors: Jessica Leonard, Joelle SJ Wolf, Michelle Degnin, Christopher A. Eide, Dorian LaTocha, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon Loh, Stephen P Hunger, Brian J Druker, Marc M Loriaux, Jeffrey W Tyner, Bill H Chang

Source: Haematologica, Vol 106, Iss 11 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10327; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/2901a1309bc34ddbb96064c714b750fc

KRAS insertion mutations are oncogenic and exhibit distinct functional properties

Authors: Yasmine White, Aditi Bagchi, Jessica Van Ziffle, Anagha Inguva, Gideon Bollag, Chao Zhang, Heidi Carias, David Dickens, Mignon Loh, Kevin Shannon, Ari J. Firestone

Source: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c8ee34111da64f238c6f182195674d48

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis.

Authors: Hartzell, Catherine, Ksionda, Olga, Lemmens, Ed, Coakley, Kristen, Ming Yang, Dail, Monique, Harvey, Richard C., Govern, Christopher, Bakker, Jeroen, Lenstra, Tineke L., Ammon, Kristin, Boeter, Anne, Winter, Stuart S., Mignon Loh, Shannon, Kevin, Chakraborty, Arup K., Wabl, Matthias, Roose, Jeroen P.

Source: Science Signaling; 3/26/2013, Vol. 6 Issue 268, p1-15, 15p

ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia.

Authors: Heng Xu¹, Cheng Cheng¹, Devidas, Meenakshi², Deqing Pei¹, Yiping Fan¹, Wenjian Yang¹, Neale, Geoff¹, Scheet, Paul³, Burchard, Esteban G.⁴, Torgerson, Dara G.⁴, Eng, Celeste⁴, Dean, Michael⁵, Antillon, Frederico⁶, Winick, Naomi J.⁷, Martin, Paul L.⁸, Willman, Cheryl L.⁹, Camitta, Bruce M.¹⁰, Reaman, Gregory H.¹¹, Carroll, William L.¹², Mignon Loh⁴

Source: Journal of Clinical Oncology. 3/1/2012, Vol. 30 Issue 7, p751-757. 7p.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

Authors: Park, Eugene¹, Eun Ji Gang¹, Yao-Te Hsieh¹, Schaefer, Paul¹, Chae, Sanna¹, Klemm, Lars², Huantes, Sandra¹, Mignon Loh³, Conway, Edward M.⁴, Eun-Suk Kang⁵, Hong Hoe Koo⁶, Hofmann, Wolf-Karsten⁷, Heisterkamp, Nora¹, Pelus, Louis⁸, Keerthivasan, Ganesan⁹, Crispino, John⁹, Kahn, Michael¹⁰, Müschen, Markus², Yong-Mi Kim¹ ymkim@chla.usc.edu

Source: Blood. 8/25/2011, Vol. 118 Issue 8, p2191-2199. 9p.

Subject Terms: *DRUG resistance in cancer cells, *HEALTH outcome assessment, *LYMPHOBLASTIC leukemia, *GENE targeting, *APOPTOSIS, *GENETICS, DISEASE relapse prevention