Prioritizing attributes of approaches to analyzing patient-centered outcomes that are truncated due to death in critical care clinical trials: a Delphi study

Authors: Melanie Bahti, Brennan C. Kahan, Fan Li, Michael O. Harhay, Catherine L. Auriemma

Source: Trials, Vol 26, Iss 1, Pp 1-9 (2025)

Subject Terms: Patient-centered outcomes, Truncation due to death, Delphi study, Consensus, Composite outcomes, Statistical approaches, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/5c1fbf0261424e4c9ecbf0585e79e010

Statistical Power and Performance of Strategies to Analyze Composites of Survival and Duration of Ventilation in Clinical Trials

Authors: Ziming Chen, MSc, Michael O. Harhay, PhD, Eddy Fan, MD, PhD, Anders Granholm, MD, Daniel F. McAuley, MD, Martin Urner, MD, Christopher J. Yarnell, MD, Ewan C. Goligher, MD, PhD, Anna Heath, PhD

Source: Critical Care Explorations, Vol 6, Iss 10, p e1152 (2024)

Subject Terms: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/CCE.0000000000001152; https://doaj.org/toc/2639-8028

Access URL: https://doaj.org/article/28444fc2973e46d1818dab9cd8cf50bc

Use of days alive without life support and similar count outcomes in randomised clinical trials – an overview and comparison of methodological choices and analysis methods

Authors: Anders Granholm, Benjamin Skov Kaas-Hansen, Theis Lange, Marie Warrer Munch, Michael O. Harhay, Fernando G. Zampieri, Anders Perner, Morten Hylander Møller, Aksel Karl Georg Jensen

Source: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-12 (2023)

Subject Terms: Days alive without life support, Days alive out of hospital, Count outcomes, Analysis methods, Statistical models, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2288

Access URL: https://doaj.org/article/2b4d970891b04239b440414083f616a4

Causal Bayesian machine learning to assess treatment effect heterogeneity by dexamethasone dose for patients with COVID-19 and severe hypoxemia

Authors: Bryan S. Blette, Anders Granholm, Fan Li, Manu Shankar-Hari, Theis Lange, Marie Warrer Munch, Morten Hylander Møller, Anders Perner, Michael O. Harhay

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a02a02e07780434ab30d93c52075a1c8

Accounting for expected attrition in the planning of cluster randomized trials for assessing treatment effect heterogeneity

Authors: Jiaqi Tong, Fan Li, Michael O. Harhay, Guangyu Tong

Source: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-14 (2023)

Subject Terms: Heterogeneity of treatment effect, Missing data, Missing at random, Missing completely at random, Power calculation, Intracluster correlation coefficient, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2288

Access URL: https://doaj.org/article/c01eadda0e0d4b92a0559137c14cc10b

A comparative study of R functions for clustered data analysis

Authors: Wei Wang, Michael O. Harhay

Source: Trials, Vol 22, Iss 1, Pp 1-8 (2021)

Subject Terms: Clustered data analysis, Cluster randomized trials, Generalized estimating equations, Mixed effects models, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/532b1c26dbba43938bd2073fd0a26764

A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals

Authors: Dustin C. Krutsinger, Kuldeep N. Yadav, Michael O. Harhay, Karsten Bartels, Katherine R. Courtright

Source: Critical Care, Vol 25, Iss 1, Pp 1-8 (2021)

Subject Terms: ARDS, Sepsis, Acute lung injury, Randomized controlled trial, Enrollment, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/1364-8535

Access URL: https://doaj.org/article/2ba4c10700b24b53b253f2cbb4601ceb

Validating a Proteomic Signature of Severe COVID-19

Authors: Christopher V. Cosgriff, MD, MPH, Todd A. Miano, PhD, PharmD, Divij Mathew, PhD, Alexander C. Huang, MD, PhD, Heather M. Giannini, MD, MS, Leticia Kuri-Cervantes, PhD, M. Betina Pampena, PhD, Caroline A. G. Ittner, PhD, Ariel R. Weisman, MS, Roseline S. Agyekum, BS, Thomas G. Dunn, BS, Oluwatosin Oniyide, BS, Alexandra P. Turner, BS, Kurt D’Andrea, BS, Sharon Adamski, BS, Allison R. Greenplate, PhD, Brian J. Anderson, MD, MSCE, Michael O. Harhay, PhD, Tiffanie K. Jones, MD, MPH, MSCE, John P. Reilly, MD, MSCE, Nilam S. Mangalmurti, MD, Michael G. S. Shashaty, MD, MSCE, Michael R. Betts, PhD, E. John Wherry, PhD, Nuala J. Meyer, MD, MS

Source: Critical Care Explorations, Vol 4, Iss 12, p e0800 (2022)

Subject Terms: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/CCE.0000000000000800; https://doaj.org/toc/2639-8028

