Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study

Authors: Allagappen, Jon, Andriesen, Jessica, Ayres, Alison, Baral, Saman, Bekker, Linda-Gail, Besethi, Asiphe, Borremans, Caroline, Braams, Esmee, Brackett, Caroline, Brumskine, William, Chilengi, Roma, Choi, Rachel, Dubula, Thozama, Dumas, Jaiden Seongmi, Dunn, Brooke, Etikala, Radhika, Euler, Zelda, Everett, Sarah, Garrett, Nigel, Gelderblom, Huub, Gill, Katherine, Gillespie, Kevin, Goedhart, Dimitri, Goosmann, Erik, Grant, Shannon, Hands, Ellie, Haynes, Barton, Herringer, Bronwill, Hoosain, Zaheer, Hosseinipour, Mina, Hunidzarira, Portia, Hutter, Julia, Inambao, Mubiana, Innes, Craig, Keyes, Taylor, Kilembe, William, Kotze, Philippus, Kotze, Sheena, Laher, Fatima, Laszlo, Imre, Lazarus, Erica, Liao, Hua-Xin, Lin, Yong, Lu, Helen, Lucas, Judith, Malahleha, Mookho, McNair, Tara, Meerts, Peter, Mgaga, Zinhle, Montlha, Mahlodi, Mosito, Boitumelo, Moultrie, Andrew, Mudrak, Sarah, Oriol-Mathieu, Valérie, Sarzotti-Kelsoe, Marcella, Mathebula, Matson Tso, Matoga, Mitch, McClennen, Rachael, Mda, Pamela, Naicker, Vimla, Naidoo, Logashvari, Okkers, Cindy-Ann, Omarjee, Saleha, Pasmans, Hella, Philip, Tricia, Pinter, Abraham, Pitsi, Annah, Ramos, Ornelia, Randhawa, April, Roels, Sanne, Rohith, Shamiska, Rutten, Lucy, Sadoff, Jerald, Salinas, Gabriela, Salzgeber, Yvonne, Scheppler, Lorenz, Schwedhelm, Katharine, Schuller, Nicolette, Sharak, Angelina, Stanfield-Oakley, Sherry, Sopher, Carrie, Tafatatha, Terence, Takuva, Simbarashe G., Tang, Chan, Vandebosch, An, Viegas, Edna, Voillet, Valentin, Wegmann, Frank, Weijtens, Mo, Wilcox, Stephany, Williams, Anthony, Yu, Chenchen, Yu, Pei-Chun, Yuan, Olive, Zhang, Xuehan, Kenny, Avi, van Duijn, Janine, Dintwe, One, Heptinstall, Jack, Burnham, Randy, Sawant, Sheetal, Zhang, Lu, Mielke, Dieter, Khuzwayo, Sharon, Omar, Faatima Laher, Goodman, Derrick, Fong, Youyi, Benkeser, David, Zou, Rodger, Hural, John, Hyrien, Ollivier, Juraska, Michal, Luedtke, Alex, van der Laan, Lars, Giorgi, Elena E., Magaret, Craig, Carpp, Lindsay N., Pattacini, Laura, van de Kerkhof, Tom, Korber, Bette, Willems, Wouter, Fisher, Leigh H., Schuitemaker, Hanneke, Swann, Edith, Kublin, James G., Pau, Maria G., Buchbinder, Susan, Tomaka, Frank, Nijs, Steven, Lavreys, Ludo, Gelderblom, Huub C., Corey, Lawrence, Mngadi, Kathryn, Gray, Glenda E., Borducchi, Erica, Hendriks, Jenny, Seaton, Kelly E., Zolla-Pazner, Susan, Barouch, Dan H., Ferrari, Guido, De Rosa, Stephen C., McElrath, M Juliana, Andersen-Nissen, Erica, Stieh, Daniel J., Tomaras, Georgia D., Gilbert, Peter B.

Source: In eBioMedicine October 2024 108

Computationally Selected Multivalent HIV-1 Subtype C Vaccine Protects Against Heterologous SHIV Challenge.

Authors: Mielke, Dieter, Tuyishime, Marina, Kelkar, Natasha S., Wang, Yunfei, Parks, Robert, Santra, Sampa, Rountree, Wes, Williams, LaTonya D., Peters, Tiffany, Eisel, Nathan, Sawant, Sheetal, Zhang, Lu, Goodman, Derrick, Jha, Shalini, Zalaquett, Adam, Ramasubramanian, Pratamesh, Stanfield-Oakley, Sherry, Matyas, Gary, Beck, Zoltan, Rao, Mangala

Source: Vaccines; Mar2025, Vol. 13 Issue 3, p231, 21p

Subject Terms: VACCINE immunogenicity, VACCINE effectiveness, STATISTICAL significance, VACCINE trials, IMMUNE response

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions.

