Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model

Authors: Jennifer Zieba, Kimberly N. Forlenza, Kelly Heard, Jorge H. Martin, Michaela Bosakova, Daniel H. Cohn, Stephen P. Robertson, Pavel Krejci, Deborah Krakow

Source: Bone Research, Vol 10, Iss 1, Pp 1-12 (2022)

Subject Terms: Biology (General), QH301-705.5, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2095-6231

Access URL: https://doaj.org/article/2c85424b96dc4b149215266a597c829b

Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR

Authors: Fabiana Csukasi, Michaela Bosakova, Tomas Barta, Jorge H. Martin, Jesus Arcedo, Maya Barad, Gustavo A. Rico-Llanos, Jennifer Zieba, Jose Becerra, Pavel Krejci, Ivan Duran, Deborah Krakow

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2023)

Subject Terms: DEPTOR, TAZ, osteogenesis, PTH signaling, Wnt, skeletal differentiation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.963389/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/68a6ecd8547542b6ac3f8a08686204e8

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

Authors: Michaela Bosakova, Sara P Abraham, Alexandru Nita, Eva Hruba, Marcela Buchtova, S Paige Taylor, Ivan Duran, Jorge Martin, Katerina Svozilova, Tomas Barta, Miroslav Varecha, Lukas Balek, Jiri Kohoutek, Tomasz Radaszkiewicz, Ganesh V Pusapati, Vitezslav Bryja, Eric T Rush, Isabelle Thiffault, Deborah A Nickerson, Michael J Bamshad, University of Washington Center for Mendelian Genomics, Rajat Rohatgi, Daniel H Cohn, Deborah Krakow, Pavel Krejci

Source: EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-20 (2020)

Subject Terms: asphyxiating thoracic dystrophy, GRK2, hedgehog, smoothened, Wnt, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/83076ddc0da44600bc5e023ad4e46b45

Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia

Authors: Maya Barad, Fabiana Csukasi, Michaela Bosakova, Jorge H. Martin, Wenjuan Zhang, S. Paige Taylor, Ralph S. Lachman, Jennifer Zieba, Michael Bamshad, Deborah Nickerson, Jessica X. Chong, Daniel H. Cohn, Pavel Krejci, Deborah Krakow, Ivan Duran

Source: EBioMedicine, Vol 62, Iss , Pp 103075- (2020)

Subject Terms: Laminin α5, LAMA5, Skeletal dysplasia, Bent bone, β1 integrin, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420304515; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/92542388a0ba41a0b688700973236fab

Regulation of TAZ by DEPTOR controls mesenchymal progenitors lineage commitment in response to PTH1R signaling

Authors: Fabiana Csukasi, Ivan Duran, Michaela Bosakova, Maya Barad, Jorge H. Martin, Daniel H. Cohn, Pavel Krejci, Deborah Krakow

Source: Bone Reports, Vol 13, Iss , Pp 100602- (2020)

Subject Terms: Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352187220303624; https://doaj.org/toc/2352-1872

Access URL: https://doaj.org/article/9d5cb0a4b032405abb509439c4c21b74

Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling

Authors: Alexandru Nita, Sara P. Abraham, Pavel Krejci, Michaela Bosakova

Source: Cells, Vol 10, Iss 6, p 1445 (2021)

Subject Terms: FGFR, fibroblast growth factor receptor, FGFR fusion, cancer, oncogenic driver, neoplastic transformation, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/6/1445; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/f3ba230a17f04e52b441aef9d441426d