Access URL: https://doaj.org/article/987a6075e22c4b8b8c873ee3a0bd699e

Mitigating selection bias in organ allocation models

Authors: Erin M. Schnellinger, Edward Cantu, Michael O. Harhay, Douglas E. Schaubel, Stephen E. Kimmel, Alisa J. Stephens-Shields

Source: BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-9 (2021)

Subject Terms: Selection bias, Survivor bias, Transplant benefit, Waitlist urgency, Organ allocation, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2288

Access URL: https://doaj.org/article/226ed4ebbb954aa39ec46ffae841e9cb

The implications of outcome truncation in reproductive medicine RCTs: a simulation platform for trialists and simulation study

Authors: Jack Wilkinson, Jonathan Y. Huang, Antonia Marsden, Michael O. Harhay, Andy Vail, Stephen A. Roberts

Source: Trials, Vol 22, Iss 1, Pp 1-15 (2021)

Subject Terms: Outcome truncation, Truncation by death, Competing risks, Censoring, Hypothetical estimand, Infertility, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/abfd96072df440e4822b0481cc07c364

Dealing with missing delirium assessments in prospective clinical studies of the critically ill: a simulation study and reanalysis of two delirium studies

Authors: Rameela Raman, Wencong Chen, Michael O. Harhay, Jennifer L. Thompson, E. Wesley Ely, Pratik P. Pandharipande, Mayur B. Patel

Source: BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-10 (2021)

Subject Terms: Summary exposure, Missing data, Critical care, Passive imputation, Active imputation, Longitudinal data, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2288

Access URL: https://doaj.org/article/181a038ffa9644309c7feff5d58b0d0e

Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review

Authors: Elizabeth Colantuoni, Mounica Koneru, Narjes Akhlaghi, Ximin Li, Mohamed D. Hashem, Victor D. Dinglas, Karin J. Neufeld, Michael O. Harhay, Dale M. Needham

Source: Trials, Vol 22, Iss 1, Pp 1-12 (2021)

Subject Terms: Systematic review, Randomized trials, Critically ill patients, Delirium, Outcome definition, Statistical methods, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/eb590fe231614c0fb8bb5a160b0d824c

Prevalence, awareness, treatment, and control of hypertension in Nigeria in 1995 and 2020: A systematic analysis of current evidence

Authors: Davies Adeloye, Eyitayo O. Owolabi, Dike B. Ojji, Asa Auta, Mary T. Dewan, Timothy O. Olanrewaju, Okechukwu S. Ogah, Chiamaka Omoyele, Nnenna Ezeigwe, Rex G. Mpazanje, Muktar A. Gadanya, Emmanuel Agogo, Wondimagegnehu Alemu, Akindele O. Adebiyi, Michael O. Harhay

Source: The Journal of Clinical Hypertension, Vol 23, Iss 5, Pp 963-977 (2021)

Subject Terms: clinical management, high blood pressure, hypertension, Nigeria, prevalence, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176

Access URL: https://doaj.org/article/cef2bef63a1b4dde922eaf54a407dc11

Estimating the prevalence of COPD in an African country: evidence from southern Nigeria

Authors: Boni M. Ale, Obianuju B. Ozoh, Muktar A. Gadanya, Yiyang Li, Michael O. Harhay, Akindele O. Adebiyi, Davies Adeloye

Source: Journal of Global Health Reports, Vol 6 (2022)

Subject Terms: Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/2399-1623

Access URL: https://doaj.org/article/151c28f48d8c48cd8b15cc2c73255b38

Estimating the prevalence of overweight and obesity in Nigeria in 2020: a systematic review and meta-analysis

Authors: Davies Adeloye, Janet O. Ige-Elegbede, Martinsixtus Ezejimofor, Eyitayo O. Owolabi, Nnenna Ezeigwe, Chiamaka Omoyele, Rex G. Mpazanje, Mary T. Dewan, Emmanuel Agogo, Muktar A. Gadanya, Wondimagegnehu Alemu, Michael O. Harhay, Asa Auta, Akindele O. Adebiyi

Source: Annals of Medicine, Vol 53, Iss 1, Pp 495-507 (2021)

Subject Terms: Obesity, overweight, prevalence, non-communicable diseases, epidemiology, Nigeria, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060

Access URL: https://doaj.org/article/8150e01a84344421a60616fd727ec25d

Analysis of multicenter clinical trials with very low event rates

Authors: Jiyu Kim, Andrea B. Troxel, Scott D. Halpern, Kevin G. Volpp, Brennan C. Kahan, Tim P. Morris, Michael O. Harhay

Source: Trials, Vol 21, Iss 1, Pp 1-14 (2020)

Subject Terms: Multicenter trial, Binary outcomes, Low event rate, Randomized clinical trial, Random effects, GEE, Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-020-04801-5; https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/26807177589a4fb0a81a3fe7c83f8ffb