Authors: Pierre, Camille N.^1,2, Adams, Lily E.³, Higgins, Jaclyn S.³, Anasti, Kara^1,4, Goodman, Derrick^1,5, Mielke, Dieter⁵, Stanfield-Oakley, Sherry⁵, Powers, John M.^3,6, Li, Dapeng^1,4, Rountree, Wes^1,4, Wang, Yunfei^1,4, Edwards, Robert J.^1,4, Alam, S. Munir^1,4, Ferrari, Guido^1,5,7, Tomaras, Georgia D.^1,5,7,8, Haynes, Barton F.^1,4,8, Baric, Ralph S.⁶, rbaric@email.unc.edu, Saunders, Kevin O.^1,5,7,8, rbaric@email.unc.edu

Source: PLoS Pathogens; 6/20/2024, Vol. 20 Issue 6, p1-23, 23p

ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection.

Authors: Mielke, Dieter^1,2 (AUTHOR), Bandawe, Gama^2,3 (AUTHOR), Zheng, Jie⁴ (AUTHOR), Jones, Jennifer⁴ (AUTHOR), Abrahams, Melissa-Rose² (AUTHOR), Bekker, Valerie⁵ (AUTHOR), Ochsenbauer, Christina⁴ (AUTHOR), Garrett, Nigel^6,7 (AUTHOR), Abdool Karim, Salim^6,8 (AUTHOR), Moore, Penny L.^5,6,9,10 (AUTHOR), Morris, Lynn^5,6,9,10 (AUTHOR), Montefiori, David¹ (AUTHOR), Anthony, Colin² (AUTHOR), Ferrari, Guido¹ (AUTHOR), Williamson, Carolyn^2,6,10 (AUTHOR) carolyn.williamson@uct.ac.za

Source: PLoS Pathogens. 11/17/2021, Vol. 17 Issue 11, p1-22. 22p.

Subject Terms: *HIV, *ANTIBODY-dependent cell cytotoxicity, *VACCINE trials, *VIRAL antibodies, *VIRAL replication

Engineered immunogens to elicit antibodies against conserved coronavirus epitopes.

Authors: Kapingidza, A. Brenda, Marston, Daniel J., Harris, Caitlin, Wrapp, Daniel, Winters, Kaitlyn, Mielke, Dieter, Xiaozhi, Lu, Yin, Qi, Foulger, Andrew, Parks, Rob, Barr, Maggie, Newman, Amanda, Schäfer, Alexandra, Eaton, Amanda, Flores, Justine Mae, Harner, Austin, Catanzaro Jr., Nicholas J., Mallory, Michael L., Mattocks, Melissa D., Beverly, Christopher

Source: Nature Communications; 5/6/2023, p1-18, 18p

Antibody Isotype Switching as a Mechanism to Counter HIV Neutralization Escape

Authors: Scheepers, Cathrine, Bekker, Valerie, Anthony, Colin, Richardson, Simone I., Oosthuysen, Brent, Moyo, Thandeka, Kgagudi, Prudence, Kitchin, Dale, Nonyane, Molati, York, Talita, Mielke, Dieter, Mabvakure, Batsirai M., Sheng, Zizhang, Lambson, Bronwen E., Ismail, Arshad, Garrett, Nigel J., Abdool Karim, Salim S., Shapiro, Lawrence, Williamson, Carolyn, Morris, Lynn, Moore, Penny L.

Source: In Cell Reports 24 November 2020 33(8)

Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.

Authors: Li, Dapeng, Martinez, David R., Schäfer, Alexandra, Chen, Haiyan, Barr, Maggie, Sutherland, Laura L., Lee, Esther, Parks, Robert, Mielke, Dieter, Edwards, Whitney, Newman, Amanda, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Gagne, Matthew, Douek, Daniel C., DeMarco, C. Todd, Denny, Thomas N., Oguin III, Thomas H., Brown, Alecia

Source: Nature Communications; 10/23/2022, Vol. 13 Issue 1, p1-15, 15p

Subject Terms: SARS-CoV-2 Delta variant, SARS-CoV-2, SARS-CoV-2 Omicron variant, COVID-19 vaccines, VACCINES

Development of flow cytometry‐based assays to assess the ability of antibodies to bind to SARS‐CoV‐2‐infected and spike‐transfected cells and mediate NK cell degranulation.

