Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

Authors: Wilson, Edward N., Umans, Jacob, Swarovski, Michelle S., Minhas, Paras S., Mendiola, Justin H., Midttun, Øivind, Ulvik, Arve, Shahid-Besanti, Marian, Linortner, Patricia, Mhatre, Siddhita D., Wang, Qian, Channappa, Divya, Corso, Nicole K., Tian, Lu, Fredericks, Carolyn A., Kerchner, Geoffrey A., Plowey, Edward D., Cholerton, Brenna, Ueland, Per M., Zabetian, Cyrus P.

Source: NPJ Parkinson's Disease; 4/26/2025, Vol. 11 Issue 1, p1-13, 13p

A prospective study of pre-diagnostic circulating tryptophan and kynurenine, and the kynurenine/tryptophan ratio and risk of glioma

Authors: Samanic, Claudine M., Yue, Yiyang, Cote, David J., Stampfer, Meir J., Wang, Molin, McCann, Adrian, Midttun, Øivind, Ueland, Per Magne, Smith-Warner, Stephanie A., Egan, Kathleen M.

Source: In Cancer Epidemiology February 2022 76

Inflammation-Related Marker Profiling of Dietary Patterns and All-cause Mortality in the Melbourne Collaborative Cohort Study

Authors: Li, Sherly X ^*, Hodge, Allison M, MacInnis, Robert J, Bassett, Julie K, Ueland, Per M, Midttun, Øivind, Ulvik, Arve, Rinaldi, Sabina, Meyer, Klaus, Navionis, Anne-Sophie, Shivappa, Nitin, Hébert, James R, Flicker, Leon, Severi, Gianluca, Jayasekara, Harindra, English, Dallas R, Vineis, Paolo, Southey, Melissa C, Milne, Roger L, Giles, Graham G, Dugué, Pierre-Antoine

Source: In The Journal of Nutrition October 2021 151(10):2908-2916

Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.

Authors: Vikøren, Linn A., Drotningsvik, Aslaug, Midttun, Øivind, McCann, Adrian, Bergseth, Marthe T., Austgulen, Maren H., Mellgren, Gunnar, Ueland, Per Magne, Gudbrandsen, Oddrun A.

Source: In Nutrition Research August 2021 92:72-83

A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Authors: Clasen, Joanna L, Heath, Alicia K, Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C, Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B, Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C, Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J, Muller, David C ^*

Source: In The American Journal of Clinical Nutrition July 2021 114(1):338-347

Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium

Authors: Koole, Janna L, Bours, Martijn JL, Geijsen, Anne JMR, Gigic, Biljana, Ulvik, Arve, Kok, Dieuwertje E, Brezina, Stefanie, Ose, Jennifer, Baierl, Andreas, Böhm, Jürgen, Brenner, Hermann, Breukink, Stéphanie O, Chang-Claude, Jenny, van Duijnhoven, Fränzel JB, van Duijvendijk, Peter, Gumpenberger, Tanja, Habermann, Nina, van Halteren, Henk K, Hoffmeister, Michael, Holowatyj, Andreana N, Janssen-Heijnen, Maryska LG, Keulen, Eric TP, Kiblawi, Rama, Kruyt, Flip M, Li, Christopher I, Lin, Tengda, Midttun, Øivind, Peoples, Anita R, van Roekel, Eline H, Schneider, Martin A, Schrotz-King, Petra, Ulrich, Alexis B, Vickers, Kathy, Wesselink, Evertine, de Wilt, Johannes HW, Gsur, Andrea, Ueland, Per M, Ulrich, Cornelia M, Kampman, Ellen, Weijenberg, Matty P ^*

Source: In The American Journal of Clinical Nutrition June 2021 113(6):1468-1481

Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients

Authors: Ulvik, Arve ^*, Midttun, Øivind, McCann, Adrian, Meyer, Klaus, Tell, Grethe, Nygård, Ottar, Ueland, Per M

Source: In The American Journal of Clinical Nutrition January 2020 111(1):178-186

The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites

Authors: Aarsland, Tore Ivar, Leskauskaite, Ieva, Midttun, Øivind, Ulvik, Arve, Ueland, Per Magne, Oltedal, Leif, Erchinger, Vera Jane, Oedegaard, Ketil Joachim, Haavik, Jan, Kessler, Ute

Source: In Brain Stimulation September-October 2019 12(5):1135-1142

Smoking in pregnancy, cord blood cotinine and risk of celiac disease diagnosis in offspring

Authors: Mårild, Karl, Tapia, German, Midttun, Øivind, Ueland, Per M., Magnus, Maria C., Rewers, Marian, Stene, Lars C., Størdal, Ketil

Source: European Journal of Epidemiology, 2019 Jan 01. 34(7), 637-649.

