Long read sequencing identifies complex structural variant landscape and recurrent TERT rearrangements in mucoepidermoid carcinoma

Authors: Gensterblum-Miller, Elizabeth, Bhangale, Apurva, Majid, Dana Al, Pienkowski, Victor Murcia, Rydzanicz, Malgorzata, Janiszewska, Joanna, Kostrzewska-Poczekaj, Magdalena, Chang, Clifford, Brummel, Collin, Michmerhuizen, Nicole L., Wang, Jiayu, Sandford, Erin, Tewari, Muneesh, Wierzbicka, Malgorzata, Birkeland, Andrew C., McHugh, Jonathan B., Spector, Matthew E., Giefing, Maciej, Jarmuz-Szymczak, Malgorzata, Heft Neal, Molly E., Brenner, J. Chad

Source: In Oral Oncology December 2024 159

Multi-kinase compensation rescues EGFR knockout in a cell line model of head and neck squamous cell carcinoma

Authors: Ludwig, Megan L., Michmerhuizen, Nicole L., Wang, Jiayu, Birkeland, Andrew C., Majchrowski, Behirda K., Nimmagadda, Sai, Zhai, Jingyi, Bhangale, Apurva, Kulkarni, Aditi, Jiang, Hui, Swiecicki, Paul L., Brenner, J. Chad

Source: In Archives of Oral Biology December 2023 156

Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma

Authors: Heft Neal, Molly, Michmerhuizen, Nicole, Kovatch, Kevin, Owen, John, Zhai, Jingyi, Jiang, Hui, McKean, Erin, Prince, Mark, Brenner, J.

Source: Journal of neurological surgery.Part B.Skull base. 83(1):087-098

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191735829.0x000001&indx=1&recIds=ETOCvdc_100191735829.0x000001

Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma

Authors: Michmerhuizen, Nicole L., Ludwig, Megan L., Birkeland, Andrew C., Nimmagadda, Sai, Zhai, Jingyi, Wang, Jiayu, Jewell, Brittany M., Genouw, Dylan, Remer, Lindsay, Kim, Daniel, Foltin, Susan K., Bhangale, Apurva, Kulkarni, Aditi, Bradford, Carol R., Swiecicki, Paul L., Carey, Thomas E., Jiang, Hui, Brenner, J. Chad

Source: Head & neck. 44(5):1192-1205

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150111482.0x000001&indx=1&recIds=ETOCvdc_100150111482.0x000001

Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies

Authors: Michmerhuizen, Nicole L., Klco, Jeffery M., Mullighan, Charles G.

Source: In Blood 12 November 2020 136(20):2275-2289

Rationale for Using Irreversible Epidermal Growth Factor Receptor Inhibitors in Combination with Phosphatidylinositol 3-Kinase Inhibitors for Advanced Head and Neck Squamous Cell Carcinoma

Authors: Michmerhuizen, Nicole L., Leonard, Elizabeth, Matovina, Chloe, Harris, Micah, Herbst, Gabrielle, Kulkarni, Aditi, Zhai, Jingyi, Jiang, Hui, Carey, Thomas E., Brenner, J. Chad ^*

Source: In Molecular Pharmacology May 2019 95(5):528-536

The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines

Authors: Ludwig, Megan L., Kulkarni, Aditi, Birkeland, Andrew C., Michmerhuizen, Nicole L., Foltin, Susan K., Mann, Jacqueline E., Hoesli, Rebecca C., Devenport, Samantha N., Jewell, Brittany M., Shuman, Andrew G., Spector, Matthew E., Carey, Thomas E., Jiang, Hui, Brenner, J. Chad

Source: In Oral Oncology December 2018 87:144-151

AML-283 The Genetic Landscape of NUP98-Rearranged Pediatric Leukemia

Authors: Umeda, Masayuki ¹, Michmerhuizen, Nicole ¹, Ma, Jing ¹, Westover, Tamara ¹, Walsh, Michael P ¹, Song, Guangchun ¹, Mecucci, Cristina ², Giacomo, Danika Di ², Locatelli, Franco ³, Masetti, Riccardo ⁴, Bertuccio, Salvatore Nicola ⁴, Pigazzi, Martina ⁵, Iacobucci, Ilaria ¹, Mullighan, Charles G ¹, Klco, Jeffery M ¹