Authors: Mielke, Dieter, Stanfield‐Oakley, Sherry, Jha, Shalini, Keyes, Taylor, Zalaquett, Adam, Dunn, Brooke, Rodgers, Nicole, Oguin, Thomas, Sempowski, Greg D., Binder, Raquel A., Gray, Gregory C., Karuna, Shelly, Corey, Lawrence, Hural, John, Tomaras, Georgia D., Pollara, Justin, Ferrari, Guido

Source: Cytometry. Part A; Jun2022, Vol. 101 Issue 6, p483-496, 14p

Selection of HIV Envelope Strains for Standardized Assessments of Vaccine-Elicited Antibody-Dependent Cellular Cytotoxicity- Mediating Antibodies.

Authors: Mielke, Dieter¹ dieter.mielke@duke.edu, Stanfield-Oakley, Sherry¹, Borate, Bhavesh^2,3, Fisher, Leigh H.³, Faircloth, Katelyn¹, Tuyishime, Marina¹, Greene, Kelli¹, Hongmei Gao¹, Williamson, Carolyn^4,5,6, Morris, Lynn^5,6,7,8, Ochsenbauer, Christina⁹, Tomaras, Georgia^1,10,11, Haynes, Barton F.^11,12,13, Montefiori, David^1,12, Pollara, Justin^1,12, deCamp, Allan C.³, Ferrari, Guido^1,10,12 gflmp@duke.edu

Source: Journal of Virology. Jan2022, Vol. 96 Issue 2, p1-16. 16p.

Subject Terms: *ANTIBODY-dependent cell cytotoxicity, *VACCINE trials, *IMMUNOGLOBULINS, *ANTIBODY formation, *HIV, *MOLECULAR cloning

Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway.

Authors: Mielke, Dieter, Bandawe, Gama, Pollara, Justin, Abrahams, Melissa-Rose, Nyanhete, Tinashe, Moore, Penny L., Thebus, Ruwayhida, Yates, Nicole L., Kappes, John C., Ochsenbauer, Christina, Garrett, Nigel, Abdool Karim, Salim, Tomaras, Georgia D., Montefiori, David, Morris, Lynn, Ferrari, Guido, Williamson, Carolyn

Source: Frontiers in Immunology; 12/11/2019, Vol. 10, p1-14, 14p

Subject Terms: ANTIBODY-dependent cell cytotoxicity, IMMUNOGLOBULINS, MONOCLONAL antibodies, ESCAPES, VIRAL replication

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Improved killing of HIV-infected cells using three neutralizing and non-neutralizing antibodies.

Authors: Tuyishime, Marina, Garrido, Carolina, Jha, Shalini, Moeser, Matt, Mielke, Dieter, LaBranche, Celia, Montefiori, David, Haynes, Barton F., Joseph, Sarah, Margolis, David M., Ferrari, Guido

Source: Journal of Clinical Investigation. Oct2020, Vol. 130 Issue 10, p5157-5170. 14p.

Subjects: ANTIBODY-dependent cell cytotoxicity, KILLER cells, IMMUNOGLOBULINS, CELLS, T cells

Boosting with AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity breadth and potency.

Authors: Easterhoff, David¹ david.easterhoff@duke.edu, Pollara, Justin¹, Kan Luo¹, Tolbert, William D.², Young, Brianna³, Mielke, Dieter¹, Jha, Shalini¹, O'Connell, Robert J.⁴, Vasan, Sandhya^4,5,6, Jerome Kim⁵, Michael, Nelson L.^5,6, Excler, Jean-Louis^5,6, Robb, Merlin L.^5,6, Rerks-Ngarm, Supachai⁷, Kaewkungwal, Jaranit⁸, Punnee Pitisuttithum⁸, Sorachai Nitayaphan⁹, Sinangil, Faruk¹⁰, Tartaglia, James¹¹, Phogat, Sanjay¹¹

Source: Journal of Virology. 2/15/2020, Vol. 94 Issue 4, p1-54. 54p.

Subject Terms: *VACCINE effectiveness, *ANTIBODY-dependent cell cytotoxicity, *AIDS vaccines, *MONOCLONAL antibodies, *ANTIBODY formation