Access URL: https://www.jstor.org/stable/48693724

Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors

Authors: Sande, Jon Sigurd, Ulvik, Arve, Midttun, Øivind, Ueland, Per M, Hammer, Hilde B, Valen, Merete, Apalset, Ellen M, Gjesdal, Clara G

Source: In The Journal of Nutrition May 2019 149(5):770-775

Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat—a randomized controlled dietary intervention study

Authors: Ulven, Stine M ^*, Christensen, Jacob J, Nygård, Ottar, Svardal, Asbjørn, Leder, Lena, Ottestad, Inger, Lysne, Vegard, Laupsa-Borge, Johnny, Ueland, Per Magne, Midttun, Øivind, Meyer, Klaus, McCann, Adrian, Andersen, Lene F, Holven, Kirsten B

Source: In The American Journal of Clinical Nutrition May 2019 109(5):1239-1250

The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study

Authors: Solvang, Stein-Erik Hafstad, Nordrehaug, Jan Erik, Tell, Grethe S., Nygård, Ottar, McCann, Adrian, Ueland, Per Magne, Midttun, Øivind, Meyer, Klaus, Vedeler, Christian A., Aarsland, Dag, Refsum, Helga, Smith, A. David, Giil, Lasse Melvaer

Source: In Brain Behavior and Immunity January 2019 75:155-162

Parental Smoking and Risk of Childhood-onset Type 1 Diabetes

Authors: Magnus, Maria C., Tapia, German, Olsen, Sjurdur F., Granstrom, Charlotta, Mårild, Karl, Ueland, Per M., Midttun, Øivind, Svensson, Jannet, Johannesen, Jesper, Skrivarhaug, Torild, Joner, Geir, Njølstad, Pål R., Størdal, Ketil, Stene, Lars C.

Source: Epidemiology, 2018 Nov 01. 29(6), 848-856.

Access URL: https://www.jstor.org/stable/26600823

A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium.

Authors: Midttun, Øivind¹ (AUTHOR) oivind.midttun@bevital.no, Ulvik, Arve¹ (AUTHOR), Meyer, Klaus¹ (AUTHOR), Zahed, Hana² (AUTHOR), Giles, Graham G.^3,4,5 (AUTHOR), Manjer, Jonas^6,7 (AUTHOR), Sandsveden, Malte⁸ (AUTHOR), Langhammer, Arnulf^9,10 (AUTHOR), Sørgjerd, Elin Pettersen^9,11 (AUTHOR), Behndig, Annelie F.¹² (AUTHOR), Johansson, Mikael¹³ (AUTHOR), Freedman, Neal D.¹⁴ (AUTHOR), Huang, Wen-Yi¹⁴ (AUTHOR), Chen, Chu¹⁵ (AUTHOR), Prentice, Ross¹⁵ (AUTHOR), Stevens, Victoria L.¹⁶ (AUTHOR), Wang, Ying¹⁶ (AUTHOR), Le Marchand, Loïc¹⁷ (AUTHOR), Weinstein, Stephanie J.¹⁴ (AUTHOR), Cai, Qiuyin¹⁸ (AUTHOR)

Source: Scientific Reports. 1/18/2023, Vol. 13 Issue 1, p1-13. 13p.

Subject Terms: *LUNG cancer, *TRYPTOPHAN, *QUINOLINIC acid, *CROSS-sectional method, *NEOPTERIN, *C-reactive protein, *NAD (Coenzyme), *PLANT metabolites

Geographic Terms: HONG Kong (China)

Performance of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting

Authors: Midttun, Øivind, Ulvik, Arve, Nygård, Ottar ^*, Ueland, Per M

Source: In The American Journal of Clinical Nutrition June 2018 107(6):941-947

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

Authors: Agudelo, Leandro Z., Ferreira, Duarte M.S., Cervenka, Igor, Bryzgalova, Galyna, Dadvar, Shamim, Jannig, Paulo R., Pettersson-Klein, Amanda T., Lakshmikanth, Tadepally, Sustarsic, Elahu G., Porsmyr-Palmertz, Margareta, Correia, Jorge C., Izadi, Manizheh, Martínez-Redondo, Vicente, Ueland, Per M., Midttun, Øivind, Gerhart-Hines, Zachary, Brodin, Petter, Pereira, Teresa, Berggren, Per-Olof, Ruas, Jorge L.

Source: In Cell Metabolism 6 February 2018 27(2):378-392

The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK)

Authors: Zuo, Hui, Tell, Grethe S, Ueland, Per M, Nygård, Ottar, Vollset, Stein E, Midttun, Øivind, Meyer, Klaus, Ulvik, Arve

Source: In The American Journal of Clinical Nutrition January 2018 107(1):105-112

Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A

Authors: Olsen, Thomas, Vinknes, Kathrine J., Svingen, Gard F.T., Pedersen, Eva R., Tell, Grethe S., Blomhoff, Rune, Drevon, Christian A., Ueland, Per M., Midttun, Øivind, Refsum, Helga, Nygård, Ottar K.

Source: In Atherosclerosis October 2017 265:325-330

Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris

Authors: DeRatt, Barbara N, Ralat, Maria A, Lysne, Vegard, Tayyari, Fariba, Dhar, Indu, Edison, Arthur S, Garrett, Timothy J, Midttun, Øivind, Ueland, Per Magne, Nygård, Ottar Kjell, Gregory, Jesse F, III ^*

Source: In The Journal of Nutrition September 2017 147(9):1658-1668

Ratios of One-Carbon Metabolites Are Functional Markers of B-Vitamin Status in a Norwegian Coronary Angiography Screening Cohort

Authors: Ulvik, Arve ^{*, **}, Hustad, Steinar, McCann, Adrian, Midttun, Øivind, Nygård, Ottar K, Ueland, Per M

Source: In The Journal of Nutrition June 2017 147(6):1167-1173