Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions

Authors: Suifang Mao, Rui Song, Shibo Jin, Song Pang, Aleksandra Jovanovic, Adam Zimmerman, Peng Li, Xinying Wu, Michael F. Wendland, Kerry Lin, Wei-Chi Chen, Semil P. Choksi, Gang Chen, Michael J. Holtzman, Jeremy F. Reiter, Ying Wan, Zhenyu Xuan, Yang K. Xiang, C. Shan Xu, Srigokul Upadhyayula, Harald F. Hess, Lin He

Source: Cell Reports, Vol 44, Iss 3, Pp 115383- (2025)

Subject Terms: CP: Cell biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124725001548; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/afd461f17d574ec5bbf3dcb0a3a93cc2

Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease

Authors: Michael J. Holtzman, Yong Zhang, Kangyun Wu, Arthur G. Romero

Source: European Respiratory Review, Vol 33, Iss 171 (2024)

Subject Terms: Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://err.ersjournals.com/content/33/171/230220.full; https://doaj.org/toc/0905-9180; https://doaj.org/toc/1600-0617

Access URL: https://doaj.org/article/52053c9ec17e48adbc0a4e10ba4774bc

Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

Authors: Ryann M. Fame, Peter N. Kalugin, Boryana Petrova, Huixin Xu, Paul A. Soden, Frederick B. Shipley, Neil Dani, Bradford Grant, Aja Pragana, Joshua P. Head, Suhasini Gupta, Morgan L. Shannon, Fortunate F. Chifamba, Hannah Hawks-Mayer, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Mark L. Andermann, Naama Kanarek, Jonathan O. Lipton, Maria K. Lehtinen

Source: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/65a235ece7c54d3eb0893bd324dbe181

Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate

Authors: Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M. Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J. Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole

Source: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/783639a1891e4da285bddfe49ade0a61

Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia

Authors: Jit Chatterjee, Shilpa Sanapala, Olivia Cobb, Alice Bewley, Andrea K. Goldstein, Elizabeth Cordell, Xia Ge, Joel R. Garbow, Michael J. Holtzman, David H. Gutmann

Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e627dfd988e34a69a26d27c59e8d639b

Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Authors: Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin, Maria K. Lehtinen

Source: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1226adb34adc4634871fcd9db63032d8

Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease

Authors: Ella Katz-Kiriakos, Deborah F. Steinberg, Colin E. Kluender, Omar A. Osorio, Catie Newsom-Stewart, Arjun Baronia, Derek E. Byers, Michael J. Holtzman, Dawn Katafiasz, Kristina L. Bailey, Steven L. Brody, Mark J. Miller, Jennifer Alexander-Brett

Source: JCI Insight, Vol 6, Iss 4 (2021)

Subject Terms: Immunology, Pulmonology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/29001148d51348f79a6b151d3ea730a7

The choroid plexus is an important circadian clock component

Authors: Jihwan Myung, Christoph Schmal, Sungho Hong, Yoshiaki Tsukizawa, Pia Rose, Yong Zhang, Michael J. Holtzman, Erik De Schutter, Hanspeter Herzel, Grigory Bordyugov, Toru Takumi

Source: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/707c2f42059b4009a9d4a81449745eaf

Author Correction: The choroid plexus is an important circadian clock component

Authors: Jihwan Myung, Christoph Schmal, Sungho Hong, Yoshiaki Tsukizawa, Pia Rose, Yong Zhang, Michael J. Holtzman, Erik De Schutter, Hanspeter Herzel, Grigory Bordyugov, Toru Takumi

Source: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1db0fc8e25194b488ad7e28e7f2b10f1

Correction: Tissue-Dependent Consequences of Inactivation on Proliferation and Differentiation of Ciliated Cell Progenitors via Wnt and Notch Signaling.

Authors: Aimin Li, Belinda Chan, Juan C. Felix, Yiming Xing, Min Li, Steven L. Brody, Yong Zhang, Michael J. Holtzman, Zea Borok, Changgong Li, Parviz Minoo

Source: PLoS ONE, Vol 8, Iss 5 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3671936; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6468cb00cbd94979913894738a4e6f4e

Correction: SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells.

Authors: Bret Poat, Sidhartha Hazari, Partha K. Chandra, Feyza Gunduz, Luis A. Balart, Xavier Alvarez, Yong Zhang, Michael J. Holtzman, Srikanta Dash

Source: PLoS ONE, Vol 5, Iss 11 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2993119; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5b76c9a198874723b4ebd54e87ec5c34

The Induction of Pattern-Recognition Receptor Expression against Influenza A Virus through Duox2-Derived Reactive Oxygen Species in Nasal Mucosa.

Authors: Hyun Jik Kim, Chang-Hoon Kim, Min-Ji Kim, Ji-Hwan Ryu, Sang Yeop Seong, Sujin Kim, Su Jin Lim, Michael J. Holtzman, Joo-Heon Yoon

Source: American Journal of Respiratory Cell & Molecular Biology; Oct2015, Vol. 53 Issue 4, p525-535, 11p, 1 Diagram, 7 Graphs

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The autophagy protein ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

Authors: Pooja Popli, Arin K Oestreich, Vineet K Maurya, Marina N Rowen, Yong Zhang, Michael J Holtzman, Ramya Masand, John P Lydon, Shizuo Akira, Kelle Moley, Ramakrishna Kommagani

Source: eLife, Vol 13 (2025)

Subject Terms: autophagy, oviduct, inflammation, pregnancy, Atg14, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/97325; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/932af126b5cc490799966a44ae2f8145

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Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.

Authors: Saul S Siller, Himanshu Sharma, Shuai Li, June Yang, Yong Zhang, Michael J Holtzman, Wipawee Winuthayanon, Holly Colognato, Bernadette C Holdener, Feng-Qian Li, Ken-Ichi Takemaru

Source: PLoS Genetics, Vol 13, Iss 12, p e1007128 (2017)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5747467?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/9320a9d52c3341d98b08f60583384dcf

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Authors: Daniel L Kober, Jennifer M Alexander-Brett, Celeste M Karch, Carlos Cruchaga, Marco Colonna, Michael J Holtzman, Thomas J Brett

Source: eLife, Vol 5 (2016)

Subject Terms: Alzheimer's disease, crystallography, microglia, inflammation, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/20391; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/7f535c3839034845a7ec354cf07f2651

Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease.

Authors: Quentin Philippot, Gaëtan Deslée, Tracy L Adair-Kirk, Jason C Woods, Derek Byers, Susan Conradi, Sandra Dury, Jeanne Marie Perotin, François Lebargy, Christelle Cassan, Richard Le Naour, Michael J Holtzman, Richard A Pierce

Source: PLoS ONE, Vol 9, Iss 5, p e96285 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096285&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/000a7d45cdeb483a8cc8abc4b0d9e971