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2022 22 Supplement 2:S233-S233

AML-158 Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation

Authors: Michmerhuizen, Nicole ¹, Chandra, Bappaditya ¹, Shirnekhi, Hazheen ¹, Tripathi, Swarnendu ¹, Pioso, Brittany ¹, Baggett, David ¹, Mitrea, Diana ¹, lacobucci, Ilaria ¹, White, Michael ¹, Chen, Jingjing ², Park, Cheon-Gil ¹, Wu, Huiyun ¹, Pounds, Stanley ¹, Medyukhina, Anna ¹, Khairy, Khaled ¹, Gao, Qingsong ¹, Qu, Chunxu ¹, Gorman, Scott ¹, Bawa, Simran ¹, Maslanka, Carolyn ¹, Kinger, Swati ¹, Dogra, Priyanka ¹, Giacomo, Danika Di ³, Mecucci, Cristina ³, Klco, Jeffery ¹, Mullighan, Charles ¹, Kriwacki, Richard ¹

Source: In Clinical Lymphoma, Myeloma and Leukemia October 2022 22 Supplement 2:S220-S220

Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma

Authors: Hoesli, Rebecca, Birkeland, Andrew C., Rosko, Andrew J., Issa, Mohamad, Chow, Kelsey L., Michmerhuizen, Nicole L., Mann, Jacqueline E., Chinn, Steven B., Shuman, Andrew G., Prince, Mark E., Wolf, Gregory T., Bradford, Carol R., McHugh, Jonathan B., Brenner, J. Chad, Spector, Matthew E.

Source: In Oral Oncology February 2018 77:83-89

Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma

Authors: Birkeland, Andrew C., Foltin, Susan K., Michmerhuizen, Nicole L., Hoesli, Rebecca C., Rosko, Andrew J., Byrd, Serena, Yanik, Megan, Nor, Jacques E., Bradford, Carol R., Prince, Mark E., Carey, Thomas E., McHugh, Jonathan B., Spector, Matthew E., Brenner, J. Chad

Source: In Oral Oncology May 2017 68:5-8

Combined Pik3ca-H1047R and loss-of-function Notch1 alleles decrease survival time in a 4-nitroquinoline N-oxide-driven head and neck squamous cell carcinoma model

Authors: Michmerhuizen, Nicole L., Heenan, Caitlin, Wang, Jiayu, Leonard, Elizabeth, Bellile, Emily, Loganathan, Sampath K., Wong, Sunny Y., Lei, Yu L., Brenner, J. Chad

Source: Oral oncology. 126

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156217406.0x000001&indx=1&recIds=ETOCvdc_100156217406.0x000001

Uncovering the leukemogenic mechanism of non-canonical NUP98 fusion oncoproteins

Authors: Pioso, Brittany J., Michmerhuizen, Nicole L., Tripathi, Swarnendu, Freyaldenhoven, Toler, Phillips, Aaron H., Mullighan, Charles G., Kriwacki, Richard

Source: Biophysical journal. 122(S1):486a-486a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185940546.0x000001&indx=1&recIds=ETOCvdc_100185940546.0x000001

Poster: AML-158 Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation

Authors: Michmerhuizen, Nicole, Chandra, Bappaditya, Shirnekhi, Hazheen, Tripathi, Swarnendu, Pioso, Brittany, Baggett, David, Mitrea, Diana, Iacobucci, Ilaria, White, Michael, Chen, Jingjing, Park, Cheon-Gil, Wu, Huiyun, Pounds, Stanley, Medyukhina, Anna, Khairy, Khaled, Gao, Qingsong, Qu, Chunxu, Gorman, Scott, Bawa, Simran, Maslanka, Carolyn, Kinger, Swati, Dogra, Priyanka, Giacomo, Danika Di, Mecucci, Cristina, Klco, Jeffery, Mullighan, Charles, Kriwacki, Richard