Semiparametric estimation of the attributable fraction when there are interactions under monotonicity constraints

Authors: Wei Wang, Dylan S. Small, Michael O. Harhay

Source: BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-8 (2020)

Subject Terms: Attributable fraction, B-splines, Interaction, Monotonicity constraint, Quadratic programming, Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12874-020-01118-4; https://doaj.org/toc/1471-2288

Access URL: https://doaj.org/article/234c23c1f5694a678b9987c80ecdfa4d

Correction: Accounting for expected attrition in the planning of cluster randomized trials for assessing treatment effect heterogeneity

Authors: Jiaqi Tong, Fan Li, Michael O. Harhay, Guangyu Tong

Source: BMC Medical Research Methodology, Vol 23, Iss 1, Pp 1-1 (2023)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2288

Access URL: https://doaj.org/article/60d9b1503fa5409594de86759d19d83e

Current prevalence pattern of tobacco smoking in Nigeria: a systematic review and meta-analysis

Authors: Davies Adeloye, Asa Auta, Ademola Fawibe, Muktar Gadanya, Nnenna Ezeigwe, Rex G. Mpazanje, Mary T. Dewan, Chiamaka Omoyele, Wondimagegnehu Alemu, Michael O. Harhay, Isaac F. Adewole

Source: BMC Public Health, Vol 19, Iss 1, Pp 1-14 (2019)

Subject Terms: Smoking, Tobacco, Prevalence, Non-communicable diseases, Risk, Nigeria, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2458

Access URL: https://doaj.org/article/901953fad06a41fb9b85a97af1a0e949

Assessing the Course of Organ Dysfunction Using Joint Longitudinal and Time-to-Event Modeling in the Vasopressin and Septic Shock Trial

Authors: Michael O. Harhay, PhD, Alessandro Gasparini, PhD, Allan J. Walkey, MD, MS, Gary E. Weissman, MD, MSHP, Michael J. Crowther, PhD, Sarah J. Ratcliffe, PhD, James A. Russell, MD, on behalf of the Vasopressin and Septic Shock Trial (VASST) Investigators, J. A. Russell, K. R. Walley, C. L. Holmes Boulton, J. T. Granton, P. C. Hebert, D. J. Cooper, S. Mehta, J. Singer, A. C. Gordon, M. M. Storms, S. Jones, G. R. Bernard, A. S. Slutsky, G. A. Wells, A. Gasparini, B. Savage, D. Ayers, R. Woods, K. Wu, M. Maralit, L. Smith, K. Foley, A. Suri, M. Steinberg, B. Howe, P. Galt, A. Higgins, M. E. LeBlanc, A. M. Sutherland, A. Sham, A. McLeod, D. R. Dorscheid, M. Hameed, L. Lazosky, S. Helderweirt, C. Honeyman, T. Terins, D. Chittock, J. Ronco, S. Logie, G. Wood, F. Auld, V. Stedham, M. Mantle, L. Fox, G. D. McCauley, J. D. Rolf, C. Erbacher, G. Martinka, S. Goulding, S. Silverwood, L. Leung, S. Keenan, J. Murray, M. Van Osch, B. Light, M. Dominique, P. Gray, R. Stimpson, S. Rosser, D. Bell, W. Janz, T. McArdle, I. Watpool, A. Matte-Martyn, D. J Cook, E. McDonald, F. Clarke, A. Tkaczyk, N. Zytaruk, T. Stewart, C. Martinez-Motta, R. MacDonald, V. Sivanantham, R. Hodder, J. Foxall, M. Lewis, M. Ward, C. Dos Santos, J. Friedrich, D. Scales, O. Smith, I. DeCampos, A. Richards, H. Michalopoulos, U. Bakshi, W. Sibbald, T. Smith, K. Code, B. Bojilov, C. Dale, M. Keogh, M. Meade, L. Hand, C. Martin, J. Kehoe, V. Binns, M. McGuire, G. Poirier, L. Provost, J. Muscedere, C. Diemer, V. Pellegrino, A. Hilton, S. Morrison, C. Weatherburn, K. Moulden, C. Harry, J. J. Presneill, M. S Robertson, J. F. Cade, B. D. Howe, D. K. Barge, C. A. Boyce, F. Healy, C. Wright, D. Weyandt, J. Barrett, C. Walker, S. Burton, G. Dobb, S. Perryman, J. Chamberlain, L. Thomas, A. Bersten, L. Daly, T. Hunt, D. Wood, B. Patel, J. Larson, M. Rady, G. LeBrun, E. Boyd, R. Rush

Source: Critical Care Explorations, Vol 2, Iss 4, p e0104 (2020)

Subject Terms: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/CCE.0000000000000104; https://doaj.org/toc/2639-8028

Access URL: https://doaj.org/article/2056019742ec46f58eab1b0a39ae1800