Source: Clinical lymphoma, myeloma & leukemia. 22(S2):S129-S129

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172885518.0x000001&indx=1&recIds=ETOCvdc_100172885518.0x000001

Poster: AML-283 The Genetic Landscape of NUP98-Rearranged Pediatric Leukemia

Authors: Umeda, Masayuki, Michmerhuizen, Nicole, Ma, Jing, Westover, Tamara, Walsh, Michael P, Song, Guangchun, Mecucci, Cristina, Giacomo, Danika Di, Locatelli, Franco, Masetti, Riccardo, Bertuccio, Salvatore Nicola, Pigazzi, Martina, Iacobucci, Ilaria, Mullighan, Charles G, Klco, Jeffery M

Source: Clinical lymphoma, myeloma & leukemia. 22(S2):S132-S132

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172885336.0x000001&indx=1&recIds=ETOCvdc_100172885336.0x000001

The role of phase separation by NUP98 fusion oncoproteins in leukemia

Authors: Chandra, Bappaditya, Michmerhuizen, Nicole, Shirnekhi, Hazheen, Tripathi, Swarnendu, Pioso, Brittany, Medyukhina, Anna, Khairy, Khaled, White, Michael R., Mitrea, Diana M., Iacobucci, Ilaria, Klco, Jeffery M., Mullighan, Charles G., Kriwacki, Richard

Source: Biophysical journal. 121(S1):357a-357a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155585512.0x000001&indx=1&recIds=ETOCvdc_100155585512.0x000001

Understanding the mechanism of TCF3-HLF fusion oncoprotein-driven leukemogenesis

Authors: Shirnekhi, Hazheen K., Gorman, Scott D., Michmerhuizen, Nicole L., Tripathi, Swarnendu, Medyukhina, Anna, Khairy, Khaled A., Mullighan, Charles G., Kriwacki, Richard W.

Source: Biophysical journal. 121(S1):356a-356a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155585526.0x000001&indx=1&recIds=ETOCvdc_100155585526.0x000001

Cover Image

Authors: Michmerhuizen, Nicole L., Ludwig, Megan L., Birkeland, Andrew C., Nimmagadda, Sai, Zhai, Jingyi, Wang, Jiayu, Jewell, Brittany M., Genouw, Dylan, Remer, Lindsay, Kim, Daniel, Foltin, Susan K., Bhangale, Apurva, Kulkarni, Aditi, Bradford, Carol R., Swiecicki, Paul L., Carey, Thomas E., Jiang, Hui, Brenner, J. Chad

Source: Head & neck. 44(5):C1-C1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150111523.0x000001&indx=1&recIds=ETOCvdc_100150111523.0x000001

Genetic and Functional Characterization of NUP98-Rearranged Leukemia

Authors: Umeda, Masayuki, Michmerhuizen, Nicole, Hiltenbrand, Ryan, Barajas, Juan, Arthur, Bright, Walsh, Michael P, Song, Guangchun, Ma, Jing, Westover, Tamara, Mecucci, Cristina, Di Giacomo, Danika, Locatelli, Franco, Masetti, Riccardo, Bertuccio, Salvatore, Pigazzi, Martina, Iacobucci, Ilaria, Mullighan, Charles G., Klco, Jeffery M.

Source: In Blood 2 November 2023 142 Supplement 1:1562-1562

Human Models of NUP98-Rearranged Leukemia Reveal Fusion-Specific Molecular Mechanisms

Authors: Umeda, Masayuki ^*, Michmerhuizen, Nicole L., Hiltenbrand, Ryan ^*, Barajas, Juan M., Arthur, Bright ^*, Abdelhamed, Sherif, Ma, Jing ^*, Westover, Tamara ^*, Miller, Jonathan, Mullighan, Charles G., Klco, Jeffery M.

Source: In Blood 15 November 2022 140 Supplement 1:5833-5834